Differential immunologic modulatory effects of tetrahydrocannabinol as a function of age

Mechanisms of Ageing and Development

Volumn 96, Issue 1-3, 1997, Pages 117-126

  Ramarathinam, Lakshmi ^a   Pross, Susan ^a   Plescia, Otto ^a   Newton, Cathy ^a   Widen, Ray ^a   Friedman, Herman ^a  

^a UNIVERSITY OF SOUTH FLORIDA   (United States)

Author keywords

Aging; Immunity; Lymphocytes; Mice; T cells; Tetrahydrocannabinol

Indexed keywords

CONCANAVALIN A; INTERLEUKIN 10; INTERLEUKIN 4; MONOCLONAL ANTIBODY CD3; TETRAHYDROCANNABINOL;

AGING; ANIMAL CELL; ARTICLE; IMMUNOMODULATION; LYMPHOID CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; SPLEEN CELL;

ADJUVANTS, IMMUNOLOGIC; AGING; ANIMALS; CD4-CD8 RATIO; CYTOKINES; IMMUNE SYSTEM; MICE; MICE, INBRED BALB C; SPLEEN; TETRAHYDROCANNABINOL;

EID: 0030925889     PISSN: 00476374     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0047-6374(97)01886-1     Document Type: Article

References (20)

1. T. Makinodan and M. Kay, Age influence on the immune system. Adv. Immunol., 29 (1980) 287-330.
2. B. Cinader, G. Doria, A. Facchini, C. Kurashima, G.J. Thorbecke and M.E. Weksler, Aging and the immune system: workshop # 4 of 8th International Congress of Immunology, Budapest, Hungary. Aging:Immunol. Infect. Dis., 4 (1993) 47-65.
3. P. Pawelec, M. Abizadeh, H. Pohla and K. Schaudt, Immunosenescence: ageing of the immune system. Immunol. Today, 16 (1995) 420-422.
4. J. Sindermann, A. Kruse, H.J. Frercks, R. Schutz and H. Kirchner, Investigations of the lymphokine system in elderly individuals. Mech. Ageing. Dev. 70 (1993) 149-159.
5. M. Kubo and B. Cinader, Polymorphism of age-related changes in interleukin (IL) production: differential changes of T helper subpopulations, synthesizing IL2, IL3 and IL4. Eur. J. Immunol., 20 (1990) 1289-1296.
6. R.A. Miller, The aging immune system: primer and prospectus. Science, 273 (1996) 70-74.
7. J.E. McElhaney, G.S. Meneilly, B.L. Beattie et al., The effect of influenza vaccination on IL2 production in healthy elderly: implications for current vaccination practices. J. Gerontol., 47(1) (1992) M3-8.
8. D.C. Powers and R.B. Belshe, Vaccine-induced antibodies to heterologous influenza A H1N1 viruses: effects of aging and 'original antigenic sin'. J. Infect. Dis., 169(5) (1994) 1125-1129.
9. L.L. Murphy, J. Gher and A. Szary, Effects of prenatal exposure to delta-9-tetrahydrocannabinol on reproductive, endocrine and immune parameters of male and female rat offspring. Endocrine, 3 (1995) 875-879.
10. S. Pross, Y. Nakano, S. McHugh, R. Widen and H. Friedman, Age related immunomodulation in murine splenocytes induced by delta-9-tetrahydrocannabinol (THC). Mech. Ageing Dev., 61 (1993) 11-26.
11. T. W. Klein, C. Newton, R. Widen and H. Friedman, Delta 9-tetrahydrocannabinol injection induces cytokine-mediated mortality of mice infected with Legionaella pneumophila. J. Pharmac., 267 (1993) 635-640.
12. L.A. Matsuda, S.J. Lolait, M.J. Brownstein, A.C. Young and T.I Bonner, Structure of a cannabinoid receptor and functional expression of the cloned cDNA. Nature, 3436 (1990) 561-564.
13. R. Mechoulam, L. Hanus and B. Martin, Search for endogenous ligands of the cannabinoid receptor. Biochem. Pharmac., 48 (1994) 1537-1544.
14. Y. Nakano, S. Pross and H. Friedman, Contrasting effect of delta-9-tetrahydrocannabinol on IL-2 activity in spleen and lymph node cells of mice of different ages. Life Sci., 52 (1992) 41-51.
15. G.A. Cabral, E. M. Mishkin, F. Marciano-Cabral, P. Coleman, L. Harris and A.E. Munson, Effect of delta 9-tetrahydrocannabinol on herpes simplex virus type 2 vaginal infection in the guinea pig. Proc. Soc. Exp. Biol. Med., 182 (1986) 181-186.
16. D.R. Jackola, J.K. Ruger and R.A. Miller, Age-associated changes in human T cell phenotype and function. Aging., 6 (1994) 25-34.
17. D.N. Ernst, O. Weigle, and M.V. Hobbs, Aging and lymphokine gene expression by T cell subsets. Nutr. Rev., 53 (1995) S18-26.
18. X. Yang, J. Streda and J. Cerny, Relative contribution of T and B cells to hypermutation and selection of the antibody repertoire in germinal centers of aged mice. J. Exp. Med., 183 (1996) 959-970.
19. C. Nicoletti and J. Cerny, The repertoire diversity and magnitude of antibody responses to bacterial antigens in aged mice: 1. age-associated changes in antibody responses differ according to the mouse strain. Cell. Immunol., 133 (1991) 72-83.
20. M.L. Thoman, D.N. Ernst, M.V. Hobbs and W.O. Weigle, T cell differentiation and functional maturation in aging mice. Adv. Exp. Med. and Biol., 330 (1993) 93-106.