Chemical arrows for enzymatic targets

FASEB Journal

Volumn 11, Issue 4, 1997, Pages 217-226

  Colman, Roberta F ^a  

^a UNIVERSITY OF DELAWARE   (United States)

Author keywords

adenylosuccinate synthetase; affinity cleavage; enzyme; glutamate dehydrogenase; isocitrate dehydrogenase

Indexed keywords

ADENYLOSUCCINATE LYASE; ADENYLOSUCCINATE SYNTHASE; ENZYME; GLUTAMATE DEHYDROGENASE; GLUTATHIONE TRANSFERASE; ISOCITRATE DEHYDROGENASE; NUCLEOTIDE DERIVATIVE;

AFFINITY LABELING; ALLOSTERISM; BINDING AFFINITY; CONFORMATIONAL TRANSITION; COVALENT BOND; ENZYME ACTIVE SITE; ENZYME BINDING; LIGAND BINDING; PRIORITY JOURNAL; REVIEW; SITE DIRECTED MUTAGENESIS; XENOBIOTIC METABOLISM;

EID: 0030932349     PISSN: 08926638     EISSN: None     Source Type: Journal    
DOI: 10.1096/fasebj.11.4.9068610     Document Type: Review

References (27)

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8. Saenger, W. (1984) Principles of Nucleic Acta Structure, Chapter 4, Springer-Verlag, New York
9. Lee, T. L., Dixon, J. E., and Colman, R. F. (1996) Identification of His-141 in the active of B. subtilis adenylosuccinate lyase by affinity labeling with 6-(4-bromo-2,3-dioxobutylthio)adenosine 5′-monophosphate. FASEB J. 10, A1101 (abstr.)
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15. Dombrowski, K. E., and Colman, R. F. (1989) 5′-p-Fluorosulfonylbenzoyl-8-azidoadenosine: A new bifunctional affinity label for nucleotide binding sites in proteins. Arch. Biochem. Biophys. 275, 302-308
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17. Haselbeck, R. J., Colman, R. F., and McAlister-Henn, L. (1992) Isolation and sequence of a cDNA encoding porcine mitochondrial NADP-specific isocitrate dehydrogenase. Biochemistry 31, 6219-6223
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22. Ji, X., Zhang, P., Armstrong, R. N., and Gilliland, G. L. (1992) The three-dimensional structure of a glutalhione S-transferase from the mu gene class. Structural analysis of the binary complex of isoenzyme 3-3 and glutathione at 2.2 Å resolution. Biochemistry 31, 10169-10184
23. Reinemer, P., Dirr, H. W., Ladenstein, R., Huber, R., LoBello, M., Federici, G., and Parker, M. W. (1992) Three-dimensional structure of class π glutathione S-transferase from human placenta in complex with S-hexylglutathione at 2.8 Å resolution. J. Mol. Biol. 227, 214-226.
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25. Katusz, R. M., Bono, B., and Colman, R. F. (1992) Identification of Tyr115 labeled by S-(4-bromo-2,3-dioxobutyl)glutathione in the hydrophobic substrate binding site of glutathione S-transferase, isoenzyme 3-3. Arch. Biochem. Biophys. 298, 667-677
26. 115 to be an important determinant of xenobiotic substrate specificity. Biochemistry 32, 13002-13011
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