Silver-resistant mutants of Escherichia coli display active efflux of Ag+ and are deficient in porins

Journal of Bacteriology

Volumn 179, Issue 19, 1997, Pages 6127-6132

  Li, Xian Zhi ^a,d   Nikaido, Hiroshi ^b   Williams, Kurt E ^a,c  

^a UNIVERSITY OF SASKATCHEWAN   (Canada)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c UNIVERSITY OF SASKATCHEWAN   (Canada)

^d QUEEN S UNIVERSITY   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIAL PROTEIN; CEFALOTIN; CEFEPIME; CEFPIROME; CHLORAMPHENICOL; MEMBRANE PROTEIN; MERCURIC CHLORIDE; PORIN; SILVER NITRATE; SULFADIAZINE SILVER; TETRACYCLINE;

ARTICLE; BACTERIAL MEMBRANE; BACTERIUM MUTANT; CATION TRANSPORT; CELL MEMBRANE PERMEABILITY; ESCHERICHIA COLI; NONHUMAN; OUTER MEMBRANE; PRIORITY JOURNAL;

BACTERIA (MICROORGANISMS); ESCHERICHIA COLI;

EID: 0030929425     PISSN: 00219193     EISSN: None     Source Type: Journal    
DOI: 10.1128/jb.179.19.6127-6132.1997     Document Type: Article

References (33)

1. Anonymous. 1989. The Merck index, 11th ed. Merck & Co., Inc., Rahway, N.J.
2. Bavoil, P., H. Nikaido, and K. von Meyenburg. 1977. Pleiotropic transport mutants of Escherichia coli lack porin, a major outer membrane protein. Mol. Gen. Genet. 158:23-33.
3. Cervantes, C., and S. Silver. 1996. Metal resistance in Pseudomonas: genes and mechanisms, p. 398. In T. Nakazawa, K. Furukawa, D. Haas, and S. Silver (ed.), Molecular biology of pseudomonads. American Society for Microbiology, Washington, D.C.
4. Deshpande, L. M., and B. A. Chopade. 1994. Plasmid mediated silver resistance in Acinetobacter baumannii. BioMetals 7:49-56.
5. Haefeli, C., C. Frankin, and K. Hardy. 1984. Plasmid-determined silver resistance in Pseudomonas stutzeri isolated from a silver mine. J. Bacteriol. 158:389-392.
6. Harder, K., H. Nikaido, and M. Matsuhashi. 1981. Mutants of Escherichia coli that are resistant to certain β-lactam compounds lack the ompF porin. Antimicrob. Agents Chemother. 20:549-552.
7. Hendry, A. T., and I. O. Stewart. 1979. Silver-resistant Enterobacteriaceae from hospital patients. Can. J. Microbiol. 25:915-921.
8. Li, X.-Z., D. M. Livermore, and H. Nikaido. 1994. Role of efflux pump(S) in intrinsic resistance of Pseudomonas aeruginosa: resistance to tetracycline, chloramphenicol, and norfloxacin. Antimicrob. Agents Chemother. 38:1732-1741.
9. Li, X.-Z., H. Nikaido, and K. Poole. 1995. Role of MexA-MexB-OprM in antibiotic efflux in Pseudomonas aeruginosa. Antimicrob. Agents Chemother. 39:1948-1953.
10. Li, X.-Z., and K. E. Williams. 1996. Role of loss of major porins in silver resistance of Escherichia coli, abstr. C41, p. 41. In Abstracts of the 36th Interscience Conference on Antimicrobial Agents and Chemotherapy 1996. American Society for Microbiology, Washington, D.C.
11. Li, X.-Z., and K. E. Williams. Unpublished data.
12. Lutkenhaus, J. F. 1977. Role of a major outer membrane protein in Escherichia coli. J. Bacteriol. 131:631-637.
13. Ma, D., M. Alberti, C. Lynch, H. Nikaido, and J. E. Hearst. 1996. The local repressor AcrR plays a modulating role in the regulation of acrAB genes of Escherichia coli by global stress signals. Mol. Microbiol. 19:101-112.
14. Matsui, K., F. Roberto, P. Goodlove, X.-Z. Li, A. Gupta, and S. Silver. 1997. Cloning, physiological, and genetic analysis of plasmid-determined resistance to silver cations in Escherichia coli, abstr. H40, p. 291. In Abstracts of the 97th General Meeting of the American Society for Microbiology 1997. American Society for Microbiology, Washington, D.C.
15. McHugh, G. L., R. C. Moellering, C. C. Hopkins, and M. N. Swartz. 1975. Salmonella typhimurium resistant to silver nitrate, chloramphenicol, and ampicillin. Lancet i:235-240.
16. McMurry, L., R. E. Petrucci, Jr., and S. B. Levy. 1980. Active efflux of tetracycline encoded by four genetically different tetracycline resistance determinants in Escherichia coli. Proc. Natl. Acad. Sci. USA 77:3974-3977.
17. Miller, J. H. 1992. A short course in bacterial genetics: a laboratory manual and handbook for Escherichia coli and related bacteria. Cold Spring Harbor Laboratory Press, Plainview, N.Y.
18. Modak, S. M., and C. R. Fox, Jr. 1973. Binding of silver sulfadiazine to the cellular components of Pseudomonas aeruginosa. Biochem. Pharmacol. 22: 2391-2404.
19. Modak, S. M., and C. R. Fox, Jr. 1981. Sulfadiazine silver-resistant Pseudomonas in burns. Arch. Surg. 116:854-857.
20. Nakajima, H., K. Kobayashi, M. Kobayashi, H. Asako, and R. Aono. 1995. Overexpression of the robA gene increases organic solvent tolerance and multiple antibiotic and heavy metal ion resistance in Escherichia coli. Appl. Environ. Microbiol. 61:2302-2307.
21. Nesbitt, R. U., Jr., and B. J. Sandmann. 1977. Solubility studies of silver sulfadiazine. J. Pharm. Sci. 66:519-522.
22. Nikaido, H. 1994. Prevention of drug access to bacterial targets: role of permeability barrier and active efflux. Science 264:382-388.
23. Nikaido, H. 1996. Multidrug efflux pumps of gram-negative bacteria. J. Bacteriol. 178:5853-5859.
24. Nikaido, H., E. Y. Rosenberg, and J. Foulds. 1983. Porin channels in Escherichia coli: studies with β-lactams in intact cells. J. Bacteriol. 153:232-240.
25. + extrusion by CopB. Biochem. Biophys. Res. Commun. 202:44-48.
26. Pugsley, A. P., and C. A. Schnaitman. 1978. Outer membrane proteins of Escherichia coli. VII. Evidence that bacteriophage-directed protein 2 functions as a pore. J. Bacteriol. 133:1181-1189.
27. Silver, S., and L. T. Phung. 1996. Bacterial heavy metal resistance mechanisms: new surprises. Annu. Rev. Microbiol. 50:753-789.
28. Silver, S., and G. Ji. 1994. Newer systems for bacterial resistance to toxic heavy metals. Environ. Health Perspect. 102(Suppl. 3):107-113.
29. Silver, S., R. D. Perry, Z. Tynecka, and T. G. Kinscherf. 1982. Mechanisms of bacterial resistance to the toxic heavy metals antimony, arsenic, cadmium, mercury, and silver, p. 347. In S. Mitsuhashi (ed.), Drug resistance in bacteria - genetics, biochemistry and molecular biology. Japan Scientific Societies Press, Tokyo, Japan, and Thieme-Stratton Inc., New York, N.Y.
30. Solioz, M., and A. Odermatt. 1995. Copper and silver transport by CopB-ATPase in membrane vesicles of Enterococcus hirae. J. Biol. Chem. 270: 9217-9221.
31. Starodub, M.-E., and J. T. Trevors. 1989. Silver resistance in Escherichia coli R1. J. Med. Microbiol. 29:101-110.
32. Starodub, M.-E., and J. T. Trevors. 1990. Silver accumulation and resistance in Escherichia coli R1. J. Inorg. Biochem. 39:317-325.
33. Thanassi, D. G., G. S. B. Suh, and H. Nikaido. 1995. Role of outer membrane barrier in efflux-mediated tetracycline resistance of Escherichia coli. J. Bacteriol. 177:998-1007.