Determination of urinary metabolites of polycyclic aromatic hydrocarbons (PAH) for the risk assessment of PAH-exposed workers

International Archives of Occupational and Environmental Health

Volumn 69, Issue 4, 1997, Pages 231-239

  Grimmer, G ^a   Jacob, J ^a,b   Dettbarn, G ^a   Naujack, K W ^a  

^a Biochem Inst Environ Carcinogens   (Germany)

^b NONE   (Germany)

Author keywords

Benzo a pyrene; Chrysene; Dihydrodiols; Monohydroxyderivates; Phenanthrene; Pyrene

Indexed keywords

ARYLSULFATASE; BENZO[A]PYRENE; BETA GLUCURONIDASE; CHRYSENE; DIAZOMETHANE; DIMETHYL ETHER; FLUORANTHENE; PHENANTHRENE; PHENOL DERIVATIVE; POLYCYCLIC AROMATIC HYDROCARBON; PYRENE;

ANIMAL EXPERIMENT; ARTICLE; CASE REPORT; GAS CHROMATOGRAPHY; HUMAN; MASS SPECTROMETRY; METABOLITE; NONHUMAN; OCCUPATIONAL EXPOSURE; OCCUPATIONAL HAZARD; RAT; RISK ASSESSMENT; URINALYSIS;

ADMINISTRATION, INHALATION; AEROSOLS; ANIMALS; CHEMICAL INDUSTRY; COAL TAR; FEMALE; GAS CHROMATOGRAPHY-MASS SPECTROMETRY; HUMANS; OCCUPATIONAL DISEASES; OCCUPATIONAL EXPOSURE; POLYCYCLIC HYDROCARBONS, AROMATIC; RATS; RATS, WISTAR; REPRODUCIBILITY OF RESULTS; RISK ASSESSMENT;

EID: 0030932664     PISSN: 03400131     EISSN: None     Source Type: Journal    
DOI: 10.1007/s004200050141     Document Type: Article

References (31)

1. Angerer J, Schaller KH, Lehnert G (1993) Bio-Monitoring von beruflichen Belastungen gegenüber polycyclischen aromatischen Kohlenwasserstoffen. Hochdruckflüssigkeitschromatographische Bestimmung des Metaboliten 1-Hydroxypyren im Harn. In: Moncelon B (ed) Maitriser le risque au post de travail. Presses Universitaires de Nancy. Nancy, pp 163-171
2. Boos K-S, Lintelmann J, Kettrup A (1992) Coupled-column high-performance liquid Chromatographic method for the determination of 1-hydroxypyrene in urine of subjects exposed to polycyclic aromatic hydrocarbons. J Chromatogr 600:189-194
3. DFG (1990) Analyses of hazardous substances in biological materials, vol 3. (Angerer J, Schaller KH, eds) VCH, Weinheim, pp 151-169
4. Grimmer G, Dettbarn G, Naujack K-W (1990) A method for the determination of phenanthrene and five isomeric hydroxyphenanthrenes in urine of man and rat. In: Cooke M, Loening K, Merritt J (eds) Polycyclic aromatic hydrocarbons: measurement, means, and metabolism. Battelle Press, Columbus, Ohio pp 389-403
5. Grimmer G, Naujack K-W, Dettbarn G (1993 a) Bestimmung der Harnmetaboliten polycyclischer aromatischer Kohlenwasserstoffe bei Kokereibeschäftigten. In: Moncelon B (ed) Maitriser le risque au poste de travail. Presses Universitaires de Nancy, Nancy, pp 227-233
6. Grimmer G, Dettbarn G, Jacob J (1993b) Biomonitoring of polycyclic aromatic hydrocarbons in highly exposed coke plant workers by measurement of urinary phenanthrene and pyrene metabolites (phenols and dihydrodiols). Int Arch Occup Environ Health 65:189-199
7. Grimmer G, Dettbarn G, Naujack K-W, Jacob J (1994) Relationship between inhaled PAH and urinary excretion of phenanthrene, pyrene and benzo[a]pyrene metabolites in coke plant workers. Polycyclic Aromat Compds 5:269-277
8. Hansen AM, Poulsen OM, Christensen JM, Hansen SH (1991) Assessment of occupational PAH exposure by biological monitoring of metabolites in urine. In: Garrigues P, Lamotte M (eds) Polycyclic aromatic compounds: synthesis, properties, analytical measurements, occurrence and biological effects. Gordon and Breach, London, pp 1015-1022
9. Heinrich U, Peters L, Creutzenberg O, Dasenbrock C, Hoymann H-G (1994a) Inhalation exposure of rats to tar/pitch condensation aerosol or carbon black alone or in combination with irritant gases. In: Mohr U, Dungworth DL, Mauderly JL, Oberdörster G (eds) Toxic and carcinogenic effects of solid particles in the respiratory tract. ILSI-Press, Washington DC, pp 433-441
10. Heinrich U, Dungworth DL, Pott F, Peters L, Dasenbrock C, Levsen K, Koch W, Creutzenberg O, Schulte A (1994b) The carcinogenic effects of carbon black particles and tar-pitch condensation aerosol after inhalation exposure of rats. Ann Occup Hyg 38 [Suppl 1]:351-356
11. Herikstad BV, Øvrebø S, Haugen A, Hagen I (1993) Determination of polycyclic aromatic hydrocarbons in urine from cokeoven workers with a radioimmunoassay. Carcinogenesis 14: 307-309
12. Jongeneelen FJ (1987) Biological monitoring of occupational exposure to polycyclic aromatic hydrocarbons. Thesis, University of Nijmegen, p 181
13. Jongeneelen FJ, Anzion RBM, Leijdekkers CM, Bos RP, Henderson PT (1985 a) 1-Hydroxypyrene in human urine after exposure to coal tar and a coal tar derived product. Int Arch Occup Environ Health 57:47-55
14. Jongeneelen FJ, Leijdekkers CM, Bos RP, Theuws JLG, Renderson PT (1985b) Excretion of 3-hydroxybenzo[a]pyrene and mutagenicity in rat urine after exposure to benzo[a]pyrene. J Appl Toxicol 5:277-282
15. Jongeneelen FJ, Bos RP, Anzion RBM, Theuws JLG, Henderson PT (1986) Biological monitoring of polycyclic aromatic hydrocarbons: metabolites in urine. Scand J Work Environ Health 12: 137-143
16. Jongeneelen FJ, Anzion RBM, Henderson PT (1987) Determination of hydroxylated metabolites of polycyclic aromatic hydrocarbons in urine. J Chromatogr 413:227-232
17. Jongeneelen FJ, Bos RP, Henderson PT (1988 a) Metabolites of PAH in urine of exposed workers. Toxicol Environ Health 57: 47-55
18. Jongeneelen FJ, Akker W vd, Bos RP, Anzion RBM, Theuws JLG, Roelofs H, Henderson PT (1988b) 1-Hydroxypyrene as an indicator of the mutagenicity of coal tar after activation with human liver preparations. Mutat Res 204:195-201
19. Lintelmann J, Boos K-S (1990) Bestimmung des PAK-Metaboliten 1-Hydroxypyren mittels HPLC-Säulenschalttechnik. In: Günther W, Mattes JP, Perkampus H-H (eds) Com '90. Instrumentalized analytical chemistry and computer technology. Git, Darmstadt, pp 128-129
20. Lintelmann J, Boos K-S, Kettrup A (1994) Biomonitoring bei PAK-Belastung mit Hilfe einer LC-LC Kopplung für die Bestimmung von 1-Hydroxypyren in Urin. BlOforum 17:442-445
21. Martin F, Hoepfner I, Scherer G, Adlkofer F, Dettbarn G, Grimmer G (1989) Urinary excretion of hydroxy-phenanthrenes after intake of polycyclic aromatic hydrocarbons. Environ Int 15: 41-17
22. Ouyang Z, Greenberg A (1994) A rapid assay for urinary metabolites of benzo[a]pyrene (B[a]P). Polycyc Arom Comp 5:259-268
23. Rooij JGM van (1994) Dermal PAH exposure in the workplace: cross-sectional studies. In: Rooij JGM van (ed) Dermal exposure to polycyclic aromatic hydrocarbons among workers. Thesis, University of Nijmegen, pp 109-162
24. Rooij JGM van, De Roos JHC, Bodelier-Bade MM, Jongeneelen FJ (1993 a) Absorption of polycyclic aromatic hydrocarbons through human skin: differences between anatomical sites and individuals. J Toxicol Environ Health 38:355-368
25. Rooij JGM van, van Lieshout EMA, Bodelier-Bade MM, Jongeneelen FJ (1993b) Effect of the reduction of skin contamination on the internal dose of creosote workers exposed to polycyclic aromatic hydrocarbons. Scand J Work Environ Health 19:200-207
26. Rooij JGM van, Bodelier-Bade MM, Jongeneelen FJ (1993c) Estimation of individual dermal and respiratory uptake of polycyclic aromatic hydrocarbons in 12 coke oven workers. Br J Ind Med 50:623-632
27. Schaller KH, Angerer J, Hausmann N (1991) The determination of 1-hydroxypyrene in urine as a tool for the biological monitoring of PAH-exposed persons. In: Garrigues P, Lamotte M (eds) Polycyclic aromatic compounds: synthesis, properties, analytical measurements, occurrence and biological effects. Gordon and Breach, London, pp 1023-1030
28. Solbakken JE, Palmork KH, Neppelber T, Scheline RR (1980) Urinary and biliary metabolites of phenanthrene in the coalfish (Pollachius virens). Acta Pharmacol Toxicol 46:127-132
29. Weston A, Bowman ED, Carr P, Rothman N, Strickland PT (1993) Detection of metabolites of polycyclic aromatic hydrocarbons in human urine. Carcinogenesis 14:1053-1055
30. Yang Y, Sjövall J, Rafter J, Gustafsson J-A (1994) Characterization of neutral metabolites of benzo[a]pyrene in urine from germ-free rats. Carcinogenesis 15:681-687
31. Zhao Z-H, Quan W-Y, Tian D-H (1990) Urinary 1-hydroxypyrene as an indicator of human exposure to ambient polycyclic aromatic hydrocarbons in a coal-burning environment. Sci Total Environ 92:145-154