The mode of action of anticoccidial quinolones (6-decyloxy-4-hydroxyquinoline-3-carboxylates) in chickens

International Journal for Parasitology

Volumn 27, Issue 1, 1997, Pages 101-111

  Williams, R B ^a,b  

^a May and Baker Limited   (United Kingdom)

^b Mallinckrodt Veterinary Ltd   (United Kingdom)

Author keywords

chickens; cidal effect; coccidia; drug absorption; Eimeria acervulina; Eimeria tenella; inhibitory effect; mode of action; oocyst sporulation; quinolones

Indexed keywords

DECOQUINATE; MB 15584; QUINOLONE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; CHICKEN; COCCIDIA; COCCIDIOSIS; CONTROLLED STUDY; DRUG ABSORPTION; DRUG MECHANISM; EIMERIA; EIMERIA TENELLA; NONHUMAN; OOCYST; ORAL DRUG ADMINISTRATION; SPOROGENESIS;

ANIMALS; CHICKENS; COCCIDIOSIS; COCCIDIOSTATS; DECOQUINATE; DRUG ADMINISTRATION SCHEDULE; EIMERIA; EIMERIA TENELLA; HYDROXYQUINOLINES; MALE; POULTRY DISEASES; REGRESSION ANALYSIS; TIME FACTORS;

EID: 0030932545     PISSN: 00207519     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0020-7519(96)00156-7     Document Type: Article

References (50)

1. Arakawa A., Tanaka Y., Baba E. & Fukata T. 1991. Effects of clopidol on sporulation and infectivity of Eimeria tenella oocysts. Veterinary Parasitology 38: 55-60.
2. Ball S. J. 1966. The responses of different strains of Eimeria acervulina and Eimeria tenella to medication. Research in Veterinary Science 7: 312-325.
3. Ball S. J. & Warren E. W. 1965. Treatment of experimental avian coccidiosis with a soluble combination of sulphaquinoxaline and diaveridine. Veterinary Record 77: 1252-1256.
4. Ball S. J. & Warren E. W. 1966. Effects of chlortetracycline, oxytetracycline and spiramycin on Eimeria tenella in chicks. Journal of Comparative Pathology and Therapeutics 76: 255-259.
5. Ball S. J., Pittilo R. M., Norton C. C. & Joyner L. P. 1985. Morphological effects of arprinocid on developmental stages of Eimeria tenella and E. brunetti. Parasitology 91: 31-43.
6. Ball S. J., Davis M., Hodgson J. N., Lucas J. M. S., Parnell E. W., Sharp B. W. & Warburton D. 1968. A new anticoccidial drug. Chemistry and Industry (13 January): 56-57.
7. Biggs P. M. 1982. The world of poultry disease. Avian Pathology 11: 281-300.
8. Bowie R. A., Cairns J.20P., Grant M. S., Hayes A., Jones W. G. M. & Ryley J. F. 1967. A new wide spectrum coccidiostat. Nature, London 214: 1349.
9. Brackett S. & Bliznick A. 1949. The effect of small doses of drugs on oocyst production of infections with Eimeria tenella. Annals of the New York Academy of Sciences 52: 595-610.
10. Brewer R. N. & Reid W. M. 1967. Efficacy of buquinolate against six species of coccidia. Poultry Science 46: 642-646.
11. Button R. G., Muggleton D. F. & Parnell E. W. 1969. Decoquinate II. - Absorption and residue studies in chickens. Journal of the Science of Food and Agriculture 20: 70-73.
12. Challey J. R. & Johnson C. A. 1968. Penetration and development of Eimeria maxima sporozoites and the static effect of decoquinate. Poultry Science 47: 1660.
13. 14C administered orally to chickens. Journal of Agricultural and Food Chemistry 19: 1228-1233.
14. Cuckler A. C. & Malanga C. 1955. Studies on drug-resistance in coccidia. Journal of Parasitology 41: 302-311.
15. Dunkley M. J. W. 1968. Laboratory trials with buquinolate - a new broad-spectrum coccidiostat for poultry. Veterinary Record 83: 30-34.
16. 14C-labelled decoquinate. Journal of the Science of Food and Agriculture 20: 65-69.
17. Fry M. & Williams R. B. 1984. Effects of decoquinate and clopidol on electron transport in mitochondria of Eimeria tenella (Apicomplexa: Coccidia). Biochemical Pharmacology 33: 229-240.
18. Hodgson J. N. 1968a. Studies with decoquinate. In: Veterinary Pesticides, pp. 139-144. S.C.I. Monograph 33. Society of Chemical Industry, London.
19. Hodgson J. N. 1968b. A new anti-coccidial drug (M&B 15,497): activity studies against laboratory and field strains of Eimeria. British Veterinary Journal 124: 209-218.
20. Joyner L. P. & Norton C. C. 1969. A comparison of two laboratory strains of Eimeria tenella. Parasitology 59:907-913.
21. Joyner L. P. & Norton C. C. 1977. The anticoccidial effects of amprolium, dinitolmide and monensin against Eimeria maxima, E. brunetti and E. acervulina with particular reference to oocyst sporulation. Parasitology 75: 155-164.
22. Leathern W. D. 1973. Buquinolate and immunization to Eimeria acervulina. Poultry Science 52: 1468-1472.
23. Leathem W. D. & Engle A. T. 1970. Effect of two levels of buquinolate on endogenous development and oocyst suppression of Eimeria tenella. Poultry Science 49: 1109-1113.
24. Long P. L. & Millard B. J. 1968. Eimeria: effect of meticlorpindol and methyl benzoquate on endogenous stages in the chicken. Experimental Parasitology 23: 331-338.
25. Long P. L. & Rowell J. G. 1958. Counting oocysts of chicken coccidia. Laboratory Practice 7: 515-519.
26. Lucas J. M. S. 1968. M&B 15,497: acute, sub-acute and chronic tolerance studies in chickens. British Veterinary Journal 124: 219-226.
27. McDonald V. & Rose M. E. 1987. Eimeria tenella and E. necatrix: a third generation of schizogony is an obligatory part of the developmental cycle. Journal of Parasitology 73: 617-622.
28. McDougald L. R. 1982. Chemotherapy of coccidiosis. In: The Biology of the Coccidia (Edited by Long P. L.), pp. 373-427. Edward Arnold, London.
29. McDougald L. R. & Galloway R. B. 1973. Eimeria tenella: anticoccidial drug activity in cell cultures. Experimental Parasitology 34: 189-196.
30. McDougald L. R. & Galloway R. B. 1976. Anticoccidial drugs: effects on infectivity and survival intracellularly of Eimeria tenella sporozoites. Experimental Parasitology 40: 314-319.
31. Pittilo R. M., Ball S. J., Joyner L. P. & Norton C. C. 1981. Ultrastructural changes in the macrogamete and early oocyst of Eimeria maxima resulting from drug treatment. Parasitology 83: 285-291.
32. Porter D. B. & Johnson C. A. 1966. Buquinolate - a broad-spectrum coccidiostat. Proceedings of the Twelfth World's Poultry Congress, Kiev, pp. 443-451.
33. Raines T. V. 1968. Buquinolate - a review. Poultry Science 47:1425-1432.
34. Reid W. M. 1969. Efficacy studies on some new anticoccidial drugs. Acta Veterinaria, Brno 38: 137-145.
35. Reid W. M., Taylor E. M. & Johnson J. 1969. A technique for demonstration of coccidiostatic activity of anticoccidial agents. Transactions of the American Microscopical Society 88: 148-159.
36. Ruff M. D., Anderson W. I. & Reid W. M. 1978. Effect of the anticoccidial arprinocid on production, sporulation, and infectivity of Eimeria oocysts. Journal of Parasitology 64: 306-311.
37. Ryley J. F. 1967a. Methyl benzoquate, a new wide-spectrum coccidiostat for chickens. British Veterinary Journal 123: 513-520.
38. Ryley J. F. 1967b. Studies on the mode of action of quinolone and pyridone coccidiostats. Journal of Parasitology 53: 1151-1160.
39. Ryley J. F. & Betts M. J. 1973. Chemotherapy of chicken coccidiosis. Advances in Pharmacology and Chemotherapy 11: 221-293.
40. Shirley M. W. 1986. New methods for the identification of species and strains of Eimeria. In: Research in Avian Coccidiosis (Edited by McDougald L. R., Long P. L. & Joyner L. P.), pp. 13-35. University of Georgia, Athens, GA.
41. Shirley M. W., Jeffers T. K. & Long P. L. 1983. Studies to determine the taxonomic status of E. mitis, Tyzzer 1929 and E. mivati, Edgar & Seibold 1964. Parasitology 87:185-198.
42. Spencer C. F., Engle A., Yu C. N., Finch R. C., Watson E. J., Ebetino F. F. & Johnson C. A. 1966. Anticoccidial activity in a series of alkyl 6, 7-dialkoxy-4-hydroxy-3-quinolinecarboxylates. Journal of Medicinal Chemistry 9: 934-936.
43. Tamas T., Olson G., Smith D. A. & Miller B. M. 1978. Effect of 6-amino-9-(substituted benzyl) purines on oocyst sporulation. Poultry Science 57: 381-385.
44. Vetterling J. M. & Thompson D. E. 1972. A polychromatic stain for use in parasitology. Stain Technology 47: 164-165.
45. Wang C. C. 1975. Studies of the mitochondria from Eimeria tenella and inhibition of electron transport by quinolone coccidiostats. Biochimica et Biophysica Acta 396: 210-219.
46. Wang C. C. 1976. Inhibition of the respiration of Eimeria tenella by quinolone coccidiostats. Biochemical Pharmacology 25: 343-349.
47. Weppelman R. M., Battaglia J. A. & Wang C. C. 1977. Eimeria tenella: the selection and frequency of drug-resistant mutants. Experimental Parasitology 42: 56-66.
48. Williams R. B. 1973. Effects of different infection rates on the oocyst production of Eimeria acervulina or Eimeria tenella in the chicken. Parasitology 67: 279-288.
49. Williams R. B., Farebrother D. A. & Latter V. S. 1995. Coccidiosis: a radiological study of sulphaquinoxaline distribution in infected and uninfected chickens. Journal of Veterinary Pharmacology and Therapeutics 18: 172-179.
50. Yvoré P. 1968. Chimioprévention des coccidioses aviaires. Pouvoir anticoccidien et toxicité du 19080 R.P. (M.B. 15,497). Recueil Médecine Vétérinaire 144: 485-503.