Production of IL-12 from gene modified human dermal fibroblasts: A preclinical study for IL-12 cancer gene therapy

Experimental and Molecular Medicine

Volumn 29, Issue 1, 1997, Pages 65-69

  Park, Chaehwa ^a   Kang, Won Ki ^a   Oh, Misook ^a   Kim, Won Seog ^a   Yang, Jung Hyun ^a   Lotze, Michael T ^b   Kim, Sunyoung ^c   Park, Keunchil ^a   Park, Chan H ^a  

^a Samsung Medical Center   (South Korea)

^b UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^c Seoul National University   (South Korea)

Author keywords

Cancer gene therapy; Human fibroblast; IL 12

Indexed keywords

ANTIBIOTIC G 418; COLLAGENASE; INTERLEUKIN 12; NEOMYCIN;

ADULT; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; EXPRESSION VECTOR; FEMALE; FIBROBLAST CULTURE; GENE THERAPY; GENE TRANSFER; GENETIC TRANSDUCTION; HUMAN; HUMAN CELL; HUMAN TISSUE; MALE; PROTEIN SYNTHESIS; RETROVIRUS; SKIN CELL; SKIN FIBROBLAST;

UNIDENTIFIED RETROVIRUS;

EID: 0030928869     PISSN: 12263613     EISSN: 20926413     Source Type: Journal    
DOI: 10.1038/emm.1997.10     Document Type: Article

References (3)

1. Barr, E. and Leiden, J. M. (1991) Systemic delivery of recombinant proteins by genetically modified myoblasts. Science 254: 1507-1509
2. Bramson, J. L., Hitt, M., Addison, C. L., Muller, W. J., Gauldie, J. and Graham, F. L. (1996) Direct intratumoral injection of an adenovirus expressing interleukin-12 induces regression and long-lasting immunity that is associated with highly localized expression of interleukin-12. Hum. Gene Ther. 7: 1995-2002
3. Chan, S. H., Perussia, B., Gupta, J. W., Kobayashi, M., Pospisil, M., Young, H. A., Wolf, S. F., Young, D., Clark, S. C. and Trinchieri, G. (1991) Induction of Interferon-γ production by natural killer cell stimulatory factor: characterization of the responder cells and synergy with other inducers. J. Exp. Med. 173: 869-879