A new approach to the synthesis of the 25-hydroxy-22-oxa-vitamin D3 side chain

Tetrahedron Letters

Volumn 38, Issue 27, 1997, Pages 4909-4912

  Fall, Yagamare ^a  

^a UNIVERSITY OF SANTIAGO DE COMPOSTELA   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

CALCITRIOL DERIVATIVE; FUNCTIONAL GROUP;

ARTICLE; OXIDATION; PARTIAL DRUG SYNTHESIS; REACTION ANALYSIS; STEREOCHEMISTRY;

EID: 0030925268     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0040-4039(97)01056-3     Document Type: Article

References (25)

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22. (b) Alcohol 4 was easily separable from its C20 (R) epimer by column chromatography (Hexane/EtOAc 4%). Ratio 4(S):4(R) = 3/2. Proton NMR of the two epimers showed as expected a difference in the value of the chemical shifts of the C18 methyl groups : δ C18 = 0.916 ppm for 4(S) whereas δ C18 = 0.994 ppm for 4(R).
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