Postmortem serum and tissue redistribution of fluoxetine and norfluoxetine in dogs following oral administration of fluoxetine hydrochloride (Prozac®)

Journal of Forensic Sciences

Volumn 42, Issue 5, 1997, Pages 812-816

  Pohland, Raymond C ^a   Bernhard, Norman R ^b  

^a ELI LILLY AND COMPANY   (United States)

^b NONE

Author keywords

Fluoxetine; Forensic science; Forensic toxicology; Norfluoxetine; Postmortem redistribution; Prozac

Indexed keywords

ANTIDEPRESSANT AGENT; FLUOXETINE; NORFLUOXETINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BLOOD SAMPLING; CADAVER; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG TISSUE LEVEL; FORENSIC SCIENCE; NONHUMAN; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL; TISSUE DISTRIBUTION; TOXICOLOGY;

EID: 0030931030     PISSN: 00221198     EISSN: None     Source Type: Journal    
DOI: 10.1520/jfs14213j     Document Type: Article

References (24)

1. Shepherd MF, Lake KD, Kamps MA. Postmortem changes and pharmacokinetics: review of the literature and case report. Ann Pharmacother 1992 Apr;26(4):510-4.
2. Gomez HF, McKinney P, Phillips S, Robert DV, Brent J, Watson WA. Postmortem acetaminophen pharmacokinetics: an experimental study of site and time-dependent concentration changes. J Forensic Sci 1995 Nov;40(6):980-2.
3. Hilberg T, Bugge A, Beylich KM, Ingum J, Bjorneboe A, Morland J. An animal model of postmortem amitriptyline redistribution. J Forensic Sci 1993 Jan;38(1):81-90.
4. Hilberg T, Morland J, Bjorneboe A. Postmortem release of amitriptyline from the lungs: a mechanism of postmortem drug redistribution. Forensic Sci Int 1994 Jan;64(1):47-55.
5. Koren G, Klein J. Postmortem redistribution of morphine in rats. Ther Drug Monit 1992 Dec;14(6):461-3.
6. Sawyer WR, Forney RB. Postmortem disposition of morphine in rats. Forensic Sci Int 1988 Sep;38(3-4):259-73.
7. Koren G, MacLeod SM. Postmortem redistribution of digoxin in rats. J Forensic Sci 1985 Jan;30(1):92-6.
8. Quatrehomme G, Bourre F, Liao Z, Ollier A. An experimental methodology for the study of postmortem changes in toxic concentrations of drugs using secobarbital as an example. J Forensic Sci 1994 Sep;39(5):1300-4.
9. Imamura T, Nagata T, Kimura K, Kudo K, Urakawa N. Pharmacokinetics and postmortem changes of cimetidine in body tissues. Nippon Hoigaku Zasshi 1994 Apr;48(2):75-8.
10. Aderjan R, Buhr H, Schmidt G. Investigation of cardiac glycoside levels in human postmortem blood and tissues determined by a special radioimmunoassay procedure. Arch Toxicol 1979 Jun;42(2):107-14.
11. Aderjan R, Mattem R. Validity of digoxin concentrations in blood determined postmortem. Z Rechtsmed 1980;86(1):13-20.
12. Hearn WL, Keran EE, Wei HA, Hime G. Site-dependent postmortem changes in blood cocaine concentrations. J Forensic Sci 1991 May;36(3):673-84.
13. Levine B, Wu SC, Dixon A, Smialek JE. Site dependence of postmortem blood methadone concentrations. Am J Forensic Med Pathol 1995 Jun;16(2):97-100.
14. Miyazaki T, Kojima T, Yashiki M, Wakamoto H, Iwasaki Y, Taniguchi T. Site dependence of methamphetamine concentrations in blood samples collected from cadavers of people who had been methamphetamine abusers. Am J Forensic Med Pathol 1993 Jun;14(2):121-4.
15. Kuhlman JJ Jr, Mayers RW, Levine B, Jones R, Wagner GN, Smith ML. Chloroquine distribution in postmortem cases. J Forensic Sci 1991 Sep;36(5):1572-9.
16. Pounder DJ, Hartley AK, Watmough PJ. Postmortem redistribution and degradation of dothiepin: human case studies and an animal model. Am J Forensic Med Pathol 1994 Sep;15(3):231-5.
17. Pounder DJ, Owen V, Quigley C. Postmortem changes in blood amitriptyline concentration. Am J Forensic Med Pathol 1994 Sep;15(3):224-30.
18. Yonemits K, Pounder DJ. Postmortem changes in blood tranylcypromine concentration: competing redistribution and degradation effects. Forensic Sci Int 1993 May;59(2):177-84.
19. Yonemitsu K, Pounder DJ. Postmortem toxicokinetics of co-proxamol. Int J Leg Med 1992;104(6):347-53.
20. Hanzlick R. Postmortem tricyclic antidepressant concentrations: lethal versus nonlethal levels. Am J Forensic Med Pathol 1989 Dec;10(4):326-9.
21. Martin A, Pounder DJ. Postmortem toxicokinetics of trazodone. Forensic Sci Int 1992 Oct;56(2):201-7.
22. Pounder DJ, Davies JI. Zopiclone poisoning: tissue distribution and potential for postmortem diffusion. Forensic Sci Int 1994 May;65(3):177-83.
23. Nash JF, Bopp RJ, Carmichael RH, Fand KZ, Lemberger L. Determination of fluoxetine and norfluoxetine in plasma by gas chromatography with electron-capture detection. Clin Chem 1992 Oct;28(10):2100-2.
24. Pounder DJ, Jones GR. Postmortem drug redistribution - a toxicological nightmare. Forensic Sci Int 1990 Apr;45(3):253-63.