Impaired microvascular vasoconstrictive responses to vasopressin in septic rats

Critical Care Medicine

Volumn 25, Issue 5, 1997, Pages 869-873

  Hollenberg, Steven M ^a   Tangora, Jennifer J ^a   Piotrowski, Mark J ^a   Easington, Cordus ^a   Parrillo, Joseph E ^a  

^a RUSH UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

N(G) methyl L arginine; Nitric oxide; Nitric oxide synthase; Sepsis; Vasopressin; Vasopressor responsiveness; Videomicroscopy

Indexed keywords

ENDOTHELIN 1; N(G) METHYLARGININE; NITRIC OXIDE; NITRIC OXIDE SYNTHASE INHIBITOR; NORADRENALIN; VASOPRESSIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; MALE; MICROSCOPY; NONHUMAN; PRIORITY JOURNAL; RAT; SEPSIS; SKELETAL MUSCLE; VASCULAR RESISTANCE; VASOCONSTRICTION; VASODILATATION; VIDEORECORDING;

ANIMALS; ARTERIOLES; ENZYME INHIBITORS; LIGATION; MALE; MUSCLE, SMOOTH, VASCULAR; NITRIC OXIDE SYNTHASE; OMEGA-N-METHYLARGININE; RATS; RATS, SPRAGUE-DAWLEY; SEPSIS; VASOCONSTRICTION; VASOCONSTRICTOR AGENTS; VASOPRESSINS;

EID: 0030926958     PISSN: 00903493     EISSN: None     Source Type: Journal    
DOI: 10.1097/00003246-199705000-00025     Document Type: Article

References (31)

1. Hollenberg SM, Cunnion RE: Endothelial and vascular smooth muscle function in sepsis. J Crit Care 1994; 9:262-280
2. Parrillo JE: Pathogenetic mechanisms of septic shock. N Engl J Med 1993; 328:1471-1477
3. Chernow B, Rainey TR, Lake CR: Endogenous and exogenous catecholamines in critical care medicine. Crit Care Med 1982; 10:409-416
4. Cunnion RE, Parrillo JE: Myocardial dysfunction in sepsis. Recent insights. Chest 1989; 95:941-945
5. Fronek K, Zweifach BW: Microvascular pressure distribution in skeletal muscle and the effect of vasodilation. Am J Physiol 1975; 228:791-796
6. McKenna TM: Prolonged exposure of rat aorta to low levels of endotoxin in vitro results in impaired contractility. Association with vascular cytokine release. J Clin Invest 1990; 86:160-168
7. Parratt JR: Myocardial and circulatory effects of E. coli endotoxin: Modification of responses to catecholamines. Br J Pharmacol 1973; 47:12-18
8. Baez S: An open cremaster muscle preparation for the study of blood vessels by in vivo microscopy. Microvasc Res 1973; 5:384-394
9. Hollenberg SM, Cunnion RE, Zimmerberg J: Nitric oxide synthase inhibition reverses arteriolar hyporesponsiveness to catecholamines in septic rats. Am J Physiol 1993; 264: H660-H663
10. G-methyl-L-arginine. Abstr. J Am Coll Cardiol 1995; 25:187A
11. Ganeshram V, Piotrowski MJ, Parrillo JE, et al: Nitric oxide synthase inhibition reverses impaired arteriolar responsiveness to angiotensin II in septic rats. Abstr. J Invest Med 1995; 43:241A
12. Hinshaw LB: Elevated plasma vasopressin concentrations during endotoxin and E. coli shock. Adv Shock Res 1981; 6:15-26
13. Schaller MD, Waeber B, Nussberger J, et al: Angiotensin II, vasopressin, and sympathetic activity in conscious rats with endotoxemia. Am J Physiol 1985; 249:H1086-H1092
14. Alexander HR, Sheppard BC, Jensen JC, et al: Treatment with recombinant human tumor necrosis factor-alpha protects rats against the lethality, hypotension, and hypothermia of Gramnegative sepsis. J Clin Invest 1991; 88: 34-39
15. 4, in rat cremaster muscle. Microcirc Endothelium Lymphatics 1988; 5:355-375
16. Wiedeman MP: Architecture of the terminal vascular bed. In: Physical Bases of Circulatory Transport: Regulation and Exchange. Reeve EB, Guyton AC (Eds). Philadelphia, WB Saunders, 1976, pp 307-312
17. Altura BM: Microcirculatory and vascular smooth muscle behavior in the Brattleboro rat: Relationship to reticuloendothelial system function and resistance to shock and trauma. Ann N Y Acad Sci 1982; 394:375-391
18. Baker CH, Sutton ET, Zhou Z, et al: Microvascular vasopressin effects during endotoxin shock in the rat. Circ Shock 1990; 30:81-95
19. Lang CH, Bagby GJ, Ferguson JL, et al: Cardiac output and redistribution of organ blood flow in hypermetabolic sepsis. Am J Physiol 1984; 246:R331-R337
20. Watanabe Y, Tokuda H, Suzuki A, et al: Glucocorticoid amplifies vasopressin-induced phosphoinositide hydrolysis in aortic smooth muscle cells. J Cell Biochem 1995; 57:522-529
21. Nishizuka Y: Studies and perspectives of protein kinase C. Science 1986; 233: 305-312
22. 2+]i responses are negatively modulated via a cGMP-dependent protein kinase I pathway. J Biol Chem 1995; 270:22277-22282
23. Baudry N, Vicaut E, Ba ZF: Role of nitric oxide in effects of tumor necrosis factor-α on microcirculation in rat. J Appl Physiol 1993; 75:2392-2399
24. Szabo C, Mitchell JA, Thiemermann C, et al: Nitric oxide-mediated hyporeactivity to noradrenaline precedes the induction of nitric oxide synthase in endotoxin shock. Br J Pharmacol 1993; 108:786-792
25. Paya D, Gray GA, Fleming I, et al: Effect of dexamethasone on the onset and persistence of vascular hyporeactivity induced by E. coli lipopolysaccharide in rats. Circ Shock 1993; 41:103-112
26. Salvemini D, Misko TP, Masferrer JL, et al: Nitric oxide activates cyclooxygenase enzymes. Proc Natl Acad Sci U S A 1993; 90:7240-7244
27. Cobb JP, Cunnion RE, Danner RL: Nitric oxide as a target for therapy in septic shock. Crit Care Med 1993; 21: 1261-1263
28. ω-amino-L-arginine, an inhibitor of nitric oxide synthase, raises vascular resistance but increases mortality rates in awake canines challenged with endotoxin. J Exp Med 1992; 176:1175-1182
29. Meyer J, Traber LD, Nelson S, et al: Reversal of hyperdynamic response to continuous endotoxin administration by inhibition of NO synthesis. J Appl Physiol 1992; 73:324-328
30. Petros A, Lamb G, Leone A, et al: Effects of a nitric oxide synthase inhibitor in humans with septic shock. Cardiovasc Res 1995; 28:34-39
31. Harbrecht BG, Billiar TR, Stadler J, et al: Inhibition of nitric oxide synthesis during endotoxemia promotes intrahepatic thrombosis and an oxygen radical-mediated hepatic injury. J Leukoc Biol 1992; 52:390-394