Contrasting effects of K8 and K18 on stabilizing K19 expression, cell motility and tumorigenicity in the BSp73 adenocarcinoma

Journal of Cell Science

Volumn 110, Issue 8, 1997, Pages 965-974

  Pankov, Roumen ^a,b   Simcha, Inbal ^a   Zöller, Margot ^c   Oshima, Robert G ^d   Ben Ze'ev, Avri ^a,b  

^a WEIZMANN INSTITUTE OF SCIENCE   (Israel)

^b UNIVERSITY OF SOFIA   (Bulgaria)

^c GERMAN CANCER RESEARCH CENTER DKFZ   (Germany)

^d BURNHAM INSTITUTE   (United States)

Author keywords

Keratin induction; Simple keratin; Tumorigenesis

Indexed keywords

KERATIN; VIMENTIN;

ANIMAL CELL; ARTICLE; CARCINOGENICITY; CELL MOTILITY; INTERMEDIATE FILAMENT; NONHUMAN; PANCREAS ADENOCARCINOMA; PRIORITY JOURNAL; RAT;

ADENOCARCINOMA; ANIMALS; CELL DIVISION; CELL MOVEMENT; GENE EXPRESSION REGULATION, NEOPLASTIC; KERATINS; NEOPLASMS, EXPERIMENTAL; PANCREATIC NEOPLASMS; RATS; TRANSFECTION; TUMOR CELLS, CULTURED;

EID: 0030925825     PISSN: 00219533     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (57)

1. Bader, B. L., Jahn, L. and Franke, W. W. (1988). Low level expression of cytokeratins 8, 18 and 19 in vascular smooth muscle cells of human umbilical cord and in cultured cells derived therefrom, with an analysis of the chromosomal locus containing the cytokeratin 19 gene. Eur. J. Biochem. 47, 300-319.
2. Bauman, P. A., Dalton, W. S., Anderson, J. M. and Cress, A. E. (1994). Expression of cytokeratin confers multiple drug resistance. Proc. Nat. Acad. Sci. USA 91, 5311-5314.
3. Baribault, H., Price, J., Miyai, K. and Oshima, R. G. (1993). Mid-gestational lethality in mice lacking keratin 8. Genes Dev. 7, 1191-1202.
4. Baribault, H., Penner, J., Izzo, V. and Wilson-Heiner, M. (1994). Colorectal adenomatous hyperplasia in keratin 8-deficient FVB/N mice. Genes Dev. 8, 2964-2973.
5. Ben-Ze'ev, A. (1984). Differential control of cytokeratins and vimentin synthesis by cell-cell contact and cell spreading in cultured epithelial cells. J. Cell Biol. 99, 1424-1433.
6. Ben-Ze'ev, A. (1985). Cell density and cell shape-related regulation of vimentin and cytokeratin synthesis. Exp Cell. Res. 157, 520-532.
7. Ben-Ze'ev, A., Zöller, M. and Raz, A. (1986). Differential expression of intermediate filament proteins in metastatic and nonmetastatic variants of the BSp73 tumor. Cancer Res. 46, 785-790.
8. Ben-Ze'ev, A. (1990). Application of two-dimensional gel electrophoresis in the study of cytoskeletal protein regulation during growth activation and differentiation. Electrophoresis 11, 191-200.
9. Ben-Ze'ev, A., Reiss, R., Bendori, R. and Gorodecki, B. (1990) Transient induction of vinculin gene expression in 3T3 fibroblasts stimulated by serum growth factors. Cell Regul. 1, 621-636.
10. Bottger, V., Stasiak, P. C., Harrison, D. L., Mellerick, D. M. and Lane, E. B. (1995). Epitope mapping of monoclonal antibodies to keratin 19 using keratin fragments, synthetic peptides and phage peptide library. Eur. J. Biochem. 231, 475-485.
11. Brulet, P., Babinet, C., Kemler, R. and Jacob, F. (1980). Monoclonal antibodies against trophectoderm-specific markers during mouse blastocyst formation. Proc. Nat. Acad. Sci. USA 77, 4113-4117.
12. Chomczynski, P. and Sacchi, N. (1987). Single step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal. Biochem. 162, 156-159.
13. Chou, C.-F., Riopel, C. L., Rott, L. S. and Omary, M. B. (1993). A significant soluble keratin fraction in 'simple' epithelial cells: lack of an apparent phosphorylation and glycosylation role in keratin solubility. J. Cell Sci. 105, 433-444.
14. Chu, Y.-W., Runyan, R. B., Oshima, R. G. and Hendrix, M. J. C. (1993). Expression of complete keratin filaments in mouse L cells alignments cell migration and invasion. Proc. Nat. Acad. Sci. USA 90, 4261-4265.
15. Chu, Y. W., Seftor, E. A., Romer, L. H. and Hendrix, M. J. (1996). Experimental coexpression of vimentin and keratin intermediate filaments in human melanoma augments motility. Am. J. Pathol. 148, 63-69.
16. Darmon, M. (1985). Coexpression of specific acid and basic cytokeratins in teratocarcinoma-derived fibroblasts treated with 5-azacytidine. Dev. Biol. 110, 47-52.
17. Eichner, R., Bonitz, P. and Sun, T. T. (1984). Classification of epidermal keratins according to their immunoreactivity, isoelectric point, and mode of expression. J Cell Biol. 98, 1388-1396.
18. Franke, W. W., Schmid, E. and Weber, K. (1978). Different intermediate-sized filaments distinguished by immunofluorescence microscopy. Proc. Nat. Acad. Sci. USA 75, 5034-5038.
19. Franke, W. W., Denk, H., Kalt, R. and Schmid, E. (1981). Biochemical and immunological identification of cytokeratin proteins present in hepatocytes of mammalian cells. Exp. Cell Res. 131, 299-318.
20. Franke, W. W., Grund, C., Kuhn, C., Jackson, B. W. and Illmensee, K. (1982). Formation of cytoskeletal elements during mouse embryogenesis. III. Primary mesenchymal cells and the first appearance of vimentin filaments. Differentiation 23, 43-59.
21. Franke, W. W., Winter, S., Schmid, E., Sollner, P., Hammerling, G. and Achtstatter, T. (1987). Monoclonal cytokeratin antibody recognizing a heterotypic complex: immunological probing of conformational states of cytoskeletal proteins in filaments and solution. Exp. Cell Res. 173, 17-37.
22. Fuchs, E. V. and Weber, K. (1994). Intermediate filaments: structure, dynamics, function, and disease. Annu. Rev. Biochem. 63, 345-382.
23. Gall, Y. and Karsenti, E. (1987). Soluble cytokeratins in Xenopus laevis oocytes and eggs. Biol. Cell. 61, 33-38.
24. Geiger, B., Schmid, E. and Franke, W. W. (1983). Spatial distribution of proteins specific for desmosomes and adherens junctions in epithelial cells demonstrated by double immunofluorescence microscopy. Differentiation 23, 189-205.
25. Giudice, G. J. and Fuchs, E. (1987). The transfection of epidermal keratin genes into fibroblasts and simple epitelial cells: evidence for inducing a type I keratin by a type II gene. Cell 48, 453-463.
26. Gunning, P., Leavitt, J., Muscat, G., Ng, S. and Kedes, L. (1987). A human beta-actin expression vector sytem directs high-level accumulation of antisense transcripts. Proc. Nat. Acad. Sci. USA 84, 4831-4835.
27. Günther, A., Kinjo, M., Winter, H., Sonka, J. and Volm, M. (1984). Differential expression of intermediate-filament proteins in murine sarcoma 180 ascites or solid tumor. Cancer Res. 44, 2590-2594.
28. Günthert, U., Hofmann, M., Rudy, W., Reber, S., Zöller, M., Haussmann, I., Matzku, S., Wenzel, A., Ponta, H. and Herrlich, P. (1991). A new variant of glycoprotein CD44 confers metastatic potential to rat carcinoma cells. Cell 65, 13-24.
29. Hatzfeld, M. and Franke, W. W. (1985). Pair formation and promiscuity of cytokeratins: formation in vitro of heterotypic complexes and intermediate-sized filaments by homologous and heterologous recombinations of purified polypeptides. J. Cell Biol. 101, 1826-1841.
30. Hendrix, M. J. C., Seftor, E. A., Chu, Y.-W., Seftor, R. E. B., Nagle, R. B., McDaniel, K. M., Leong, S. P. L., Yohem, K. H., Leibovitz, A. M., Meyskens, F. L., Conaway, D. H., Welch, D. R., Liotta, L. A. and Stetler-Stevenson, W. (1992). Coexpression of vimentin and keratins by human melanoma tumor cells: correlation with invasive and metastatic potential. J. Nat. Cancer Inst. 84, 165-174.
31. Jackson, B. W., Grund, C., Schmid, E., Burke, K. and Franke, W. W. (1980). Formation of cytoskeletal elements during mouse embryogenesis. Intermediate filaments of the cytokeratin type and desmosomes in preimplantation embryos. Differentiation 17, 161-179.
32. Kulesh, D. and Oshima, R. (1988). Cloning of the human K18 gene and its expression in nonepithelial mouse cells. Mol. Cell. Biol. 8, 1540-1550.
33. Kulesh, D. A., Cecena, G., Darmon, Y. M., Vasseur, M. and Oshima, R. G. (1989). Posttranslational regulation of keratins: degradation of mouse and human keratins 18 and 8. Mol. Cell. Biol. 9, 1553-1565.
34. Laemmli, U. K. (1970). Cleavage of structural proteins during the assembly of the head of the bacteriophage T4. Nature 227, 680-685.
35. Lane, E. B., Goodman, S. L. and Trejdosiewicz, L. K. (1982). Disruption of the keratin filament network during epithelial cell division. EMBO J. 1, 1365-1372.
36. Lane, E. B., Hogan, B. L. M., Kurkinen, M. and Garrels, J, I. (1983) Co-expression of vimentin and cytokeratins in parietal endoderm cells of early mouse embryo. Nature 303, 701-704.
37. Lee, S. W., Tomasetto, C. and Sager, R. (1991). Positive selection of candidate tumor-suppresor genes by substractive hybridization. Proc. Nat. Acad. Sci. USA 88, 2825-2829.
38. Lehtonen, E., Lehto, V.-P., Paasivuo, R. and Virtanen, I. (1983). Parietal and visceral endoderm differ in their expression of intermediate filaments. EMBO J. 2, 1023-1028.
39. Lu, X. and Lane, E. B. (1990). Retrovirus-mediated transgenic keratin expression in cultured fibroblasts: specific domain functions in keratin stabilization and filament formation. Cell 62, 681-696.
40. Lu, X., Quinlan, R. A., Steel, J. B. and Lane, E. B. (1993). Network incorporation of intermediate filament molecules differs between preexisting and newly assembling filaments. Exp. Cell Res. 208, 218-225.
41. Luthamn, H. and Magnusson, G. (1983). High efficiency polyoma DNA transfection of chloroquine treated cells. Nucl. Acid Res. 11, 1295-1308.
42. Matzku, S., Komitowski, D., Mildenberger, M. and Zöller, M. (1983). Characterization of BSp73, a spontaneous rat tumor and its in vivo selected variants showing different metastasizing capacities. Invasion Metast. 3, 109-123.
43. Miettinen, M. and Franssila, K. (1989). Immunohistochemical spectrum of malignant melanoma. The common presence of keratins. Lab. Invest. 61, 623-628.
44. Nagle, R. B., Ahmann, F. R., McDaniel, K. M., Paquin, M. L., Clark, V. A. and Cleniker, A. (1987). Cytokeratin characterization of human prostatic carcinoma and its derived cell lines. Cancer Res. 47, 281-286.
45. Nagle, R. B., Brawer, M. K., Kittelson, J. and Clark, V. (1991). Phenotypic realtionships of prostatic intraepithelial neoplasia to invasive prostatic carcinoma. Am. J. Pathol. 138, 119-128.
46. O'Farrell, P. H. (1975). High resolution two-dimensional electrophoresis of proteins. J. Biol. Chem. 150, 4007-4021.
47. Oshima, R. G., Howe, W. E., Klier, F. G., Adamson, E. D. and Shevinsky, L. H. (1983). Intermediate filament protein synthesis in preimplantation murine embryos. Dev. Biol. 99, 447-455.
48. Oshima, R. G., Baribault, H. and Caulin, C. (1996). Oncogenic regulation and function of keratins 8 and 18. Cancer Metast. Rev. (in press).
49. Ramaekers, F. C. S., Haag, D., Kant, A., Moesker, O., Jap, P. H. K. and Vooijs, G. P. (1983). Coexpression of keratin- and vimentin-type intermediate filaments in human metastatic carcinoma cells. Proc. Nat. Acad Sci. USA 80, 2618-2622.
50. Raz, A., Zöller, M. and Ben-Ze'ev, A. (1986). Cell configuration and adhesive properties of metastasizing and non-metastasizing BSp73 rat adenocarcinoma cells. Exp. Cell Res. 162, 127-141.
51. Rodríguez Fernández, J. L., Geiger, B., Salomon, D. and Ben-Ze'ev, A. (1992a). Overexpression of vinculin suppresses cell motility in Balb/C 3T3 cells Cell Motil. Cytoskel. 22, 127-134.
52. Rodríguez Fernández, J. L., Geiger, B., Salomon, D., Sabanay, I., Zöller, M. and Ben-Ze'ev, A. (1992b). Suppression of tumorigenicity in transformed cells after transtection with vinculin cDNA. J. Cell Biol. 119, 427-438.
53. Schaafsma, E., van der Velden, L. A., Manni, J. J., Peters, H., Link, M., Ruiter, D. J. and Ramaekers, F. C. S. (1993). Increased expression of cytokeratin 8, 18 and vimentin in the invasion front of mucosal squamous cell carcinoma. J. Pathol. 170, 77-86.
54. Schussler, M. H., Skoudy, A., Ramaekers, F. and Real, F. X. (1992). Intermediate filaments as differentiation markers of normal pancreas and pancreas cancer. Am. J. Pathol. 140, 559-568.
55. Thompson, E. W., Paik, S., Brunner, N., Sommers, C. L., Zugmaier, G., Clarke, R., Shima, T. B., Torri, J., Donahue, S. Lippman, M. E., Martin, J. R. and Dickson, R. B. (1992). Association of increased basement membrane invasiveness with absence of estrogen receptor and expression of vimentin in human breast cancer cell lines. J. Cell Physiol. 150, 534-544.
56. Trejdosievicz, L. K., Southgate, J., Kemshead, J. T. and Hodges, G. M. (1986). Phenotypic analysis of cultured melanoma cells: Expression of cytokeratin-type intermediate filaments by the M5 human melanoma cell line. Exp. Cell Res. 164, 388-398.
57. Virtanen, I., Lehto, V.-P., Lehtonen, E., Vario, T., Stenman, S., Kurki, P., Wagner, O., Small, J. V., Dahl, D. and Bradley, R. A. (1981). Expression of intermediate filaments in cultured cells. J. Cell Sci. 50, 45-63.