Analysis of the mutagenic potential of ENU and MMS in germ cells of male C57BL/6 lacI transgenic mice

Mutation Research - Genetic Toxicology and Environmental Mutagenesis

Volumn 388, Issue 2-3, 1997, Pages 175-178

  Winegar, Richard A ^a   Carr, Greg ^b   Mirsalis, Jon C ^a  

^a SRI INTERNATIONAL   (United States)

^b PROCTER AND GAMBLE COMPANY   (United States)

Author keywords

Ethylnitrosourea; Germ cell mutagenesis; Methylmethane sulfonate; Transgenic mutation assay

Indexed keywords

ETHYLNITROSOUREA; MESYLIC ACID METHYL ESTER;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; GERM CELL; MALE; MOUSE; MUTAGEN TESTING; MUTAGENESIS; MUTATION RATE; NONHUMAN; PRIORITY JOURNAL; SEMINIFEROUS TUBULE; TRANSGENIC MOUSE;

ANIMALIA; MUS MUSCULUS;

EID: 0030926726     PISSN: 13835718     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1383-5718(96)00114-3     Document Type: Article

References (5)

1. Carr, G.J. and N.J. Gorelick (1994) Statistical tests of significance in transgenic mutation assays: Considerations on the experimental unit. Environ. Mol. Mutagen., 24, 276-282.
2. Carr, G.J. and N.J. Gorelick (1995) Statistical design and analysis of mutation studies in transgenic mice. Environ. Mol. Mutagen., 25, 246-255.
3. Monforte, J.A., R.A. Winegar and C.J. Rudd (1994) Megabase genomic DNA isolation procedure for use in transgenic mutagenesis assays. Environ. Mol. Mutagen., 23 (Suppl. 23), 46.
4. Monforte, J.A., R.A. Winegar and C.J. Rudd (1996) Megabase genomic DNA isolation for use in transgenic mutagenesis assays, in preparation.
5. Provost, G.S. and J.M. Short (1994) Characterization of mutations induced by ethylnitrosourea in seminiferous tubule germ cells of transgenic B6C3F1 mice. Proc. Natl. Acad. Sci. USA, 91, 6564-6568.