A recombinant Bacillus anthracis strain producing the Clostridium perfringens Ib component induces protection against iota toxins

Infection and Immunity

Volumn 65, Issue 6, 1997, Pages 2029-2033

  Sirard, Jean Claude ^a   Weber, Martine ^a   Duflot, Edith ^a   Popoff, Michel R ^a   Mock, Michèle ^a  

^a INSTITUT PASTEUR   (France)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBODY RESPONSE; ANTIBODY SPECIFICITY; ARTICLE; BACILLUS ANTHRACIS; CLOSTRIDIUM PERFRINGENS; GENE FUSION; GENETIC RECOMBINATION; NONHUMAN; PHAGOCYTOSIS; PRIORITY JOURNAL; PROMOTER REGION; PROTECTION; PROTEIN INDUCTION; PROTEIN SECRETION; PROTEIN SYNTHESIS REGULATION; STRAIN DIFFERENCE;

ADP RIBOSE TRANSFERASES; ANIMALS; BACILLUS ANTHRACIS; BACTERIAL TOXINS; BACTERIAL VACCINES; CLOSTRIDIUM PERFRINGENS; FEMALE; GENETIC VECTORS; MICE; VACCINES, SYNTHETIC;

EID: 0030927399     PISSN: 00199567     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (36)

1. Bartkus, J. M., and S. H. Leppla. 1989. Transcriptional regulation of the protective antigen gene of Bacillus anthracis. Infect. Immun. 57:2295-2300.
2. Butterton, J. R., D. T. Beattie, C. L. Gardel, P. A. Carroll, T. Hyman, K. P. Killeen, J. J. Mekalanos, and S. B. Calderwood. 1995. Heterologous antigen expression in Vibrio cholerae vector strains. Infect. Immun. 63:2689-2696.
3. Dai, Z., J.-C. Sirard, M. Mock, and T. M. Koehler. 1995. The atxA gene product activates transcription of the anthrax toxin genes and is essential for virulence. Mol. Microbiol. 16:1171-1181.
4. Desmettre, P. 1095. Live bacterial vaccines for animals. Dev. Biol, Stand. 84:221-225.
5. Ellis,T. M., A. R. Gregory, and G. D. Logue. 1991, Evaluation of a toxoid for protection of rabbits against enterotoxaemia experimentally induced by trypsin-activated supernatant of Clostridium spiroforme. Vet. Microbiol. 28:93- 102.
6. Etienne-Toumelin, I., J.-C. Sirard, E. Duflot, M. Mock, and A. Fouet. 1995. Characterization of the Bacillus anthracis S-layer: cloning and sequencing of the structural gene. J. Bacieriol. 177:614-620.
7. Fayolle, C., D. O'Callaghan, P. Martineau, A. Charbit, J. M. Clément, M. Hofnung, and C. Leclerc. 1994. Genetic control of antibody responses induced against an antigen delivered by recombinant attenuated Salmonella typhimurium Infect. Immun. 62:4310-4319.
8. + T cells in vivo: a study with the nucleoprotein of the lymphocytic choriomeningitis virus. Int. Immunol. 7:797-805.
9. Hambleton, P., J. A. Carman, and J. Melling. 1984. Anthrax: the disease in relation to vaccines. Vaccine 2:125-132.
10. Hoiseth, S. K., and B. A. D. Stocker. 1981. Aromatic-dependent Salmonella typhimurium are non-virulent and effective as live vaccines. Nature 291:238- 239.
11. Ivins, B. E., J. W. J. Ezzell, J. Jemski, K. W. Hedlund, J. D. Ristroph, and S. H. Leppla. 1986. Immunization studies with attenuated strains of Bacillus anthracis. Infect. Immun. 52:454-458.
12. 2 and a trans-acting element activate transcription from one of two promoters. J. Bacteriol. 176:586-595.
13. Leclerc, C., A. Charbit, P. Martineau, E. Deriaud, and M. Hofnung. 1991. The cellular location of a foreign B cell epitope expressed by recombinant bacteria determines its T cell-independent or T cell-dependent characteristics. J. Immunol. 147:3545-3552.
14. Leppla, S. 1995. Anthrax toxins. Handb. Nat. Toxins 8:543-572.
15. Perelle, S., M. Gibert, P. Boquet, and M. R. Popoff. 1993. Characterization of Clostridium perfringens iota-toxin genes and expression in Escherichia coli. Infect. Immun. 61:5147-5156.
16. Perelle, S., S. Scalzo, S. Kochi, M. Mock, and M. R. Popoff. 1997. Immunological and functional comparison between Clostridium perfringens iota toxin, Clostridium spiroforme toxin, and anthrax toxins. FEMS Microbiol. Lett. 146:117-121.
17. Pezard, C., P. Berche, and M. Mock. 1991, Contribution of individual toxin components to virulence of Bacillus anthracis. Infect. Immun. 59:3472-3477.
18. Pezard, C., E. Duflot, and M. Mock. 1993. Construction of Bacillus anthracis mutant strains producing a single toxin component. J. Gen. Microbiol. 139: 2459-2463.
19. Pezard, C., M. Weber, J.-C. Sirard, P. Berche, and M. Mock. 1995. Protective immunity induced by Bacillus anthracis toxin-deficient strains. Infect. Immun. 63:1369-1372.
20. Phalipon, A., and P. Sansonetti. 1995. Live attenuated Singella flexneri mutants as vaccine candidates against shigellosis and vectors for antigen delivery. Biologicals 23:125-134.
21. Popoff, M. R., and P. Boquet. 1988. Clostridium spiroforme toxin is a binary toxin which ADP-ribosylates cellular actin. Biochem. Biophys. Res. Commun. 152:1361-1368.
22. Popoff, M. R., F. W. Milward, B. Bancillon, and P. Boquet. 1989. Purification of the Clostridium spiroforme binary toxin and activity of the toxin on HEp-2 cells. Infect. Immun. 57:2462-2469.
23. Ristroph, J. D., and B. E. Ivins. 1983. Elaboration of Bacillus anthracis antigens in a new, defined culture medium. Infect. Immun. 39:483-486.
24. Roberts, M., S. N. Chatfield, and G. Dougan. 1994. Salmonella as carriers of heterologous antigens, p. 27-58. In D. T. O'Hagan (ed.), Novel delivery systems for oral vaccines. CRC Press, Inc., New York, N.Y.
25. Sakurai, J., and K. Kobayashl. 1995. Lethal and dermonecrotic activities of Clostridium perfringens iota toxin: biological activities induced by cooperation of two nonlinked components. Microbiol. Immunol. 39:249-253.
26. Sambrook, J., E. F. Fritsch, and T. Maniatis. 1989. Molecular cloning: a laboratory manual, 2nd ed. Cold Spring Harbor Laboratory, Cold Spring Harbor, N.Y.
27. Sirard, J.-C., M. Mock, and A. Fouet. 1994. The three Bacillus anthracis toxin genes are coordinately regulated by bicarbonate and temperature. J. Bacteriol. 176:5188-5192.
28. Soutschek-Bauer, E., and W. L. Staudenbauer. 1987. Synthesis and secretion of a heat-stable carboxymethylcellulase from Clostridium thermocellum in Bacillus subtilis and Bacillus stearothermophilus. Mol. Gen. Genet. 208:537- 541.
29. Stiles, B. G., and T. D. Wilkins. 1986. Clostridium perfringens iota toxin: synergism between two proteins. Toxicon 24:767-773.
30. Stiles, B. G., and T. D. Wilkins. 1986. Purification and characterization of Clostridium perfringens iota toxin: dependence on two nonlinked proteins for biological activity. Infect. Immun. 54:683-688.
31. Stover, C. K., V. F. de la Cruz, T. R. Fuerst, J. E. Burlein, L. A. Benson, L. T. Bennett, G. P. Bansal, J. F. Young, M. H. Lee, G. F. Hatfull, S. B. Snapper, R. G. Barletta, W. R. Jacobs, Jr., and B. R. Bloom. 1991. New use of BCG for recombinant vaccines. Nature 351:456-460.
32. Trieu-Cuot, P., C. Carlier, C. Poyart-Salmeron, and P. Courvalin. 1991. An integrative vector exploiting the transposition properties of Tn1545 for insertional mutagenesis and cloning of genes from Gram-positive bacteria. Gene 106:21-27.
33. Uchida, I., J. M. Hornung, C. B. Thorne, K. R. Klimpel, and S. H. Leppla. 1993. Cloning and characterization of a gene whose product is a trans activator of anthrax toxin synthesis. J. Bacteriol. 175:5329-5338.
34. Welkos, S. L., and A. M. Friedlander. 1988. Pathogenesis and genetic control of resistance to the Sterne strain of Bacillus anthracis. Microb. Pathog. 4:53-69.
35. Welkos, S. L., T. J. Keener, and P. H. Gibbs. 1986. Differences in susceptibility of inbred mice to Bacillus anthracis. Infect. Immun. 51:795-800.
36. Welkos, S. L., J. R. Lowe, F. Eden-Mc Cutchan, M. Vodkin, S. H. Leppla, and J. J. Schmidt. 1988. Sequence and analysis of the DNA encoding protective antigen of Bacillus anthracis. Gene 69:287-300.