Differential expression of alternatively spliced pX mRNAs in HTLV-I-infected cell lines

Leukemia

Volumn 11, Issue 6, 1997, Pages 866-870

  Cereseto, A ^a   Berneman, Z ^a,c   Koralnik, I ^a   Vaughn, J ^a   Franchini, G ^a   Klotman, M E ^a,b  

^a NATIONAL CANCER INSTITUTE   (United States)

^b MOUNT SINAI SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF ANTWERP   (Belgium)

Author keywords

Adult T cell leukemia (ATL); Alternative splicing; HTLV I

Indexed keywords

INTERLEUKIN 2; MESSENGER RNA; VIRUS RNA;

ALTERNATIVE RNA SPLICING; ARTICLE; HUMAN; HUMAN CELL; HUMAN T CELL LEUKEMIA VIRUS 1; MONONUCLEAR CELL; OPEN READING FRAME; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SPASTIC PARESIS; T CELL LEUKEMIA; VIRUS CELL TRANSFORMATION; VIRUS PATHOGENESIS;

EID: 0030925885     PISSN: 08876924     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.leu.2400665     Document Type: Article

References (13)

1. Gallo RC. Human T-cell leukemia-lymphoma virus and T-cell malignancies in adults. Cancer Surv 1984; 3: 113-159.
2. Cessain A, Barin F, Vernant JC, Gout O, Maurs L, Calendar A, de The G. Antibodies to human T-lymphotropic virus type I in patients with tropical spastic paraparesis. Lancet 1985; 2: 407-409.
3. Ciminale V, Pavlakis GN, Derse D, Cunningham CP, Felber BK. Complex splicing in the human T-cell leukemia virus (HTLV) family of retroviruses: novel mRNAs and proteins produced by HTLV type I. J Virol 1992; 66: 1737-1745.
4. Berneman ZN, Gartenhaus RB, Reitz MS Jr, Blattner WA, Manns A, Hanchard B, Ikehara O, Gallo RC, Klotman ME. Expression of alternatively spliced human T-lymphotropic virus type 1 pX mRNA in infected cell lines and in primary uncultured cells from patients with adult T-cell leukemia/lymphoma and healthy carriers. Proc Natl Acad Sci USA 1992; 89: 3005-3009.
5. Koralnik IJ, Gessain A, Klotman ME, Lo Monico A, Berneman ZN, Franchini C. Protein isoforms encoded by the pX region of human T-cell leukemia/lymphotropic virus type I. Proc Natl Acad Sci USA 1992; 89: 8813-8817.
6. Orita S, Saigo A, Takagi S, Tanaka T, Okumuna K, Aono Y, Hinuma Y, Igarashi H. A novel alternatively spliced viral mRNA transcribed in cells infected with human T cell leukemia virus type 1 is mainly responsible for expressing p21X protein. FEBS Lett 1991; 295: 127-134.
7. Koralnik IJ, Fullen J, Franchini G. The p121, p1311, and p3011 proteins encoded by human T-cell leukemia/lymphotropic virus type I open reading frames I and II are localized in three different cellular compartments. J Virol 1993; 67: 2360-2366.
8. Kinoshita T, Shimoyama M, Tobinai K, Ito M, Ikeda S, Tajima K, Shimohtono K, Sugimura T. Detection of mRNA for the tax1/rex1 gene of human T-cell leukemia virus type I in fresh peripheral blood mononuclear cells of adult T-cell leukemia patients and viral carriers by using the polymerase chain reaction. Proc Natl Acad Sci USA 1989; 86: 5620-5624.
9. Hirata M, Ikematsu H, Nakashima K, Hayashi J, Kashiwagi S. Higher expression levels of alternatively spliced pX mRNA in human T lymphotropic virus type I asymptomatic carriers positive for antibodies to p40tax protein. J Infect Dis 1995; 172: 1098-1102.
10. Orita S, Takagi S, Saiga A, Minoura N, Araki K, Kinoshita K, Kondo T, Hinuma Y, Igarashi H. Human T cell leukaemia virus type 1 p21X mRNA: constitutive expression in peripheral blood mononuclear cells of patients with adult T cell leukaemia, J Gen Virol 1992; 73: 2283-2289.
11. Markham PD, Salahuddin SZ, Kalyanaraman VS, Popovic M, Sarin P, Gallo RC. Infection and transformation of fresh human umbilical cord blood cells by multiple sources of human T-cell leukemia-lymphoma virus (HTLV). Int J Cancer 1983; 31: 413-420.
12. Hall WW, Kaplan MH, Salahuddin SZ, Oyaizu N, Gurgo C, Coronesi M, Nagashima K, Gallo RC. In: Blattner WA (ed). Human Retrovirology: HTLV. Raven Press: New York, 1990, pp 115-127.
13. Salahuddin SZ, Markham PD, Wong-Staal F, Franchini G, Kalyanaraman VS, Gallo RC. Restricted expression of human T-cell leukemia-lymphoma virus (HTLV) in transformed human umbilical cord blood lymphocytes. Virology 1983; 129: 51-64.