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Volumn 24, Issue 5, 1997, Pages 573-589

Bile acid therapy in pediatric hepatobiliary disease: The role of ursodeoxycholic acid

Author keywords

[No Author keywords available]

Indexed keywords

BILE DUCT ATRESIA; CHOLESTASIS; CLINICAL FEATURE; CYSTIC FIBROSIS; DISABILITY; DISEASE ASSOCIATION; HEPATOBILIARY DISEASE; HUMAN; INFANT; LIVER TRANSPLANTATION; ORGAN PRESERVATION; PRIORITY JOURNAL; PRURITUS; QUALITY OF LIFE; REVIEW; SURVIVAL RATE;

EID: 0030926783     PISSN: 02772116     EISSN: None     Source Type: Journal    
DOI: 10.1097/00005176-199705000-00016     Document Type: Review
Times cited : (93)

References (184)
  • 1
    • 0342343580 scopus 로고    scopus 로고
    • Ursodeoxycholic acid therapy in pediatric patients with chronic cholestasis
    • Lentze M, Reichen J, eds. Lancaster, England: Kluwer Academic Press
    • Balistreri WF, A-Kader HH, Setchell KDR and the Ursodeoxycholic Acid Study Group. Ursodeoxycholic acid therapy in pediatric patients with chronic cholestasis. In: Lentze M, Reichen J, eds. Paediatric cholestasis: novel approaches to treatment. Lancaster, England: Kluwer Academic Press 1997:333-44.
    • (1997) Paediatric Cholestasis: Novel Approaches to Treatment , pp. 333-344
    • Balistreri, W.F.1    A-Kader, H.H.2    Setchell, K.D.R.3
  • 2
    • 0001812916 scopus 로고
    • Biochemical and clinical response to ursodeoxycholic acid administration in pediatric patients with chronic cholestasis
    • Paumgartner G, Stiehl A, Gerok W, eds. Lancaster, England: Kluwer Academic Publishers
    • Balistreri WF, A-Kader HH, Ryckman FC, Whitington PF, Heubi JE, Setchell KDR. Biochemical and clinical response to ursodeoxycholic acid administration in pediatric patients with chronic cholestasis. In: Paumgartner G, Stiehl A, Gerok W, eds. Bile acids as therapeutic agents. Lancaster, England: Kluwer Academic Publishers, 1991:323-33.
    • (1991) Bile Acids as Therapeutic Agents , pp. 323-333
    • Balistreri, W.F.1    A-Kader, H.H.2    Ryckman, F.C.3    Whitington, P.F.4    Heubi, J.E.5    Setchell, K.D.R.6
  • 3
    • 0022379003 scopus 로고
    • Targeting drugs to the enterohepatic circulation: Lessons from bile acids and other endobiotics
    • Hofmann AF. Targeting drugs to the enterohepatic circulation: lessons from bile acids and other endobiotics. J Controlled Release 1985;2:3-11.
    • (1985) J Controlled Release , vol.2 , pp. 3-11
    • Hofmann, A.F.1
  • 4
    • 0025863624 scopus 로고
    • Fetal and neonatal bile acid synthesis and metabolism - Clinical implications
    • Balistreri WF. Fetal and neonatal bile acid synthesis and metabolism - clinical implications. J Inherit Metab Dis 1991; 14:459-77.
    • (1991) J Inherit Metab Dis , vol.14 , pp. 459-477
    • Balistreri, W.F.1
  • 5
    • 0020318866 scopus 로고
    • Ursodeoxycholic acid in the treatment of cholesterol cholelithiasis
    • Bachrach WH, Hofmann AF. Ursodeoxycholic acid in the treatment of cholesterol cholelithiasis. Dig Dis Sci 1982;24: 737-61; 833-56.
    • (1982) Dig Dis Sci , vol.24 , pp. 737-761
    • Bachrach, W.H.1    Hofmann, A.F.2
  • 6
    • 0004779202 scopus 로고
    • Clinical experience with ursodeoxycholic acid (S-urso) for chronic hepatitis
    • Ichida F. Clinical experience with ursodeoxycholic acid (S-urso) for chronic hepatitis. Diagn Treat 1961;36:388.
    • (1961) Diagn Treat , vol.36 , pp. 388
    • Ichida, F.1
  • 7
    • 0027998655 scopus 로고
    • Pharmacology of ursodeoxycholic acid, an enterohepatic drug
    • Hofmann AF. Pharmacology of ursodeoxycholic acid, an enterohepatic drug. Scand J Gastroenterol 1994;29 (suppl): S1-15.
    • (1994) Scand J Gastroenterol , vol.29 , Issue.SUPPL.
    • Hofmann, A.F.1
  • 9
    • 0030020934 scopus 로고    scopus 로고
    • Intestinal absorption of bile acids in the rabbit: Different transport rates in jejunum and ileum
    • Aldini R, Montagnani M, Roda A, Hrelia S, Biagi PL, Roda E. Intestinal absorption of bile acids in the rabbit: different transport rates in jejunum and ileum. Gastroenterology 1996;110:459-68.
    • (1996) Gastroenterology , vol.110 , pp. 459-468
    • Aldini, R.1    Montagnani, M.2    Roda, A.3    Hrelia, S.4    Biagi, P.L.5    Roda, E.6
  • 10
    • 0028891443 scopus 로고
    • The role of sodium in the uptake of ursodeoxycholic acid in isolated hamster hepatocytes
    • Bouscarel B, Nussbaum R, Dubner H, Fromm H. The role of sodium in the uptake of ursodeoxycholic acid in isolated hamster hepatocytes. Hepatology 1995;21:145-54.
    • (1995) Hepatology , vol.21 , pp. 145-154
    • Bouscarel, B.1    Nussbaum, R.2    Dubner, H.3    Fromm, H.4
  • 11
    • 0022397043 scopus 로고
    • Bioavailability, gastrointestinal transit, solubilization and faecal excretion of ursodeoxycholic acid in man
    • Parquet M, Metman EH, Raizman A, Rambaud JC, Berthaux N, Infante R. Bioavailability, gastrointestinal transit, solubilization and faecal excretion of ursodeoxycholic acid in man. Eur J Clin Invest 1985;15:171-8.
    • (1985) Eur J Clin Invest , vol.15 , pp. 171-178
    • Parquet, M.1    Metman, E.H.2    Raizman, A.3    Rambaud, J.C.4    Berthaux, N.5    Infante, R.6
  • 12
    • 0022877380 scopus 로고
    • Effect of ursodeoxycholic acid and chenodeoxycholic acid on cholesterol and bile acid metabolism
    • Tint GS, Salen G, Shefer S. Effect of ursodeoxycholic acid and chenodeoxycholic acid on cholesterol and bile acid metabolism. Gastroenterology 1986;91:1007-18.
    • (1986) Gastroenterology , vol.91 , pp. 1007-1018
    • Tint, G.S.1    Salen, G.2    Shefer, S.3
  • 14
    • 0021178162 scopus 로고
    • Influence of hydroxylation and conjugation of bile salts on their membrane-damaging properties - Studies on isolated hepatocytes and lipid membrane vesicles
    • Schlomerich J, Becher MS, Schmidt K, et al. Influence of hydroxylation and conjugation of bile salts on their membrane-damaging properties - studies on isolated hepatocytes and lipid membrane vesicles. Hepatology 1984;4:661-6.
    • (1984) Hepatology , vol.4 , pp. 661-666
    • Schlomerich, J.1    Becher, M.S.2    Schmidt, K.3
  • 15
    • 0015415107 scopus 로고
    • Bile acids, liver injury, and liver disease
    • Palmer RH. Bile acids, liver injury, and liver disease. Arch Intern Med 1972;130:606-17.
    • (1972) Arch Intern Med , vol.130 , pp. 606-617
    • Palmer, R.H.1
  • 16
    • 0022481962 scopus 로고
    • Differing effects of nor-ursodeoxycholic or ursodeoxycholic acid on hepatic histology and bile acid metabolism in the rabbit
    • Cohen BI, Hofmann AF, Mosbach EH, et al. Differing effects of nor-ursodeoxycholic or ursodeoxycholic acid on hepatic histology and bile acid metabolism in the rabbit. Gastroenterology 1986;91:189-97.
    • (1986) Gastroenterology , vol.91 , pp. 189-197
    • Cohen, B.I.1    Hofmann, A.F.2    Mosbach, E.H.3
  • 18
    • 0019831281 scopus 로고
    • In vitro transformation of chenodeoxycholic acid and ursodeoxycholic acid by human intestinal flora, with particular reference to the natural conversion between the two bile acids
    • Hirano S, Masuda N, Oda H. In vitro transformation of chenodeoxycholic acid and ursodeoxycholic acid by human intestinal flora, with particular reference to the natural conversion between the two bile acids. J Lipid Res 1981;22: 735-43.
    • (1981) J Lipid Res , vol.22 , pp. 735-743
    • Hirano, S.1    Masuda, N.2    Oda, H.3
  • 19
    • 0027209627 scopus 로고
    • Hepatoprotective properties of ursodeoxycholic acid
    • Heuman DM. Hepatoprotective properties of ursodeoxycholic acid [Editorial; Comment]. Gastroenterology 1993; 104:1865-70.
    • (1993) Gastroenterology , vol.104 , pp. 1865-1870
    • Heuman, D.M.1
  • 20
    • 0028934905 scopus 로고
    • Functional and ultrastructural features of ethanol/bile salts interaction in the isolated perfused rat liver
    • Alvaro D, Benedetti A, Gigliozzi A, et al. Functional and ultrastructural features of ethanol/bile salts interaction in the isolated perfused rat liver. Hepatology 1995;21:1120-9.
    • (1995) Hepatology , vol.21 , pp. 1120-1129
    • Alvaro, D.1    Benedetti, A.2    Gigliozzi, A.3
  • 21
    • 0028910059 scopus 로고
    • Evidence of preservation injury to bile ducts by bile salts in the pig and its prevention by infusions of hydrophilic bile salts
    • Hertel M, Harvey RC, Swanson PE, et al. Evidence of preservation injury to bile ducts by bile salts in the pig and its prevention by infusions of hydrophilic bile salts. Hepatology 1995;21:1130-7.
    • (1995) Hepatology , vol.21 , pp. 1130-1137
    • Hertel, M.1    Harvey, R.C.2    Swanson, P.E.3
  • 22
    • 0028351832 scopus 로고
    • Ursodeoxycholate conjugates protect against disruption of cholesterol-rich membranes by bile salts
    • Heuman DM, Bajaj R. Ursodeoxycholate conjugates protect against disruption of cholesterol-rich membranes by bile salts. Gastroenterology 1994;106:1333-41.
    • (1994) Gastroenterology , vol.106 , pp. 1333-1341
    • Heuman, D.M.1    Bajaj, R.2
  • 24
    • 0020031555 scopus 로고
    • Tauroursodeoxycholate prevents taurocholate induced cholestasis
    • Kitani K, Kanai S. Tauroursodeoxycholate prevents taurocholate induced cholestasis. Life Sci 1982;30:515-23.
    • (1982) Life Sci , vol.30 , pp. 515-523
    • Kitani, K.1    Kanai, S.2
  • 25
    • 0027192272 scopus 로고
    • Protection against hydrophobic bile salt-induced cell membrane damage by liposomes and hydrophilic bile salts
    • Sagawa H, Tazuma S, Kajiyama G. Protection against hydrophobic bile salt-induced cell membrane damage by liposomes and hydrophilic bile salts. Am J Physiol 1993;264:G835-9.
    • (1993) Am J Physiol , vol.264
    • Sagawa, H.1    Tazuma, S.2    Kajiyama, G.3
  • 26
    • 0027371595 scopus 로고
    • Taurine conjugate of ursodeoxycholate plays a major role in the hepatoprotective effect against cholestasis induced by taurochenodeoxycholate in rats
    • Tsukahara K, Kanai S, Ohta M, Kitani K. Taurine conjugate of ursodeoxycholate plays a major role in the hepatoprotective effect against cholestasis induced by taurochenodeoxycholate in rats. Liver 1993;13:262-9.
    • (1993) Liver , vol.13 , pp. 262-269
    • Tsukahara, K.1    Kanai, S.2    Ohta, M.3    Kitani, K.4
  • 27
    • 0028148195 scopus 로고
    • Hepatoprotection by hydrophilic bile salts
    • Queneau PE, Montet JC. Hepatoprotection by hydrophilic bile salts. J Hepatol 1994;21:260-8.
    • (1994) J Hepatol , vol.21 , pp. 260-268
    • Queneau, P.E.1    Montet, J.C.2
  • 28
    • 0025155478 scopus 로고
    • Ursodeoxycholate reduces hepatotoxicity of bile salts in primary human hepatocytes
    • Galle PR, Theilmann L, Radesch R, Otto G, Stiehl A. Ursodeoxycholate reduces hepatotoxicity of bile salts in primary human hepatocytes. Hepatology 1990;12:486-91.
    • (1990) Hepatology , vol.12 , pp. 486-491
    • Galle, P.R.1    Theilmann, L.2    Radesch, R.3    Otto, G.4    Stiehl, A.5
  • 29
    • 0025790578 scopus 로고
    • Conjugates of ursodeoxycholate protect against cytotoxicity of more hydrophobic bile salts: In vitro studies in rat hepatocytes and human erythrocytes
    • Heuman DM, Pandak WM, Hylemon PB, Vlahcevic ZR. Conjugates of ursodeoxycholate protect against cytotoxicity of more hydrophobic bile salts: in vitro studies in rat hepatocytes and human erythrocytes. Hepatology 1991;14:920-6.
    • (1991) Hepatology , vol.14 , pp. 920-926
    • Heuman, D.M.1    Pandak, W.M.2    Hylemon, P.B.3    Vlahcevic, Z.R.4
  • 30
    • 0012571630 scopus 로고
    • The effect of ursodeoxycholic acid and chenodeoxycholic acid on human hepatocyte and erythrocyte membranes
    • Lim AG, Ahmed HA, Jazrawi RP, Northfield TC. The effect of ursodeoxycholic acid and chenodeoxycholic acid on human hepatocyte and erythrocyte membranes Gut 1993;34:45.
    • (1993) Gut , vol.34 , pp. 45
    • Lim, A.G.1    Ahmed, H.A.2    Jazrawi, R.P.3    Northfield, T.C.4
  • 31
    • 0028864517 scopus 로고
    • Enhanced biliary excretion of canalicular membrane enzymes in ethynylestradiol-induced cholestasis - Effects of ursodeoxycholic acid administration
    • Arrese M, Pizarro, Solis N, Koenig C, Accatino L. Enhanced biliary excretion of canalicular membrane enzymes in ethynylestradiol-induced cholestasis - Effects of ursodeoxycholic acid administration. Biochem Pharmacol 1995;50:1223-32.
    • (1995) Biochem Pharmacol , vol.50 , pp. 1223-1232
    • Arrese, M.1    Pizarro2    Solis, N.3    Koenig, C.4    Accatino, L.5
  • 32
    • 0028816461 scopus 로고
    • Ursodeoxycholate inhibits the mitochondrial membrane permeability transition induced by glycochenodeoxycholate: A mechanism of UDCA cytoprotection
    • Botla R, Spivey JR, Aguilar H, Bronk SF, Gores FJ. Ursodeoxycholate inhibits the mitochondrial membrane permeability transition induced by glycochenodeoxycholate: a mechanism of UDCA cytoprotection. J Pharmacol Exp Ther 1995;272:930-8.
    • (1995) J Pharmacol Exp Ther , vol.272 , pp. 930-938
    • Botla, R.1    Spivey, J.R.2    Aguilar, H.3    Bronk, S.F.4    Gores, F.J.5
  • 35
    • 0027408588 scopus 로고
    • Ursodeoxycholic acid mobilizes intracellular calcium and activates phosphorylase A in isolated hepatocytes
    • Bouscarel B, Fromm H, Nussbaum R. Ursodeoxycholic acid mobilizes intracellular calcium and activates phosphorylase A in isolated hepatocytes. Am J Physiol 1993;264:G243-G51.
    • (1993) Am J Physiol , vol.264
    • Bouscarel, B.1    Fromm, H.2    Nussbaum, R.3
  • 36
    • 0029126559 scopus 로고
    • Ursodeoxycholate increases cytosolic calcium concentration and activates Cl- Currents in a biliary cell line
    • Shimokura GH, McGill JM, Schlanker T, Fitz JG. Ursodeoxycholate increases cytosolic calcium concentration and activates Cl- currents in a biliary cell line. Gastroenterology 1995;109:965-72.
    • (1995) Gastroenterology , vol.109 , pp. 965-972
    • Shimokura, G.H.1    McGill, J.M.2    Schlanker, T.3    Fitz, J.G.4
  • 37
    • 0028151424 scopus 로고
    • Ursodeoxycholate protects oxidative mitochondrial metabolism from bile acid toxicity: Dose-response study in isolated rat liver mitochondria
    • Krahenbuhl S, Fischer S, Talos C, Reichen J. Ursodeoxycholate protects oxidative mitochondrial metabolism from bile acid toxicity: dose-response study in isolated rat liver mitochondria. Hepatology 1994;20:1595-1601.
    • (1994) Hepatology , vol.20 , pp. 1595-1601
    • Krahenbuhl, S.1    Fischer, S.2    Talos, C.3    Reichen, J.4
  • 38
    • 0028091169 scopus 로고
    • Toxicity of bile acids on the electron transport chain of isolated rat liver mitochondria
    • Krahenbuhl S, Talos C, Fischer S, Reichen J. Toxicity of bile acids on the electron transport chain of isolated rat liver mitochondria. Hepatology 1994;19:471-9.
    • (1994) Hepatology , vol.19 , pp. 471-479
    • Krahenbuhl, S.1    Talos, C.2    Fischer, S.3    Reichen, J.4
  • 39
    • 0029145255 scopus 로고
    • Reduced antioxidative capacity in liver mitochondria from bile duct ligated rats
    • Krahenbuhl S, Talos C, Lauterburg BH, Reichen J. Reduced antioxidative capacity in liver mitochondria from bile duct ligated rats. Hepatology 1995;22:607-12.
    • (1995) Hepatology , vol.22 , pp. 607-612
    • Krahenbuhl, S.1    Talos, C.2    Lauterburg, B.H.3    Reichen, J.4
  • 40
    • 0027207769 scopus 로고
    • Evidence for involvement of oxygen free radicals in bile acid toxicity to isolated rat hepatocytes
    • Sokol RJ, Devereaux M, Khandwala R, O'Brien K. Evidence for involvement of oxygen free radicals in bile acid toxicity to isolated rat hepatocytes. Hepatology 1993;17:869-81.
    • (1993) Hepatology , vol.17 , pp. 869-881
    • Sokol, R.J.1    Devereaux, M.2    Khandwala, R.3    O'Brien, K.4
  • 42
    • 0029123537 scopus 로고
    • Generation of hydroperoxides in isolated rat hepatocytes and hepatic mitochondria exposed to hydrophobic bile acids
    • Sokol RJ, Winklhofer-Roob BM, Devereaux MW, McKim JM Jr. Generation of hydroperoxides in isolated rat hepatocytes and hepatic mitochondria exposed to hydrophobic bile acids. Gastroenterology 1995;109:1249-56.
    • (1995) Gastroenterology , vol.109 , pp. 1249-1256
    • Sokol, R.J.1    Winklhofer-Roob, B.M.2    Devereaux, M.W.3    McKim J.M., Jr.4
  • 43
    • 0020684859 scopus 로고
    • Interactions between different bile salts in the biliary excretion of the rat
    • Kitani K, Kanai S. Interactions between different bile salts in the biliary excretion of the rat. Chem Path Pharm 1983; 39:139-52.
    • (1983) Chem Path Pharm , vol.39 , pp. 139-152
    • Kitani, K.1    Kanai, S.2
  • 45
    • 0028954737 scopus 로고
    • Ursodeoxycholic acid inhibits glucagon-induced cAMP formation in hamster hepatocytes: A role for PKC
    • Bouscarel B, Gettys TW, Fromm H, Dubner H. Ursodeoxycholic acid inhibits glucagon-induced cAMP formation in hamster hepatocytes: a role for PKC. Am J Physiol 1995; 268:G300-10.
    • (1995) Am J Physiol , vol.268
    • Bouscarel, B.1    Gettys, T.W.2    Fromm, H.3    Dubner, H.4
  • 46
    • 0019294767 scopus 로고
    • Hypercholeresis induced by ursodeoxycholic acid and ketolithocholic acid in the rat: Possible role of bicarbonate transport
    • Dumont M, Erlinger S, Uchman S. Hypercholeresis induced by ursodeoxycholic acid and ketolithocholic acid in the rat: possible role of bicarbonate transport. Gastroenterology 1980;79:82-9.
    • (1980) Gastroenterology , vol.79 , pp. 82-89
    • Dumont, M.1    Erlinger, S.2    Uchman, S.3
  • 47
    • 0022650127 scopus 로고
    • Effect of side-chain shortening on the physiologic properties of bile acids: Hepatic transport and effect on biliary secretion of 23-nor-ursodeoxycholate in rodents
    • Yoon YB, Hagey LR, Hofmann AF, Gurantz D, Michelotti EL, Steinbach JH. Effect of side-chain shortening on the physiologic properties of bile acids: hepatic transport and effect on biliary secretion of 23-nor-ursodeoxycholate in rodents. Gastroenterology 1986;90:837-52.
    • (1986) Gastroenterology , vol.90 , pp. 837-852
    • Yoon, Y.B.1    Hagey, L.R.2    Hofmann, A.F.3    Gurantz, D.4    Michelotti, E.L.5    Steinbach, J.H.6
  • 48
    • 0027490192 scopus 로고
    • Effect of ursodeoxycholic acid on intracellular pH regulation in isolated rat bile duct epithelial cells
    • Alvaro D, Mennone A, Boyer JL. Effect of ursodeoxycholic acid on intracellular pH regulation in isolated rat bile duct epithelial cells. Am J Physiol 1993;265:G783-G971.
    • (1993) Am J Physiol , vol.265
    • Alvaro, D.1    Mennone, A.2    Boyer, J.L.3
  • 49
    • 0028049491 scopus 로고
    • Ursodeoxycholate-induced hypercholeresis in cirrhotic rats: Further evidence for cholehepatic shunting
    • Elsing C, Sagessar H, Reichen J. Ursodeoxycholate-induced hypercholeresis in cirrhotic rats: further evidence for cholehepatic shunting. Hepatology 1994;20:1048-54.
    • (1994) Hepatology , vol.20 , pp. 1048-1054
    • Elsing, C.1    Sagessar, H.2    Reichen, J.3
  • 50
    • 0028084463 scopus 로고
    • Kinetics of hepatic bile acid handling in cholestatic liver disease: Effect of ursodeoxycholic acid
    • Jazrawi RP, De Caestecker JS, Goggin PM, et al. Kinetics of hepatic bile acid handling in cholestatic liver disease: effect of ursodeoxycholic acid. Gastroenterology 1994;106:134-42.
    • (1994) Gastroenterology , vol.106 , pp. 134-142
    • Jazrawi, R.P.1    De Caestecker, J.S.2    Goggin, P.M.3
  • 51
    • 0028907388 scopus 로고
    • New insights into the mechanism of bile acid-induced biliary lipid secretion
    • Verkade HJ, Vonk RJ, Kuipers F. New insights into the mechanism of bile acid-induced biliary lipid secretion. Hepatology 1995;21:1174-88.
    • (1995) Hepatology , vol.21 , pp. 1174-1188
    • Verkade, H.J.1    Vonk, R.J.2    Kuipers, F.3
  • 52
    • 0025017364 scopus 로고
    • Acute effects of ursodeoxycholic and chenodeoxycholic acid on the small intestinal absorption of bile acids
    • Stiehl A, Radesch R, Rudolph G. Acute effects of ursodeoxycholic and chenodeoxycholic acid on the small intestinal absorption of bile acids. Gastroenterology 1990;98:424-8.
    • (1990) Gastroenterology , vol.98 , pp. 424-428
    • Stiehl, A.1    Radesch, R.2    Rudolph, G.3
  • 53
    • 0027467410 scopus 로고
    • Tauroursodeoxycholate and tauro-β-muricholate exert cytoprotection by reducing intrahepatic taurochenodeoxycholate content
    • Ohiwa T, Katagiri K, Hoshino M, Hayakawa T, Nakai T. Tauroursodeoxycholate and tauro-β-muricholate exert cytoprotection by reducing intrahepatic taurochenodeoxycholate content. Hepatology 1993;17:470-6.
    • (1993) Hepatology , vol.17 , pp. 470-476
    • Ohiwa, T.1    Katagiri, K.2    Hoshino, M.3    Hayakawa, T.4    Nakai, T.5
  • 54
    • 0027159022 scopus 로고
    • Involvement of microtubles in the swelling-induced stimulation of transcellular taurocholate transport in perfused rat liver
    • Haussinger D, Saha N, Hallbrucker C, Lang F, Gerok W. Involvement of microtubles in the swelling-induced stimulation of transcellular taurocholate transport in perfused rat liver. Biochem J 1993;291:355-60.
    • (1993) Biochem J , vol.291 , pp. 355-360
    • Haussinger, D.1    Saha, N.2    Hallbrucker, C.3    Lang, F.4    Gerok, W.5
  • 55
    • 0027788161 scopus 로고
    • Effect of tauroursodeoxycholate on actin filament alteration induced by cholestatic agents. A study in isolated rat hepatocyte couplets
    • Thibault N, Maurice M, Maratrat M, Cordier A, Feldmann G, Ballet F. Effect of tauroursodeoxycholate on actin filament alteration induced by cholestatic agents. A study in isolated rat hepatocyte couplets. J Hepatol 1993;19:367-76.
    • (1993) J Hepatol , vol.19 , pp. 367-376
    • Thibault, N.1    Maurice, M.2    Maratrat, M.3    Cordier, A.4    Feldmann, G.5    Ballet, F.6
  • 56
    • 0028926092 scopus 로고
    • Isolation of the microtubule-vesicle motor kinesin from rat liver: Selective inhibition by cholestatic bile acids
    • Marks DL, LaRusso NF, McNiven MA. Isolation of the microtubule-vesicle motor kinesin from rat liver: selective inhibition by cholestatic bile acids. Gastroenterology 1995;108: 824-33.
    • (1995) Gastroenterology , vol.108 , pp. 824-833
    • Marks, D.L.1    LaRusso, N.F.2    McNiven, M.A.3
  • 57
    • 0026442917 scopus 로고
    • Microtubule-independent choleresis and anti-cholestatic action of tauroursodeoxycholate in colchicine-treated rat liver
    • Nakai T, Katagiri K, Hoshino M, Hayakawa T, Ohiwa T. Microtubule-independent choleresis and anti-cholestatic action of tauroursodeoxycholate in colchicine-treated rat liver. Biochemical J 1992;288:613-17.
    • (1992) Biochemical J , vol.288 , pp. 613-617
    • Nakai, T.1    Katagiri, K.2    Hoshino, M.3    Hayakawa, T.4    Ohiwa, T.5
  • 58
    • 0027936704 scopus 로고
    • Tubulovesicular transport of horseradish peroxidase in isolated rat hepatocyte couplets: Effects of low temperature, cytochalasin B and bile acids
    • Sakisaka S, Harada M, Gondo K, Yoshitake M, Tanikawa K. Tubulovesicular transport of horseradish peroxidase in isolated rat hepatocyte couplets: effects of low temperature, cytochalasin B and bile acids. Hepatology 1994;20:1015-23.
    • (1994) Hepatology , vol.20 , pp. 1015-1023
    • Sakisaka, S.1    Harada, M.2    Gondo, K.3    Yoshitake, M.4    Tanikawa, K.5
  • 59
    • 0025098908 scopus 로고
    • Hepatic expression of class I and class II major histocompatibility complex molecules in primary biliary cirrhosis: Effect of ursodeoxycholic acid
    • Calmus Y, Gane P, Rouger P, Poupon R. Hepatic expression of class I and class II major histocompatibility complex molecules in primary biliary cirrhosis: effect of ursodeoxycholic acid. Hepatology 1990;11:12-15.
    • (1990) Hepatology , vol.11 , pp. 12-15
    • Calmus, Y.1    Gane, P.2    Rouger, P.3    Poupon, R.4
  • 60
    • 0026663426 scopus 로고
    • Immunosuppressive properties of chenodeoxycholic and ursodeoxycholic acids in the mouse
    • Calmus Y, Weill B, Osier Y, Chereau C, Houssin D, Poupon R. Immunosuppressive properties of chenodeoxycholic and ursodeoxycholic acids in the mouse. Gastroenterology 1992; 103:617-21.
    • (1992) Gastroenterology , vol.103 , pp. 617-621
    • Calmus, Y.1    Weill, B.2    Osier, Y.3    Chereau, C.4    Houssin, D.5    Poupon, R.6
  • 61
    • 0027034708 scopus 로고
    • Ursodeoxycholic acid for the treatment of cholestatic diseases
    • Boyer JL, Ockner RK, eds. Philadelphia: WB Saunders
    • Poupon RE, Poupon R. Ursodeoxycholic acid for the treatment of cholestatic diseases. In: Boyer JL, Ockner RK, eds. Progress in liver disease. vol 10. Philadelphia: WB Saunders, 1992:219-38.
    • (1992) Progress in Liver Disease , vol.10 , pp. 219-238
    • Poupon, R.E.1    Poupon, R.2
  • 62
    • 0027221534 scopus 로고
    • The immunosuppressive effect of ursodeoxycholic acid: A comparative in vitro study on human peripheral blood mononuclear cells
    • Lacaille F, Paradis K. The immunosuppressive effect of ursodeoxycholic acid: a comparative in vitro study on human peripheral blood mononuclear cells. Hepatology 1993;18: 165-72.
    • (1993) Hepatology , vol.18 , pp. 165-172
    • Lacaille, F.1    Paradis, K.2
  • 63
    • 0023668488 scopus 로고
    • Bile acid metabolism in cirrhotic liver tissue-altered synthesis and impaired hepatic secretion
    • Akashi Y, Miyazaki H, Yanagisawa J, Nakayama F. Bile acid metabolism in cirrhotic liver tissue-altered synthesis and impaired hepatic secretion. Clin Chim Acta 1987;168: 199-206.
    • (1987) Clin Chim Acta , vol.168 , pp. 199-206
    • Akashi, Y.1    Miyazaki, H.2    Yanagisawa, J.3    Nakayama, F.4
  • 64
    • 0015676651 scopus 로고
    • Determination of bile acids in needle biopsies of human liver
    • Greim H, Czygan P, Schaffner F, Popper H. Determination of bile acids in needle biopsies of human liver. Biochem Med 1973;8:280-6.
    • (1973) Biochem Med , vol.8 , pp. 280-286
    • Greim, H.1    Czygan, P.2    Schaffner, F.3    Popper, H.4
  • 65
    • 0015434595 scopus 로고
    • Mechanism of cholestasis V and VI. Bile acids in human livers with or without biliary obstruction
    • Greim H, Trulzsch D, Czygan P, et al. Mechanism of cholestasis V and VI. Bile acids in human livers with or without biliary obstruction. Gastroenterology 1972;63:837-45; 846-50.
    • (1972) Gastroenterology , vol.63 , pp. 837-845
    • Greim, H.1    Trulzsch, D.2    Czygan, P.3
  • 66
    • 0028135420 scopus 로고
    • Increases of intracellular magnesium promote glycodeoxycholate-induced apoptosis in rat hepatocytes
    • Patel T, Bronk SF, Gores GJ. Increases of intracellular magnesium promote glycodeoxycholate-induced apoptosis in rat hepatocytes. J Clin Invest 1994;94:2183-92.
    • (1994) J Clin Invest , vol.94 , pp. 2183-2192
    • Patel, T.1    Bronk, S.F.2    Gores, G.J.3
  • 67
    • 0029012444 scopus 로고
    • Apoptosis and hepatobiliary disease
    • Patel T, Gores GJ. Apoptosis and hepatobiliary disease. Hepatology 1995;21:1725-39.
    • (1995) Hepatology , vol.21 , pp. 1725-1739
    • Patel, T.1    Gores, G.J.2
  • 68
    • 0022656312 scopus 로고
    • Bile acid-induced liver toxicity: Relation to the hydrophobichydrophilic balance of bile acids
    • Attili AF, Angelico M, Cantafora A, Alvaro D, Capocaccia L. Bile acid-induced liver toxicity: relation to the hydrophobichydrophilic balance of bile acids. Med Hypotheses 1986;19: 57-68.
    • (1986) Med Hypotheses , vol.19 , pp. 57-68
    • Attili, A.F.1    Angelico, M.2    Cantafora, A.3    Alvaro, D.4    Capocaccia, L.5
  • 69
    • 0343648748 scopus 로고
    • Experimental cirrhosis of the liver in rabbits induced by gastric instillation of desiccated whole bile
    • Holsti P. Experimental cirrhosis of the liver in rabbits induced by gastric instillation of desiccated whole bile. Acta Pathol Microbiol Scand 1956;112:1-67.
    • (1956) Acta Pathol Microbiol Scand , vol.112 , pp. 1-67
    • Holsti, P.1
  • 70
    • 0019507465 scopus 로고
    • Chenodiol (chenodeoxycholic acid) for dissolution of gallstones: The National Cooperative Gallstone Study: A controlled trial of efficacy and safety
    • Schoenfield LJ, Lachin JM Chenodiol (chenodeoxycholic acid) for dissolution of gallstones: The National Cooperative Gallstone Study: a controlled trial of efficacy and safety. Ann Intern Med 1981;95:257-82.
    • (1981) Ann Intern Med , vol.95 , pp. 257-282
    • Schoenfield, L.J.1    Lachin, J.M.2
  • 71
    • 0017323763 scopus 로고
    • Effect of deoxycholic acid ingestion on bile acid metabolism and biliary lipid secretion in normal subjects
    • La Russo NF, Szcepanik PA, Hofmann AF. Effect of deoxycholic acid ingestion on bile acid metabolism and biliary lipid secretion in normal subjects. Gastroenterology 1977; 72:132-40.
    • (1977) Gastroenterology , vol.72 , pp. 132-140
    • La Russo, N.F.1    Szcepanik, P.A.2    Hofmann, A.F.3
  • 72
  • 73
    • 0028795316 scopus 로고
    • Liver cell necrosis: Cellular mechanisms and clinical implications
    • Rosser BG, Gores GJ. Liver cell necrosis: cellular mechanisms and clinical implications. Gastroenterology 1995;108: 252-75.
    • (1995) Gastroenterology , vol.108 , pp. 252-275
    • Rosser, B.G.1    Gores, G.J.2
  • 74
    • 0027227827 scopus 로고
    • Glycochenodeoxycholate-induced lethal hepatocellular injury in rat hepatocytes: Role of ATP depletion and cytosolic free calcium
    • Spivey JR, Bronk SF, Gores GJ. Glycochenodeoxycholate-induced lethal hepatocellular injury in rat hepatocytes: role of ATP depletion and cytosolic free calcium. J Can Invest 1993;92:17-24.
    • (1993) J Can Invest , vol.92 , pp. 17-24
    • Spivey, J.R.1    Bronk, S.F.2    Gores, G.J.3
  • 75
    • 0027406096 scopus 로고
    • Serum bile acids in primary biliary cirrhosis: Effect of ursodeoxycholic acid therapy
    • Poupon RE, Chretien Y, Poupon R, Paumgartner G. Serum bile acids in primary biliary cirrhosis: effect of ursodeoxycholic acid therapy. Hepatology 1993;17:599-604.
    • (1993) Hepatology , vol.17 , pp. 599-604
    • Poupon, R.E.1    Chretien, Y.2    Poupon, R.3    Paumgartner, G.4
  • 76
    • 0028129397 scopus 로고
    • The major metabolites of ursodeoxycholic acid in human urine are conjugated with N-acetylglucosamine
    • Marschall HU, Griffiths WJ, Gotze U, et al. The major metabolites of ursodeoxycholic acid in human urine are conjugated with N-acetylglucosamine. Hepatology 1994;20:845-53.
    • (1994) Hepatology , vol.20 , pp. 845-853
    • Marschall, H.U.1    Griffiths, W.J.2    Gotze, U.3
  • 77
    • 0026352217 scopus 로고
    • Changes in bile acid composition in patients with primary biliary cirrhosis induced by ursodeoxycholic-acid administration
    • Crosignani A, Podda M. Battezzati PM, et al. Changes in bile acid composition in patients with primary biliary cirrhosis induced by ursodeoxycholic-acid administration. Hepatology 1991;14:1000-7.
    • (1991) Hepatology , vol.14 , pp. 1000-1007
    • Crosignani, A.1    Podda, M.2    Battezzati, P.M.3
  • 78
    • 0025047432 scopus 로고
    • Ursodeoxycholic acid-induced changes of plasma and urinary bile acids in patients with primary biliary cirrhosis
    • Stiehl A, Rudolph G, Raedsch R, et al. Ursodeoxycholic acid-induced changes of plasma and urinary bile acids in patients with primary biliary cirrhosis. Hepatology 1990; 12:492-7.
    • (1990) Hepatology , vol.12 , pp. 492-497
    • Stiehl, A.1    Rudolph, G.2    Raedsch, R.3
  • 79
    • 0021029789 scopus 로고
    • Comparative effects of ursodeoxycholic acid and chenodeoxycholic acid on bile acid kinetics and biliary lipid secretion in humans. Evidence for different modes of action on bile acid synthesis
    • Nilsell K, Angelin B, Leijd B, Einarsson K. Comparative effects of ursodeoxycholic acid and chenodeoxycholic acid on bile acid kinetics and biliary lipid secretion in humans. Evidence for different modes of action on bile acid synthesis. Gastroenterology 1983;85:1248-56.
    • (1983) Gastroenterology , vol.85 , pp. 1248-1256
    • Nilsell, K.1    Angelin, B.2    Leijd, B.3    Einarsson, K.4
  • 80
    • 0027280229 scopus 로고
    • Effect of ursodeoxycholic acid on the kinetics of cholic acid and chenodeoxycholic acid in patients with primary sclerosing cholangitis
    • Rudolph G, Endele R, Senn M, Stiehl A. Effect of ursodeoxycholic acid on the kinetics of cholic acid and chenodeoxycholic acid in patients with primary sclerosing cholangitis. Hepatology 1993;17:1028-32.
    • (1993) Hepatology , vol.17 , pp. 1028-1032
    • Rudolph, G.1    Endele, R.2    Senn, M.3    Stiehl, A.4
  • 81
    • 0027297995 scopus 로고
    • Ursodeoxycholic acid administration on bile acid metabolism in patients with early stages of primary biliary cirrhosis
    • Mazella G, Parini P, Bazzoli F, et al. Ursodeoxycholic acid administration on bile acid metabolism in patients with early stages of primary biliary cirrhosis. Dig Dis Sci 1993;38: 896-902.
    • (1993) Dig Dis Sci , vol.38 , pp. 896-902
    • Mazella, G.1    Parini, P.2    Bazzoli, F.3
  • 82
    • 0029095596 scopus 로고
    • Effects of ursodeoxycholic acid and chenodeoxycholic acid on human hepatocytes in primary culture
    • Hillaire S, Ballet F, Franco D, Setchell KDR, Poupon R. Effects of ursodeoxycholic acid and chenodeoxycholic acid on human hepatocytes in primary culture. Hepatology 1995;22:82-7.
    • (1995) Hepatology , vol.22 , pp. 82-87
    • Hillaire, S.1    Ballet, F.2    Franco, D.3    Setchell, K.D.R.4    Poupon, R.5
  • 83
    • 0024467084 scopus 로고
    • Effect of ursodeoxycholic acid on bile acid metabolism in primary biliary cirrhosis
    • Batta AK, Salen G, Arora R, et al. Effect of ursodeoxycholic acid on bile acid metabolism in primary biliary cirrhosis. Hepatology 1989;10:414-19.
    • (1989) Hepatology , vol.10 , pp. 414-419
    • Batta, A.K.1    Salen, G.2    Arora, R.3
  • 84
    • 0025893620 scopus 로고
    • Protective effect of tauroursodeoxycholate against chenodeoxycholate-induced damage to cultured rabbit gastric cells
    • Ota S, Tsukahara H, Terano A, et al. Protective effect of tauroursodeoxycholate against chenodeoxycholate-induced damage to cultured rabbit gastric cells. Dig Dis Sci 1991;36:409-26.
    • (1991) Dig Dis Sci , vol.36 , pp. 409-426
    • Ota, S.1    Tsukahara, H.2    Terano, A.3
  • 85
    • 0025202952 scopus 로고
    • Effect of chronic administration of ursodeoxycholic acid on the ileal absorption of endogenous bile acids in man
    • Marteau P, Chazouilleres O, Myara A, Jian R, Rambaud JC, Poupon R. Effect of chronic administration of ursodeoxycholic acid on the ileal absorption of endogenous bile acids in man. Hepatology 1990;12:1206-8.
    • (1990) Hepatology , vol.12 , pp. 1206-1208
    • Marteau, P.1    Chazouilleres, O.2    Myara, A.3    Jian, R.4    Rambaud, J.C.5    Poupon, R.6
  • 86
    • 0024819478 scopus 로고
    • Characterization of serum and urinary bile acids in patients with primary biliary cirrhosis by gas-liquid chromatographymass spectrometry: Effect of ursodeoxycholic acid treatment
    • Batta AK, Arora R, Salen G, Tint GS, Eskreis D, Katz S. Characterization of serum and urinary bile acids in patients with primary biliary cirrhosis by gas-liquid chromatographymass spectrometry: effect of ursodeoxycholic acid treatment. J Lipid Res 1989;30:1953-62.
    • (1989) J Lipid Res , vol.30 , pp. 1953-1962
    • Batta, A.K.1    Arora, R.2    Salen, G.3    Tint, G.S.4    Eskreis, D.5    Katz, S.6
  • 87
    • 0025823660 scopus 로고
    • Effect of ursodeoxycholic acid treatment on ileal absorption of bile acids in man as determined by the SeHCAT Test
    • Eusafzai S, Ericsson S, Cederlund T, Einarsson K, Angelin B. Effect of ursodeoxycholic acid treatment on ileal absorption of bile acids in man as determined by the SeHCAT Test. GUT 1991;32:1044-8.
    • (1991) GUT , vol.32 , pp. 1044-1048
    • Eusafzai, S.1    Ericsson, S.2    Cederlund, T.3    Einarsson, K.4    Angelin, B.5
  • 88
    • 0025193141 scopus 로고
    • Comprehensive study of the biliary bile acid composition of patients with cystic fibrosis and associated liver disease before and after UDCA administration
    • Nakagawa M, Colombo C, Setchell KDR. Comprehensive study of the biliary bile acid composition of patients with cystic fibrosis and associated liver disease before and after UDCA administration. Hepatology 1990;12:322-4.
    • (1990) Hepatology , vol.12 , pp. 322-324
    • Nakagawa, M.1    Colombo, C.2    Setchell, K.D.R.3
  • 89
    • 0023508466 scopus 로고
    • Ursodeoxycholate stimulates Na+,H+ exchange in rat liver basolateral plasma membrane vesicles
    • Moseley RH, Ballatori N, Smith DJ, Boyer JL. Ursodeoxycholate stimulates Na+,H+ exchange in rat liver basolateral plasma membrane vesicles. J Clin Invest 1987;80:684-90.
    • (1987) J Clin Invest , vol.80 , pp. 684-690
    • Moseley, R.H.1    Ballatori, N.2    Smith, D.J.3    Boyer, J.L.4
  • 90
    • 0026086134 scopus 로고
    • Conjugates of ursodeoxycholate protect against cholestasis and hepatocellular necrosis caused by more hydrophobic bile salts
    • Heuman DM, Mills AS, McCall J, Hylemon PB, Pandak WM, Vlahcevic ZR. Conjugates of ursodeoxycholate protect against cholestasis and hepatocellular necrosis caused by more hydrophobic bile salts. Gastroenterology 1991;100: 203-11.
    • (1991) Gastroenterology , vol.100 , pp. 203-211
    • Heuman, D.M.1    Mills, A.S.2    McCall, J.3    Hylemon, P.B.4    Pandak, W.M.5    Vlahcevic, Z.R.6
  • 91
    • 0025247125 scopus 로고
    • Hepatic injury induced by bile salts: Correlation between biochemical and morphological events
    • Schmucker DL, Ohta M, Kanai S, Sato Y, Kitani K. Hepatic injury induced by bile salts: correlation between biochemical and morphological events. Hepatology 1990;12:1216-21.
    • (1990) Hepatology , vol.12 , pp. 1216-1221
    • Schmucker, D.L.1    Ohta, M.2    Kanai, S.3    Sato, Y.4    Kitani, K.5
  • 92
    • 0021809682 scopus 로고
    • Gallstone dissolution with ursodeoxycholic acid in patients with chronic active hepatitis and two years follow-up. A pilot study
    • Leuschner U, Leuschner M, Sieratzki J, Kurtz W, Hubner K. Gallstone dissolution with ursodeoxycholic acid in patients with chronic active hepatitis and two years follow-up. A pilot study. Dig Dis Sci 1985;30:642-9.
    • (1985) Dig Dis Sci , vol.30 , pp. 642-649
    • Leuschner, U.1    Leuschner, M.2    Sieratzki, J.3    Kurtz, W.4    Hubner, K.5
  • 93
    • 84933047295 scopus 로고    scopus 로고
    • Ursodeoxycholic acid or clofibrate in the treatment of non-alcohol-induced steatohepatitis: A pilot study
    • Laurin JM, Lindor KD, Crippin JS, et al. Ursodeoxycholic acid or clofibrate in the treatment of non-alcohol-induced steatohepatitis: a pilot study. Hepatology 1996;23:1464-6.
    • (1996) Hepatology , vol.23 , pp. 1464-1466
    • Laurin, J.M.1    Lindor, K.D.2    Crippin, J.S.3
  • 94
    • 0028942689 scopus 로고
    • Familial giant cell hepatitis with low bile acid concentrations and increased urinary excretion of specific bile alcohols: A new inborn error of bile acid synthesis?
    • Clayton PT, Casteels M, Mieli-Vergani G, Lawson AM. Familial giant cell hepatitis with low bile acid concentrations and increased urinary excretion of specific bile alcohols: a new inborn error of bile acid synthesis? Pediatr Res 1995;37:424-31.
    • (1995) Pediatr Res , vol.37 , pp. 424-431
    • Clayton, P.T.1    Casteels, M.2    Mieli-Vergani, G.3    Lawson, A.M.4
  • 95
    • 0008313272 scopus 로고
    • Effects of ursodeoxycholic acid on biochemical parameters in children with primary sclerosing cholangitis
    • Bousvaros A, Werlin S, Tolia V, Raynaud S, Ferry G, Kirschner B. Effects of ursodeoxycholic acid on biochemical parameters in children with primary sclerosing cholangitis [Abstract]. J Pediatr Gastroenterol Nutr 1995;21:325.
    • (1995) J Pediatr Gastroenterol Nutr , vol.21 , pp. 325
    • Bousvaros, A.1    Werlin, S.2    Tolia, V.3    Raynaud, S.4    Ferry, G.5    Kirschner, B.6
  • 96
    • 0028934949 scopus 로고
    • The pruritus of cholestasis: Potential pathogenic and therapeutic implications of opioids
    • Bergasa NV, Jones EJ. The pruritus of cholestasis: potential pathogenic and therapeutic implications of opioids. Gastroenterology 1995;108:1582-8.
    • (1995) Gastroenterology , vol.108 , pp. 1582-1588
    • Bergasa, N.V.1    Jones, E.J.2
  • 97
    • 36949052159 scopus 로고
    • Bile acids on the skin of patients with pruritic hepatobiliary disease
    • Schoenfield LJ, Sjovall J, Penman E. Bile acids on the skin of patients with pruritic hepatobiliary disease. Nature 1967;213:93-4.
    • (1967) Nature , vol.213 , pp. 93-94
    • Schoenfield, L.J.1    Sjovall, J.2    Penman, E.3
  • 98
    • 0023122940 scopus 로고
    • Pruritus of cholestasis is related to the effects of bile salts on the liver, not the skin
    • Ghent CN. Pruritus of cholestasis is related to the effects of bile salts on the liver, not the skin. Am J Gastroenterol 1987;82:117-8.
    • (1987) Am J Gastroenterol , vol.82 , pp. 117-118
    • Ghent, C.N.1
  • 99
    • 0025426954 scopus 로고
    • The pruritus of cholestasis: From bile acids to opiate agonists
    • Jones EA, Bergasa NV. The pruritus of cholestasis: from bile acids to opiate agonists. Hepatology 1990;11:884-7.
    • (1990) Hepatology , vol.11 , pp. 884-887
    • Jones, E.A.1    Bergasa, N.V.2
  • 100
    • 0027198566 scopus 로고
    • Plasma from patients with the pruritus of cholestasis induces opioid receptor-mediated scratching in monkeys
    • Bergasa NV, Thomas DA, Vergalla J, Turner ML, Jones EA. Plasma from patients with the pruritus of cholestasis induces opioid receptor-mediated scratching in monkeys. Life Sci 1993;53:1253-7.
    • (1993) Life Sci , vol.53 , pp. 1253-1257
    • Bergasa, N.V.1    Thomas, D.A.2    Vergalla, J.3    Turner, M.L.4    Jones, E.A.5
  • 101
    • 0023125182 scopus 로고
    • Is ursodeoxycholic acid an effective treatment for primary biliary cirrhosis?
    • Poupon R, Chretien Y, Poupon RE, Ballet F, Calmus Y, Darnis F. Is ursodeoxycholic acid an effective treatment for primary biliary cirrhosis? Lancet 1987;1:834-6.
    • (1987) Lancet , vol.1 , pp. 834-836
    • Poupon, R.1    Chretien, Y.2    Poupon, R.E.3    Ballet, F.4    Calmus, Y.5    Darnis, F.6
  • 102
    • 0024464260 scopus 로고
    • Ursodeoxycholic acid in primary biliary cirrhosis - Results of a controlled double-blind trial
    • Leuschner U, Fischer H, Kurtz W, et al. Ursodeoxycholic acid in primary biliary cirrhosis - results of a controlled double-blind trial. Gastroenterology 1989;97:1268-74.
    • (1989) Gastroenterology , vol.97 , pp. 1268-1274
    • Leuschner, U.1    Fischer, H.2    Kurtz, W.3
  • 103
    • 0029041723 scopus 로고
    • Characterisation of patients with a complete biochemical response to ursodeoxycholic acid
    • Jorgensen RA, Dickson ER, Hofmann AF, Rossi SS, Lindor KD. Characterisation of patients with a complete biochemical response to ursodeoxycholic acid. Gut 1995;36:935-8.
    • (1995) Gut , vol.36 , pp. 935-938
    • Jorgensen, R.A.1    Dickson, E.R.2    Hofmann, A.F.3    Rossi, S.S.4    Lindor, K.D.5
  • 104
    • 0025876404 scopus 로고
    • A multicenter, controlled trial of ursodiol for the treatment of primary biliary cirrhosis
    • Poupon RE, Baikau B, Eschwege E, Poupon R, and the UDCA-PBC Study Group. A multicenter, controlled trial of ursodiol for the treatment of primary biliary cirrhosis. N Engl J Med 1991;324:1548-54.
    • (1991) N Engl J Med , vol.324 , pp. 1548-1554
    • Poupon, R.E.1    Baikau, B.2    Eschwege, E.3    Poupon, R.4
  • 105
    • 0028294206 scopus 로고
    • Ursodiol for the long-term treatment of primary biliary cirrhosis
    • Poupon RE, Poupon R, Balkau B, and the UDCA-PBC Study Group. Ursodiol for the long-term treatment of primary biliary cirrhosis. N Engl J Med 1994;330:1342-7.
    • (1994) N Engl J Med , vol.330 , pp. 1342-1347
    • Poupon, R.E.1    Poupon, R.2    Balkau, B.3
  • 106
    • 0027537002 scopus 로고
    • Cholesterollowering effect of ursodeoxycholic acid in patients with primary biliary cirrhosis
    • Poupon RE, Ouguerram K, Chretien Y, et al. Cholesterollowering effect of ursodeoxycholic acid in patients with primary biliary cirrhosis. Hepatology 1993;17:577-82.
    • (1993) Hepatology , vol.17 , pp. 577-582
    • Poupon, R.E.1    Ouguerram, K.2    Chretien, Y.3
  • 107
    • 0029127685 scopus 로고
    • A randomized, double-blind, placebo-controlled trial of ursodeoxycholic acid in primary biliary cirrhosis
    • Combes B, Carithers RL Jr, Maddrey WC, et al. A randomized, double-blind, placebo-controlled trial of ursodeoxycholic acid in primary biliary cirrhosis. Hepatology 1995; 22:759-66.
    • (1995) Hepatology , vol.22 , pp. 759-766
    • Combes, B.1    Carithers R.L., Jr.2    Maddrey, W.C.3
  • 108
    • 0028346255 scopus 로고
    • The Canadian multicenter double-blind randomized controlled trial of ursodeoxycholic acid in primary biliary cirrhosis
    • Heathcote EJ, Cauch-Dudek K, Walker V, et al. The Canadian multicenter double-blind randomized controlled trial of ursodeoxycholic acid in primary biliary cirrhosis. Hepatollogy 1994;19:1149-56.
    • (1994) Hepatollogy , vol.19 , pp. 1149-1156
    • Heathcote, E.J.1    Cauch-Dudek, K.2    Walker, V.3
  • 109
    • 0028331716 scopus 로고
    • Ursodeoxycholic acid in the treatment of primary biliary cirrhosis
    • Lindor KD, Dickson ER, Baldus WP, et al. Ursodeoxycholic acid in the treatment of primary biliary cirrhosis. Gastroenterology 1994;106:1284-90.
    • (1994) Gastroenterology , vol.106 , pp. 1284-1290
    • Lindor, K.D.1    Dickson, E.R.2    Baldus, W.P.3
  • 111
    • 0342268992 scopus 로고
    • Effects of ursodeoxycholic acid in patients with primary sclerosing cholangitis
    • Paumgartner G, Stiehl A, Gerok W, eds. London: Kluwer Academic Press
    • Stiehl L, Rudolph G, Raedsch R, Stiehl A. Effects of ursodeoxycholic acid in patients with primary sclerosing cholangitis. In: Paumgartner G, Stiehl A, Gerok W, eds. Bile acids as therapeutic agents: from basic science to clinical practice. London: Kluwer Academic Press, 1991:305-7.
    • (1991) Bile Acids as Therapeutic Agents: From Basic Science to Clinical Practice , pp. 305-307
    • Stiehl, L.1    Rudolph, G.2    Raedsch, R.3    Stiehl, A.4
  • 112
    • 0027938076 scopus 로고
    • Ursodeoxycholic acid in the treatment of primary sclerosing cholangitis
    • Stiehl A. Ursodeoxycholic acid in the treatment of primary sclerosing cholangitis. Ann Med 1994;26:345-9.
    • (1994) Ann Med , vol.26 , pp. 345-349
    • Stiehl, A.1
  • 113
    • 0024997057 scopus 로고
    • Ursodeoxycholic acid for primary sclerosing cholangitis
    • Chazouilleres O, Poupon R, Capron J-P, et al. Ursodeoxycholic acid for primary sclerosing cholangitis. J Hepatol 1990;11:120-3.
    • (1990) J Hepatol , vol.11 , pp. 120-123
    • Chazouilleres, O.1    Poupon, R.2    Capron, J.-P.3
  • 114
    • 0025790576 scopus 로고
    • Ursodeoxycholic acid for the treatment of primary sclerosing cholangitis: A 30-month pilot study
    • O'Brien CB, Senior JR, Arora-Mirchandani R, Batta AK, Salen G. Ursodeoxycholic acid for the treatment of primary sclerosing cholangitis: a 30-month pilot study. Hepatology 1991;14:838-47.
    • (1991) Hepatology , vol.14 , pp. 838-847
    • O'Brien, C.B.1    Senior, J.R.2    Arora-Mirchandani, R.3    Batta, A.K.4    Salen, G.5
  • 116
    • 0026740735 scopus 로고
    • Effects of ursodeoxycholic acid in patients with intrahepatic cholestasis of pregnancy
    • Palma J, Reyes H, Ribalta J, et al. Effects of ursodeoxycholic acid in patients with intrahepatic cholestasis of pregnancy. Hepatology 1992;15:1043-7.
    • (1992) Hepatology , vol.15 , pp. 1043-1047
    • Palma, J.1    Reyes, H.2    Ribalta, J.3
  • 119
    • 0026779860 scopus 로고
    • Pilot trial of prophylactic ursodiol to decrease the incidence of veno-occlusive disease of the liver in allogeneic bone marrow transplant patients
    • Essell JH, Thompson JM, Harman GS, et al. Pilot trial of prophylactic ursodiol to decrease the incidence of veno-occlusive disease of the liver in allogeneic bone marrow transplant patients Bone Marrow Transplant 1992;10:367-72.
    • (1992) Bone Marrow Transplant , vol.10 , pp. 367-372
    • Essell, J.H.1    Thompson, J.M.2    Harman, G.S.3
  • 120
    • 0028718516 scopus 로고
    • A possible role of ursodeoxycholic acid in liver transplantation
    • Friman S, Svanvik JK. A possible role of ursodeoxycholic acid in liver transplantation. Scand J Gastroenterol 1994;29 (suppl):62-4.
    • (1994) Scand J Gastroenterol , vol.29 , Issue.SUPPL. , pp. 62-64
    • Friman, S.1    Svanvik, J.K.2
  • 121
    • 0025368601 scopus 로고
    • Ursodeoxycholic acid for prevention of acute rejection in liver transplant recipients
    • Persson H, Friman S, Schersten T, Svanvik J, Karlberg I. Ursodeoxycholic acid for prevention of acute rejection in liver transplant recipients. Lancet 1990;2:52-3.
    • (1990) Lancet , vol.2 , pp. 52-53
    • Persson, H.1    Friman, S.2    Schersten, T.3    Svanvik, J.4    Karlberg, I.5
  • 122
    • 3142624093 scopus 로고
    • Ursodeoxycholic acid administration does not prevent rejection after OLT
    • Sama C, Mazzioti A, Grigioni W, et al. Ursodeoxycholic acid administration does not prevent rejection after OLT. J Hepatol 1991;13:S2:68.
    • (1991) J Hepatol , vol.13
    • Sama, C.1    Mazzioti, A.2    Grigioni, W.3
  • 124
    • 0028795635 scopus 로고
    • Prevention of biliary cirrhosis following hepatic arterial thrombosis after liver transplantation in children by using ursodeoxycholic acid
    • Bilik R, Superina RA, Phillips J, Edwards V. Prevention of biliary cirrhosis following hepatic arterial thrombosis after liver transplantation in children by using ursodeoxycholic acid. J Pediatr Surg 1995;30:49-52.
    • (1995) J Pediatr Surg , vol.30 , pp. 49-52
    • Bilik, R.1    Superina, R.A.2    Phillips, J.3    Edwards, V.4
  • 125
    • 0028326265 scopus 로고
    • The effect of ursodeoxycholic acid on serum enzymes and liver histology in patients with chronic active hepatitis; a 12 month double-blind, placebo-controlled trial
    • Atilli AF, Rusticali A, Varriale M, Carli L, Repice AM, Callea F. The effect of ursodeoxycholic acid on serum enzymes and liver histology in patients with chronic active hepatitis; a 12 month double-blind, placebo-controlled trial. J Hepatol 1994;20:315-20.
    • (1994) J Hepatol , vol.20 , pp. 315-320
    • Atilli, A.F.1    Rusticali, A.2    Varriale, M.3    Carli, L.4    Repice, A.M.5    Callea, F.6
  • 126
    • 0027715655 scopus 로고
    • Ursodiol in the long- Term treatment of chronic hepatitis: A double-blind multicenter clinical trial
    • Bellentani S, Podda M, Tiribelli C, et al. Ursodiol in the long- term treatment of chronic hepatitis: a double-blind multicenter clinical trial. J Hepatol 1993;19:459-64.
    • (1993) J Hepatol , vol.19 , pp. 459-464
    • Bellentani, S.1    Podda, M.2    Tiribelli, C.3
  • 127
    • 0026062522 scopus 로고
    • Effects of ursodeoxycholic acid on serum liver enzymes and bile acid metabolism in chronic active hepatitis: A dose-response study
    • Crosignani A, Battezzati PM, Setchell KD, et al. Effects of ursodeoxycholic acid on serum liver enzymes and bile acid metabolism in chronic active hepatitis: a dose-response study. Hepatology 1991;13:339-44.
    • (1991) Hepatology , vol.13 , pp. 339-344
    • Crosignani, A.1    Battezzati, P.M.2    Setchell, K.D.3
  • 129
    • 0025257161 scopus 로고
    • Effects of ursodeoxycholic acid on serum liver enzymes and bile acids in chronic hepatitis
    • Podda M, Ghezzi C, Battezzati PM, Crosignani A, Zuin M, Roda A. Effects of ursodeoxycholic acid on serum liver enzymes and bile acids in chronic hepatitis. Gastroenterology 1990;98:1044-50.
    • (1990) Gastroenterology , vol.98 , pp. 1044-1050
    • Podda, M.1    Ghezzi, C.2    Battezzati, P.M.3    Crosignani, A.4    Zuin, M.5    Roda, A.6
  • 130
    • 0028293869 scopus 로고
    • Ursodeoxycholic therapy in chronic liver disease: A meta-analysis in primary biliary cirrhosis and in chronic hepatitis
    • Simko V, Michael S, Prego V. Ursodeoxycholic therapy in chronic liver disease: a meta-analysis in primary biliary cirrhosis and in chronic hepatitis. Am J Gastroenterol 1994;89:392-8.
    • (1994) Am J Gastroenterol , vol.89 , pp. 392-398
    • Simko, V.1    Michael, S.2    Prego, V.3
  • 131
    • 0028960364 scopus 로고
    • Interferon and ursodeoxycholic acid combined therapy in the treatment of chronic viral C hepatitis: Results from a controlled randomized trial in 80 patients
    • Boucher E, Jouanolle H, Andre P, et al. Interferon and ursodeoxycholic acid combined therapy in the treatment of chronic viral C hepatitis: results from a controlled randomized trial in 80 patients. Hepatology 1995;21:322-7.
    • (1995) Hepatology , vol.21 , pp. 322-327
    • Boucher, E.1    Jouanolle, H.2    Andre, P.3
  • 132
    • 0027963209 scopus 로고
    • A multicenter randomized controlled dose study of ursodeoxycholic acid for chronic hepatitis C
    • Takano S, Ito Y, Yokusuka O, et al. A multicenter randomized controlled dose study of ursodeoxycholic acid for chronic hepatitis C. Hepatology 1994;20:558-64.
    • (1994) Hepatology , vol.20 , pp. 558-564
    • Takano, S.1    Ito, Y.2    Yokusuka, O.3
  • 133
    • 0024349446 scopus 로고
    • Benign recurrent intrahepatic cholestasis: Altered bile acid metabolism
    • Bijleveld CM, Vonk RJ, Kuipers F, et al. Benign recurrent intrahepatic cholestasis: altered bile acid metabolism. Gastroenterology 1989;97:427-32.
    • (1989) Gastroenterology , vol.97 , pp. 427-432
    • Bijleveld, C.M.1    Vonk, R.J.2    Kuipers, F.3
  • 134
    • 0024561649 scopus 로고
    • Benign recurrent intrahepatic cholestasis: A long-term follow-up study of two patients
    • Bijleveld CM, Vonk RJ, Kuipers F, Havinga R, Fernandes J. Benign recurrent intrahepatic cholestasis: a long-term follow-up study of two patients. Hepatology 1989;9:532-7.
    • (1989) Hepatology , vol.9 , pp. 532-537
    • Bijleveld, C.M.1    Vonk, R.J.2    Kuipers, F.3    Havinga, R.4    Fernandes, J.5
  • 135
    • 0026050266 scopus 로고
    • Failure of ursodeoxycholic acid to prevent a cholestatic episode in a patient with benign recurrent intrahepatic cholestasis: A study of bile acid metabolism
    • Crosignani A, Podda M, Bertoloni E, Battezzati PM, Zuin M, Setchell KDR. Failure of ursodeoxycholic acid to prevent a cholestatic episode in a patient with benign recurrent intrahepatic cholestasis: a study of bile acid metabolism. Hepatology 1990;13:1076-83.
    • (1990) Hepatology , vol.13 , pp. 1076-1083
    • Crosignani, A.1    Podda, M.2    Bertoloni, E.3    Battezzati, P.M.4    Zuin, M.5    Setchell, K.D.R.6
  • 136
    • 0024998297 scopus 로고
    • Effect of ursodeoxycholic acid on liver disease associated with cystic fibrosis
    • Colombo C, Setchell KDR, Podda M, et al. Effect of ursodeoxycholic acid on liver disease associated with cystic fibrosis. J Pediatr 1990;117:482-9.
    • (1990) J Pediatr , vol.117 , pp. 482-489
    • Colombo, C.1    Setchell, K.D.R.2    Podda, M.3
  • 137
    • 0025180712 scopus 로고
    • Effects of ursodeoxycholic acid treatment on nutrition and liver function in patients with cystic fibrosis and long-standing cholestasis
    • Cutting J, Lentze MJ, Reichen J. Effects of ursodeoxycholic acid treatment on nutrition and liver function in patients with cystic fibrosis and long-standing cholestasis. Gut 1990;31: 918-21.
    • (1990) Gut , vol.31 , pp. 918-921
    • Cutting, J.1    Lentze, M.J.2    Reichen, J.3
  • 138
    • 0026718322 scopus 로고
    • Effects of ursodeoxycholic acid treatment on liver in patients with cystic fibrosis and chronic cholestasis
    • Galabert C, Montet JC, Leugrand D, et al. Effects of ursodeoxycholic acid treatment on liver in patients with cystic fibrosis and chronic cholestasis. J Pediatr 1992;121:138-41.
    • (1992) J Pediatr , vol.121 , pp. 138-141
    • Galabert, C.1    Montet, J.C.2    Leugrand, D.3
  • 140
    • 0026665209 scopus 로고
    • Ursodeoxycholic acid therapy in cystic fibrosis-associated liver disease: A dose-response study
    • Colombo C, Crosignani A, Assaisso M, et al. Ursodeoxycholic acid therapy in cystic fibrosis-associated liver disease: a dose-response study. Hepatology 1992;16:924-30.
    • (1992) Hepatology , vol.16 , pp. 924-930
    • Colombo, C.1    Crosignani, A.2    Assaisso, M.3
  • 141
    • 0026584970 scopus 로고
    • Scintigraphic documentation of an improvement in bile flow in patients with cystic fibrosis and associated liver disease after treatment with ursodeoxycholic acid
    • Colombo C, Castellani MR, Balistreri WF, Seregm E, Assaisso ML, Guinta A. Scintigraphic documentation of an improvement in bile flow in patients with cystic fibrosis and associated liver disease after treatment with ursodeoxycholic acid. Hepatology 1992;15:677-84.
    • (1992) Hepatology , vol.15 , pp. 677-684
    • Colombo, C.1    Castellani, M.R.2    Balistreri, W.F.3    Seregm, E.4    Assaisso, M.L.5    Guinta, A.6
  • 142
    • 0028122016 scopus 로고
    • Cystic fibrosis: Is treatment with ursodeoxycholic acid of value?
    • Strandvik B, Lindblad A. Cystic fibrosis: is treatment with ursodeoxycholic acid of value? Scand J Gastroenterol 1994; 29(suppl):65-7.
    • (1994) Scand J Gastroenterol , vol.29 , Issue.SUPPL. , pp. 65-67
    • Strandvik, B.1    Lindblad, A.2
  • 143
    • 0342268984 scopus 로고
    • The effect of ursodeoxycholic acid in cystic fibrosis and hepatopathy: Results of a placebo-controlled study
    • Paumgartner G, Stiehl A, Gerok W, eds. London: Kluwer Academic Press
    • Bittner P, Posselt HG, Sailer T, et al. The effect of ursodeoxycholic acid in cystic fibrosis and hepatopathy: results of a placebo-controlled study. In: Paumgartner G, Stiehl A, Gerok W, eds. Bile acids as therapeutic agents: from basic science to clinical practice. London: Kluwer Academic Press, 1991:345-8.
    • (1991) Bile Acids as Therapeutic Agents: From Basic Science to Clinical Practice , pp. 345-348
    • Bittner, P.1    Posselt, H.G.2    Sailer, T.3
  • 144
    • 0026794654 scopus 로고
    • A controlled trial of ursodeoxycholic acid treatment in cystic fibrosis-related liver disease
    • O'Brien S, Fitzgerald MX, Hegarty JE. A controlled trial of ursodeoxycholic acid treatment in cystic fibrosis-related liver disease. Eur J Gastroenterol Hepatol 1992;4:857-63.
    • (1992) Eur J Gastroenterol Hepatol , vol.4 , pp. 857-863
    • O'Brien, S.1    Fitzgerald, M.X.2    Hegarty, J.E.3
  • 145
    • 19144371795 scopus 로고    scopus 로고
    • Ursodeoxycholic acid for liver disease associated with cystic fibrosis: A double-blind multicenter trial
    • Colombo C, Battezzati PM, Podda M, Bettinardi N, Giunta A. Ursodeoxycholic acid for liver disease associated with cystic fibrosis: a double-blind multicenter trial. Hepatology 1996;23:1484-90.
    • (1996) Hepatology , vol.23 , pp. 1484-1490
    • Colombo, C.1    Battezzati, P.M.2    Podda, M.3    Bettinardi, N.4    Giunta, A.5
  • 146
    • 0003027570 scopus 로고
    • Bile acid therapy in paediatric liver disease
    • Paumgartner G, Stiehl A, Gerok W, eds, London: Kluwer Academic Publishers
    • Balistreri WF, Setchell KDR, Ryckman FC, and the UDCA Study Group. Bile acid therapy in paediatric liver disease. In: Paumgartner G, Stiehl A, Gerok W, eds, Bile acids and the hepatobiliary system. London: Kluwer Academic Publishers, 1993:271-82.
    • (1993) Bile Acids and the Hepatobiliary System , pp. 271-282
    • Balistreri, W.F.1    Setchell, K.D.R.2    Ryckman, F.C.3
  • 147
    • 0342704173 scopus 로고
    • Ursodeoxycholic acid does not improve quantitative tests of hepatic function in children with intrahepatic cholestasis despite clinical improvement
    • Narkewicz MR, Sokol RJ, Smith D, Gregory C, Lear J. Ursodeoxycholic acid does not improve quantitative tests of hepatic function in children with intrahepatic cholestasis despite clinical improvement [Abstract]. Hepatology 1992;16:258.
    • (1992) Hepatology , vol.16 , pp. 258
    • Narkewicz, M.R.1    Sokol, R.J.2    Smith, D.3    Gregory, C.4    Lear, J.5
  • 148
    • 0342704172 scopus 로고
    • Use of ursodeoxycholic acid in children with cholestatic liver disease
    • Paradis K, El Arab N, Yousef I, et al. Use of ursodeoxycholic acid in children with cholestatic liver disease. Hepatology 1993;18:301.
    • (1993) Hepatology , vol.18 , pp. 301
    • Paradis, K.1    El Arab, N.2    Yousef, I.3
  • 150
  • 152
    • 0342268982 scopus 로고
    • Ursodeoxycholic acid therapy in pediatric patients with progressive familial intrahepatic cholestasis
    • Jacquemin E, Habes D, Debray D, Hadchouel M, Bernard O. Ursodeoxycholic acid therapy in pediatric patients with progressive familial intrahepatic cholestasis [Abstract]. Hepatology 1995;22:318.
    • (1995) Hepatology , vol.22 , pp. 318
    • Jacquemin, E.1    Habes, D.2    Debray, D.3    Hadchouel, M.4    Bernard, O.5
  • 153
    • 0023629252 scopus 로고
    • Treatment with ursodeoxycholic acid renders children with biliary atresia suitable for liver transplantation
    • Ullrich D, Rating D, Schroter W, et al. Treatment with ursodeoxycholic acid renders children with biliary atresia suitable for liver transplantation. Lancet 1987;2:1234.
    • (1987) Lancet , vol.2 , pp. 1234
    • Ullrich, D.1    Rating, D.2    Schroter, W.3
  • 154
    • 0024477942 scopus 로고
    • Ursodeoxycholic acid therapy in the treatment of biliary atresia
    • Nittono H, Tokita A, Hayashi M, et al. Ursodeoxycholic acid therapy in the treatment of biliary atresia. Biomed Pharmacother 1989;43:37-41.
    • (1989) Biomed Pharmacother , vol.43 , pp. 37-41
    • Nittono, H.1    Tokita, A.2    Hayashi, M.3
  • 156
    • 0001212144 scopus 로고
    • Ursodeoxycholic acid therapy for total parenteral nutrition-associated cholestasis in the neonate
    • Cocjin J, Vanderhal A, Sehgal S, Rosenthal P. Ursodeoxycholic acid therapy for total parenteral nutrition-associated cholestasis in the neonate. Gastroenterology 1993;104: A615.
    • (1993) Gastroenterology , vol.104
    • Cocjin, J.1    Vanderhal, A.2    Sehgal, S.3    Rosenthal, P.4
  • 157
    • 0342704170 scopus 로고    scopus 로고
    • The liver - The next frontier in the treatment of patients with cystic fibrosis
    • Reyee H, Leuschner V, Arias IM, eds. London: Kluwer Academic Publishers
    • Balistreri WF. The liver - the next frontier in the treatment of patients with cystic fibrosis. In: Reyee H, Leuschner V, Arias IM, eds. Pregnancy, sex hormones, and the liver. Proceedings of the Falk Symposium 89. London: Kluwer Academic Publishers, 1996:114-35.
    • (1996) Pregnancy, Sex Hormones, and the Liver. Proceedings of the Falk Symposium 89 , pp. 114-135
    • Balistreri, W.F.1
  • 158
    • 0028806678 scopus 로고
    • Malabsorption of vitamin E in cystic fibrosis improved after ursodeoxycholic acid
    • Thomas PS, Bellamy M, Geddes D. Malabsorption of vitamin E in cystic fibrosis improved after ursodeoxycholic acid. Lancet 1995;346:1230-1.
    • (1995) Lancet , vol.346 , pp. 1230-1231
    • Thomas, P.S.1    Bellamy, M.2    Geddes, D.3
  • 159
    • 0027969208 scopus 로고
    • Effect of a medium dose of ursodeoxycholic acid with or without taurine supplementation on the nutritional status of patients with cystic fibrosis: A randomized, placebo-controlled, crossover trial
    • Merli M, Bertasi S, Servi R, et al. Effect of a medium dose of ursodeoxycholic acid with or without taurine supplementation on the nutritional status of patients with cystic fibrosis: a randomized, placebo-controlled, crossover trial. J Pediatr Gastroenterol Nutr 1994;19:198-203.
    • (1994) J Pediatr Gastroenterol Nutr , vol.19 , pp. 198-203
    • Merli, M.1    Bertasi, S.2    Servi, R.3
  • 161
    • 0142015659 scopus 로고
    • Inborn errors of bile acid biosynthesis: Update on biochemical aspects
    • Hofmann AF, Paumgartner G, Stiehl A, eds. London: Kluwer Academic Publishers
    • Setchell KDR, O'Connell NC. Inborn errors of bile acid biosynthesis: update on biochemical aspects. In: Hofmann AF, Paumgartner G, Stiehl A, eds. Bile acids in gastroenterology: basic and clinical advances. London: Kluwer Academic Publishers, 1995:129-36.
    • (1995) Bile Acids in Gastroenterology: Basic and Clinical Advances , pp. 129-136
    • Setchell, K.D.R.1    O'Connell, N.C.2
  • 163
    • 0023193394 scopus 로고
    • Familial giant cell hepatitis associated with synthesis of 3β,7α-dihydroxy- and 3β,7α,12α-trihydroxy-5-cholenoic acids
    • Clayton PT, Leonard JV, Lawson AM, et al. Familial giant cell hepatitis associated with synthesis of 3β,7α-dihydroxy- and 3β,7α,12α-trihydroxy-5-cholenoic acids. J Clin Invest 1987;79:1031-8.
    • (1987) J Clin Invest , vol.79 , pp. 1031-1038
    • Clayton, P.T.1    Leonard, J.V.2    Lawson, A.M.3
  • 164
    • 0010633655 scopus 로고
    • Transport of taurine conjugates of 7α-hydroxy-3-oxo-4-cholenoic acid and 3β, 7α-dihydroxy-5-cholenoic acid in rat liver plasma membrane vesicles
    • van Berge GP, van Hoek B, de Groote J, Matern S, Stockbrugger RW, eds. London: Kluwer Academic Publishers
    • Stieger B, Zhang J, O'Neill B, Sjovall J, Meier PJ. Transport of taurine conjugates of 7α-hydroxy-3-oxo-4-cholenoic acid and 3β, 7α-dihydroxy-5-cholenoic acid in rat liver plasma membrane vesicles. In van Berge GP, van Hoek B, de Groote J, Matern S, Stockbrugger RW, eds. Cholestatic liver diseases: new strategies for prevention and treatment of hepatobiliary and cholestatic liver diseases. London: Kluwer Academic Publishers, 1994:82-7.
    • (1994) Cholestatic Liver Diseases: New Strategies for Prevention and Treatment of Hepatobiliary and Cholestatic Liver Diseases , pp. 82-87
    • Stieger, B.1    Zhang, J.2    O'Neill, B.3    Sjovall, J.4    Meier, P.J.5
  • 167
    • 0028303784 scopus 로고
    • Evidence for defective primary bile acid secretion in children with progressive familial intrahepatic cholestasis
    • Jacquemin E, Dumont M, Bernard O, Erlinger S, Hadchouel M. Evidence for defective primary bile acid secretion in children with progressive familial intrahepatic cholestasis. Eur J Pediatr 1994;153:424-8.
    • (1994) Eur J Pediatr , vol.153 , pp. 424-428
    • Jacquemin, E.1    Dumont, M.2    Bernard, O.3    Erlinger, S.4    Hadchouel, M.5
  • 168
    • 0022259173 scopus 로고
    • Bile acid profiles in siblings with progressive intrahepatic cholestasis: Absence of biliary chenodeoxycholic acid
    • Tazawa Y, Yamada M, Nakagawa M, Konno T, Tada K. Bile acid profiles in siblings with progressive intrahepatic cholestasis: absence of biliary chenodeoxycholic acid. J Pediatr Gastroenterol Nutr 1985;4:32-7.
    • (1985) J Pediatr Gastroenterol Nutr , vol.4 , pp. 32-37
    • Tazawa, Y.1    Yamada, M.2    Nakagawa, M.3    Konno, T.4    Tada, K.5
  • 169
    • 84931064756 scopus 로고    scopus 로고
    • Biliary atresia: Current concepts and research directions, summary of a symposium
    • Balistreri WF, Grand R, Hoofnagle JH, et al. Biliary atresia: current concepts and research directions, summary of a symposium. Hepatology 1996;23:1682-92.
    • (1996) Hepatology , vol.23 , pp. 1682-1692
    • Balistreri, W.F.1    Grand, R.2    Hoofnagle, J.H.3
  • 170
    • 0026503561 scopus 로고
    • Ursodeoxycholic acid acid limits liver histologic alterations and portal hypertension induced by bile duct ligation in the rat
    • Poo JL, Feldman G, Erlinger S, et al. Ursodeoxycholic acid acid limits liver histologic alterations and portal hypertension induced by bile duct ligation in the rat. Gastroenterology 1992;102:1752-9.
    • (1992) Gastroenterology , vol.102 , pp. 1752-1759
    • Poo, J.L.1    Feldman, G.2    Erlinger, S.3
  • 171
    • 0027264613 scopus 로고
    • Effect of ursodeoxycholic acid administration on bile duct proliferation and cholestasis in bile duct ligated rat
    • Frezza EE, Gerunda GE, Plebani M, et al. Effect of ursodeoxycholic acid administration on bile duct proliferation and cholestasis in bile duct ligated rat. Dig. Dis. Sci 1993; 38:1291-6.
    • (1993) Dig. Dis. Sci , vol.38 , pp. 1291-1296
    • Frezza, E.E.1    Gerunda, G.E.2    Plebani, M.3
  • 172
    • 0024985664 scopus 로고
    • Hepatobiliary consequences of parenteral nutrition
    • Balistreri WF, Bove K. Hepatobiliary consequences of parenteral nutrition: In: Progress in liver disease; vol 9. 1989: 567-601.
    • (1989) Progress in Liver Disease , vol.9 , pp. 567-601
    • Balistreri, W.F.1    Bove, K.2
  • 173
    • 0007687734 scopus 로고
    • Cytoprotection by ursodeoxycholic acid
    • van Berge Henegouwen GP, van Hoek B, de Groote J, Matern S, Stockbrugger RW, eds. London: Kluwer Academic Publishers
    • Leuschner U, Guldutuna S, Bhatti S, Sipos P, You T, Zimmer G. Cytoprotection by ursodeoxycholic acid. In: van Berge Henegouwen GP, van Hoek B, de Groote J, Matern S, Stockbrugger RW, eds. Cholestatic liver diseases (Falk Symposium 75). London: Kluwer Academic Publishers, 1994:218-25.
    • (1994) Cholestatic Liver Diseases (Falk Symposium 75) , pp. 218-225
    • Leuschner, U.1    Guldutuna, S.2    Bhatti, S.3    Sipos, P.4    You, T.5    Zimmer, G.6
  • 174
    • 0028091402 scopus 로고
    • Ursodeoxycholic acid modified gut-derived endotoxemia in neonatal rats
    • Schwarzenberg SJ, Bundy M. Ursodeoxycholic acid modified gut-derived endotoxemia in neonatal rats. Pediatr Res 1994;35:214-17.
    • (1994) Pediatr Res , vol.35 , pp. 214-217
    • Schwarzenberg, S.J.1    Bundy, M.2
  • 175
    • 0025860954 scopus 로고
    • Ursodeoxycholic acid for the treatment of home parenteral nutrition associated cholestasis - A case report
    • Lindor KD, Burnes J. Ursodeoxycholic acid for the treatment of home parenteral nutrition associated cholestasis - a case report. Gastroenterology 1991;101:250-3.
    • (1991) Gastroenterology , vol.101 , pp. 250-253
    • Lindor, K.D.1    Burnes, J.2
  • 176
    • 0028268726 scopus 로고
    • Is ursodeoxycholic acid an effective therapy for total parenteral nutrition related liver disease?
    • Beau P, Labat-Labourdette J, Ingrand P, Beauchant M. Is ursodeoxycholic acid an effective therapy for total parenteral nutrition related liver disease? J Hepatol 1994;20:240-4.
    • (1994) J Hepatol , vol.20 , pp. 240-244
    • Beau, P.1    Labat-Labourdette, J.2    Ingrand, P.3    Beauchant, M.4
  • 177
    • 26544450911 scopus 로고
    • Randomized double-blind trial of ursodeoxycholic acid versus placebo for the treatment of parenteral nutrition-associated cholestasis
    • Kowalski TE, Bosse M, Mullen J, Holt PR, Tint G, Malet PF: Randomized double-blind trial of ursodeoxycholic acid versus placebo for the treatment of parenteral nutrition-associated cholestasis. Gastroenterology 1994;106:A615.
    • (1994) Gastroenterology , vol.106
    • Kowalski, T.E.1    Bosse, M.2    Mullen, J.3    Holt, P.R.4    Tint, G.5    Malet, P.F.6
  • 178
    • 0028923472 scopus 로고
    • Defective biliary secretion during total parenteral nutrition: Probable mechanisms and possible solutions
    • Hofmann AF. Defective biliary secretion during total parenteral nutrition: probable mechanisms and possible solutions. J Pediatr Gastroenterol Nutr 1995;20:376-90.
    • (1995) J Pediatr Gastroenterol Nutr , vol.20 , pp. 376-390
    • Hofmann, A.F.1
  • 179
    • 26544478933 scopus 로고
    • Intravenous ursodeoxycholic acid reduces severity of cholestasis in parenterally fed newborn piglets
    • Duerksen D, Chan G, Thompson ABR, Van Aerde J. Intravenous ursodeoxycholic acid reduces severity of cholestasis in parenterally fed newborn piglets. Hepatology 1993;18:296A.
    • (1993) Hepatology , vol.18
    • Duerksen, D.1    Chan, G.2    Thompson, A.B.R.3    Van Aerde, J.4
  • 180
    • 0028927132 scopus 로고
    • Metabolism, pharmacokinetics, and activity of a new 6-fluoro analogue of ursodeoxycholic acid in rats and hamsters
    • Roda A, Pellicciari R, Polimeni C, et al. Metabolism, pharmacokinetics, and activity of a new 6-fluoro analogue of ursodeoxycholic acid in rats and hamsters. Gastroenterology 1995;108:1204-14.
    • (1995) Gastroenterology , vol.108 , pp. 1204-1214
    • Roda, A.1    Pellicciari, R.2    Polimeni, C.3
  • 181
    • 0028285430 scopus 로고
    • Improved intestinal absorption of an enteric-coated sodium ursodeoxycholate formulation
    • Roda A, Roda E, Marchi E, Simoni P, et al. Improved intestinal absorption of an enteric-coated sodium ursodeoxycholate formulation. Pharm Res 1994;11:642-7.
    • (1994) Pharm Res , vol.11 , pp. 642-647
    • Roda, A.1    Roda, E.2    Marchi, E.3    Simoni, P.4
  • 183
    • 0029098462 scopus 로고
    • Tauroursodeoxycholate increases rat liver ursodeoxycholate levels and limits lithocholate formation better than ursodeoxycholate
    • Rodrigues CMP, Kren BT, Steer CJ, Setchell KDR. Tauroursodeoxycholate increases rat liver ursodeoxycholate levels and limits lithocholate formation better than ursodeoxycholate. Gastroenterology 1995;109:564-72.
    • (1995) Gastroenterology , vol.109 , pp. 564-572
    • Rodrigues, C.M.P.1    Kren, B.T.2    Steer, C.J.3    Setchell, K.D.R.4
  • 184
    • 0029944782 scopus 로고    scopus 로고
    • Different protective effects of tauroursodeoxycholate, ursodeoxycholate, and 23-methyl-ursodeoxycholate against taurolithocholate-induced cholestasis
    • Baumgartner U, Schölmerich J, Sellinger M, Reinhardt M, Ruf G, Farthmann EH. Different protective effects of tauroursodeoxycholate, ursodeoxycholate, and 23-methyl-ursodeoxycholate against taurolithocholate-induced cholestasis. Dig Dis Sci 1996;41:250-5.
    • (1996) Dig Dis Sci , vol.41 , pp. 250-255
    • Baumgartner, U.1    Schölmerich, J.2    Sellinger, M.3    Reinhardt, M.4    Ruf, G.5    Farthmann, E.H.6


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