Monitoring of gentamicin serum concentrations in neonates. Usefulness in adjustment of dosage;Monitorizacion de niveles sericos de gentamicina en neonatos. Utilidad para el ajuste de dosis

Anales Espanoles de Pediatria

Volumn 46, Issue 1, 1997, Pages 47-52

  Garcia Delgado R ^a   Sanchez Romero A ^a   Tebar Gil R ^a   Marco Macian A ^a  

^a HOSPITAL GENERAL UNIVERSITARIO DE ALBACETE   (Spain)

Author keywords

gentamicin; monitoring of serum concentrations; neonates

Indexed keywords

GENTAMICIN; ANTIINFECTIVE AGENT;

AGE; ARTICLE; DOSE RESPONSE; DRUG BLOOD LEVEL; DRUG DISTRIBUTION; DRUG ELIMINATION; DRUG HALF LIFE; DRUG MONITORING; HUMAN; NEWBORN; BLOOD; BODY WEIGHT; GESTATIONAL AGE; RETROSPECTIVE STUDY; SEPSIS;

ANTI-BACTERIAL AGENTS; BODY WEIGHT; DOSE-RESPONSE RELATIONSHIP, DRUG; GENTAMICINS; GESTATIONAL AGE; HUMANS; INFANT, NEWBORN; RETROSPECTIVE STUDIES; SEPSIS;

EID: 0030929690     PISSN: 03024342     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (18)

1. a ed). Mosby, 1992; págs. 619-661.
2. a ed.). Philadelphia: WB Saunders, 1990; págs. 601-656.
3. Leonard MB, Koren G, Stevenson DK, Prober CG. Vancomycin pharmacokinetics in very low birth weight neonates. Pediatr Infect Dis J, 1989;8:282-286.
4. Paap CM, Nahata MC. Clinical pharmacokinetics of antibacterial drugs in neonates. Clin Pharmacokinet 1990;19:280-318.
5. Watterberg KL, Kelly HW, Angelus P, Backstrom C. The need for a loading dose on gentamicin in neonates. Ther Drug Monit 1989;11:16-20.
6. Faura C, Azanza JR, Honorato J. Farmacocinética de los aminoglucósidos en neonatos. Rev Esp Quimioterap 1989;2:207-208.
7. Rajchgot P, Prober CG, Soldin S, Perlman M, Good F, Harding E, Klein J, MacLeod S. Aminoglycoside-related nephrotoxicity in the premature newborn. Clin Pharmacol Ther 1984;35:394-401.
8. De Cos MA, Gómez-Ullate J, Gómez F, Armijo JA. Time course of trough serum gentamicin concentrations in preterm and term neonates. Clin Pharmacokinet 1992;23:391-401.
9. Mulhall A, De Louvois J, Hurley R. Incidence of potentially toxic concentrations of gentamicin in the neonate. Arch Dis Child 1983;58:897-900.
10. Edwards C, Low DC, Bissenden JG. Gentamicin dosage for the newborn. Lancet 1986;1:508-509.
11. Faura CC, Feret MA, Horga JR. Monitoring serum levels of gentamicin to develop a new regimen for gentamicin dosage in newborns. Ther Drug Monit 1991;13:268-276.
12. Carlstedt BC, Uaamnuichai M, Day RB, Bowman L, Brater DC. Aminoglycoside dosing in pediatric patients. Ther Drug Monit 1989;11:38-43.
13. Sawchuk RJ, Zaske DE. Pharmacokinetics of dosing regimens which utilize multiple intravenous infusions: gentamicin in burn patients. J Pharmacokinet Biopharmacol 1976;4:183-195.
14. Kasik JW, Jenkins S, Leuschen MP, Nelson RM. Postconcepcional age and gentamicin elimination half-life. J Pediatr 1985;106:502-505.
15. Szefler SJ, Wynn RJ, Clarke DF, Buckwald S, Shen D, Schentag JJ. Relationship of gentamicin serum concentrations to gestacional age in preterm and term neonates. J Pediatr 1980;97:312-315.
16. Guignard JP, John EG. Función Renal en el lactante prematuro de tamaño minúsculo. Clin Perinatol (ed esp) 1986;2:405-431.
17. Pons G, d'Athis P, Rey E, de Lauture D, Richard MO, Badoual J, Olive G. Gentamicin monitoring in neonates. Ther Drug Monit 1988;10: 421-427.
18. López-Samblas AM, Torres CL, Wang H, Feuer WJ, Goldberg RN. Effectiveness of a gentamicin dosing protocol based on postconcepional age: comparison to published neonatal guidelines. Ann Pharmacother 1992;26:534-538.