Impaired insulin induced attenuation of noradrenaline-mediated vasoconstriction in insulin-resistant obese Zucker rats

Clinical Science

Volumn 93, Issue 3, 1997, Pages 235-241

  Walker, A B ^a   Dores, J ^a   Buckingham, R E ^b   Savage, M W ^a   Williams, G ^a  

^a UNIVERSITY HOSPITAL AINTREE   (United Kingdom)

^b GLAXOSMITHKLINE   (United Kingdom)

Author keywords

Insulin resistance; Insulin vasoactive effects; Mesenteric arteries

Indexed keywords

ACETYLCHOLINE; ARGININE; CALCIMYCIN; CHOLESTEROL; GLUCOSE; INSULIN; NITRIC OXIDE; TRIACYLGLYCEROL;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTERY DIAMETER; ARTICLE; BODY WEIGHT; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; DISEASE ASSOCIATION; DRUG EFFECT; GLUCOSE BLOOD LEVEL; HEART RATE; HYPERTENSION; INSULIN BLOOD LEVEL; INSULIN RESISTANCE; MALE; MESENTERIC ARTERY; NONHUMAN; OBESITY; PRIORITY JOURNAL; RAT; SYSTOLIC BLOOD PRESSURE; TRIACYLGLYCEROL BLOOD LEVEL; VASOCONSTRICTION; VASODILATATION;

EID: 0030924055     PISSN: 01435221     EISSN: None     Source Type: Journal    
DOI: 10.1042/cs0930235     Document Type: Article

References (44)

1. Reaven GM. Role of insulin resistance in human disease. Diabetes 1988; 37: 1595-607.
2. Ferrannim E, Buzzigoli G, Bonadonna R, et al. Insulin resistance in essential hypertension. N. Engl J Med 1987; 317: 350-7.
3. Anderson EA, Hoffman RP, Balon TW, Sinkey CA, Mark AL. Hyperinsulinemia stimulates both sympathetic neural activation and vasodilatation in normal humans. J Clin Invest 1991; 87: 2246-52.
4. De Fronzo RA, Cooke CR, Andres R, Faloona GR, Davis PJ. The effect of insulin on renal handling of sodium, potassium and phosphate in man. J Clin Invest 1975; 55: 845-55.
5. Natali A, Quinones GA, Santoro D, et al. Relationship between insulin release, antinatriuresis and hypokalaemia after glucose ingestion in normal and hypertensive man. Clin Sci 1993; 85: 327-35.
6. Baron AD, Brechtel G, Johnson A, Henty D. Insulin (I) attenuates norepinephrine's (NE) pressor effect [Abstract]. Diabetes 1992; 41 (Suppl. I): 125 A.
7. Walker AB, Dores J, Savage MW, Leese GP, Williams G. Prolonged exposure to high physiological insulin levels causes impaired maximal noradrenaline-induced vasoconstriction in resistance arteries [Abstract]. Diabetes Med 1994; 11 (Suppl. 2): S28.
8. McNally PG, Lawrence IG, Watt PAC, Hillier C, Burden AC, Thurston H. The effect of insulin on the vascular reactivity of isolated resistance arteries taken from healthy volunteers. Diabetologia 1995; 38: 467-73.
9. Steinberg HO, Brechtel G, Johnson A, Fineberg N, Baron AD. Insulin-mediated skeletal muscle vasodilation is nitric oxide dependent. A novel action of insulin to increase nitric oxide release. J Clin Invest 1994; 94: 1172-9.
10. Scherrer U, Randin D, Vollenweider P, Vollenweider L, Nicod P. Nitric oxide release accounts for insulin's vascular effects in humans. J Clin Invest 1994; 94: 2511-15.
11. Walker AB, Savage MW, Dores J, Williams G. Insulin-induced attenuation of noradrenaline-mediated vasoconstriction in resistance arteries from Wistar rats is nitric oxide dependent. Clin Sci 1997; 92: 147-52.
12. Anderson EA, Balon TW, Hoffman RP, Sinkey CA, Mark AL. Insulin increases sympathetic activity but not blood pressure in borderline hypertensive humans. Hypertension 1992; 19: 621-7.
13. Terrettaz J, Jeanrenaud B. In vivo hepatic and peripheral insulin resistance in genetically obese (fa/fa) rats. Endocrinology (Baltimore) 1983; 112: 1346-51.
14. Terrettaz J, Assimacopoulos-Jeannet F, Jeanrenaud B. Severe hepatic and peripheral insulin resistance as evidenced by euglycaemic clamps in genetically obese fa/fa rats. Endocrinology (Baltimore) 1986; 118: 674-8.
15. Kurtz TW, Morris RC, Pershadsingh HA. The fatty Zucker rat as a genetic model of obesity and hypertension. Hypertension 1989; 13: 896-901.
16. Christensen KL, Mulvany MJ. Mesenteric arcade arteries contribute substantially to vascular resistance in conscious rats. J Vasc Res 1993; 30: 73-9.
17. Taylor PD, Don BB, Thomas CR, Poston L. Prevention by insulin treatment of endothelial dysfunction but not enhanced noradrenaline-induced contractility in mesenteric arteries from streptozotocin-induced diabetic rats. Br J Pharmacol 1994; 111: 35-41.
18. Mulvany MJ, Halpern W. Mechanical properties of smooth muscle cells in situ. Nature (London) 1976; 260: 617-19.
19. Mulvany MJ, Halpern W. Contractile properties of small arterial resistance vessels in spontaneously hypertensive rats. Circ Res 1977; 41: 19-26.
20. Stout RW, Bierman EL, Ross R. Effect of insulin on the proliferation of cultured primate arterial smooth muscle cells. Circ Res 1975; 36: 319-27.
21. Baron AD. Hemodynamic actions of insulin. Am J Physiol 1994; 267 (Endocrinol Metab 30): E187-202.
22. Williams G, Pickup J, Clark A, Bowcock S, Cooke E, Keen H. Changes in blood flow close to subcutaneous insulin injection sites in stable and brittle diabetics. Diabetes 1983; 32: 466-73.
23. Laakso M, Edelman SV, Brechtel G, Baron AD. Decreased effect of insulin to stimulate skeletal muscle blood flow in obese man. J Clin Invest 1990; 85: 1844-52.
24. Laakso M, Edelman SV, Brechtel G, Baron AD. Impaired insulin-mediated skeletal muscle blood flow in patients with NIDDM. Diabetes 1992; 41: 1076-83.
25. Feldman RD, Brieber GS. Insulin-mediated vasodilatation: impairment with increased blood pressure and body mass. Lancet 1993; 342: 707-9.
26. Walker AB, Dores J, Buckingham RE, Williams G. Abnormal endothelium- dependent relaxation in hypertensive, insulin-resistant Zucker rats [Abstract]. Diabetes Med 1995; 12 (Suppl. I): 534.
27. McNamee CJ, Kappagoda CT, Kunjara R, Russell JC. Defective endothelium- dependent relaxation in the JCR:LA-corpulent rat. Circ Res 1994; 74: 1126-32.
28. Phillips MS, Liu Q, Hammond HA, et al. Leptin receptor missense mutation in the fatty Zucker rat. Nature Genetics 1996; 13: 18-19.
29. Zucker LM, Antoniades HN. Insulin and obesity in the Zucker genetically obese rat 'fatty'. Endocrinology (Baltimore) 1973; 90: 1320-30.
30. Flavahan NA. Atherosclerosis or lipoprotein-induced endothelial dysfunction. Circulation 1992; 85: 1927-38.
31. Chowienczyk PJ, Watts GF, Cockcroft JR, Ritter JM. Impaired endothelium- dependent vasodilation of forearm resistance vessels in hypercholesterolaemia. Lancet 1992; 340: 1430-2.
32. Goode GK, Heagerty AM. In vitro responses of human peripheral small arteries in hypercholesterolemia and effects of therapy. Circulation 1995; 91: 2898-903.
33. Drexler H, Zeiher AM, Meinzer K, Just H. Correction of endothelial dysfunction in coronary microcirculation of hypercholesterolaemic patients by L-arginine. Lancet 1991; 338: 1546-50.
34. Reference deleted.
35. Johnstone MT, Creager SJ, Scales KM, Cusco JA, Lee BK, Creager MA. Impaired endothelium-dependent vasodilation in patients with insulin-dependent diabetes mellitus. Circulation 1993; 88: 2510-6.
36. McNally PG, Watt PAC, Rimmer T, Burden AC, Hearnshaw JR, Thurston H. Impaired endothelium-dependent relaxation in isolated resistance vessels from patients with insulin-dependent diabetes mellitus. Clin Sci 1994; 87: 31-6.
37. 2+-ATPase. Am J Hypertens 1992; 5: 637-41.
38. Standley PR, Ram JL, Sowers JR. Insulin attenuation of vasopressin-induced calcium respones in arterial smooth muscle from Zucker rats. Endocrinology (Baltimore) 1993; 133: 1693-9.
39. Sowers JR. Effects of insulin and IGF-1 on vascular smooth muscle glucose and cation metabolism. Diabetes 1996; 45 (Suppl. 3): S47-51.
40. Guler HP, Eckardt KU, Zapf J, Bauer C, Froesch ER Insulin-like growth factor 1 increases glomerular filtration rate and renal plasma flow in man. Acta Endocrinol (Copenhagen) 1989; 121: 101-6.
41. Haylor JH, Singh I, El Nahas AM. Nitric oxide synthesis inhibitor prevents vasodilation by insulin-like growth factor 1. Kidney Int 1991; 39: 333-5.
42. Schini VB, Catovsky S, Schray-Utz B, Busse R, Vanhoutte PM. Insulin-like growth factor 1 inhibits induction of nitric oxide synthase in vascular smooth muscle cells. Circ Res 1994; 74: 24-32.
43. Scott-Burden T, Schini VB, Elizondo E, Junquero DC, Vanhoutte PM. Platelet- derived growth factor suppresses and fibroblast growth factor enhances cytokine-induced production of nitric oxide by cultured smooth muscle cells: effects on cell proliferation. Circ Res 1992; 71: 1088-100.
44. Mollace V, Salvemini D, Anggard E, Vane J. Nitric oxide from vascular smooth muscle cells: regulation of platelet reactivity and smooth muscle guanylate cyclase. Br J Pharmacol 1991; 104: 633-38.