Androgen UDP-glucuronyl transferase activity is found primarily in the liver in the human

Journal of Andrology

Volumn 18, Issue 2, 1997, Pages 116-122

  Pirog, Edyta C ^a   Collins, Delwood C ^a,b  

^a UNIVERSITY OF KENTUCKY   (United States)

^b UNIVERSITY OF KENTUCKY MEDICAL CENTER   (United States)

Author keywords

androstanediol; androsterone; dihydrotestosterone; prostate; skin; Testosterone

Indexed keywords

ANDROGEN; ANDROSTANEDIOL; ANDROSTANOLONE; ANDROSTERONE; GLUCURONOSYLTRANSFERASE;

ADULT; AGED; ANDROGEN METABOLISM; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME KINETICS; ENZYME LOCALIZATION; ENZYME SUBSTRATE; FEMALE; GLUCURONIDATION; HUMAN; HUMAN CELL; HUMAN TISSUE; LIVER HOMOGENATE; LIVER MICROSOME; MALE; MICHAELIS CONSTANT; NONHUMAN; PRIORITY JOURNAL; PROSTATE; RAT; SKIN; TISSUE DISTRIBUTION;

ADULT; AGED; FEMALE; GLUCURONOSYLTRANSFERASE; HUMANS; KINETICS; LIVER; MALE; MICROSOMES, LIVER; MIDDLE AGED; ORGAN SPECIFICITY; PROSTATE; SEX CHARACTERISTICS; SKIN; SUBSTRATE SPECIFICITY;

EID: 0030923822     PISSN: 01963635     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (37)

1. Ahmed SR, Boucher AE, Manni A, Santen RJ, Bartholomew M, Demers L. Transdermal testosterone therapy in the treatment of male hypogonadism. J Clin Endocrinol Metab 1988;62:22-27.
2. Aronson NN, Touster O. Isolation of rat plasma membrane fragments in isotonic sucrose. In: Fleischer S, ed. Methods In Enzymology. Vol 31. New York: Academic Press; 1974:90-102.
3. Bartsch W, Klein H, Schiemann U, Bauer HW, Voight KD. Enzymes of androgen formation and degradation in the human prostate. NY Acad Sci 1990;595:53-66.
4. Belanger A, Couture J, Caron S, Roy R. Determination of nonconjugated and conjugated steroid levels in plasma and prostate after separation on C-18 columns. NY Acad Sci 1990;595:251-259.
5. Bock KW, Burchell B, Dutton GJ, Hanninen O, Mulder GJ, Owens IS, Siest G, Tephly TR. UDP-glucuronosyltransferase activities. Guidelines for consistent interim terminology and assay conditions. Biochem Pharmacol 1983;32:953-955.
6. Bradford M. A rapid sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 1976;72:248-254.
7. Brochu M, Belanger A, Tremblay RR. Plasma levels of C-19 steroids and 5α-reduced steroid glucuronides in hyperandrogenic and idiopathic hirsute women. Fertil Steril 1987;48:948-952.
8. Duffy DM, Stanczyk FZ, Legro RS, Lobo RA, Chang L. Metabolism of dihyrotestosterone to 5α-androstane-3α, 17β-diol glucuronide is greater in the peripheral compartment than in the splanchnic compartment. Fertil Steril 1995;64:736-740.
9. Dutton GJ. Activation and inhibition procedures. In: Dutton GJ, ed. Glucuronidation of Drugs and Other Compounds. Boca Raton: CRC Press; 1980:32-51.
10. Giagulli VA, Giorgino R, Vermeulen A. Is plasma 5α-androstane-3α,17β-diol glucuronide a biochemical marker of hirsutism in women? J Steroid Biochem 1991;39:55-61.
11. Giagulli VA, Giorgino R, Vermeulen A. Origin and significance of plasma androsterone glucuronide levels: a parameter of adrenal androgen secretion and hepatic 5α-reductase activity. J Clin Endocrinol Metab 1993;76:918-923.
12. Giagulli A, Verdonck L, Deslypere J-P, Giorgino R, Vermeulen A. Comparison of plasma androgen glucuronide levels after percutaneous or peroral androgen treatment in men: evidence for important splanchnic contribution to plasma 17β-hydroxyandrogen glucuronides. J Clin Endocrinol Metab 1993;76:429-431.
13. Giagulli VA, Verdonck L, Giorgino R, Vermeulen A. Precursors of plasma androstanediol and androgen glucuronide in women. J Steroid Biochem 1989;33:935-940.
14. Creep N, Hoopes M, Horton R. Androstanediol glucuronide plasma clearance and production rates in normal and hirsute women. J Clin Endocrinol Metab 1986;62:22-27.
15. Horton R. Dihydrotestosterone is a peripheral paracrine hormone. J Androl 1992;13:23-27.
16. Horton R, Hawks D, Lobo R. 3α,17β-androstanediol glucuronide in plasma. J Clin Invest 1982;69:1203-1206.
17. Horton R, Lobo R. Peripheral androgens and the role of androstanediol glucuronide. Clin Endocrinol Metab 1986;15:293-306.
18. Kirschner MA, Samojlik E, Szmal E. Clinical usefulness of plasma androstanediol glucuronide measurements in women with idiopathic hirsutism. J Clin Endocrinol Metab 1987;65:597-601.
19. Leakey JEA, Hume R. Burchell B. Development of multiple activities of UDP-glucuronyltransferase in human liver. Biochem J 1987;243:859-861.
20. Lobo R, Wellington LP, Gentzschein E, Serafini PC, Catalino JA, Paulson RJ, Horton R. Production of 3α-androstanediol glucuronide in human genital skin. J Clin Endocrinol Metab 1987;65:711-714.
21. Lobo RA, Goebelsmann U, Horton R. Evidence for the importance of peripheral tissue events in the development of hirsutism in polycystic ovary syndrome. J Clin Endocrinol Metab 1983;57:393-397.
22. 19 conjugates. J Clin Endocrinol Metab 1992;75:768-772.
23. Mauvais-Jarvis P, Bercovici JP, Crepy O, Gauthier E Studies on testosterone metabolism in subjects with testicular feminization syndrome. J Clin Invest 1970;49:31-40.
24. Moloney SJ, Bridges JW, Fromson JM. UDP-glucuronosyltransferase activity in rat- and hairless mouse skin-microsomes. Xenobiotica 1982;12:481-487.
25. Morimoto T, Edmiston A, Horton R. Studies on the origin of androstanediol glucuronide in young and elderly men. J Clin Endocrinol Metab 1981;52:772-779.
26. Mowszowicz I, Wright I, Vincens I, Reguad C, Nahowl K, Mariner PH, Gutlemand S, Kutlenn F, Mauvais-Jarvis P. Androgen metabolism in hirsute patients treated cyproterone acetate. J Steroid Biochem 1984;20:757-761.
27. Pasupuleti V, Horton R. Metabolism of 5α-reduced androgens by various tissues of the male rat. J Androl 1990;11:161-167.
28. Pasupuleti V, Lobo R, Horton R. Conversion of dihydrotestosterone to androstanediol glucuronide by female sexual skin. Steroids 1988;51:269-282.
29. Pirog EC, Clark RV, Collins DC. Androgen UDP-glucuronyl transferase is found primarily in liver in the rat. J Androl 1993;14:2-8.
30. Rao GS, Haueter G, Rao ML, Breuer H. Steroid glucuronyltransferases of rat liver. Biochem J 1977;162:545-556.
31. Rittmaster R. Androgen conjugates: physiology and clinical significance. Endocr Rev 1993;14:121-132.
32. Rittmaster RS, Leopold CA, Thompson DL. Preferential metabolism of dihydrotestosterone to androstanediol-17-glucuronide in rat prostate. Endocrinology 1988;123:2788-2792.
33. Rittmaster RS, Leopold CA, Thompson DL. Androgen glucuronyl transferase activity in rat liver, evidence for the importance of hepatic tissue in 5α-reduced androgen metabolism. J Steroid Biochem 1989;33:1207-1212.
34. Rittmaster RS, Zwicker HJ, Thompson DL, Konok G, Norman RW. Androgen glucuronide production in human liver, prostate and skin. Evidence for the importance of the liver in 5α-reduced androgen conjugation. J Clin Endocrinol Metab 1993;76:977-982.
35. Roy Chowdhury J, Nonikoff PM, Roy Chowdhury N, Nonikoff AB. Distribution of UDP glucuronosyl-transferase in rat tissue. Proc Natl Acad Sci USA 1985;82:2990-2994
36. Scanlon MJ, Whorwood CB, Franks S, Reed MJ, James VHT. Serum androstanediol glucuronide concentrations in normal and hirsute women and patients with thyroid dysfunction. Clin Endocrinol 1988;29:529-538.
37. Thompson DL, Horton N, Rittmaster RS. Androsterone glucuronide is a marker of adrenal hyperandrogenism in hirsute women. Clin Endocrinol 1990;32:283-292.