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Volumn 16, Issue 1, 1997, Pages 3-10

Bcl-2: The pendulum of the cell fate

Author keywords

apoptotic pathway; bcl 2

Indexed keywords

PROTEIN BCL 2;

EID: 0030933092     PISSN: 03929078     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review
Times cited : (10)

References (76)
  • 1
    • 0021821903 scopus 로고
    • Involvement of the bcl-2 gene in human follicular lymphoma
    • Tsujimoto Y., Cossman J., Jaffe E., Croce C.: Involvement of the bcl-2 gene in human follicular lymphoma. Science 228: 1440-1443, 1985.
    • (1985) Science , vol.228 , pp. 1440-1443
    • Tsujimoto, Y.1    Cossman, J.2    Jaffe, E.3    Croce, C.4
  • 2
    • 0022546957 scopus 로고
    • Analysis of the structure, transcripts, and protein products of bcl-2, the gene involved in human follicular lymphoma
    • Tsujimoto Y., Croce C.M.: Analysis of the structure, transcripts, and protein products of bcl-2, the gene involved in human follicular lymphoma. Proc. Natl. Acad. Sci. USA. 83: 5214-5218, 1986.
    • (1986) Proc. Natl. Acad. Sci. USA , vol.83 , pp. 5214-5218
    • Tsujimoto, Y.1    Croce, C.M.2
  • 3
    • 0023944248 scopus 로고
    • The reciprocal partners of both the t(14;18) and t(11;14) translocations involved in B-cell neoplasms are rearranged by the same mechanisms
    • Tsujimoto Y., Louie E., Bashir M.M., Croce C.M.: The reciprocal partners of both the t(14;18) and t(11;14) translocations involved in B-cell neoplasms are rearranged by the same mechanisms. Oncogene 2: 347-351, 1988.
    • (1988) Oncogene , vol.2 , pp. 347-351
    • Tsujimoto, Y.1    Louie, E.2    Bashir, M.M.3    Croce, C.M.4
  • 4
    • 0018749839 scopus 로고
    • Chromosome abnormalities in poorly differentiated lymphocytic lymphoma
    • Fukuhara S., Rowley J.D., Varrakojis D., Golomb H.M.: Chromosome abnormalities in poorly differentiated lymphocytic lymphoma. Cancer Research 39: 3119-3123, 1979.
    • (1979) Cancer Research , vol.39 , pp. 3119-3123
    • Fukuhara, S.1    Rowley, J.D.2    Varrakojis, D.3    Golomb, H.M.4
  • 6
    • 0022379447 scopus 로고
    • The t(14;18) chromosome translocations involved in B-cell neoplasms result from mistakes in VDJ joining
    • Tsujimoto Y., Gorham J., Cossman J., Jaffe E., Croce C.M.: The t(14;18) chromosome translocations involved in B-cell neoplasms result from mistakes in VDJ joining. Science 229: 1390-1393, 1985.
    • (1985) Science , vol.229 , pp. 1390-1393
    • Tsujimoto, Y.1    Gorham, J.2    Cossman, J.3    Jaffe, E.4    Croce, C.M.5
  • 7
    • 0021934042 scopus 로고
    • Cloning the chromosomal breakpoint of t(14;18) human lymphomas: Clustering around JH on chromosome 14 and near a transcriptional unit on chromosome 18
    • Bakhshi A., Jensen J.P., Goldman P., Wrigth J.J., McBride O.W., Epstein A.L., Korsmeyer S.J:. Cloning the chromosomal breakpoint of t(14;18) human lymphomas: Clustering around JH on chromosome 14 and near a transcriptional unit on chromosome 18. Cell 41: 899-906, 1985.
    • (1985) Cell , vol.41 , pp. 899-906
    • Bakhshi, A.1    Jensen, J.P.2    Goldman, P.3    Wrigth, J.J.4    McBride, O.W.5    Epstein, A.L.6    Korsmeyer, S.J.7
  • 8
    • 0345599219 scopus 로고    scopus 로고
    • Cytogenetics of neoplasia
    • M.I. Greene and T. Hamaoka, editors. Plenum Publishing Corporation. New York
    • Nowell P.C., and Croce C.M.: Cytogenetics of neoplasia. In Development and Recognition of the Transformed Cell. M.I. Greene and T. Hamaoka, editors. Plenum Publishing Corporation. New York.
    • Development and Recognition of the Transformed Cell
    • Nowell, P.C.1    Croce, C.M.2
  • 9
    • 0022541272 scopus 로고
    • Detection of a second t(14;18) breakpoint cluster region in human follicular lymphomas
    • Cleary M.L., Galili N., Sklar J.: Detection of a second t(14;18) breakpoint cluster region in human follicular lymphomas. J. Exp. Med. 164: 315-320, 1986.
    • (1986) J. Exp. Med. , vol.164 , pp. 315-320
    • Cleary, M.L.1    Galili, N.2    Sklar, J.3
  • 10
    • 0023779204 scopus 로고
    • Alternative promoters and exons, somatic mutation and transcriptional deregulation of the Bcl-2-Ig fusion gene in lymphoma
    • Seto M., Jaeger U., Hockett R.D., Graninger W., Bennett S., Goldman P., Korsmeyer S.J.: Alternative promoters and exons, somatic mutation and transcriptional deregulation of the Bcl-2-Ig fusion gene in lymphoma. EMBO J. 7: 123-131, 1988.
    • (1988) EMBO J. , vol.7 , pp. 123-131
    • Seto, M.1    Jaeger, U.2    Hockett, R.D.3    Graninger, W.4    Bennett, S.5    Goldman, P.6    Korsmeyer, S.J.7
  • 11
    • 0022971142 scopus 로고
    • Cloning and structural analysis of cDNAs for bcl-2 and a hybrid bcl-2/immunoglobulin transcript resulting from the t(14;18) translocation
    • Cleary M.L., Smith S.D., Sklar J.: Cloning and structural analysis of cDNAs for bcl-2 and a hybrid bcl-2/immunoglobulin transcript resulting from the t(14;18) translocation. Cell 47: 19-26, 1986.
    • (1986) Cell , vol.47 , pp. 19-26
    • Cleary, M.L.1    Smith, S.D.2    Sklar, J.3
  • 12
    • 0025204548 scopus 로고
    • Bcl-2 is an inner mitochondrial membrane protein that blocks programmed cell death
    • Hockenbery D., Nunez G., Milliman C., Schreiber R.D., Korsmeyer S.J.: Bcl-2 is an inner mitochondrial membrane protein that blocks programmed cell death. Nature 348: 334-336, 1990.
    • (1990) Nature , vol.348 , pp. 334-336
    • Hockenbery, D.1    Nunez, G.2    Milliman, C.3    Schreiber, R.D.4    Korsmeyer, S.J.5
  • 13
    • 0024501122 scopus 로고
    • The bcl-2 candidate proto oncogene product is a 24-kilodalton integral-membrane protein highly expressed in lymphoid cell lines and lymphomas carrying the t(14;18) traslocation
    • Chen-Levy Z., Nourse J., Cleary M.L.: The bcl-2 candidate proto oncogene product is a 24-kilodalton integral-membrane protein highly expressed in lymphoid cell lines and lymphomas carrying the t(14;18) traslocation. Mol. Cell. Biol. 9: 701-706, 1989.
    • (1989) Mol. Cell. Biol. , vol.9 , pp. 701-706
    • Chen-Levy, Z.1    Nourse, J.2    Cleary, M.L.3
  • 14
    • 0025213270 scopus 로고
    • Membrane topology of the bcl-2 proto oncogenic protein demonstrated in vitro
    • Chen-Levy S. and Cleary M.L.: Membrane topology of the bcl-2 proto oncogenic protein demonstrated in vitro. J. Biol. Chem. 265: 4929-4933, 1990.
    • (1990) J. Biol. Chem. , vol.265 , pp. 4929-4933
    • Chen-Levy, S.1    Cleary, M.L.2
  • 15
    • 0027362667 scopus 로고
    • Investigations of the subcellular distribution of the BCL-2 oncoprotein: Residence in the nuclear envelope, endoplasmic reticulum, and outer mithocondrial membranes
    • Krajewski S., Tanaka S., Takayama S., Schibler M.J., Fenton W., and Reed J.C.: Investigations of the subcellular distribution of the BCL-2 oncoprotein: residence in the nuclear envelope, endoplasmic reticulum, and outer mithocondrial membranes. Cancer Research 53: 4701-4714, 1993.
    • (1993) Cancer Research , vol.53 , pp. 4701-4714
    • Krajewski, S.1    Tanaka, S.2    Takayama, S.3    Schibler, M.J.4    Fenton, W.5    Reed, J.C.6
  • 16
    • 0025204548 scopus 로고
    • Bcl-2 is an inner mithocondrial membrane protein that blocks programmed cell death
    • Hockembery D., Nunez G., Milliman C., Schreiber R.D., and Korsmeyer SJ.: Bcl-2 is an inner mithocondrial membrane protein that blocks programmed cell death. Nature (Lond.) 348: 334-336, 1990.
    • (1990) Nature (Lond.) , vol.348 , pp. 334-336
    • Hockembery, D.1    Nunez, G.2    Milliman, C.3    Schreiber, R.D.4    Korsmeyer, S.J.5
  • 19
    • 0028176651 scopus 로고
    • Oxidative stress as a mediator of apoptosis
    • Buttke T.M. and Sandstrom P.A.: Oxidative stress as a mediator of apoptosis. Immunol. Today 15: 7-10, 1994.
    • (1994) Immunol. Today , vol.15 , pp. 7-10
    • Buttke, T.M.1    Sandstrom, P.A.2
  • 22
    • 0028893492 scopus 로고
    • Superoxide dismutase delays neuronal apoptosis: A role for reactive oxgen species in programmed neuronal death
    • Greenlund L.J.S, Deckwerth T.L and Johnson E.M.J.: Superoxide dismutase delays neuronal apoptosis: a role for reactive oxgen species in programmed neuronal death. Neuron 14: 303-315, 1995.
    • (1995) Neuron , vol.14 , pp. 303-315
    • Greenlund, L.J.S.1    Deckwerth, T.L.2    Johnson, E.M.J.3
  • 24
    • 0026345023 scopus 로고
    • Attenuation of focal cerebral ischemic injury in transgenic mice overexpressing CuZn superoxide dismutase
    • Kinouchi H., Epstein C.J., Mizui T., Carlson E., Chen S.F., and Chaan P.H.: Attenuation of focal cerebral ischemic injury in transgenic mice overexpressing CuZn superoxide dismutase. Proc. Natl. Acad. Sci. USA 11158-11162, 1991.
    • (1991) Proc. Natl. Acad. Sci. USA , pp. 11158-11162
    • Kinouchi, H.1    Epstein, C.J.2    Mizui, T.3    Carlson, E.4    Chen, S.F.5    Chaan, P.H.6
  • 25
    • 0029052332 scopus 로고
    • The bcl-2 family of proteins, and the regulation of neuronal survival
    • Davies A.M.: The bcl-2 family of proteins, and the regulation of neuronal survival. Trends Nurosci. 18: 355-358, 1995.
    • (1995) Trends Nurosci. , vol.18 , pp. 355-358
    • Davies, A.M.1
  • 26
    • 0025835716 scopus 로고
    • Bcl-2 protein is topographically restricted in tissues characterized by apoptotic cell death
    • Hockenbery D., Zutter M., Hickey W., Nahm M., Korsmeyer S.J.: Bcl-2 protein is topographically restricted in tissues characterized by apoptotic cell death. Proc. Natl. Acad. Sci. USA 88: 6961-6965, 1991.
    • (1991) Proc. Natl. Acad. Sci. USA , vol.88 , pp. 6961-6965
    • Hockenbery, D.1    Zutter, M.2    Hickey, W.3    Nahm, M.4    Korsmeyer, S.J.5
  • 27
    • 0025341687 scopus 로고
    • Expression of the bcl-2 oncogene protein is not specific for the 14;18 chromosome translocation
    • Pezzella F., Tse A.G., Cordell J.L., Pulford K.A.F., Guter K.C., Mason R.Y.: Expression of the bcl-2 oncogene protein is not specific for the 14;18 chromosome translocation. Am. J. Path. 137: 225-228, 1990.
    • (1990) Am. J. Path. , vol.137 , pp. 225-228
    • Pezzella, F.1    Tse, A.G.2    Cordell, J.L.3    Pulford, K.A.F.4    Guter, K.C.5    Mason, R.Y.6
  • 28
    • 0026655474 scopus 로고
    • Bcl-2 initiates a new category of oncogenes: Regulator of cell death
    • Kormayer S.: Bcl-2 initiates a new category of oncogenes: regulator of cell death. Blood. 80: 879-886, 1992.
    • (1992) Blood , vol.80 , pp. 879-886
    • Kormayer, S.1
  • 29
    • 0027172322 scopus 로고
    • Molecular regulation of apoptosis: Genetic controls on cell death
    • Williams G.T., Smith C.A.: Molecular regulation of apoptosis: Genetic controls on cell death. Cell 74: 777-779, 1993.
    • (1993) Cell , vol.74 , pp. 777-779
    • Williams, G.T.1    Smith, C.A.2
  • 31
    • 0027166048 scopus 로고
    • Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programmed cell death
    • Oltvai Z.N., Milliman C.L. and Korsmeyer S.: Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programmed cell death. Cell 74: 609-619, 1993.
    • (1993) Cell , vol.74 , pp. 609-619
    • Oltvai, Z.N.1    Milliman, C.L.2    Korsmeyer, S.3
  • 32
    • 0027480450 scopus 로고
    • MCL1, a gene expressed in programmed myeloid cell differentiation, has sequence similarity to Bcl-2
    • Kozopas K.M., Yang T., Buchan H.L., Zhou P., and Craig R.W.: MCL1, a gene expressed in programmed myeloid cell differentiation, has sequence similarity to Bcl-2. Proc. Natl. Acad. Sci. USA 90: 3516-3520, 1993.
    • (1993) Proc. Natl. Acad. Sci. USA , vol.90 , pp. 3516-3520
    • Kozopas, K.M.1    Yang, T.2    Buchan, H.L.3    Zhou, P.4    Craig, R.W.5
  • 33
    • 0027326012 scopus 로고
    • Characterization of Al, a novel haemopoietic-specific early response gene with sequence similarity to bcl-2
    • Lin E.Y., Orlofsky A., Berger M.S., and Prystowsky M.B.: Characterization of Al, a novel haemopoietic-specific early response gene with sequence similarity to bcl-2. J. Immunol. 151: 1979-1988, 1993.
    • (1993) J. Immunol. , vol.151 , pp. 1979-1988
    • Lin, E.Y.1    Orlofsky, A.2    Berger, M.S.3    Prystowsky, M.B.4
  • 34
    • 0028809209 scopus 로고
    • Bad, a heterodimeric partner for Bcl-2, displaces Bax and promotes cell death
    • Yang E., Zha J., Jockel J., Boise L.H., Thompson C.B., and Korsmeyer S.: Bad, a heterodimeric partner for Bcl-2, displaces Bax and promotes cell death. Cell 80: 285-291, 1995.
    • (1995) Cell , vol.80 , pp. 285-291
    • Yang, E.1    Zha, J.2    Jockel, J.3    Boise, L.H.4    Thompson, C.B.5    Korsmeyer, S.6
  • 38
    • 0028847915 scopus 로고
    • Cloning and functional analysis of BAG-1: A novel bcl-2 binding protein with anti-cell death activity
    • Takayama S., Sato T., Krajewski S., Kockel K., Irie S., Millan J.A., Reed J.C.: Cloning and functional analysis of BAG-1: A novel bcl-2 binding protein with anti-cell death activity. Cell. 80: 279-288, 1995.
    • (1995) Cell , vol.80 , pp. 279-288
    • Takayama, S.1    Sato, T.2    Krajewski, S.3    Kockel, K.4    Irie, S.5    Millan, J.A.6    Reed, J.C.7
  • 39
    • 0027525536 scopus 로고
    • Targeting of bcl-2 to the mitochondrial outer membrane by a COOH-terminal signal anchor sequence
    • Nguyen M., Millar D.G., Yong V.W, Korsmeyer S.J., Shore G.C.: Targeting of bcl-2 to the mitochondrial outer membrane by a COOH-terminal signal anchor sequence. J. Biol. Chem. 268: 2565-2568, 1993.
    • (1993) J. Biol. Chem. , vol.268 , pp. 2565-2568
    • Nguyen, M.1    Millar, D.G.2    Yong, V.W.3    Korsmeyer, S.J.4    Shore, G.C.5
  • 40
    • 0027225445 scopus 로고
    • Structure-function analysis of the bcl-2 oncoprotein
    • Tanaka S., Saito K. and Reed J.C.: Structure-function analysis of the bcl-2 oncoprotein. J. Biol. Chem. 268: 10920-10926, 1993.
    • (1993) J. Biol. Chem. , vol.268 , pp. 10920-10926
    • Tanaka, S.1    Saito, K.2    Reed, J.C.3
  • 42
    • 0029899181 scopus 로고    scopus 로고
    • Molecular Thanatopsis: A discourse on the BCL2 family and cell death
    • Yang E., and Korsmeeyer S.: Molecular Thanatopsis: A discourse on the BCL2 family and cell death. Blood. Vol. 88, No 2: 386-401, 1996.
    • (1996) Blood , vol.88 , Issue.2 , pp. 386-401
    • Yang, E.1    Korsmeeyer, S.2
  • 44
    • 0028206341 scopus 로고
    • BH1 and BH2 domains of bcl-2 are required for inhibition of apoptosis and heterodimerization with bax
    • Yin X.M., Oltvai Z.N. and Korsmeyer SJ.: BH1 and BH2 domains of bcl-2 are required for inhibition of apoptosis and heterodimerization with bax. Nature 369: 321-323, 1994.
    • (1994) Nature , vol.369 , pp. 321-323
    • Yin, X.M.1    Oltvai, Z.N.2    Korsmeyer, S.J.3
  • 45
    • 0028609620 scopus 로고
    • Mcl-1, a member of the bcl-2 family, delays apoptosis induced by c myc overexpression in Chinese hamster ovary cells
    • Reynolds J.E., Yang T., Qian L., Jenkinson J.D., Eastman A., Craig R.W.: Mcl-1, a member of the bcl-2 family, delays apoptosis induced by c myc overexpression in Chinese hamster ovary cells. Cancer Res. 64: 6348-6352, 1994.
    • (1994) Cancer Res. , vol.64 , pp. 6348-6352
    • Reynolds, J.E.1    Yang, T.2    Qian, L.3    Jenkinson, J.D.4    Eastman, A.5    Craig, R.W.6
  • 46
    • 0028040019 scopus 로고
    • Bcl-2 and the regulation of programmed cell death
    • Reed J.C. Bcl-2 and the regulation of programmed cell death. J. Cell. Biol. 124: 1-6, 1994
    • (1994) J. Cell. Biol. , vol.124 , pp. 1-6
    • Reed, J.C.1
  • 47
    • 0028958030 scopus 로고
    • Bcl-2: Prevention of apoptosis as a mechanism of drug resistance
    • Reed J.C.: Bcl-2: prevention of apoptosis as a mechanism of drug resistance. Hematol. Oncol. Clin. North. Am. 9: 451-474, 1995.
    • (1995) Hematol. Oncol. Clin. North. Am. , vol.9 , pp. 451-474
    • Reed, J.C.1
  • 48
    • 12644250580 scopus 로고
    • Enhanced expression of bcl-2 and the progression of human and rodent prostatic cancers
    • Furuya Y., Krajewski S., Epstein J.I., Reed J.C., Isaacs J.T.: Enhanced expression of bcl-2 and the progression of human and rodent prostatic cancers. Clin. Cancer Res. 11: 321-326, 1993.
    • (1993) Clin. Cancer Res. , vol.11 , pp. 321-326
    • Furuya, Y.1    Krajewski, S.2    Epstein, J.I.3    Reed, J.C.4    Isaacs, J.T.5
  • 49
    • 0003047959 scopus 로고
    • BCL-2 protooncogene expression in normal, hyperplastic, and neoplastic prostate tissue
    • Shabaik A.S., Krajewski S., Burgan A., Krajewska M., Reed J.C.: BCL-2 protooncogene expression in normal, hyperplastic, and neoplastic prostate tissue. J. Urol. Pathol. 3: 17-27, 1994.
    • (1994) J. Urol. Pathol. , vol.3 , pp. 17-27
    • Shabaik, A.S.1    Krajewski, S.2    Burgan, A.3    Krajewska, M.4    Reed, J.C.5
  • 50
    • 0028814213 scopus 로고
    • BCL-2 protooncogene and the gastrointestinal epithelial tumor progression model
    • Bronner M., Culin C., Reed J.C., Furth E.E.: BCL-2 protooncogene and the gastrointestinal epithelial tumor progression model. Am. J. Pathol. 146: 20-26, 1995.
    • (1995) Am. J. Pathol. , vol.146 , pp. 20-26
    • Bronner, M.1    Culin, C.2    Reed, J.C.3    Furth, E.E.4
  • 53
    • 0027286622 scopus 로고
    • A negative regulatory element in the bcl-2 5′-untranslated region inhibits expression from an upstream promoter
    • Young R.L. and Korsmeyer S.: A negative regulatory element in the bcl-2 5′-untranslated region inhibits expression from an upstream promoter. Molecular and Cellular Biology 13: 3686-3697, 1993.
    • (1993) Molecular and Cellular Biology , vol.13 , pp. 3686-3697
    • Young, R.L.1    Korsmeyer, S.2
  • 54
    • 0028292480 scopus 로고
    • Identification of a p53 dependent negative response element in the bcl-2 gene
    • Miyashita T., Harigai M., Hanada M., Reed J.C.: Identification of a p53 dependent negative response element in the bcl-2 gene. Cancer Res. 54: 3131-3135, 1994.
    • (1994) Cancer Res. , vol.54 , pp. 3131-3135
    • Miyashita, T.1    Harigai, M.2    Hanada, M.3    Reed, J.C.4
  • 55
    • 12644271680 scopus 로고    scopus 로고
    • unpublished observations
    • Blandino et al. unpublished observations.
    • Blandino1
  • 56
    • 0028072523 scopus 로고
    • DNA damage can induce apoptosis in proliferating lymphoid cells via p53-independent mechanisms inhibitable by Bcl-2
    • Strasser A., Harris A.W., Jacks T., Cory S.: DNA damage can induce apoptosis in proliferating lymphoid cells via p53-independent mechanisms inhibitable by Bcl-2. Cell. 79: 329-339, 1994.
    • (1994) Cell , vol.79 , pp. 329-339
    • Strasser, A.1    Harris, A.W.2    Jacks, T.3    Cory, S.4
  • 57
    • 0028883179 scopus 로고
    • Tumor suppressor p53 is a direct transcriptional activator of human bax gene
    • Miyashita T., Reed J.C.: Tumor suppressor p53 is a direct transcriptional activator of human bax gene. Cell. 80: 293-299, 1995.
    • (1995) Cell , vol.80 , pp. 293-299
    • Miyashita, T.1    Reed, J.C.2
  • 59
    • 0027944228 scopus 로고
    • Induction of bax by genotoxic stress in human cells correlates with normal p53 status and apoptosis
    • Zhan Q., Fan S., Bae I., Guillouf C., Liebermann D.A., O'Connor P.M., Fornace A.J. Jr.: Induction of bax by genotoxic stress in human cells correlates with normal p53 status and apoptosis. Oncogene. 9: 3743-3751, 1994.
    • (1994) Oncogene , vol.9 , pp. 3743-3751
    • Zhan, Q.1    Fan, S.2    Bae, I.3    Guillouf, C.4    Liebermann, D.A.5    O'Connor, P.M.6    Fornace Jr., A.J.7
  • 60
    • 0028928295 scopus 로고
    • Suppression of bcl-2 messenger RNA production may mediate apoptosis after ionizing radiation, tumor necrosis factor a, and ceramide
    • Chen M., Quintans J., Fuks Z., Thompson C., Kufe D.W., Weichselbaum R.R.: Suppression of bcl-2 messenger RNA production may mediate apoptosis after ionizing radiation, tumor necrosis factor a, and ceramide. Cancer Res. 55: 991-994, 1995.
    • (1995) Cancer Res. , vol.55 , pp. 991-994
    • Chen, M.1    Quintans, J.2    Fuks, Z.3    Thompson, C.4    Kufe, D.W.5    Weichselbaum, R.R.6
  • 61
    • 0026781986 scopus 로고
    • Bcl-2 gene transfer increases relative resistance of S49.1 and WEH17.2 lymphoid cells to cell death and DNA fragmentation induced by glucocorticoids and multiple chemoterapeutic drugs
    • Miyashita T., and Reed J.C.: Bcl-2 gene transfer increases relative resistance of S49.1 and WEH17.2 lymphoid cells to cell death and DNA fragmentation induced by glucocorticoids and multiple chemoterapeutic drugs. Cancer Res. 52: 5407-5411, 1992.
    • (1992) Cancer Res. , vol.52 , pp. 5407-5411
    • Miyashita, T.1    Reed, J.C.2
  • 62
    • 0027389763 scopus 로고
    • Bcl-2 oncoprotein blocks chemoterapy induced apoptosis in a human leukemia cell line
    • Miyashita T., and Reed J.C.: Bcl-2 oncoprotein blocks chemoterapy induced apoptosis in a human leukemia cell line. Blood. 81: 151-157, 1993.
    • (1993) Blood , vol.81 , pp. 151-157
    • Miyashita, T.1    Reed, J.C.2
  • 63
    • 0027196091 scopus 로고
    • Constitutive expression of human bcl-2 modulates nitrogen mustard and camptothecin induced apoptosis
    • Walton W.I., Whysong P.M., O'Connor D., Hockenbery D., Korsmeyer S.J., and Kohn K.W.: Constitutive expression of human bcl-2 modulates nitrogen mustard and camptothecin induced apoptosis. Cancer Res. 53: 1853-1861, 1993.
    • (1993) Cancer Res. , vol.53 , pp. 1853-1861
    • Walton, W.I.1    Whysong, P.M.2    O'Connor, D.3    Hockenbery, D.4    Korsmeyer, S.J.5    Kohn, K.W.6
  • 64
    • 0028054687 scopus 로고
    • Regulation of chemioresistance by the bcl-2 oncoprotein in non-Hodking's lymphoma and lymphocytic leukemia cell lines
    • Reed J.C., Kitada S., Takayama S., Miyashita T.: Regulation of chemioresistance by the bcl-2 oncoprotein in non-Hodking's lymphoma and lymphocytic leukemia cell lines. Ann. Oncol. 5: S61, 1994.
    • (1994) Ann. Oncol. , vol.5
    • Reed, J.C.1    Kitada, S.2    Takayama, S.3    Miyashita, T.4
  • 66
    • 0027246692 scopus 로고
    • Regulation by bcl-2, c-myc, and p53 of susceptibility to induction of apoptosis by heat shock and cancer chemotherapy compounds in differentiation-competent and-defective myeloid leukemic cells
    • Lotem J., and Sachs L.: Regulation by bcl-2, c-myc, and p53 of susceptibility to induction of apoptosis by heat shock and cancer chemotherapy compounds in differentiation-competent and-defective myeloid leukemic cells. Cell Growth E Diff. 4: 41-47, 1993.
    • (1993) Cell Growth E Diff. , vol.4 , pp. 41-47
    • Lotem, J.1    Sachs, L.2
  • 67
    • 0028284281 scopus 로고
    • Effects of bcl-2 antisense oligonucleotides on in vitro proliferation and survival of normal marrow progenitors and leukaemic cells
    • Campos L., Sabido O., Rouault J-P., Guyotat D.: Effects of bcl-2 antisense oligonucleotides on in vitro proliferation and survival of normal marrow progenitors and leukaemic cells. Blood. 84: 595-600, 1994.
    • (1994) Blood , vol.84 , pp. 595-600
    • Campos, L.1    Sabido, O.2    Rouault, J.-P.3    Guyotat, D.4
  • 68
    • 0025367382 scopus 로고
    • Bcl-2-mediated tumorigenicity in a T-lymphoid cell line: Synergy with c-myc and inhibition by bcl-2 antisense
    • Reed J., Haldar S., Cuddy M., Croce C.M., Makover D.: Bcl-2-mediated tumorigenicity in a T-lymphoid cell line: synergy with c-myc and inhibition by bcl-2 antisense. Proc. Natl. Acad. Sci. USA 87: 3660-3664, 1990.
    • (1990) Proc. Natl. Acad. Sci. USA , vol.87 , pp. 3660-3664
    • Reed, J.1    Haldar, S.2    Cuddy, M.3    Croce, C.M.4    Makover, D.5
  • 69
    • 0027217846 scopus 로고
    • Investigations of antisense oligonucleotides targeted against bcl-2 RNAs
    • Kitada S., Miyashita T., Tanaka S., Reed J.C.: Investigations of antisense oligonucleotides targeted against bcl-2 RNAs. Antisense Res. Dev. 3: 157-169, 1993.
    • (1993) Antisense Res. Dev. , vol.3 , pp. 157-169
    • Kitada, S.1    Miyashita, T.2    Tanaka, S.3    Reed, J.C.4
  • 70
    • 0028060247 scopus 로고
    • Reversal of chemoresistance of lymphoma cells by antisense-mediated reduction of bcl-2 gene expression
    • Kitada S., Takayama S., DeRiel K., Tanaka S., Reed J.C.: Reversal of chemoresistance of lymphoma cells by antisense-mediated reduction of bcl-2 gene expression. Antisense Res. Dev. 4: 71-79, 1994.
    • (1994) Antisense Res. Dev. , vol.4 , pp. 71-79
    • Kitada, S.1    Takayama, S.2    Deriel, K.3    Tanaka, S.4    Reed, J.C.5
  • 71
    • 0025011006 scopus 로고
    • Antisense-mediated inhibition of bcl-2 proto-oncogene expression and leukemic cell growth: Comparisons of phosphodiester and phosphorothioate oligodeoxynucleotides
    • Reed J., Stein C., Haldar S., Subasinghe C., Croce C., Yum S., Cohen J.: Antisense-mediated inhibition of bcl-2 proto-oncogene expression and leukemic cell growth: comparisons of phosphodiester and phosphorothioate oligodeoxynucleotides. Cancer Res. 50: 6565-6570, 1990.
    • (1990) Cancer Res. , vol.50 , pp. 6565-6570
    • Reed, J.1    Stein, C.2    Haldar, S.3    Subasinghe, C.4    Croce, C.5    Yum, S.6    Cohen, J.7
  • 72
    • 0029157380 scopus 로고
    • Estrogen promotes chemoterapeutic drug resistance by a mechanism involving BCL-2 protooncogene expression in human breast cancer cells
    • Texeira C., Reed J.C., Pratt M.A.C.: Estrogen promotes chemoterapeutic drug resistance by a mechanism involving BCL-2 protooncogene expression in human breast cancer cells. Cancer Res. 55: 3902-3907, 1995.
    • (1995) Cancer Res. , vol.55 , pp. 3902-3907
    • Texeira, C.1    Reed, J.C.2    Pratt, M.A.C.3
  • 76
    • 0029980043 scopus 로고    scopus 로고
    • p53 in growth control and neoplasia
    • Gottlieb T.M., and Oren M.: p53 in growth control and neoplasia. Biochem. Biophys. Acta. 1287: 77-102, 1996.
    • (1996) Biochem. Biophys. Acta. , vol.1287 , pp. 77-102
    • Gottlieb, T.M.1    Oren, M.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.