Chronotropic response to cardiac sympathetic nerve stimulation in spontaneously hypertensive rats

Canadian Journal of Physiology and Pharmacology

Volumn 75, Issue 2, 1997, Pages 97-103

  Masuda, Yukitaka ^a   Matsuoka, Hiroaki ^a  

^a DOKKYO MEDICAL UNIVERSITY   (Japan)

Author keywords

Adrenergic blockade; Ansa subclavia; Cardiac hyporesponsiveness; Neurally released norepinephrine; adrenergic receptor

Indexed keywords

BETA ADRENERGIC RECEPTOR; NORADRENALIN; PROPRANOLOL; TETRODOTOXIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BETA ADRENERGIC RECEPTOR BLOCKING; CHRONOTROPISM; CONTROLLED STUDY; FEMALE; HYPERTENSION; INTRAVENOUS DRUG ADMINISTRATION; MALE; NONHUMAN; NORADRENALIN RELEASE; PRIORITY JOURNAL; RAT; SPONTANEOUSLY HYPERTENSIVE RAT; SYMPATHETIC NERVE;

EID: 0030923308     PISSN: 00084212     EISSN: None     Source Type: Journal    
DOI: 10.1139/y96-163     Document Type: Article

References (34)

1. Adams, M.A., Bobik, A., and Korner, P.I. 1989. Differential development of vascular and cardiac hypertrophy in genetic hypertension: relation to sympathetic function. Hypertension (Dallas), 14: 191-202.
2. Antonaccio, M.J., and Kerwin, L. 1980. Evidence for prejunctional inhibition of norepinephrine release by captopril in spontaneously hypertensive rats. Eur. J. Pharmacol. 68: 209-212.
3. Atkins, F.L., Bing, O.H.L., DiMauro, P.G., Conrad, C.H., Robinson, K.G., and Brooks, W.W. 1995. Modulation of left and right ventricular β-adrenergic receptors from spontaneously hypertensive rats with left ventricular hypertrophy and failure. Hypertension (Dallas), 26: 78-82.
4. Böhm, M., Gierschik, P., Knorr, A., Schmidt, U., Weismann, K., and Erdmann, E. 1993. Cardiac adenylyl cyclase, β-adrenergic receptors, and G proteins in salt-sensitive hypertension. Hypertension (Dallas), 22: 715-727.
5. Böhm, M., Castellano, M., Agaviti-Rose, E., Flesh, M., Paul, M., and Erdmann, E. 1995a. Dose-dependent dissociation of ACE-inhibitor effects on blood pressure, cardiac hypertrophy, and β-adrenergic signal transduction. Circulation, 92: 3006-3013.
6. Böhm, M., Grabel, C., Knorr, A., and Erdmann, E. 1995b. Treatment in hypertensive cardiac hypertrophy. I. Neuropeptide Y and β-adrenoceptors. Hypertension (Dallas), 25: 954-961.
7. Debinski, W.K., and Kuchel, O.G. 1989. Responsiveness of noradrenergic neurons in rat experimental hypertension. Hypertension (Dallas), 13: 712-715.
8. DiBona, G.F., and Jones, S.Y. 1995. Analysis of renal sympathetic nerve responses to stress. Hypertension (Dallas), 25: 531-538.
9. Dyke, A.C., Angus, J.A., and Korner, P.I. 1989. A functional study of the development of the cardiac sympathetic neuroeffector junction in the SHR. J. Hypertens. 7: 345-353.
10. Ferrari, A.U., Daffonchio, A., Gerosa, S., and Mancia, G. 1991. Alterations in cardiac parasympathetic function in aged rats. Am. J. Physiol. 260: H647-H649.
11. Ferrari, A.U., Daffonchio, A., Franzelli, C., and Mancia, G. 1992. Cardiac parasympathetic hyperresponsiveness in spontaneously hypertensive rats. Hypertension (Dallas), 19: 653-657.
12. Ferner, C., Esler, M.D., Eisenhofer, G., Wallin, B.G., Horne, M., Cox, H.S., Lambert, G., and Jennings, G.L. 1992. Increased norepinephrine spillover into the jugular veins in essential hypertension. Hypertension (Dallas), 19: 62-69.
13. Gillespie, J.S., and Muir, T.C. 1967. A method of stimulating the complete sympathetic outflow from the spinal cord to blood vessels in the pithed rat. Br. J. Pharmacol. Chemother. 30: 78-87.
14. Glantz, S.A. 1987. Primer of biostatistics. 2nd ed. McGraw-Hill Inc., New York.
15. Goldstein, D.S. 1983. Plasma catecholamines and essential hypertension. Hypertension (Dallas), 5: 86-99.
16. Grobecker, H., Saavedra, J.M., Roizen, M.F., Weise, V., Kopin, I.J., and Axelrod, J. 1976. Peripheral and central catecholaminergic neurons in genetic and experimental hypertension in rats. Clin. Sci. Mol. Med. 51: 377s-380s.
17. Guzzetti, S., Piccaluga, E., Casati, R., Cerutti, S., Lombardi, F., Pagani, M., and Malliani, A. 1988. Sympathetic predominance in essential hypertension: a study employing spectral analysis of heart rate variability. J. Hypertens. 6: 711-717.
18. Head, G.A., and Adams, M.A. 1988. Time course of changes in baroreceptor reflex control of heart rate in conscious SHR and WKY: contribution of the cardiac vagus and sympathetic nerves. Clin. Exp. Pharmacol. Physiol. 15: 289-292.
19. Kao, C.Y. 1966. Tetrodotoxin, saxitoxin and their significance in the study of excitation phenomena. Pharmacol. Rev. 18: 997-1049.
20. Kaufman, L.J., and Vollmer, R.R. 1985. Endogenous angiotensin II facilitates sympathetically mediated hemodynamic responses in pithed rats. J. Pharmacol. Exp. Ther. 235: 128-134.
21. Koepke, J.P., Jones, S., and DiBona, G.F. 1986. Hypothalamic beta-2 adrenoceptor control of renal sympathetic nerve activity and urinary sodium excretion in conscious spontaneously hypertensive rats. Circ. Res. 58: 241-248.
22. Masuda, Y., and Levy, M.N. 1984. The effects of neuronal uptake blockade on the cardiac responses to sympathetic nerve stimulation and norepinephrine infusion in anesthetized dogs. J. Auton. Nerv. Syst. 10: 1-17.
23. Masuda, Y., and Levy, M.N. 1985. Heart rate modulates the disposition of neurally released norepinephrine in cardiac tissues. Circ. Res. 57: 19-27.
24. Murphy, C.A., and McCarty, R. 1995. Baroreflex control of heart rate in Dahl hypertensive (SS/Jr) and normotensive (SR/Jr) rats. J. Hypertens. 13: 1145-1151.
25. Osborn, J.W. 1991. Pathogenesis of hypertension in the sinoaortic-denervated spontaneously hypertensive rat. Hypertension (Dallas), 18: 475-482.
26. Parati, G., De Rienzo, M., Bertinieri, G., Pomidossi, G., Casadei, R., Groppelli, A., Pedotti, A., Zanchetti, A., and Mancia, G. 1988. Evaluation of the baroreceptor - heart rate reflex by 24-hour intraarterial blood pressure monitoring in humans. Hypertension (Dallas), 12: 214-222.
27. 1 (37946). Proc. Soc. Exp. Biol. Med. 145: 1025-1030.
28. Saragoca, M., and Tarazi, R.C. 1981. Impaired cardiac contractile response to isoproterenol in the spontaneously hypertensive rat. Hypertension (Dallas), 3: 380-385.
29. Sokal, R.R., and Rohlf, F.J. 1981. Biometry. 2nd ed. W.H. Freeman and Co., San Francisco, Calif.
30. Solitis, E.E., and Field, F.P. 1984. Effect of high blood pressure stress on vascular adrenergic responsiveness in the spontaneously hypertensive rat. Clin. Exp. Hypertens. A6: 1237-1255.
31. Vollmer, R.R., Meyers, S.A., Ertel, R.J., and Murthy, V.S. 1984. Diminished sympathetic responsiveness in nephrectomized rats - role of the renin angiotensin system. Clin. Exp. Hypertens. A6: 993-1009.
32. Westfall, T.C., and Meldrum, M.J. 1985. Alterations in the release of norepinephrine at the vascular neuroeffector junction in hypertension. Annu. Rev. Pharmacol. Toxicol. 25: 621-341.
33. Wong, P.C., Reilly, T.M., and Timmermans, P.B.M.W.M. 1989. Effect of a monoclonal antibody to angiotensin II on hemodynamic responses to noradrenergic stimulation in pithed rats. Hypertension (Dallas), 14: 488-497.
34. Wong, P.C., Bernard, R., and Timmermans, P.B.M.W.M. 1992. Effect of blocking angiotensin II receptor subtype on rat sympathetic nerve function. Hypertension (Dallas), 19: 663-667.