Transgenic rescue from embryonic lethality and renal carcinogenesis in the Eker rat model by introduction of a wild-type Tsc2 gene

Proceedings of the National Academy of Sciences of the United States of America

Volumn 94, Issue 8, 1997, Pages 3990-3993

  Kobayashi, Toshiyuki ^a   Mitani, Hiroaki ^a   Takahashi, Ri Ichi ^b   Hirabayashi, Masumi ^b   Ueda, Masatsugu ^b   Tamura, Hiroshi ^c   Hino, Okio ^a  

^a CANCER INSTITUTE   (Japan)

^b YS New Technology Institute Inc   (Japan)

^c TEIKYO UNIVERSITY   (Japan)

Author keywords

animal model; gene therapy; hereditary cancer; tumor suppressor gene; two hit model

Indexed keywords

ETHYLNITROSOUREA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CARCINOGENESIS; CONTROLLED STUDY; DISEASE PREDISPOSITION; DOMINANT INHERITANCE; ENVIRONMENTAL FACTOR; FAMILIAL CANCER; FEMALE; GENE FUNCTION; GENE INSERTION; GENE MUTATION; GENE REPRESSION; GENE THERAPY; GENETIC ANALYSIS; GERM LINE; HOMOZYGOTE; KIDNEY CARCINOMA; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; RAT; TRANSGENIC ANIMAL; TUMOR SUPPRESSOR GENE;

ANIMALS; ANIMALS, GENETICALLY MODIFIED; CARCINOMA; GENE EXPRESSION; GENE TRANSFER TECHNIQUES; GENES, TUMOR SUPPRESSOR; GERM-LINE MUTATION; HUMANS; KIDNEY NEOPLASMS; NEOPLASMS, EXPERIMENTAL; RATS; REPRESSOR PROTEINS; TUMOR SUPPRESSOR PROTEINS;

ANIMALIA;

EID: 0030929668     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.94.8.3990     Document Type: Article

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