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Volumn 7, Issue 12, 1997, Pages 1557-1562

Inhibition of carboxypeptidase A by N-(4-t-butylbenzoyl)-2-hydroxy-1-naphthaldehyde hydrazone

Author keywords

[No Author keywords available]

Indexed keywords

CARBOXYPEPTIDASE A; HYDRAZONE DERIVATIVE; PHENYLALANINE;

EID: 0030927294     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(97)00267-9     Document Type: Article
Times cited : (11)

References (27)
  • 15
    • 0003518480 scopus 로고
    • John Wiley and Sons: New York
    • Segel, I. H. Enzyme Kinetics; John Wiley and Sons: New York, 1993; pp 170-178.
    • (1993) Enzyme Kinetics , pp. 170-178
    • Segel, I.H.1
  • 16
    • 0000764512 scopus 로고
    • +2 was assigned a charge of +2. The minimization involved Phe, 2 and residues within a 15 A radius around the active site and was conducted until the energy difference between iterations was less than 1 cal/mol.
    • (1983) Proc. Natl. Acad. Sci. U.S.A. , vol.80 , pp. 7151
    • Rees, D.C.1    Lipscomb, W.N.2
  • 17
    • 84986870156 scopus 로고
    • +2 was assigned a charge of +2. The minimization involved Phe, 2 and residues within a 15 A radius around the active site and was conducted until the energy difference between iterations was less than 1 cal/mol.
    • (1981) Org. Mag. Res. , vol.15 , pp. 353
    • Gasteiger, J.1    Marsili, M.2
  • 20
    • 33947472850 scopus 로고
    • Expression 1.0 was derived using the King-Altman method: King, E. L.; Altman, C. J. J. Phys. Chem. 1956, 60, 1375.
    • (1956) J. Phys. Chem. , vol.60 , pp. 1375
    • King, E.L.1    Altman, C.J.2
  • 21
    • 0342999655 scopus 로고    scopus 로고
    • note
    • Kinetic data were analyzed using the software package Grafit 3.01® (©Erithacus Software Ltd.)
  • 22
    • 0022503728 scopus 로고
    • Hydrolysis, rather than product release, is the rate-limiting step for the peptidase activity of CPA: (a) Galdes, A.; Auld, D. S.; Vallee, B. L. Biochemistry 1986, 25, 646;
    • (1986) Biochemistry , vol.25 , pp. 646
    • Galdes, A.1    Auld, D.S.2    Vallee, B.L.3
  • 24
    • 0002714948 scopus 로고
    • 2+ (where His-69, Glu-72 and His-196 are the other active site ligands): (a) Lipscomb, W. N. Acc. Chem. Res. 1970, 3, 81;
    • (1970) Acc. Chem. Res. , vol.3 , pp. 81
    • Lipscomb, W.N.1
  • 27
    • 0342602813 scopus 로고
    • Chapman and Hall: New York, Molecular modeling with the ionized form of 2 yielded a structure qualitatively very similar to the complex of non-ionized 2 with CPA which is described above
    • a was determined spectrophotometrically (Albert, A; Sargeant, E. P. The Determination of Ionization Constants, 3rd ed; Chapman and Hall: New York, 1984; pp 70-101). Molecular modeling with the ionized form of 2 yielded a structure qualitatively very similar to the complex of non-ionized 2 with CPA which is described above.
    • (1984) The Determination of Ionization Constants, 3rd Ed , pp. 70-101
    • Albert, A.1    Sargeant, E.P.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.