Recurrent ulcerations on both legs since early childhood due to a factor V gene mutation

Dermatology

Volumn 194, Issue 3, 1997, Pages 297-298

  Hackenjos K ^a   Bek, M ^a   Schopf E ^a   Vanscheidt, W ^a  

^a UNIVERSITY OF FREIBURG   (Germany)

Author keywords

Activated protein C resistance; Factor V gene mutation; Factor XIII deficiency; Leg ulcer; Venous thrombosis

Indexed keywords

BLOOD CLOTTING FACTOR 13; BLOOD CLOTTING FACTOR 5;

ADULT; ARTICLE; BLOOD CLOTTING FACTOR 13 DEFICIENCY; CASE REPORT; GENE MUTATION; HUMAN; HUMAN TISSUE; LEG ULCER; MALE; MICROTHROMBUS; PRIORITY JOURNAL; RECURRENT DISEASE; WOUND HEALING;

EID: 0030926839     PISSN: 10188665     EISSN: 14219832     Source Type: Journal    
DOI: 10.1159/000246132     Document Type: Article

References (6)

1. Svensson PJ, Dahlback B: Resistance to activated protein C as a basis for venous thrombosis. N Engl J Med 1994;330:517-522.
2. Bertina RM, Koclcmann BP, Koster T. Rosendaal FR. Dirven RJ. de Ronde H. van der Velden PA. Reitsma PH: Mutation in blood coagulation factor V associated with resistance to activated protein C. Nature 1994;369:46-47.
3. Dahlback B: Inherited resistance to activated protein C, a major cause of venous thrombosis, is due to a mutation in the factor V gene (review). Haemostasis 1994;24:139-151.
4. Voorberg J, Roelse J, Koopmann R. Buller H, Berends F. ten Cate JW. Mertens K. van Mourik JA: Association of idiopathic venous thromboembolism with single point-mutation at Arg506 of factor V. Lancet 1994:343: 1535-1536.
5. Pcus D, von Schmiedeberg S. Pier A. Seharf RE. Wehmeier A. Ruicka T. Krutmann J: Coagulation factor V gene mutation associated with activated protein C resistance leading to recurrent thrombosis, leg ulcers and lymphedema: Successful treatment with intermittent compression. J Am Acad Dermatol 1996:35: 306-309.
6. Vanscheidt W. Hasler K, Wokalek H. Niedner R. Schopf E: Factor XIII deficiency in the blood of venous leg ulcer patients. Acta Derm Venereol (Stockh) 1991;71:55-57.