The pharmacokinetics and metabolism of α-trinositol (D-myo-inositol 1,2,6-trisphosphate). Studies involving intravenous infusion in rats, metabolism in human platelets and leukocytes, and dephosphorylation by bovine alkaline phosphatases

European Journal of Pharmaceutical Sciences

Volumn 5, Issue 5, 1997, Pages 267-275

  Lennernäs, Hans ^a   Lundqvist, Thomas ^a   Authi, Kalwant S ^b,c   Lindahl, Anneli ^d   Okkola, Sinikka ^d   Gustafsson, Torgny O ^d  

^a UPPSALA UNIVERSITY   (Sweden)

^b THROMBOSIS RESEARCH INSTITUTE   (United Kingdom)

^c ROYAL COLLEGE OF SURGEONS OF ENGLAND   (United Kingdom)

^d Perstorp Pharma ^*  (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

ALKALINE PHOSPHATASE; INOSITOL 1,2,6 TRISPHOSPHATE;

ANIMAL EXPERIMENT; ARTICLE; CATTLE; DRUG METABOLISM; ENZYME LOCALIZATION; ENZYME PHOSPHORYLATION; INFLAMMATION; INTRAVENOUS DRUG ADMINISTRATION; LEUKOCYTE; NONHUMAN; PRIORITY JOURNAL; RAT; THROMBOCYTE; TISSUE SPECIFICITY;

EID: 0030930609     PISSN: 09280987     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0928-0987(97)00019-5     Document Type: Article

References (21)

1. Authi, K.S., Evenden, B.J., Crawford, N., 1986. Metabolic and functional consequences of introducing inositol 1,4,5-trisphosphate into saponin-permeabilized human platelets. Biochem. J. 233, 707-718.
2. 3H]inositol into phosphoinositides of human platelets during reversible electropermeabilisation. FEBS Lett. 254, 52-58.
3. Berridge, M.J., Irvine, R.F., 1984. Inositol trisphosphate, a novel second messenger in cellular signal transduction. Nature 312, 315-321.
4. Cassuto, J., Jönsson, A., Tarnow, P., Nellgård, P., Rimbäck, G., 1993. Anti-inflammation mediated effects in several acute conditions by PP56 (D-myo-inositol-1,2,6-trisphosphate). Circ. Shock Suppl. 1, 51.
5. Claxson, A., Morris, C., Blake, D., Siren, M., Halliwell, B., Gustafsson, T., Löfkvist, B., Bergelin, I., 1990. The anti-inflammatory effects of D-myo-inositol-1.2.6-trisphosphate (PP56) on animal models of inflammation. Agents Actions 29, 68-70.
6. Clements, Jr R.S., Diethelm, A.G., 1979. The metabolism of myo-inositol by the human kidney. J. Lab. Clin. Med. 93, 210-219.
7. Connolly, T.M., Bansal, V.S., Bross, T.E., Irvine, R.F., Majerus, P.W., 1987. The metabolism of tris- and tetraphosphates of inositol by 5-phosphomonoesterase and 3-kinase enzymes. J. Biol. Chem. 262, 2146-2149.
8. Daniel, J.-L., Dangelmair, C.A., Smith, J.B., 1989. Formation and metabolism of inositol 1,4,5-trisphosphate in human platelets. Biochem. J. 246, 109-144.
9. Davies, N.T., Flett, A.A., 1978. The similarities between alkaline phosphatase (EC3131) and phytate (EC3138) activities in rat intestine and their importance in phytate induced zinc deficiency. Br. J. Nutr. 39, 307-316.
10. Edvinsson, L., Adamsson, M., Jansen, I., 1990. Neuropeptide Y antagonistic properties of D-myo-inositol-1.2.6-trisphosphate in Guinea pig basilar arteries. Neuropeptides 17, 99-105.
11. Eggleton, P., Gargan, R., Fisher, D., 1989. Rapid method for the isolation of neutrophils in high yield without use of dextran or density gradient polymers. J. Immunol. Methods 121, 105-133.
12. Ferris, C.D., Snyder, S.H., 1992. Ligand-activated calcium channels in multiple form. In: Advances in second messenger and phosphoprotein research. Vol. 26: Inositol phosphates and calcium signalling, edited by J.W. Putney. Raven Press, New York, pp. 95-107.
13. Goldschmidt, B., 1990. Preparative separation of myo inositol bisphosphate and trisphosphate isomers by anion exchange chromatography. Carbohydr. Res. 208, 105-110.
14. Hedner, T., Hedner, J., Hedman, C., Jiang, W., 1989. Farmakokinetik av D-myo-inositol-1.2.6-trisfosfat hos friska frivilliga. Svenska Läkaresällskapets riksstämma 1989, 222.
15. 2+ entry into cells? In: Advances in second messenger and phosphoprotein research. Vol. 26: Inositol phosphates and calcium signalling, edited by J.W. Putney. Raven Press, New York, pp. 161-185.
16. Lund, T., Reed, R.K., 1993. α-trinositol inhibits edema generation and albumin extravasation in thermally injured skin. J. Trauma 36, 761-765.
17. Nakazawa, H., Gustafsson, T.O., Traber, L.D., Herndon, D.N., Traber, D.L., 1993. α-trinositol decreases lung edema formation following smoke inhalation in an ovine model. J. Appl. Physiol. 76, 278-282.
18. Sandberg, A.S., Larsen, T., Sandström, B., 1993. High dietary calcium level decreases colonic phytate digestion in pigs fed a rapeseed diet. J. Nutr. 123, 559-566.
19. Shears, S.B., 1992. Metabolism of inositol phosphates. In: Advances in second messenger and phosphoprotein research. Vol. 26: Inositol phosphates and calcium signalling, edited by J.W. Putney. Raven Press, New York, pp. 63-92.
20. Vallejo, M., Jackson, I., Lightman, S., Hanley, M.R., 1988. Occurrence and extracellular actions of inositol pentakis- and hexakisphosphate in mammalian brain. Nature 330, 656-658.
21. 3H-inositol phosphate binding sites in rat brain. Soc. Neurosci. Abstr. 18, 477.