Absence of the inducible form of nitric oxide synthase in the brains of patients with the acquired immunodeficiency syndrome

Journal of NeuroVirology

Volumn 3, Issue 2, 1997, Pages 153-167

  Bagasra, Omar ^a   Bobroski, Lisa ^a   Sarker, Ashit ^a   Bagasra, Anisah ^a   Saikumari, P ^a   Pomerantz, Roger J ^a  

^a THOMAS JEFFERSON UNIVERSITY   (United States)

Author keywords

Brain; CNS; HIV 1; In situ PCR; iNOS

Indexed keywords

CYTOKINE; MESSENGER RNA; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; VIRUS PROTEIN;

ACQUIRED IMMUNE DEFICIENCY SYNDROME; ADULT; AGED; ARTICLE; AUTOPSY; BRAIN LEVEL; CENTRAL NERVOUS SYSTEM DISEASE; CLINICAL ARTICLE; COGNITIVE DEFECT; COORDINATION; ENCEPHALITIS; FEMALE; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; HUMAN TISSUE; MACROPHAGE; MALE; MOTOR DYSFUNCTION; MULTIPLE SCLEROSIS; NEUROLOGIC DISEASE; NEUROPATHOLOGY; NORMAL HUMAN; OPPORTUNISTIC INFECTION; PARENCHYMA; PRESCHOOL CHILD; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TOXICITY;

EID: 0030932385     PISSN: 13550284     EISSN: None     Source Type: Journal    
DOI: 10.3109/13550289709015805     Document Type: Article

References (46)

1. Achim CL, Heyes MP, Wiley CA (1993). Quantitation of human immunodeficiency virus, immune activation factors, and quinolinic acid in AIDS brains. J Clin Invest 91: 2769.
2. Bagasra O, Hauptman SP, Lischner HW, Sachs M, Pomerantz RJ (1992). Detection of human immunodeficiency virus type 1 in mononuclear cells by in situ polymerase chain reaction. N Engl J Med 326: 1385-1391.
3. Bagasra O, Michaels F, Zheng YM, Bobroski L, Spitsin SV, Fu ZF, Koprowski H (1995). Activation of the inducible form of nitric oxide synthetase in the brains of patients with multiple sclerosis. Proc Natl Acad Sci (USA) 92: 12041-12045.
4. Bagasra O, Seshamma T, Hansen J, Pomerantz RJ (1995). In situ polymerase chain reaction and hybridization to detect low abundance nucleic acid targets. In: Current Protocols in Molecular Biology (EDS) Ausubel F, Brent R, Kingston RE et al. (Pub. Wiley Interscience, New York) Sec. 14.8.1-14.8.24.
5. Bagasra O, Lavi U, Bobroski L, Khalili K, Pestaner JP, Pomerantz RJ (1996). Cellular reservoirs of HIV-1 in the central nervous system of infected-individuals: Identification by the combination of in situ PCR and immunohistochemistry. AIDS 10: 573-585.
6. Beckman JS, Crow JP (1993). Pathological implications of nitric oxide, superoxide, and peroxynitrite formation. Biochem Soc Trans 21: 330-334.
7. Beckman JS, Ye YZ, Anderson P, Chen J, Accavetti MA, Tarpey MM, White CR (1994). Extensive nitration of protein tyrosines in human atherosclerosis detected by immunohistochemistry. Biol Chem Hoppe-Seyler 375: 81-88.
8. Benos DJ, Hahn BH, Bubien JK, Ghosh SK, Mashburn NA, Chaikin MA, Shaw GM, Benveniste EN (1994). Envelope glycoprotein gp120 of human immunodeficiency virus type 1 alters ion transport in astrocytes: implications for AIDS dementia complex. Proc Natl Acad Sci (USA) 91: 494-498.
9. Bell JE, Busuttil A, Ironside JW et al (1993). Human immunodeficiency virus and the brain: investigation of virus load and neuropathologic changes in pre-AIDS subjects. J Infect Dis 168: 818-824.
10. Bo L, Dawson TM, Wesslingh S, Mork S, Choi S, Kong PA, Hanley D, Trapp BD (1994). Induction of nitric oxide synthase in demyelinating regions of multiple sclerosis brains. Ann Neurol 36: 778-786.
11. Budka H (1991). Neuropathology of human immunodeficiency virus infection. Brain Pathol 1: 163-175.
12. Bukrinsky MI, Nottet HSLM, Schmidtmayerova H, Dubrovsky L, Flanagan CR, Mullins ME, Lipton SA, Gendelman HE (1995). Regulation of nitric oxide synthase activity in human immunodeficiency virus type 1 (HIV-1)-infected monocytes: Implications for HIV-associated neurological disease. J Exp Med 181: 735-745.
13. Corboy JR, Buzy JM, Zink MC, Clements JE (1992). Expression directed from HIV long terminal repeats in the central nervous system of transgenic mice. Science 258: 1804-1808.
14. Dugas B, Mossalayi MD, Damais C, Kolb J-P (1996). Nitric oxide production by human monocytes: evidence for a role of CD23. Immunol Today 17: 149-152.
15. Eilbott DJ, Peress N, Burger H et al (1989). Human immunodeficiency virus type 1 in spinal cords of acquired immunodeficiency syndrome patients with myelopathy: expression and replication in macrophages. Proc Natl Acad Sci (USA) 86: 3337-3341.
16. Embretson J, Zupancic M, Beneke T et al (1993). Analysis of human immunodeficiency virus-infected tissues by amplification and in situ hybridization reveals latent and permissive infections at single-cell resolution. Proc Natl Acad Sci (USA) 90: 357-361.
17. Everall IP, Glass JD, McArthur J, Spargo E, Lantos P (1994). Neuronal density in the superior frontal and temporal gyri does not correlate with the degree of human immunodeficiency virus-associated dementia. Acta Neuropathol 88: 538-544.
18. Gabuzda DH, Ho DD, de la Monte SM et al (1986). Immunohistochemical identification of HTLV-III antigen in brains of patients with AIDS. Ann Neurol 20: 289-295.
19. Gartner S, Markowits P, Marlovitz DM, Betts RF, Popovic M (1986). Virus isolation from and identification of HTLV-III/LAV-producing cells in brain tissue from a patient with AIDS. JAMA 256: 2365-2371.
20. Genis P, Jett M, Bernton EW et al (1992). Cytokines and arachidonic metabolites produced during human immunodeficiency virus (HIV)-infected macrophage-astroglia interactions: implications for the neuropathogenesis of HIV disease. J Exp Med 176: 1703-1718.
21. Guilian DL, Vaca K, Noonan CA (1990). Secretion of neurotoxins by mononuclear phagocytes infected with HIV-1. Science 250: 1593-1596.
22. Gyorkey F, Melnick JL, Gyorkey P (1987). Human immunodeficiency virus in brain biopsies of patients with AIDS and progressive encephalopathy. J Infect Dis 155: 870-876.
23. Haddad IY, Ischiropoulous H, Holm BA, Beckman JS, Baker JR, Matalon S (1993). Mechanisms of peroxynitite-induced injury to pulmonary surfactants. Am J Physiol 265: L555-L564.
24. Ketzler S, Weis S, Haug H, Budka H (1990). Loss of neurons in the frontal cortex in AIDS brains. Acta Neuropathol 80: 92-94.
25. Koenig S, Gendelman HE, Orenstein JM et al (1986). Detection of AIDS virus in macrophages in brain tissue from AIDS patients with encephalopathy. Science 233: 1089-1093.
26. Koka P, He K, Zack JA, Peacock W, Fried I, Tran T, Yashar SS, Merrill JE (1995). Human immunodeficiency virus 1 envelop proteins induce interleukin 1, tumor necrosis factor α, and nitric oxide in glial cultures derived from fetal, neonatal, and adult human brain. J Exp Med 182: 941-951.
27. Kooy NW, Royall JA, Ye YZ, Kelly DR, Beckman JS (1995). Evidence for in vivo peroxynitrite production in human acute lung injury. Am J Respir Crit Care Med 151: 1250-1254.
28. Kure K, Lyman WD, Weidenheim KM, Dickson DW (1990). Cellular localization of an HIV-1 antigen in subacute AIDS encephalitis using an improved double-labeling immunohistochemical method. Am J Pathol 136: 1085-1092.
29. Lane TE, Buckmeier MJ, Watry DD, Fox HG (1996). Expression of inflammatory cytokines and inducible nitric oxide synthase in the brains of SIV-infected Rhesus monkeys. Mol Med 2: 27-37.
30. Lee SC, Dickson DW, Liu W, Brosnan CF (1993). Induction of nitric oxide synthase activity in human astrocytes by interleukin-1β and interferon-γ. J Neuroimmunol 46: 19-24.
31. Levy JA (1993). Pathogenesis of human immunodeficiency virus infection. Microbiol Rev 57: 183-289.
32. Lipton SA, Gendelman HE (1995). Dementia-associated with the acquired immunodeficiency syndrome. N Engl J Med 332: 934-940.
33. Mankowski JL, Spelman JP, Ressetar HG et al (1994). Neurovirulent simian immunodeficiency virus replicates productively in endothelial cells of the central nervous system in vivo and in vitro. J Virol 68: 8202-8208.
34. Moncada S, Palmer RMJ, Higgs EA (1991). Nitric oxide: physiology, pathophysiology, and pharmacology. Pharmacol Rev 43: 109-142.
35. Moses AV, Bloom FE, Pauza CD, Nelson JA (1993). Human immunodeficiency virus infection of human brain capillary endothelial cells occurs via a CD4/ galactosylceramide-indepondent mechanism. Proc Natl Acad Sci (USA) 90: 10474-10478.
36. Nuovo GJ, Gallary G, MacConnell P, Braun A (1994). In situ detection of polymerase chain reaction-amplified HIV-I nucleic acids and tumor necrosis factor-α RNA in the central nervous system. Amer J Pathol 144: 659-666.
37. Patterson BK, Till M, Otto P et al (1993). Detection of HIV-1 DNA and messenger RNA in individual cells by PCR-driven in situ hybridization and flow cytometry. Science 260: 976-980.
38. Pumarola-Sune T, Navia BA, Cordon-Cardo C, Cho ES, Price RW (1987). HIV antigen in the brains of patients with the AIDS dementia complex. Ann Neurol 21: 490-496.
39. Saito Y, Sharer LR, Epstein LG et al (1994). Overexpression of nef as a marker for restricted HIV-1 infection of astrocytes in post-mortem pediatric central nervous tissues. Neurology 44: 474-481.
40. Toggas SM, Masliah E, Rockenstein EM, Rall GF, Abraham CR, Mucke L (1994). Central nervous system damage produced by expression of the HIV-1 coat protein gp120 in transgenic mice. Nature 267: 188-193.
41. Tornatore C, Changra R, Berger JR, Major EO (1994). HIV-1 infection of subcortical astrocytes in the pediatric central nervous system. Neurology 44: 481-487.
42. Tyor WR, Glass JD, Griffin JW et al (1992). Cytokine expression in the brain during the acquired immunodeficiency syndrome. Ann Neurol 31: 349-360.
43. Vazeuz R, Brousse N, Jarry A et al (1987). AIDS subacute encephalitis: identification of HIV-infected cells. Amer J Pathol 126: 403-411.
44. Ward JM, O'Leary TJ, Baskin GB et al (1987). Immunohistochemical localization of human and simian immunodeficiency viral antigens in fixed tissue sections. Am J Pathol 127: 199-205.
45. Weiser B, Peress N, La Neve D, Eilbott DJ, Seidman R, Burger H (1990). Human immunodeficiency virus type 1 expression in the central nervous system correlates directly with extent of disease. Proc Natl Acad Sci (USA) 87: 3997-4001.
46. Wiley CA, Schrier RD, Nelson JA, Lamport PW, Oldstone MBA (1986). Cellular localization of human immunodeficiency virus infection within the brains of acquired immune deficiency syndrome patients. Proc Natl Acad Sci (USA) 83: 7089-7093.