Microdialysis-coupled place cell detection in the hippocampus: A new strategy for the search for cognition enhancer drugs

Progress in Neuro-Psychopharmacology and Biological Psychiatry

Volumn 21, Issue 2, 1997, Pages 249-271

  Ludvig, Nandor ^a  

^a SUNY DOWNSTATE MEDICAL CENTER   (United States)

Author keywords

cognition enhancer drugs; hippocampus; microdialysis; place cell

Indexed keywords

2 AMINO 4 (METHYLSULFONYL)BUTYRYLGLUTAMYLHISTIDYLPHENYLALANYL DEXTRO LYSYLPHENYLALANINE; 2 ETHYL 8 METHYL 2,8 DIAZASPIRO[4.5]DECANE 1,3 DIONE; 2,8 DIMETHYL 1,3 DIOXA 8 AZASPIRO[4.5]DECANE; AMIRIDINE; ARECOLINE; BETHANECHOL; CORTICOTROPIN DERIVATIVE; DESMOPRESSIN; DONEPEZIL; OXOTREMORINE; PHYSOSTIGMINE; SEGLITIDE; TACRINE; VELNACRINE MALEATE;

ALZHEIMER DISEASE; ANIMAL EXPERIMENT; COGNITION; DRUG DEVELOPMENT; DRUG RESEARCH; HIPPOCAMPUS; MICRODIALYSIS; NONHUMAN; RAT; REVIEW;

ANIMALS; COGNITION; HIPPOCAMPUS; MICRODIALYSIS; PSYCHOTROPIC DRUGS; RATS;

EID: 0030933469     PISSN: 02785846     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0278-5846(97)00001-8     Document Type: Review

References (80)

1. AMARAL, D.G. and INSAUSTI, R. (1990) Hippocampal Formation. In: The Human Nervous System, G. Paxinos (Ed.), pp. 711-755, Academic Press, New York.
2. ARENDT, T., HOLZER, M., FRUTH, R., BRUCKNER, M.K. and GARTNER, U. (1995) Paired helical filament-like phosphorylation of tau, deposition of β/A4-amyloid and memory impairment in rat induced by chronic inhibition of phosphatase 1 and 2A. Neuroscience. 69: 691-698.
3. BAXTER, M.G., ROHRBACH, K.W., TAM, S.W., ZACZEK, R., FRICK, K.M., GOLSKI, S. WAN, R-Q. and OLTON, D.S. (1994) Effects of linopirdine (DuP 996) and X9121 on age-related memory impairments and on the cholinergic system. Drug Dev. Res. 31: 186-196.
4. BENVENISTE, H and HUTTEMEIER, P.C. (1990) Microdialysis - theory and application. Prog. Neurobiol. 35: 195-215.
5. BERGER, T.W. and THOMPSON, R.F. (1978) Identification of pyramidal cells as the critical elements in hippocampal neuronal plasticity during learning. Proc. Natl. Acad. Sci. USA 75: 1572-1576.
6. BLISS, T.V.P. and LOMO, T. (1973) Long-lasting potentiation of synaptic transmission in the dentate area of the anesthetized rabbit following stimulation of the perforant path. J. Physiol. 232: 331-356.
7. BREESE, C.R., HAMPSON, R.E. and DEADWYLER, S.A. (1989) Hippocampal place cells: stereotypy and plasticity. J. Neurosci. 9: 1097-1111.
8. CRICK, F. (1984) Function of the thalamic reticular complex: The searchlight hypothesis. Proc. Natl. Acad. Sci. USA 81: 4586-4590.
9. CUTLER, N.R., HAXBY, J.V., NARANG, P.K., MAY, C., BURG, C. and REINES, S.A. (1985) Evaluation of an analogue of somatostatin (L363,586) in Alzheimer's disease. N. Engl. J. Med. 312: 725.
10. DAVIES, P. and MALONEY, A.J.F. (1976) Selective loss of central cholinergic neurons in Alzheimer's disease. Lancet 2: 1403.
11. DEUTSCH, J.A. (1971) The cholinergic synapse and the site of memory. Science 174: 788-794.
12. DEVANAND, D.P., SACKEIM, H.A., BROWN, R.P. and MAYEUX, R. (1989) A pilot study of haloperidol treatment of psychosis and behavioral disturbance in Alzheimer's disease. Arch. Neurol. 46: 854-857.
13. 2 antagonists as potential drugs for cognitive disorders. Drugs Fut. 20: 157-164.
14. DUARA, R., GRADY, C., HAXBY, J., INGVAR, D., SOKOLOFF, L., MARGOLIN, R.A., MANNING, R.G., CUTLER, N.R. and RAPOPORT, S.I. (1984) Human brain glucose utilization and cognitive function in relation to age. Ann. Neurol. 16: 702-713.
15. EICHENBAUM, H. and COHEN, N.J. (1988) Representation in the hippocampus: what do hippocampal neurons code? TiNS 11: 244-248.
16. FOSTER, T.C., CASTRO, C.A. and McNAUGHTON, B.L. (1989) Spatial selectivity of rat hippocampal neurons: dependence on preparedness for movement. Science 244:1580-1582.
17. FOX, S.E. (1990) A model of the enhanced location-specific firing of CA1 pyramids during translational movements. Soc. Neurosci. Abstr. 16: 1097.
18. FOX, S.E. and RANCK, J.B., Jr. (1981) Electrophysiological characteristics of hippocampal complex-spike cells and theta cells. Exp. Brain Res. 41: 399-410.
19. FOX, S.E., LUDVIG, N., KUBIE, J.L., MULLER, R.U., STEAD, M. and FENTON, A. (1996) The effects of scopolamine, delivered via intrahippocampal microdialysis, on the firing of local place cells. Soc. Neurosci. Abstr. 22: 431.
20. FROSTL, W. and MAITRE, L. (1989) The families if cognition enhancers. Pharmacopsychiat. 22: 54-100.
21. GOULIAEV, A.M. and SENNING, A. (1994) Piracetam and other structurally related nootropics. Brain Res. Rev. 19: 180-222.
22. HEBB, D.O. (1949) The Organization of Behavior. Wiley & Sons, New York.
23. HEISE, G.A. (1987) Facilitation of memory and cognition by drugs. TiPS 8: 65-68.
24. HODES, R.J. (1994) Alzheimer's disease: treatment research finds new targets. J. Am. Geriatr. Soc. 42: 679-681.
25. HUGHES, J.R., WILLIAMS, J.G. and CURRIER, R.D. (1976) An ergot alkaloid preparation (Hydergine) in the treatment of dementia: critical review of the clinical literature. J. Am. Geriatr. Soc. 24: 490-497.
26. JOHNSTON, M.V. (1992) Cognitive Disorders. In: Principles of Drug Therapy in Neurology, M.V. Johnston, R.L. Macdonald and A.B. Young (Eds.), pp 226-267, F.A. Davis Company, Philadelphia.
27. KARPATI, E. and SZPORNY, L. (1976) General and cerebral haemodynamic activity of ethyl apovincaminate. Arzneim.-Forsch. 26: 1908-1912.
28. KOVACS, G.L. and DE WIED, D. (1994) Peptidergic modulation of learning and memory processes. Pharmacol. Rew. 46: 269-291.
29. LARSON, J. and LYNCH, G. (1986) Induction of synaptic potentiation in hippocampus by patterned stimulation involves two events. Science 232: 985-988.
30. LeDOUX, J.E. (1993) Emotional memory systems in the brain. Behav. Brain Res. 58: 69-79.
31. LUDVIG, N., MISHRA, P.K., YAN, Q.S., LASLEY, S.M., BURGER, R.L. and JOBE, P.C. (1992a) The combined EEG - intracerebral microdialysis technique: a new tool for neuropharmacological studies on freely behaving animals. J. Neurosci. Meth. 43: 129-137.
32. LUDVIG, N., LASLEY, S.M. and JOBE, P.C. (1992b) Stimulation of the cAMP system potentiates the excitatory effects of NMDA in the rat hippocampus, in vivo. Soc.Neurosci. Abstr. 18: 106.
33. LUDVIG, N., POTTER, P.E. and FOX. S.E. (1994a) Simultaneous single-cell recording and microdialysis within the same brain site in freely behaving rats: a novel neurobiological method. J. Neurosci. Meth. 55: 31-40.
34. LUDVIG, N., POTTER, P.E. and FOX. S.E. (1994b) The combined single cell recording -intracerebral microdialysis method in freely behaving rats. Neurosci. Prot. module 4 (section 070): 1-17.
35. LUDVIG, N., ALTURA, B.T., FOX, S.E. and ALTURA, B.M. (1995) The suppressant effect of ethanol, delivered via intrahippocampal microdialysis, on the firing of local pyramidal cells in freely behaving rats. Alcohol 12: 417-421.
36. + via microdialysis. Hippocampus 6: 97-108.
37. MANNING, F.C. (1994) Tacrine therapy for the dementia of Alzheimer's disease. Am. Fam. Physician. 50:819-823.
38. MARIN, D.B. and DAVIS, K.L. (1995) Experimental Therapeutics. In: Psychopharmacology: the Fourth Generation of Progress, F.E.Bloom and D.J. Kupfer (Eds.), pp 1417-1426, Raven Press, New York.
39. MARKRAM, H. and SEGAL, M. (1990) Acetylcholine potentiates responses to N-methyl-D-aspartate in the rat hippocampus. Neurosci. Lett. 113: 62-65.
40. MAYEUX, R. (1990) Therapeutic strategies in Alzheimer's disease. Neurology 40: 175-180.
41. MAYFORD, M., ABEL, T. and KANDEL, E.R. (1995) Transgenic approaches to cognition. Curr. Opin. Neurobiol. 5: 141-148.
42. McEWEN, B.S. and SAPOLSKY, R.M. (1995) Stress and cognitive function. Curr. Opin. Neurobiol. 5: 205-216.
43. McNAMARA, R.K. and SKELTON, R.W. (1993) The neuropharmacological and neurochemical basis of place cell learning in the Morris water maze. Brain Res. Rev. 18: 33-49,
44. McNAUGHTON, B.L., BARNES, C.A., GERRARD, J.L., GOTHARD, K., JUNG, M.W., KNIERIM, J.J., KUDRIMOTI, H., QIN, Y., SKAGGS, W.E., SUSTER, M. and WEAVER, K.L. (1996) Deciphering the hippocampal polyglot: the hippocampus as a path integration system. J. Exp. Biol. 199: 173-185.
45. MOLLER H.J., MAURER, I. and SALETU, B. (1994) Placebo-controlled trial of the xanthine derivative propentofylline in dementia. Pharmacopsychiat. 27:159-165.
46. MONDADORI, C. (1994) In search of the mechanism of action of the nootropics: new insights and potential clinical implications. Life Sci. 55: 2171-2178.
47. MULLER, R.U., KUBIE, J.L. AND RANCK, J.B., Jr. (1987) Spatial firing patterns of hippocampal complex-spike cells in a fixed environment. J. Neurosci. 7: 1935-1950.
48. MULLER, R.U. and KUBIE, J.L. (1987) The effects of changes in the environment on the spatial firing of hippocampal complex-spike cells. J. Neurosci. 7: 1951-1968.
49. MULLER, R.U., STEAD, M. and PACH, J. (1996) The hippocampus as a cognitive graph. J. Gen. Physiol. 107: 663-694.
50. NAPPI, G., FACCHINETTI, F., MARTIGNONI, E., PETRAGLIA, F., SINFORIANI, E., BONO, G. and GENAZZANI, A.R. (1988) N-terminal ACTH fragments increase the CSF β-EP content in Alzheimer type dementia. Acta Neurol. Scand. 78: 146-151.
51. NICHOLSON, C.D. (1990) Pharmacology of nootropics and metabolically active compounds in relation to their use in dementia. Psychopharmacol. 101: 147-159.
52. NORDBERG, A. (1993) Clinical studies in Alzheimer patients with positron emission tomography. Behav. Brain Res. 57: 215-224.
53. O'KEEFE, J. and DOSTROVSKY, J. (1971) The hippocampus as a spatial map. Preliminary evidence from unit activity in the freely-moving rat. Brain Res. 34: 171-175.
54. O'KEEFE, J. (1979) A review of the hippocampal place cells. Prog. Neurobiol. 13: 419-439.
55. O'KEEFE, J. and NADEL, L. (1978) The Hippocampus as a Cognitive Map. Clarendon Press, Oxford.
56. OLTON, S., BECKER, J.T. and HANDELMANN, G.E. (1979) Hippocampus, space, and memory. Behav. Brain Sci. 2: 313-365.
57. OTTO, T., EICHENBAUM, H., WIENER, S.I. and WIBLE, C.G. (1991) Learning-related patterns of CA1 spike trains parallel stimulation parameters optimal for inducing hippocampal long-term potentiation. Hippocampus 1: 181-192.
58. PAVLIDES, C. and WINSON, J. (1989) Influences of hippocampal place cell firing in the awake state on the activity of these cells during subsequent sleep episodes. J. Neurosci. 9: 2907-2918.
59. PEABODY, C.A., DAVIES, H., BERGER, P.A. and TINKLENBERG, J.R. (1986) Desamino-D-arginine-vasopressin (DDAVP) in Alzheimer's disease. Neurobiol. Aging 7: 301-303.
60. PETRIDES, M., ALIVISATOS, B., MEYER, E. and EVANS, A.C. (1993) Functional activation of the human frontal cortex during the performance of verbal working memory tasks. Proc. Natl. Acad. Sci. USA 90: 878-882.
61. PORSOLT, R.D., ROUX, S. and WETTSTEIN, J.G. (1995) Animal models of dementia. Drug Dev. Res. 35: 214-229.
62. ROGERS, R.L., MEYER, J.S., MORTEL, K.F., MAHURIN, R.K. and JUDD, B.W. (1986) Decreased cerebral blood flow precedes multi-infarct dementia, but follows senile dementia of Alzheimer type. Neurology 36: 1-6.
63. SALETU, B., ANDERER, P., FISCHHOF, P.K., LORENZ, H., BAROUSCH, R. and BOHMER, F. (1992) EEG mapping and psychopharmacological studies with denbufylline in SDAT and MID. Biol. Psychiatry 32: 668-681.
64. SANGER, D.J. and JOLY, D. (1990) Keynote lecture 5: psychopharmacological strategies in the search for cognition enhancers. Pharmacopsychiat. 23 (Suppl): 70-74.
65. SARTER, M. (1991) Taking stock of cognition enhancers. TiPS 12: 456-461.
66. SARTER, M., HAGAN, J. and DUDCHENKO, P. (1992) Behavioral screening for cognition enhancers: from indiscriminate to valid testing: Part I. Psychopharmacol. 107: 144-159.
67. SCOVILLE, W.B. and MILNER, B. (1957) Loss of recent memory after bilateral hippocampal lesions. J. Neurol. Neurosurg. Psychiat. 20: 11-21.
68. SQUIRE, L.R. and ZOLA-MORGAN, S. (1991) The medial temporal lobe memory system. Science 253: 1380-1386.
69. STAUBLI, U. and LYNCH, G. (1987) Stable hippocampal long-term potentiation elicited by 'theta' pattern stimulation. Brain Res. 435: 227-234.
70. SUNDERLAND, T., WEINGARTNER, H., COHEN, R.M., TARIOT, P.N., NEWHOUSE, P.A., THOMPSON, K.E., LAWLOR, B.A. and MUELLER, E.A. (1989) Low-dose oral lorazepam administration in Alzheimer subjects and age-matched controls. Psychopharmacol. 99: 129-133.
71. TARIOT, P.N., SUNDERLAND, T., WEINGARTNER, H., MURPHY, D.L., WELKOWITZ, J.A., THOMPSON, K. and COHEN, R.M. (1987) Cognitive effects of L-deprenyl in Alzheimer's disease. Psychopharmacol. 91: 489-495.
72. TERRY, R.D., MASLIAH, E., SALMON, D.P., BUTTERS, N., DiTERESA, R., HILL, R., HANSEN, L.A. and KATZMAN, R. (1991) Physical basis of cognitive alterations in Alzheimer's disease: synapse loss is the major correlate of cognitive impairment. Ann. Neurol. 30: 572-580.
73. THAL, L.J., SALMON, D.P., LASKER, B., BOWER, D. and KLAUBER, M.R. (1989) The safety and lack of efficacy of vinpocetine in Alzheimer's disease. J. Am. Geriatr. Soc. 37: 515-520.
74. THOMPSON, L.T. and BEST, P.J. (1990) Long-term stability of the place-field activity of single units recorded from the dorsal hippocampus of freely behaving rats. Brain Res. 509: 299-308.
75. THOMPSON II, T.L., FILLEY, C.M., MITCHELL, W.D., CULIG, K.M., LoVERDE, M. and BYYNY, R.L. (1990) Lack of efficacy of Hydergine in patients with Alzheimer's disease. N. Engl. J. Med. 323: 445-448.
76. VIZI, E.S. and LABOS, E. (1991) Non-synaptic interactions at presynaptic level. Prog. Neurobiol. 37: 145-163.
77. WILSON, M.A. and McNAUGHTON, B.L. (1993) Dynamics of the hippocampal ensemble code for space. Science 261: 1055-1058.
78. WOLTHUIS, O.L. (1971) Experiments with UCB 6215, a drug which enhances acquisition in rats: its effects compared with those of metamphetamine. Eur. J. Pharmacol. 16: 283-297.
79. ZILLES, K. and WREE, A (1985) Cortex: areal and laminar structure. In: The Rat Nervous System. G. Paxinos (Ed.), pp 375-415, Academic Press, New York.
80. ZOLA-MORGAN, S.M. and SQUIRE, L.R. (1990) The primate hippocampal formation: evidence for a time-limited role in memory storage. Science 250: 288-289.