Enantioselective biotransformation of the chiral antihistaminic drug dimethindene in humans and rats

Arzneimittel-Forschung/Drug Research

Volumn 47, Issue 5, 1997, Pages 653-658

  Prien, Dagmar ^a   Rehn, Dieter ^b   Blaschke, Gottfried ^a  

^a UNIVERSITY OF MÜNSTER   (Germany)

^b Zyma GmbH   (Germany)

Author keywords

Antihistamines; CAS 3614 69 5; CAS 5636 83 9; Dimethindene maleate; Dimethindene, biotransformation; Fenistil

Indexed keywords

ANTIHISTAMINIC AGENT; DIMETINDENE; DRUG METABOLITE;

ADULT; ANIMAL EXPERIMENT; ARTICLE; CLINICAL TRIAL; DOSE RESPONSE; DRUG ELIMINATION; DRUG STRUCTURE; DRUG TRANSFORMATION; DRUG URINE LEVEL; FEMALE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HISTAMINE RELEASE; HUMAN; HUMAN EXPERIMENT; MALE; NONHUMAN; NORMAL HUMAN; ORAL DRUG ADMINISTRATION; RAT; STEREOCHEMISTRY;

ADULT; ANIMALS; BIOTRANSFORMATION; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DIMETHINDENE; FEMALE; GAS CHROMATOGRAPHY-MASS SPECTROMETRY; HISTAMINE H1 ANTAGONISTS; HUMANS; MALE; RATS; STEREOISOMERISM;

EID: 0030924621     PISSN: 00044172     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

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