메뉴 건너뛰기




Volumn 3, Issue 1, 1997, Pages 83-101

Neuroprotective profile of riluzole in in vivo models of acute neurodegenerative diseases

Author keywords

Brain irradiation; Glutamate; Hypoxia; In vivo models; Ischemia; Na+ channel blockade; Neurotrauma; Riluzole

Indexed keywords

6 (1 IMIDAZOLYL) 7 NITRO 2,3 QUINOXALINEDIONE; APTIGANEL; DIZOCILPINE; LAMOTRIGINE; LUBELUZOLE; RILUZOLE;

EID: 0030930499     PISSN: 1080563X     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1527-3458.1997.tb00318.x     Document Type: Review
Times cited : (22)

References (79)
  • 1
    • 0028957178 scopus 로고
    • Acute effects of irradiation of the rat brain: Protection by glutamate blockade
    • Alaoui F, Pratt J, Trocherie S, Court L, Stutzmann JM. Acute effects of irradiation of the rat brain: Protection by glutamate blockade. Eur J Pharmacol 1995;276:55-60.
    • (1995) Eur J Pharmacol , vol.276 , pp. 55-60
    • Alaoui, F.1    Pratt, J.2    Trocherie, S.3    Court, L.4    Stutzmann, J.M.5
  • 2
    • 0025347454 scopus 로고
    • Long-term potentiation in the rat hippocampus induced by the mast cell degranulating peptide: Analysis of the release of endogenous excitatory amino acids and proteins
    • Aniksztejn L, Charriaut-Marlangue C, Roisin MP, Ben-Ari Y. Long-term potentiation in the rat hippocampus induced by the mast cell degranulating peptide: Analysis of the release of endogenous excitatory amino acids and proteins. Neuroscience 1990;35:63.
    • (1990) Neuroscience , vol.35 , pp. 63
    • Aniksztejn, L.1    Charriaut-Marlangue, C.2    Roisin, M.P.3    Ben-Ari, Y.4
  • 3
    • 0018177287 scopus 로고
    • Effects of whole body gamma irradiation on the activity of rabbit hippocampal neurons
    • Bassant MH, Court L. Effects of whole body gamma irradiation on the activity of rabbit hippocampal neurons. Radiat Res 1978;75:593-606.
    • (1978) Radiat Res , vol.75 , pp. 593-606
    • Bassant, M.H.1    Court, L.2
  • 4
    • 0029064501 scopus 로고
    • Treating acute ischemic stroke
    • Bath PMW. Treating acute ischemic stroke. Br Med J 1995;311:139-140.
    • (1995) Br Med J , vol.311 , pp. 139-140
    • Bath, P.M.W.1
  • 5
    • 0022384359 scopus 로고
    • 2-Amino-6-trifluoromethoxy benzothiazole, a possible antagonist of excitatory amino acid neurotransmission. II. Biochemical properties
    • Benavides J, Camelin JC, Mitrani N, et al. 2-Amino-6-trifluoromethoxy benzothiazole, a possible antagonist of excitatory amino acid neurotransmission. II. Biochemical properties. Neuropharmacology 1985;24:1085-1092.
    • (1985) Neuropharmacology , vol.24 , pp. 1085-1092
    • Benavides, J.1    Camelin, J.C.2    Mitrani, N.3
  • 6
    • 0026334826 scopus 로고
    • + channels in myelinated nerve fibre
    • + channels in myelinated nerve fibre. Pflüger's Arch 1991;419:603-609.
    • (1991) Pflüger's Arch , vol.419 , pp. 603-609
    • Benoit, E.1    Escande, D.2
  • 7
    • 0028097839 scopus 로고
    • A controlled trial of riluzole in amyotrophic lateral sclerosis
    • Bensimon G, Lacomblez L, Meininger V, ALS/Riluzole Study Group. A controlled trial of riluzole in amyotrophic lateral sclerosis. N Engl J Med 1994;330:585-591.
    • (1994) N Engl J Med , vol.330 , pp. 585-591
    • Bensimon, G.1    Lacomblez, L.2    Meininger, V.3
  • 8
    • 0028297544 scopus 로고
    • AMPA receptor antagonists and local cerebral glucose utilization in the rat
    • Browne SE, McCulloch J. AMPA receptor antagonists and local cerebral glucose utilization in the rat. Brain Res 1994;641:10-20.
    • (1994) Brain Res , vol.641 , pp. 10-20
    • Browne, S.E.1    McCulloch, J.2
  • 9
    • 0026490217 scopus 로고
    • Riluzole inhibits the release of glutamate in the caudate nucleus of the cat in vivo
    • Chéramy A, Barbeito L, Godeheu G, Glowinski J. Riluzole inhibits the release of glutamate in the caudate nucleus of the cat in vivo. Neurosci Lett 1992;147:209-212.
    • (1992) Neurosci Lett , vol.147 , pp. 209-212
    • Chéramy, A.1    Barbeito, L.2    Godeheu, G.3    Glowinski, J.4
  • 10
    • 0024093449 scopus 로고
    • Glutamate neurotoxicity and diseases of the central nervous system
    • Choi DW. Glutamate neurotoxicity and diseases of the central nervous system. Neuron 1988;1:623-634.
    • (1988) Neuron , vol.1 , pp. 623-634
    • Choi, D.W.1
  • 11
    • 0019974841 scopus 로고
    • Some effects of excitatory amino acid receptor antagonists on synaptic transmission in the rat olfactory cortex slice
    • Collins GS. Some effects of excitatory amino acid receptor antagonists on synaptic transmission in the rat olfactory cortex slice. Brain Res 1982;244:311-318.
    • (1982) Brain Res , vol.244 , pp. 311-318
    • Collins, G.S.1
  • 14
    • 0027213025 scopus 로고
    • Inhibition by riluzole of electrophysiological responses mediated by rat kainate and NMDA receptors expressed in Xenopus oocytes
    • Debono MW, Le Guern J, Canton T, et al. Inhibition by riluzole of electrophysiological responses mediated by rat kainate and NMDA receptors expressed in Xenopus oocytes. Eur J Pharmacol 1993;235:283-289.
    • (1993) Eur J Pharmacol , vol.235 , pp. 283-289
    • Debono, M.W.1    Le Guern, J.2    Canton, T.3
  • 16
    • 3142564684 scopus 로고
    • Lubeluzole in the acute treatment of ischemic stroke: Results of phase-2 trial
    • Diener HC, Hacke W, Hennerici M, et al. Lubeluzole in the acute treatment of ischemic stroke: Results of phase-2 trial. J Cereb Blood Flow Metab (Suppl) 1995;15:S128.
    • (1995) J Cereb Blood Flow Metab , vol.15 , Issue.SUPPL.
    • Diener, H.C.1    Hacke, W.2    Hennerici, M.3
  • 17
    • 0030069170 scopus 로고    scopus 로고
    • Lubeluzole in acute ischemic stroke. A double-blind, placebo-controlled phase II trial
    • Diener HC, Hacke W, Hennerici M, et al. Lubeluzole in acute ischemic stroke. A double-blind, placebo-controlled phase II trial. Stroke 1996:27:76-81.
    • (1996) Stroke , vol.27 , pp. 76-81
    • Diener, H.C.1    Hacke, W.2    Hennerici, M.3
  • 18
  • 19
    • 0024360073 scopus 로고
    • Pharmacology of excitatory amino acid receptors coupled to inositol phosphate metabolism in neonatal rat striatum
    • Doble A, Perrier ML. Pharmacology of excitatory amino acid receptors coupled to inositol phosphate metabolism in neonatal rat striatum. Neurochem Int 1989;15:1-8.
    • (1989) Neurochem Int , vol.15 , pp. 1-8
    • Doble, A.1    Perrier, M.L.2
  • 20
    • 0029021812 scopus 로고
    • Protective effect of riluzole on excitatory amino acid-mediated neurotoxicity in motoneuron-enriched cultures
    • Estevez A, Stutzmann JM, Barbeito L. Protective effect of riluzole on excitatory amino acid-mediated neurotoxicity in motoneuron-enriched cultures. Eur J Pharmacol 1995;280:47-53.
    • (1995) Eur J Pharmacol , vol.280 , pp. 47-53
    • Estevez, A.1    Stutzmann, J.M.2    Barbeito, L.3
  • 21
    • 0028074425 scopus 로고
    • Pathomorphologic effects of N-methyl-D-aspartate antagonists in the rat posterior cingulate/retrosplenial cerebral cortex: A review
    • Fix AS, Long GG, Wozniak DF, Olney JW. Pathomorphologic effects of N-methyl-D-aspartate antagonists in the rat posterior cingulate/retrosplenial cerebral cortex: A review. Drug Dev Res 1994;32:147-152.
    • (1994) Drug Dev Res , vol.32 , pp. 147-152
    • Fix, A.S.1    Long, G.G.2    Wozniak, D.F.3    Olney, J.W.4
  • 23
    • 0028587095 scopus 로고
    • The neuroprotective effects of the decahydroisoquinoline, LY 215490; A novel AMPA antagonist in focal ischemia
    • Gill R, Lodge D. The neuroprotective effects of the decahydroisoquinoline, LY 215490; a novel AMPA antagonist in focal ischemia. Neuropharmacology 1994;33:1529-1536.
    • (1994) Neuropharmacology , vol.33 , pp. 1529-1536
    • Gill, R.1    Lodge, D.2
  • 24
    • 0013570153 scopus 로고
    • D. Riluzole antagonizes excitatory amino acid-evoked firing in rat facial motoneurons in vivo
    • Girdlestone D, Dupuy A, Coston A, et al. D. Riluzole antagonizes excitatory amino acid-evoked firing in rat facial motoneurons in vivo. Br J Pharmacol (Suppl 583P) 1989;97.
    • (1989) Br J Pharmacol , Issue.SUPPL. 583P , pp. 97
    • Girdlestone, D.1    Dupuy, A.2    Coston, A.3
  • 26
    • 0019997415 scopus 로고
    • Subgranular zone of the dentate gyms of young rabbits as a secondary matrix
    • Gueneau G, Privat A, Drouet J, Court L. Subgranular zone of the dentate gyms of young rabbits as a secondary matrix. Develop Neurosci 1982;5:345-358.
    • (1982) Develop Neurosci , vol.5 , pp. 345-358
    • Gueneau, G.1    Privat, A.2    Drouet, J.3    Court, L.4
  • 27
    • 12644280427 scopus 로고
    • Thrombolytic therapy in acute ischemic stroke - An update
    • Krieglstein J, ed. Boca Raton: CRC Press
    • Hacke W, Niedermaier N, Wildemann B. Thrombolytic therapy in acute ischemic stroke - an update. In: Krieglstein J, ed. Pharmacology of Cerebral Ischemia. Boca Raton: CRC Press, 1994;617-623.
    • (1994) Pharmacology of Cerebral Ischemia , pp. 617-623
    • Hacke, W.1    Niedermaier, N.2    Wildemann, B.3
  • 29
    • 0021811144 scopus 로고
    • High glucose treatment improves neurological recovery in head-injury mice
    • Hall ED. High glucose treatment improves neurological recovery in head-injury mice. J Neurosurg 1995;62:882-887.
    • (1995) J Neurosurg , vol.62 , pp. 882-887
    • Hall, E.D.1
  • 30
    • 0027933906 scopus 로고
    • Stroke: Early pathophysiology and treatment
    • Heros RC. Stroke: Early pathophysiology and treatment. Stroke 1994;25:1877-1881.
    • (1994) Stroke , vol.25 , pp. 1877-1881
    • Heros, R.C.1
  • 32
    • 12644296578 scopus 로고
    • Sernyl (CI-395) in clinical anesthesia
    • Johnstone M, Evans V, Baigel S. Sernyl (CI-395) in clinical anesthesia. Br J Anaesth 1959;96:25-135.
    • (1959) Br J Anaesth , vol.96 , pp. 25-135
    • Johnstone, M.1    Evans, V.2    Baigel, S.3
  • 33
    • 0023681297 scopus 로고
    • Final report on phase 1 trial of WR-2721 before protracted fractionated radiation therapy
    • Kligerman MM, Turrisi AT, Urtasun RC, et al. Final report on phase 1 trial of WR-2721 before protracted fractionated radiation therapy. Int J Radiat Oncol Biol Phys 1988;14:1119-1122.
    • (1988) Int J Radiat Oncol Biol Phys , vol.14 , pp. 1119-1122
    • Kligerman, M.M.1    Turrisi, A.T.2    Urtasun, R.C.3
  • 35
    • 0029977337 scopus 로고    scopus 로고
    • Dose-ranging study of riluzole in amyotrophic lateral sclerosis
    • Lacomblez L, Bensimon G, Nigel Leigh P, et al. Dose-ranging study of riluzole in amyotrophic lateral sclerosis. Lancet 1996;347:1425-1431.
    • (1996) Lancet , vol.347 , pp. 1425-1431
    • Lacomblez, L.1    Bensimon, G.2    Nigel Leigh, P.3
  • 36
    • 0019412712 scopus 로고
    • Harmaline distribution in single muscle fibres and the inhibition of sodium efflux
    • Lea TJ, Ashley CC. Harmaline distribution in single muscle fibres and the inhibition of sodium efflux. Biochim Biophys Acta 1981;664:74-81.
    • (1981) Biochim Biophys Acta , vol.664 , pp. 74-81
    • Lea, T.J.1    Ashley, C.C.2
  • 37
    • 0027287896 scopus 로고
    • BW619C89, a glutamate release inhibitor, protects against focal cerebral ischemic damage
    • Leach MJ, Swan JH, Eisenthal D, et al. BW619C89, a glutamate release inhibitor, protects against focal cerebral ischemic damage. Stroke 1993;24:1063-I067.
    • (1993) Stroke , vol.24
    • Leach, M.J.1    Swan, J.H.2    Eisenthal, D.3
  • 38
    • 0026446959 scopus 로고
    • Therapeutic interventions in acute stroke
    • Lees KR. Therapeutic interventions in acute stroke. Br J Clin Pharmacol 1992;34:486-493.
    • (1992) Br J Clin Pharmacol , vol.34 , pp. 486-493
    • Lees, K.R.1
  • 39
    • 0023513782 scopus 로고
    • Amino acid influences on seizures elicited within the inferior colliculus
    • MacCown TJ, Givens BS, Breese GR. Amino acid influences on seizures elicited within the inferior colliculus. J Pharmacol Exp Ther 1987;243:603-608.
    • (1987) J Pharmacol Exp Ther , vol.243 , pp. 603-608
    • MacCown, T.J.1    Givens, B.S.2    Breese, G.R.3
  • 40
    • 0026701712 scopus 로고
    • Excitatory amino acid antagonists and their potential for the treatment of ischemic brain damage in man
    • MacCulloch J. Excitatory amino acid antagonists and their potential for the treatment of ischemic brain damage in man. Br J Clin Pharmacol 1992;34:106-114.
    • (1992) Br J Clin Pharmacol , vol.34 , pp. 106-114
    • MacCulloch, J.1
  • 41
    • 0027507561 scopus 로고
    • Effect of the kappa-1 opioid agonist CI-977 on ischemic brain damage and cerebral blood flow after middle cerebral artery occlusion in the rat
    • Mackay KB, Kusumoto K, Graham DI, MacCulloch J. Effect of the kappa-1 opioid agonist CI-977 on ischemic brain damage and cerebral blood flow after middle cerebral artery occlusion in the rat. Brain Res 1993;629:10-18.
    • (1993) Brain Res , vol.629 , pp. 10-18
    • Mackay, K.B.1    Kusumoto, K.2    Graham, D.I.3    MacCulloch, J.4
  • 42
    • 0024307317 scopus 로고
    • Riluzole, a novel anti-glutamate, prevents memory loss and hippocampal neuronal damage in ischemic gerbils
    • Malgouris C, Bardot F, Daniel M, et al. Riluzole, a novel anti-glutamate, prevents memory loss and hippocampal neuronal damage in ischemic gerbils. J Neurosci 1989;9:3720-3727.
    • (1989) J Neurosci , vol.9 , pp. 3720-3727
    • Malgouris, C.1    Bardot, F.2    Daniel, M.3
  • 43
    • 0001335522 scopus 로고
    • The neuroprotective agent riluzole inhibits release of L-glutamate and L-aspartate from slices of hippocampal area CA1
    • Martin D, Thompson MA, Nadler JV. The neuroprotective agent riluzole inhibits release of L-glutamate and L-aspartate from slices of hippocampal area CA1. Dr J Pharmacol (Suppl) 1991;104:240P.
    • (1991) Dr J Pharmacol , vol.104 , Issue.SUPPL.
    • Martin, D.1    Thompson, M.A.2    Nadler, J.V.3
  • 44
    • 0347060612 scopus 로고
    • Riluzole, a compound which interferes with glutamate neurotransmission, improves cognitive deficit following experimental brain injury in rats
    • McIntosh TK, Voddi M, Smith D, Stutzmann JM. Riluzole, a compound which interferes with glutamate neurotransmission, improves cognitive deficit following experimental brain injury in rats. J Neurotrauma 1995;12:379.
    • (1995) J Neurotrauma , vol.12 , pp. 379
    • McIntosh, T.K.1    Voddi, M.2    Smith, D.3    Stutzmann, J.M.4
  • 45
    • 0030468988 scopus 로고    scopus 로고
    • Riluzole, a novel neuroprotective agent, attenuates both neurological motor and cognitive dysfunction following traumatic brain injury in the rat
    • McIntosh TK, Smith DH, Voddi M, Perri BR, Stutzmann JM. Riluzole, a novel neuroprotective agent, attenuates both neurological motor and cognitive dysfunction following traumatic brain injury in the rat. J Neurotrauma 1996;13:767-780.
    • (1996) J Neurotrauma , vol.13 , pp. 767-780
    • McIntosh, T.K.1    Smith, D.H.2    Voddi, M.3    Perri, B.R.4    Stutzmann, J.M.5
  • 46
    • 0342670421 scopus 로고
    • Excitatory amino acids and anticonvulsant drug action
    • Hertz L, Kvamme E, McGeer E, Schousboe A, eds. New York: Alan R. Liss
    • Meldrum BS, Chapman AG. Excitatory amino acids and anticonvulsant drug action. In: Hertz L, Kvamme E, McGeer E, Schousboe A, eds. Glutamine, Glutamate and GABA in the Central Nervous System. New York: Alan R. Liss, 1983:625-642.
    • (1983) Glutamine, Glutamate and GABA in the Central Nervous System , pp. 625-642
    • Meldrum, B.S.1    Chapman, A.G.2
  • 47
    • 0021912595 scopus 로고
    • Possible therapeutic applications of antagonists of excitatory amino acid neurotransmitters
    • Meldrum BS. Possible therapeutic applications of antagonists of excitatory amino acid neurotransmitters. Clin Sci 1985;68:113-122.
    • (1985) Clin Sci , vol.68 , pp. 113-122
    • Meldrum, B.S.1
  • 48
    • 0025063609 scopus 로고
    • Excitatory amino acid neurotoxicity and neurodegenerative disease
    • Meldrum BS, Garthwaite J. Excitatory amino acid neurotoxicity and neurodegenerative disease. Trends Pharmacol Sci 1990;11:379-387.
    • (1990) Trends Pharmacol Sci , vol.11 , pp. 379-387
    • Meldrum, B.S.1    Garthwaite, J.2
  • 49
    • 0027165858 scopus 로고
    • Amino acids as dietary excitotoxins: A contribution to understanding neurodegenerative disorders
    • Meldrum DS. Amino acids as dietary excitotoxins: A contribution to understanding neurodegenerative disorders. Brain Res Rev 1993;18:293-314.
    • (1993) Brain Res Rev , vol.18 , pp. 293-314
    • Meldrum, D.S.1
  • 50
    • 0029072501 scopus 로고
    • Dual inhibitory action of enadoline (CI 977) on release of amino acids in the rat hippocampus
    • Millan MH, Chapman AG, Meldrum BS. Dual inhibitory action of enadoline (CI 977) on release of amino acids in the rat hippocampus. Eur J Pharmacol 1995;279:75-81.
    • (1995) Eur J Pharmacol , vol.279 , pp. 75-81
    • Millan, M.H.1    Chapman, A.G.2    Meldrum, B.S.3
  • 51
    • 0022362589 scopus 로고
    • 2-Amino-6-trifluoromethoxy benzothiazole, a possible antagonist of excitatory amino acid neurotransmission. I. Anticonvulsant properties
    • Mizoule J, Meldrum B. Mazadier M, et al. 2-Amino-6-trifluoromethoxy benzothiazole, a possible antagonist of excitatory amino acid neurotransmission. I. Anticonvulsant properties. Neuropharmacology 1985;24:767-773.
    • (1985) Neuropharmacology , vol.24 , pp. 767-773
    • Mizoule, J.1    Meldrum, B.2    Mazadier, M.3
  • 53
    • 0028897733 scopus 로고
    • Clinical experience with excitatory amino acid antagonist drugs
    • Muir KW, Lees KR. Clinical experience with excitatory amino acid antagonist drugs. Stroke 1995;26:503-513.
    • (1995) Stroke , vol.26 , pp. 503-513
    • Muir, K.W.1    Lees, K.R.2
  • 54
    • 0026339216 scopus 로고
    • NMDA antagonist neurotoxicity mechanism and prevention
    • Olney JW, Labruyere J, Wang G, et al. NMDA antagonist neurotoxicity mechanism and prevention. Science 1991;254:1515-1518.
    • (1991) Science , vol.254 , pp. 1515-1518
    • Olney, J.W.1    Labruyere, J.2    Wang, G.3
  • 55
    • 0001060522 scopus 로고
    • The effects of the novel neuroprotective compound lubeluzole on sodium current and veratridine induced sodium load in rat brain neurons and synaptosomes
    • Osikowska-Evers BA, Wihelm D, Nebel U, et al. The effects of the novel neuroprotective compound lubeluzole on sodium current and veratridine induced sodium load in rat brain neurons and synaptosomes. J Cereb Blood Flow Metab (Suppl) 1995:15:8380.
    • (1995) J Cereb Blood Flow Metab , vol.15 , Issue.SUPPL. , pp. 8380
    • Osikowska-Evers, B.A.1    Wihelm, D.2    Nebel, U.3
  • 56
    • 0026767197 scopus 로고
    • Neuroprotective action of riluzole in rodent models of global and focal cerebral ischemia
    • Pratt J, Rataud J, Bardot F, et al. Neuroprotective action of riluzole in rodent models of global and focal cerebral ischemia. Neurosci Lett 1992;140:251-254.
    • (1992) Neurosci Lett , vol.140 , pp. 251-254
    • Pratt, J.1    Rataud, J.2    Bardot, F.3
  • 57
    • 12644304464 scopus 로고
    • Neuronal protection by riluzole against ischemic brain damage in gerbils
    • Krieglstein J, ed. Boca Raton: CRC Press
    • Rataud J, Malgouris C, Bardot F, et al. Neuronal protection by riluzole against ischemic brain damage in gerbils. In: Krieglstein J, ed. Pharmacology of Cerebral Ischemia. Boca Raton: CRC Press, 1988:261-264.
    • (1988) Pharmacology of Cerebral Ischemia , pp. 261-264
    • Rataud, J.1    Malgouris, C.2    Bardot, F.3
  • 58
    • 12644303816 scopus 로고
    • R & D focus. 1995;4:8.
    • (1995) R & D Focus , vol.4 , pp. 8
  • 59
    • 12644262963 scopus 로고    scopus 로고
    • R & D focus. 1996;5:6.
    • (1996) R & D Focus , vol.5 , pp. 6
  • 60
    • 0022620257 scopus 로고
    • Glutamate and the pathophysiology of hypoxic-ischemic brain damage
    • Rothman SM, Olney JW. Glutamate and the pathophysiology of hypoxic-ischemic brain damage. Ann Neurol 1986;19:105-111.
    • (1986) Ann Neurol , vol.19 , pp. 105-111
    • Rothman, S.M.1    Olney, J.W.2
  • 61
    • 0026567724 scopus 로고
    • Medical treatment of acute ischemic stroke
    • Sandercock P, Willems H. Medical treatment of acute ischemic stroke. Lancet 1992;339:537-539.
    • (1992) Lancet , vol.339 , pp. 537-539
    • Sandercock, P.1    Willems, H.2
  • 62
    • 0026485961 scopus 로고
    • The NMDA macromolecular complex as a target for the development of anti-ischemic drugs
    • Scatton B, Benavides J, Carter C, et al. The NMDA macromolecular complex as a target for the development of anti-ischemic drugs. Clin Neuropharmacol 1992;15:S133-437.
    • (1992) Clin Neuropharmacol , vol.15
    • Scatton, B.1    Benavides, J.2    Carter, C.3
  • 63
    • 0000071608 scopus 로고
    • Extracellular changes of glutamate in the periinfarct zone. Effect of lubeluzole
    • Scheller D, Kolb J, Szathmary S, Zacharias E, et al. Extracellular changes of glutamate in the periinfarct zone. Effect of lubeluzole. J Cereb Blood Flow Metab (Suppl) 1995;15:S379.
    • (1995) J Cereb Blood Flow Metab , vol.15 , Issue.SUPPL.
    • Scheller, D.1    Kolb, J.2    Szathmary, S.3    Zacharias, E.4
  • 64
    • 0027509786 scopus 로고
    • Prophylaxis and treatment of stroke
    • Sila CA. Prophylaxis and treatment of stroke. Drugs 1993;45:329-337.
    • (1993) Drugs , vol.45 , pp. 329-337
    • Sila, C.A.1
  • 65
    • 0027421635 scopus 로고
    • Cerebroprotectivc effect of BW619C89 after focal or global cerebral ischemia in the rat
    • Smith SE, Lekieffre D, Sowinski P, Meldrum BS. Cerebroprotectivc effect of BW619C89 after focal or global cerebral ischemia in the rat. Neuroreport 1993;4:1339-1342.
    • (1993) Neuroreport , vol.4 , pp. 1339-1342
    • Smith, S.E.1    Lekieffre, D.2    Sowinski, P.3    Meldrum, B.S.4
  • 67
    • 12644279479 scopus 로고
    • Strategies in stroke treatment and prophylaxis
    • February
    • Strategies in stroke treatment and prophylaxis. Pharma Projects. Executive Briefing. February 1995;25-29.
    • (1995) Pharma Projects. Executive Briefing , pp. 25-29
  • 68
    • 12644309879 scopus 로고
    • Riluzole prevents hyperexcitability produced by the mast cell degranulating peptide and dentrotoxin 1 in the rat
    • Stutzmann JM, Böhme GA, Gandolfo G, ct al. Riluzole prevents hyperexcitability produced by the mast cell degranulating peptide and dentrotoxin 1 in the rat. Eur J Pharmacol 1991;193-223.
    • (1991) Eur J Pharmacol , pp. 193-223
    • Stutzmann, J.M.1    Böhme, G.A.2    Gandolfo, G.3
  • 69
    • 0029976154 scopus 로고    scopus 로고
    • Riluzole's Effect on post-traumatic spinal cord injury in the rat
    • Stutzmann JM, Pratt J, Boraud T, Gross C. Riluzole's Effect on post-traumatic spinal cord injury in the rat. Neuroreport 1996;7(2):387-392.
    • (1996) Neuroreport , vol.7 , Issue.2 , pp. 387-392
    • Stutzmann, J.M.1    Pratt, J.2    Boraud, T.3    Gross, C.4
  • 70
    • 0001664297 scopus 로고
    • Blockade of glutaminergic transmission and neuroprotection: The strange case of riluzole
    • Jolles G, Stutzmann JM, eds. New York: Academic Press
    • Stutzmann JM, Doble A. Blockade of glutaminergic transmission and neuroprotection: The strange case of riluzole. In: Jolles G, Stutzmann JM, eds. Neurodegeneratice Disease. New York: Academic Press, 1994;205-214.
    • (1994) Neurodegeneratice Disease , pp. 205-214
    • Stutzmann, J.M.1    Doble, A.2
  • 71
    • 0028799544 scopus 로고
    • Neuroprotective effects of 619C89, a use-dependent sodium channel blocker, in rat traumatic brain injury
    • Sun FY, Faden AI. Neuroprotective effects of 619C89, a use-dependent sodium channel blocker, in rat traumatic brain injury. Brain Res 1995;673:133-140.
    • (1995) Brain Res , vol.673 , pp. 133-140
    • Sun, F.Y.1    Faden, A.I.2
  • 72
    • 0019868418 scopus 로고
    • Focal cerebral ischemia in the rat: I. Description of technique and early neuropathological consequences following middle cerebral artery occlusion
    • Tamura A, Graham DI, MacCulloch J, Teasdale GM. Focal cerebral ischemia in the rat: I. Description of technique and early neuropathological consequences following middle cerebral artery occlusion. J Cereb Blood Flow Metab 1981;1:53-60.
    • (1981) J Cereb Blood Flow Metab , vol.1 , pp. 53-60
    • Tamura, A.1    Graham, D.I.2    MacCulloch, J.3    Teasdale, G.M.4
  • 73
    • 0023850459 scopus 로고
    • Sodium fluxes modulating neuronal glutamate uptake: Differential effects of local anesthetic and anticonvulsant drugs
    • Taylor C, Tsai C, Lehmann J. Sodium fluxes modulating neuronal glutamate uptake: Differential effects of local anesthetic and anticonvulsant drugs. J Pharmacol Exp Ther 1988;244:666-673.
    • (1988) J Pharmacol Exp Ther , vol.244 , pp. 666-673
    • Taylor, C.1    Tsai, C.2    Lehmann, J.3
  • 74
    • 0026598251 scopus 로고
    • Probenecid pretreatment enhances anticonvulsant action of NBQX in mice
    • Taylor CP, Vartanian MG. Probenecid pretreatment enhances anticonvulsant action of NBQX in mice. Em J Phannacol 1992;213:151-153.
    • (1992) Em J Phannacol , vol.213 , pp. 151-153
    • Taylor, C.P.1    Vartanian, M.G.2
  • 75
    • 0026544260 scopus 로고
    • Clinical trial of nimodipine in acute ischemic stroke
    • The American Nimodipine Study Group. Clinical trial of nimodipine in acute ischemic stroke. Stroke 1992;23:3-8.
    • (1992) Stroke , vol.23 , pp. 3-8
  • 77
    • 0027469132 scopus 로고
    • Effects of riluzole on focal cerebral ischemia in rats
    • Wahl F, Allix M, Plotkine M, Boulu RG. Effects of riluzole on focal cerebral ischemia in rats. Eur J Phannacol 1993:230:209-214.
    • (1993) Eur J Phannacol , vol.230 , pp. 209-214
    • Wahl, F.1    Allix, M.2    Plotkine, M.3    Boulu, R.G.4
  • 79
    • 0025319344 scopus 로고
    • Comparison of the neuroprotective effects of N-methyl-D-aspartate antagonist MK-801 and the opiate-receptor antagonist nalmefene in experimental spinal cord ischemia
    • Yum SW, Saden AI. Comparison of the neuroprotective effects of N-methyl-D-aspartate antagonist MK-801 and the opiate-receptor antagonist nalmefene in experimental spinal cord ischemia. Arch Neurol 1990;47:277-281.
    • (1990) Arch Neurol , vol.47 , pp. 277-281
    • Yum, S.W.1    Saden, A.I.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.