Mechanisms of drug-induced lupus III. Sex-specific differences in T cell homing may explain increased disease severity in female mice

Arthritis and Rheumatism

Volumn 40, Issue 7, 1997, Pages 1334-1343

  Yung, Raymond ^a   Williams, Robert ^a   Johnson, Kent ^a   Phillips, Carrie ^a   Stoolman, Lloyd ^a   Chang, Sandra ^a   Richardson, Bruce ^a,b  

^a UNIVERSITY OF MICHIGAN   (United States)

^b Ann Arbor Vet Admin Hospital ^*  (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AUTOANTIBODY; CHROMIUM 51; DNA ANTIBODY; FLUORESCEIN DIACETATE; PROCAINAMIDE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIBODY TITER; ARTICLE; AUTOIMMUNITY; CONTROLLED STUDY; DISEASE SEVERITY; DRUG INDUCED DISEASE; ETIOLOGY; FEMALE; LIVER DISEASE; LUPUS ERYTHEMATOSUS; LYMPHOCYTE CLONE; LYMPHOCYTE HOMING; MOUSE; NONHUMAN; OVARIECTOMY; PRIORITY JOURNAL; SEX DIFFERENCE; SPLENECTOMY; T LYMPHOCYTE;

EID: 0030929290     PISSN: 00043591     EISSN: None     Source Type: Journal    
DOI: 10.1002/art.1780400719     Document Type: Article

References (30)

1. Hochberg MC: The Epidemiology of Systemic Lupus Erythematosus. Philadelphia, Lea & Febiger, 1993
2. Cutolo M, Sulli A, Seriolo B, Accardo S, Masi AT: Estrogens, the immune response and autoimmunity. Clin Exp Rheumatol 13:217-226, 1995
3. Grossman CJ: Interactions between the gonadal steroids and the immune system. Science 227:257-260, 1985
4. Yung RL, Quddus J, Chrisp CE, Johnson KJ, Richardson BC: Mechanisms of drug induced lupus. I. Cloned Th2 cells modified with DNA methylation inhibitors in vitro cause autoimmunity in vivo. J Immunol 154:3025-3035, 1995
5. Quddus J, Johnson KJ, Gavalchin J, Amento EP, Warren JS, Chrisp C, Yung RL, Richardson BC: Treating activated CD4+ T cells with either of two distinct DNA methyltransferase inhibitors, 5-azacytidine or procainamide, is sufficient to induce a lupus-like disease in syngeneic mice. J Clin Invest 92:38-53, 1993
6. Richardson BC, Liebling MR, Hudson JL: CD4+ cells treated with DNA methylation inhibitors induce autologous B cell differentiation. Clin Immunol Immunopathol 55:368-381, 1990
7. Pals S, Radaszkiewicz T, Roozendaal L, Gleichmann E: Chronic progressive polyarthritis and other symptoms of collagen vascular disease induced by graft-vs-host reaction. J Immunol 134:1475-1482, 1985
8. Yung R, Powers D, Johnson K, Amento E, Carr D, Laing T, Yang J, Chang S, Hemati N, Richardson BC: Mechanisms of drug-induced lupus. II. T cells overexpressing lymphocyte function-associated antigen 1 become autoreactive and cause a lupus-like disease in syngeneic recipients. J Clin Invest 97:2866-2871, 1996
9. Stoolman LM: Adhesion molecules controlling lymphocyte migration. Cell 56:907-910, 1989
10. Cid MC, Kleinman HK, Grant DS, Schnaper HW, Fauci AS, Hoffman GS: Estradiol enhances leukocyte binding to tumor necrosis factor (TNF)-stimulated endothelial cells via an increase in TNF-induced adhesion molecules E-selectin, intercellular adhesion molecule type 1, and vascular cell adhesion molecule type 1. J Clin Invest 93:17-25, 1994
11. Gumkowski F, Kaminska G, Kaminski M, Morrissey LW, Auerbach R: Heterogeneity of mouse vascular endothelium: in vitro studies of lymphatic, large blood vessel and microvascular endothelial cells. Blood Vessels 24:11-23, 1987
12. Kaye J, Porcelli S, Tile J, Jones B, Janeway CA Jr: Both a monoclonal antibody and antisera specific for determinants unique to individual cloned helper T cell lines can substitute for antigen and antigen-presenting cells in the activation of T cells. J Exp Med 158:836-856, 1983
13. Saizawa MK, Hug E, Haque S, Portoles P, Suzuki S, Eichmann K: Autoreactivity of low but not of high CD4 variants of an antigen-specific, I-A-restricted mouse T cell clone. J Immunol 148:702-709, 1992
14. Richardson B, Kahn L, Lovett EJ, Hudson J: Effect of an inhibitor of DNA methylation on T cells. I. 5-azacytidine induces T4 expression on T8+ T cells. J Immunol 137:35-39, 1986
15. Roubinian JR, Papoian R, Talal N: Androgenic hormones modulate autoantibody responses and improve survival in murine lupus. J Clin Invest 59:1066-1070, 1977
16. Pober JS, Cotran RS: Immunologic interactions of T lymphocytes with vascular endothelium. Adv Immunol 50:261-302, 1991
17. 1 mice. J Exp Med 147:1568-1583, 1978
18. Wofsy D, Seaman WE: Reversal of advanced murine lupus in NZB/NZW F1 mice by treatment with monoclonal antibody to L3T4. J Immunol 138:3247-3253, 1987
19. Michieletti P, Wanless IR, Katz A, Scheuer PJ, Yeaman SJ, Bassendine MF, Palmer JM, Heathcote EJ: Antimitochondrial antibody negative primary biliary cirrhosis: a distinct syndrome of autoimmune cholangitis. Hepatology 18:10-15, 1993
20. Jung LKL, Good RA, Fernandes GA: Studies on lymphocyte homing in autoimmune prone NZB mice. Immunol Invest 15:11-23, 1986
21. Smathers PA, Santoro TJ, Chused TM, Reeves JP, Steinberg AD: Studies of lymphoproliferation in MRL-lpr/lpr mice. J Immunol 133:1955-1961, 1984
22. 1 hybrid mouse: a laboratory model of systemic lupus erythematosus. Aust Ann Med 14:185-191, 1965
23. Roubinian JR, Papioan R, Sawada S, Talal N: Immunological regulation of spontaneous antibodies to DNA and RNA. III. Early effects of neonatal thymectomy and splenectomy. Immunology 33:399-406, 1977
24. Swanson PC, Yung RL, Blatt NB, Eagan MA, Norris JN, Richardson BC, Johnson KJ, Glick GD: Ligand recognition by anti-DNA autoantibodies. II. Genetic analysis and pathogenicity. J Clin Invest 97:1748-1760, 1996
25. Koffler D, Schur PH, Kunkel HG: Immunological studies concerning the nephritis of systemic lupus erythematosus. J Exp Med 126:607-623, 1967
26. Lambert PH, Dixon FJ: Pathogenesis of the glomerulonephritis of NZB/W mice. J Exp Med 127:507-521, 1968
27. Strausser HR, Fiore RP, Belisle EH: Alterations in Immune Function with Age, Sex Hormones, and Stress. New York, Marcel Dekker, 1984
28. Rozing J, Brons NHC, Benner R: Effects of splenectomy on the humoral immune system: a study in neonatally and adult splenectomized mice. Immunology 34:909-917, 1978
29. Best WR, Darling DR: A critical look at the splenectomy S.L.E. controversy. Med Clin North Am 46:19-47, 1962
30. Gruenberg JC, van Slyck EJ, Abraham JP: Splenectomy in systemic lupus erythematosus. Am Surg 52:366-370, 1986