메뉴 건너뛰기




Volumn 6, Issue 5, 1997, Pages 496-503

Gene therapy for the treatment of renal disease: Prospects for the future

Author keywords

[No Author keywords available]

Indexed keywords

VIRUS VECTOR;

EID: 0030929058     PISSN: 10624821     EISSN: None     Source Type: Journal    
DOI: 10.1097/00041552-199709000-00015     Document Type: Review
Times cited : (3)

References (76)
  • 1
    • 0029134946 scopus 로고
    • Gene therapy: Promise, pitfalls, and prognosis
    • Leiden J: Gene therapy: promise, pitfalls, and prognosis. N Engl J Med 1995, 333:871-873.
    • (1995) N Engl J Med , vol.333 , pp. 871-873
    • Leiden, J.1
  • 2
    • 0028875936 scopus 로고
    • Transfer of genes to humans: Early lessons and obstacles to success
    • Crystal G: Transfer of genes to humans: early lessons and obstacles to success. Science 1995, 270:404-411.
    • (1995) Science , vol.270 , pp. 404-411
    • Crystal, G.1
  • 3
    • 0030271317 scopus 로고    scopus 로고
    • Strategies for targeted gene therapy
    • Harris JD, Lemoine NR: Strategies for targeted gene therapy. Trends in Genetics 1996, 12:400-405.
    • (1996) Trends in Genetics , vol.12 , pp. 400-405
    • Harris, J.D.1    Lemoine, N.R.2
  • 4
    • 0030062296 scopus 로고    scopus 로고
    • Human gene therapy: An immature genie, but certainly out of the bottle
    • Friedmann T: Human gene therapy: an immature genie, but certainly out of the bottle. Nature Med 1996, 2:144-147.
    • (1996) Nature Med , vol.2 , pp. 144-147
    • Friedmann, T.1
  • 6
    • 0031025998 scopus 로고    scopus 로고
    • Gene therapy for cancer
    • Roth JC, Cristiano RJ: Gene therapy for cancer. J Natl Cancer Inst 1997, 89:21-39. The authors reviewed the current status of and future strategies for human gene therapy, and included an appendix of protocols for human gene therapy on cancer.
    • (1997) J Natl Cancer Inst , vol.89 , pp. 21-39
    • Roth, J.C.1    Cristiano, R.J.2
  • 7
    • 0028053835 scopus 로고
    • Transfer of exogenous genes into the kidney
    • Kitamura M: Transfer of exogenous genes into the kidney. Exp Nephrol 1994, 2:313-317.
    • (1994) Exp Nephrol , vol.2 , pp. 313-317
    • Kitamura, M.1
  • 8
    • 0028821229 scopus 로고
    • The potential gene therapy for treatment of kidney diseases
    • Riley DJ, Lee W-H: The potential gene therapy for treatment of kidney diseases. Semin Nephrol 1995, 15:57-69.
    • (1995) Semin Nephrol , vol.15 , pp. 57-69
    • Riley, D.J.1    Lee, W.-H.2
  • 9
    • 0029930993 scopus 로고    scopus 로고
    • Gene transfer into the kidney: Promise for unravelling disease mechanisms, limitations for human gene therapy
    • Fine LG: Gene transfer into the kidney: promise for unravelling disease mechanisms, limitations for human gene therapy [editorial]. Kidney Int 1996, 49:612-619. This is a comprehensive review on gene transfer and gene therapy from the view point of the nephrologist.
    • (1996) Kidney Int , vol.49 , pp. 612-619
    • Fine, L.G.1
  • 11
    • 0029855653 scopus 로고    scopus 로고
    • Molecular biological intervention
    • Isaka Y, Imai E: Molecular biological intervention. Semin Nephrol 1996, 16:591-598.
    • (1996) Semin Nephrol , vol.16 , pp. 591-598
    • Isaka, Y.1    Imai, E.2
  • 12
    • 0027728743 scopus 로고
    • Treatment of severe combined immunodeficiency disease (SCID) due to adenosine deaminase deficiency with CD34 + selected autologous peripheral blood cells transduced with a human ADA gene. Amendment to clinical research project, Project 90-C-195
    • Blaese RM, Culver KW, Chang L, Anderson WF, Mullen C, Nienhuis A, Carter C, Dunber C, Berger M: Treatment of severe combined immunodeficiency disease (SCID) due to adenosine deaminase deficiency with CD34 + selected autologous peripheral blood cells transduced with a human ADA gene. Amendment to clinical research project, Project 90-C-195. Hum Gene Ther 1993, 4:521-527.
    • (1993) Hum Gene Ther , vol.4 , pp. 521-527
    • Blaese, R.M.1    Culver, K.W.2    Chang, L.3    Anderson, W.F.4    Mullen, C.5    Nienhuis, A.6    Carter, C.7    Dunber, C.8    Berger, M.9
  • 13
    • 9844263065 scopus 로고    scopus 로고
    • Gene therapy and acquired diseases
    • Wivel N: Gene therapy and acquired diseases. Bull Jpn Soc Gene Ther 1997, 3:2-5.
    • (1997) Bull Jpn Soc Gene Ther , vol.3 , pp. 2-5
    • Wivel, N.1
  • 15
    • 0029993858 scopus 로고    scopus 로고
    • Efficient transfer, integration, and sustained long-term expression of the transgene in adult rat brains injected with a lentiviral vector
    • Naldini L, Blomer U, Gage FH, Trono D, Verma IM: Efficient transfer, integration, and sustained long-term expression of the transgene in adult rat brains injected with a lentiviral vector. Proc Natl Acad Sci U S A 1996, 93:11382-11388.
    • (1996) Proc Natl Acad Sci U S A , vol.93 , pp. 11382-11388
    • Naldini, L.1    Blomer, U.2    Gage, F.H.3    Trono, D.4    Verma, I.M.5
  • 17
    • 0028937785 scopus 로고
    • Cellular and humoral immune responses to viral antigens create barriers to lung-directed gene therapy with recombinant adenoviruses
    • Yang Y, Li Q, Ertl C, Wilson JM: Cellular and humoral immune responses to viral antigens create barriers to lung-directed gene therapy with recombinant adenoviruses. J Virol 1995, 69:2004-2015.
    • (1995) J Virol , vol.69 , pp. 2004-2015
    • Yang, Y.1    Li, Q.2    Ertl, C.3    Wilson, J.M.4
  • 18
    • 0028246338 scopus 로고
    • Ablation of E2A in recombinant adenoviruses improves transgene persistence and decreases inflammatory response in mouse liver
    • Engelhardt JF, Ye X, Doranz B, Wilson JM: Ablation of E2A in recombinant adenoviruses improves transgene persistence and decreases inflammatory response in mouse liver. Proc Natl Acad Sci U S A 1994, 91:6196-6120.
    • (1994) Proc Natl Acad Sci U S A , vol.91 , pp. 6196-16120
    • Engelhardt, J.F.1    Ye, X.2    Doranz, B.3    Wilson, J.M.4
  • 19
    • 0029664338 scopus 로고    scopus 로고
    • Elimination of both E1 and E2a from adenovirus vectors further improves prospects for in vivo human gene therapy
    • Gorziglia MI, Kadan MJ, Yei S, Lim J, Lee GM, Luthra R, Trapnell BC: Elimination of both E1 and E2a from adenovirus vectors further improves prospects for in vivo human gene therapy. J Virol 1996, 70:4173-4178.
    • (1996) J Virol , vol.70 , pp. 4173-4178
    • Gorziglia, M.I.1    Kadan, M.J.2    Yei, S.3    Lim, J.4    Lee, G.M.5    Luthra, R.6    Trapnell, B.C.7
  • 20
    • 0029655456 scopus 로고    scopus 로고
    • Efficient dual transcomplementation of adenovirus E1 and E4 regions from a 293-derived cell line expressing a minimal E4 functional unit
    • Yeh P, Dedieu J-F, Orsini C, Vigne E, Deneffe P, Perricaudet M: Efficient dual transcomplementation of adenovirus E1 and E4 regions from a 293-derived cell line expressing a minimal E4 functional unit. J Virol 1996, 70:559-565.
    • (1996) J Virol , vol.70 , pp. 559-565
    • Yeh, P.1    Dedieu, J.-F.2    Orsini, C.3    Vigne, E.4    Deneffe, P.5    Perricaudet, M.6
  • 24
    • 0029797538 scopus 로고    scopus 로고
    • Expression of the human multidrug resistance and glucocerebrosidase cDNA from adeno-associated vectors: Efficient promotor activity of AAV sequences and in vivo delivery via liposomes
    • Baudard M, Flotte TR, Aran JM, Thierry AR, Pastan I, Pang M-G, Kearns WG, Gottesman MM: Expression of the human multidrug resistance and glucocerebrosidase cDNA from adeno-associated vectors: efficient promotor activity of AAV sequences and in vivo delivery via liposomes. Hum Gene Ther 1996, 7:1309-1322.
    • (1996) Hum Gene Ther , vol.7 , pp. 1309-1322
    • Baudard, M.1    Flotte, T.R.2    Aran, J.M.3    Thierry, A.R.4    Pastan, I.5    Pang, M.-G.6    Kearns, W.G.7    Gottesman, M.M.8
  • 26
    • 0029147628 scopus 로고
    • Nonviral gene therapy: The promise of genes as pharmaceutical products
    • Ledley F: Nonviral gene therapy: the promise of genes as pharmaceutical products. Hum Gene Ther 1995, 6:1129-1144.
    • (1995) Hum Gene Ther , vol.6 , pp. 1129-1144
    • Ledley, F.1
  • 29
    • 0028938878 scopus 로고
    • Gene therapy using DC-chol liposomes
    • Goyal K, Huang L: Gene therapy using DC-chol liposomes. J Liposome Res 1995, 5:49-60.
    • (1995) J Liposome Res , vol.5 , pp. 49-60
    • Goyal, K.1    Huang, L.2
  • 32
    • 0029012861 scopus 로고
    • Increased expression of DNA cointroduced with nuclear protein in adult rat liver
    • Kaneda Y, Morishita R, Tomita N: Increased expression of DNA cointroduced with nuclear protein in adult rat liver. J Mol Med 1995, 73:289-297.
    • (1995) J Mol Med , vol.73 , pp. 289-297
    • Kaneda, Y.1    Morishita, R.2    Tomita, N.3
  • 33
    • 10144227768 scopus 로고    scopus 로고
    • Inhibition of TGF-beta;1 expression by glomerulonephritis
    • Akagi Y, Isaka Y, Arai M, Kaneko T, Takenaka M, Moriyama T, Kaneda Y, Ando A, Orita Y, Kamada T et al.: Inhibition of TGF-beta;1 expression by glomerulonephritis. Kidney Int 1996, 50:148-155. This is the first report of application of antisense therapy to experimental glomerulonephritis. Antisense ODN against TGF-β inhibits its expression in the nephritic glomeruli, and the diminution of TGF-β expression was similar to suppression of the ECM expansion.
    • (1996) Kidney Int , vol.50 , pp. 148-155
    • Akagi, Y.1    Isaka, Y.2    Arai, M.3    Kaneko, T.4    Takenaka, M.5    Moriyama, T.6    Kaneda, Y.7    Ando, A.8    Orita, Y.9    Kamada, T.10
  • 34
    • 0030936587 scopus 로고    scopus 로고
    • Gene transfer into the glomerulus by the hemagglutinating virus of Japan-liposome method
    • Imai E, Isaka Y, Akagi Y, Kaneda Y: Gene transfer into the glomerulus by the hemagglutinating virus of Japan-liposome method. Exp Nephrol 1997, 5:112-117.
    • (1997) Exp Nephrol , vol.5 , pp. 112-117
    • Imai, E.1    Isaka, Y.2    Akagi, Y.3    Kaneda, Y.4
  • 36
    • 0027138877 scopus 로고
    • Glomerulosclerosis induced by in vivo transfection of transforming growth factor-beta or platelet-derived growth factor gene into the rat kidney
    • Isaka Y, Fujiwara Y, Ueda N, Kaneda Y, Kamada T, Imai E: Glomerulosclerosis induced by in vivo transfection of transforming growth factor-beta or platelet-derived growth factor gene into the rat kidney. J Clin Invest 1993, 92:2597-2601.
    • (1993) J Clin Invest , vol.92 , pp. 2597-2601
    • Isaka, Y.1    Fujiwara, Y.2    Ueda, N.3    Kaneda, Y.4    Kamada, T.5    Imai, E.6
  • 37
    • 0028961469 scopus 로고
    • In vivo transfection of genes for renin and angiotensinogen into the glomerular cells induced enotypic change of the mesangial cells and glomerular sclerosis
    • Arai M, Wada A, Isaka Y, Akagi Y, Sugiura T, Miyazaki M, Moriyama T, Kaneda Y, Naruse K, Naruse M et al.: In vivo transfection of genes for renin and angiotensinogen into the glomerular cells induced enotypic change of the mesangial cells and glomerular sclerosis. Biochem Biophys Res Commun 1995, 206:525-532.
    • (1995) Biochem Biophys Res Commun , vol.206 , pp. 525-532
    • Arai, M.1    Wada, A.2    Isaka, Y.3    Akagi, Y.4    Sugiura, T.5    Miyazaki, M.6    Moriyama, T.7    Kaneda, Y.8    Naruse, K.9    Naruse, M.10
  • 38
    • 0029959895 scopus 로고    scopus 로고
    • Adenovirus-mediated gene transfer into kidney glomeruli using an ex vivo and in vivo kidney perfusion system: First steps towards gene therapy of Alport syndrome
    • Heikkila P, Parpala T, Lukkarinen O, Weber M, Tryggvason K: Adenovirus-mediated gene transfer into kidney glomeruli using an ex vivo and in vivo kidney perfusion system: first steps towards gene therapy of Alport syndrome. Gene Ther 1996, 3:21-27. This is the first report of in-vivo gene transfer using adenovirus vector system. Outstanding efficacy of glomerulus-selective gene transfer was achieved using reno perfusion of adenovirus.
    • (1996) Gene Ther , vol.3 , pp. 21-27
    • Heikkila, P.1    Parpala, T.2    Lukkarinen, O.3    Weber, M.4    Tryggvason, K.5
  • 39
    • 0028098730 scopus 로고
    • Gene transfer into the rat renal glomerulus via a mesangial cell vector: Site-specific delivery, in situ amplificaton, and sustained expression of an exogenous gene in vivo
    • Kitamura M, Taylor S, Unwin R, Burton S, Shimizu F, Fine LG: Gene transfer into the rat renal glomerulus via a mesangial cell vector: site-specific delivery, in situ amplificaton, and sustained expression of an exogenous gene in vivo. J Clin Invest 1994, 94:497-505.
    • (1994) J Clin Invest , vol.94 , pp. 497-505
    • Kitamura, M.1    Taylor, S.2    Unwin, R.3    Burton, S.4    Shimizu, F.5    Fine, L.G.6
  • 40
    • 0030887638 scopus 로고    scopus 로고
    • Gene delivery into the glomerulus via mesangial cell vectors
    • Kitamura M: Gene delivery into the glomerulus via mesangial cell vectors. Exp Nephrol 1997, 5:118-125. A newly developed technique that allows selective gene transfer to the glomerulus might provide a device for glomerular engineering.
    • (1997) Exp Nephrol , vol.5 , pp. 118-125
    • Kitamura, M.1
  • 43
    • 0030935354 scopus 로고    scopus 로고
    • Liposome-mediated gene transfer into kidney tubules
    • Len Y-H H, Lai L-W: Liposome-mediated gene transfer into kidney tubules. Exp Nephrol 1997, 5:132-136.
    • (1997) Exp Nephrol , vol.5 , pp. 132-136
    • Len, Y.-H.H.1    Lai, L.-W.2
  • 44
    • 0027341691 scopus 로고
    • Gene transfer into the mammalian kidney: Direct retrovirus transduction of regenerating tubular epithelial cells
    • Bosch RJ, Woolf AS, Fine LG. Gene transfer into the mammalian kidney: direct retrovirus transduction of regenerating tubular epithelial cells. Exp Nephrol 1993, 1:49-54.
    • (1993) Exp Nephrol , vol.1 , pp. 49-54
    • Bosch, R.J.1    Woolf, A.S.2    Fine, L.G.3
  • 46
    • 0029917240 scopus 로고    scopus 로고
    • In vivo adenovirus-mediated gene transfer into normal and cystic rat kidneys
    • Zhu G, Nicolson AG, Cowley BD, Rosen S, Sukhatme VP: In vivo adenovirus-mediated gene transfer into normal and cystic rat kidneys. Gene Ther 1996, 3:298-304.
    • (1996) Gene Ther , vol.3 , pp. 298-304
    • Zhu, G.1    Nicolson, A.G.2    Cowley, B.D.3    Rosen, S.4    Sukhatme, V.P.5
  • 48
    • 0030888024 scopus 로고    scopus 로고
    • Application of a gene transfer strategy to identify molecules that incite autoimmune kidney injury
    • Kelly VR, Moore KJ: Application of a gene transfer strategy to identify molecules that incite autoimmune kidney injury. Exp Nephrol 1997, 5:144-151.
    • (1997) Exp Nephrol , vol.5 , pp. 144-151
    • Kelly, V.R.1    Moore, K.J.2
  • 49
    • 0027376439 scopus 로고
    • Antisense oligonucleotides as therapeutic agents: Is the bullet really magical?
    • Stein CA, Cheng YC: Antisense oligonucleotides as therapeutic agents: is the bullet really magical? Science 1993, 261:1004-1012.
    • (1993) Science , vol.261 , pp. 1004-1012
    • Stein, C.A.1    Cheng, Y.C.2
  • 50
    • 0030051756 scopus 로고    scopus 로고
    • Antisense-oligonucleotide therapy
    • Askari FM: Antisense-oligonucleotide therapy. N Engl J Med 1996, 334:316-318. This review outlines the recent concept on antisense therapy and describes its application and limitation in clinical medicine.
    • (1996) N Engl J Med , vol.334 , pp. 316-318
    • Askari, F.M.1
  • 51
    • 0028019410 scopus 로고
    • Gene inhibition using antisense oligodeoxynucleotides
    • Wanger R: Gene inhibition using antisense oligodeoxynucleotides. Nature 1994, 372:333-335.
    • (1994) Nature , vol.372 , pp. 333-335
    • Wanger, R.1
  • 52
    • 0028920561 scopus 로고
    • Mitogen-activated protein (MAP) kinase is regulated by the MAP kinase phosphatase (MKP-1) in vascular smooth muscle cells
    • Duff JM, Monia BP, Berk BC: Mitogen-activated protein (MAP) kinase is regulated by the MAP kinase phosphatase (MKP-1) in vascular smooth muscle cells. J Biol Chem 1995, 7161-7166.
    • (1995) J Biol Chem , pp. 7161-7166
    • Duff, J.M.1    Monia, B.P.2    Berk, B.C.3
  • 54
  • 55
    • 0030936996 scopus 로고    scopus 로고
    • Therapeutic intervention in glomerulonephritis by oligonucleotides
    • Kashihara N, Maeshima Y, Makino H: Therapeutic intervention in glomerulonephritis by oligonucleotides. Exp Nephrol 1997, 5:126-131.
    • (1997) Exp Nephrol , vol.5 , pp. 126-131
    • Kashihara, N.1    Maeshima, Y.2    Makino, H.3
  • 56
    • 0029929229 scopus 로고    scopus 로고
    • In vivo targeting of inducible NO synthase with oligodeoxynucleotides protects rat kidney against ischemia
    • Noiri E, Peresleni T, Miller F, Goligorsky MS: In vivo targeting of inducible NO synthase with oligodeoxynucleotides protects rat kidney against ischemia. J Clin Invest 1996, 97:2377-2383.
    • (1996) J Clin Invest , vol.97 , pp. 2377-2383
    • Noiri, E.1    Peresleni, T.2    Miller, F.3    Goligorsky, M.S.4
  • 58
    • 0029859574 scopus 로고    scopus 로고
    • Fusigenic viral liposome for gene therapy in cardiovascular diseases
    • Dzau VJ, Mann MJ, Morishita R, Kaneda Y: Fusigenic viral liposome for gene therapy in cardiovascular diseases. Proc Natl Acad Sci U S A 1996, 93:11421-11425.
    • (1996) Proc Natl Acad Sci U S A , vol.93 , pp. 11421-11425
    • Dzau, V.J.1    Mann, M.J.2    Morishita, R.3    Kaneda, Y.4
  • 59
    • 16944364154 scopus 로고    scopus 로고
    • Putting muscle to work for gene therapy
    • Miller A: Putting muscle to work for gene therapy. Nature Med 1997, 3:278-279. Skeletal muscle is now highlighted as a tissue to be targeted by gene therapy because the muscle is easily transfected, is abundant and is highly vascularized. After gene transfer the transgene can produce secreted protein stably for long periods.
    • (1997) Nature Med , vol.3 , pp. 278-279
    • Miller, A.1
  • 60
    • 0028032357 scopus 로고
    • Stable delivery of physiologic levels of recombinant erythropoietin to the systemic circulation by intramuscular injection of replication-defective adenovirus
    • Tripathy SK, Goldwasser E, Lu MM, Barr E, Leiden JM: Stable delivery of physiologic levels of recombinant erythropoietin to the systemic circulation by intramuscular injection of replication-defective adenovirus. Proc Natl Acad Sci U S A 1994, 91:11557-11561.
    • (1994) Proc Natl Acad Sci U S A , vol.91 , pp. 11557-11561
    • Tripathy, S.K.1    Goldwasser, E.2    Lu, M.M.3    Barr, E.4    Leiden, J.M.5
  • 61
    • 0028790442 scopus 로고
    • Muscle-mediated gene therapy
    • Blau HM, Springer ML: Muscle-mediated gene therapy. N Engl J Med 1995, 333:1554-1556.
    • (1995) N Engl J Med , vol.333 , pp. 1554-1556
    • Blau, H.M.1    Springer, M.L.2
  • 62
    • 0029905441 scopus 로고    scopus 로고
    • Gene therapy by skeletal muscle expression of decorin prevents fibrotic disease in rat kidney
    • Isaka Y, Brees DK, Ikegaya K, Kaneda Y, Imai E, Noble NA, Border WA: Gene therapy by skeletal muscle expression of decorin prevents fibrotic disease in rat kidney. Nature Med 1996, 2:418-423. Overproduction of a TGF-β inhibitor, decorin, in the skeletal muscle by in-vivo gene transfer inhibits ECM expansion. This is the first report of gene therapy for glomerulonephritis.
    • (1996) Nature Med , vol.2 , pp. 418-423
    • Isaka, Y.1    Brees, D.K.2    Ikegaya, K.3    Kaneda, Y.4    Imai, E.5    Noble, N.A.6    Border, W.A.7
  • 65
    • 0026720075 scopus 로고
    • Tight control of gene expression in mammalian cells by tetracycline-responsive promoters
    • Gossen M, Bujard H: Tight control of gene expression in mammalian cells by tetracycline-responsive promoters. Proc Natl Acad Sci U S A 1992, 89:5547-5551.
    • (1992) Proc Natl Acad Sci U S A , vol.89 , pp. 5547-5551
    • Gossen, M.1    Bujard, H.2
  • 66
    • 0029901865 scopus 로고    scopus 로고
    • Creation of a reversible on/off-switch for foreign gene activity in the glomerulus: The marriage of mesangial cell vectors with a tetracycline regulatory system
    • Kitamura M: Creation of a reversible on/off-switch for foreign gene activity in the glomerulus: the marriage of mesangial cell vectors with a tetracycline regulatory system. Proc Natl Acad Sci U S A 1996, 93:7387-7391. This is the first report of an application of tetracycline regulatory gene expression system to the mesangial vector system that allows inducible gene expression in the glomerulus.
    • (1996) Proc Natl Acad Sci U S A , vol.93 , pp. 7387-7391
    • Kitamura, M.1
  • 67
    • 0031040987 scopus 로고    scopus 로고
    • Long-term control of erythropoietin secretion by deoxycycline in mice transplanted with engineered primary myo-blasts
    • Bohl D, Naffakh N, Heard JM: Long-term control of erythropoietin secretion by deoxycycline in mice transplanted with engineered primary myo-blasts. Nature Med 1997, 3:299-305.
    • (1997) Nature Med , vol.3 , pp. 299-305
    • Bohl, D.1    Naffakh, N.2    Heard, J.M.3
  • 68
    • 0029865151 scopus 로고    scopus 로고
    • Ecdysone-inducible gene expression in mammalian cells and transgenic mice
    • No D, Yao T-P, Evans RM: Ecdysone-inducible gene expression in mammalian cells and transgenic mice. Proc Natl Acad Sci U S A 1996, 93:3346-3351.
    • (1996) Proc Natl Acad Sci U S A , vol.93 , pp. 3346-3351
    • No, D.1    Yao, T.-P.2    Evans, R.M.3
  • 69
    • 0029919753 scopus 로고    scopus 로고
    • TAXI/UAS: A molecular switch to control expression of genes in vivo
    • Delort JP, Capecchi MR: TAXI/UAS: a molecular switch to control expression of genes in vivo. Hum Gene Ther 1996, 7:809-820.
    • (1996) Hum Gene Ther , vol.7 , pp. 809-820
    • Delort, J.P.1    Capecchi, M.R.2
  • 70
    • 0024509412 scopus 로고
    • Cre-stimulated recommbination at LoxP-containing DNA sequences placed into the mammalian genome
    • Sauer B, Henderson N: Cre-stimulated recommbination at LoxP-containing DNA sequences placed into the mammalian genome. Nucleic Acids Res 1989, 17:147-161.
    • (1989) Nucleic Acids Res , vol.17 , pp. 147-161
    • Sauer, B.1    Henderson, N.2
  • 71
    • 0028059099 scopus 로고
    • Deleton of a DNA polymerase b gene segment in T cells using cell type-specific gene targeting
    • Gu H, Marth JD, Orban PC, Mossmann H, Rajewsky K: Deleton of a DNA polymerase b gene segment in T cells using cell type-specific gene targeting. Science 1994, 265:103-106.
    • (1994) Science , vol.265 , pp. 103-106
    • Gu, H.1    Marth, J.D.2    Orban, P.C.3    Mossmann, H.4    Rajewsky, K.5
  • 72
    • 0029043548 scopus 로고
    • Site-specific recombination mediated by an adenovirus vector expressing the Cre recombinase protein: A molecular switch for control of gene expression
    • Anton MG, Graham FL: Site-specific recombination mediated by an adenovirus vector expressing the Cre recombinase protein: a molecular switch for control of gene expression. J Virol 1995, 69:4600-4606.
    • (1995) J Virol , vol.69 , pp. 4600-4606
    • Anton, M.G.1    Graham, F.L.2
  • 73
    • 0028799961 scopus 로고
    • Efficient gene activation in mammalian cells by using recombinant adenovirus expressing site-specific Cre recombinase
    • Kanegae Y, Lee G, Sato Y, Tanaka M, Nakai M, Sasaki T, Sugano S, Saito I: Efficient gene activation in mammalian cells by using recombinant adenovirus expressing site-specific Cre recombinase. Nucleic Acids Res 1995, 23:3816-3821.
    • (1995) Nucleic Acids Res , vol.23 , pp. 3816-3821
    • Kanegae, Y.1    Lee, G.2    Sato, Y.3    Tanaka, M.4    Nakai, M.5    Sasaki, T.6    Sugano, S.7    Saito, I.8
  • 74
    • 0030902552 scopus 로고    scopus 로고
    • Transfer of genetically engineered macrophages into the glomerulus
    • Kitamura M, Suto TS: Transfer of genetically engineered macrophages into the glomerulus. Kidney Int 1997, 51:1274-1279.
    • (1997) Kidney Int , vol.51 , pp. 1274-1279
    • Kitamura, M.1    Suto, T.S.2
  • 75
    • 0030600387 scopus 로고    scopus 로고
    • Gene transfer of interleukin-1 receptor antagonist into the renal glomerulus via a mesangial cell vector
    • Yokoo T, Kitamura M: Gene transfer of interleukin-1 receptor antagonist into the renal glomerulus via a mesangial cell vector. Biochem Biophys Res Commun 1996, 226:883-888.
    • (1996) Biochem Biophys Res Commun , vol.226 , pp. 883-888
    • Yokoo, T.1    Kitamura, M.2
  • 76
    • 0029874799 scopus 로고    scopus 로고
    • Application of gene and cell therapies in the tissue engineering of a bioartificial kidney
    • Humes H: Application of gene and cell therapies in the tissue engineering of a bioartificial kidney. Int J Artif Organs 1996, 19:215-217.
    • (1996) Int J Artif Organs , vol.19 , pp. 215-217
    • Humes, H.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.