Cytoprotective effect of epidermal growth factor on acid- and pepsin- induced damage to rat gastric epithelial cells: Roles of Na+/H+ exchangers

Journal of Gastroenterology and Hepatology (Australia)

Volumn 12, Issue 5, 1997, Pages 353-359

  Furukawa, O ^a   Okabe, S ^a  

^a KYOTO PHARMACEUTICAL UNIVERSITY   (Japan)

Author keywords

epidermal growth factor; gastric epithelial cell damage; RGM1

Indexed keywords

16,16 DIMETHYLPROSTAGLANDIN E2; EPIDERMAL GROWTH FACTOR; GENISTEIN; SUCRALFATE;

ACIDIFICATION; ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CALCIUM BLOOD LEVEL; CELL CULTURE; CELL DAMAGE; CELL LINE; CELL PROTECTION; DNA SYNTHESIS; ENZYME ACTIVITY; NONHUMAN; PRIORITY JOURNAL; PROTEIN TRANSPORT; RAT; SODIUM BLOOD LEVEL;

EID: 0030923294     PISSN: 08159319     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1440-1746.1997.tb00442.x     Document Type: Article

References (17)

1. Furukawa O, Okabe S. A model of cell damage induced by HCl or HCl + pepsin in a rat gastric epithelial cell line. Gastroenterology 1996; 110: A112.
2. Furukawa O, Nakamura E, Okabe S. Characterization of a novel cell damage model induced by acid and pepsin using rat gastric epithelial cells: Protective effect of sucralfate. J. Gastroenterol. Hepatol. 1997; 12 (in press).
3. Hiraishi H, Terano A, Ohta S, Ishii M, Ivy KJ, Sugimoto T. Epidermal growth factor protects rat gastric mucosal cells against indomethacin-induced damage in monolayer culture. Gastroenterology 1984; 86: A1113.
4. Ito M, Joh T, Imai S et al. Experimental and clinical studies on epidermal growth factor for gastric mucosal protection and healing of gastric ulcers. J. Clin. Gastroenterol. 1988; 10 (Suppl. 1): S7-12.
5. Ishikawa T, Fukuda T, Sugiyama M, Tarnawski A. Direct protective action of epidermal growth factor on isolated gastric mucosal surface epithelial cells. J. Physiol. Pharmacol. 1992; 43: 323-32.
6. + exchanger isoform. J. Biol. Chem. 1993; 268: 206-11.
7. + exchanger isoforms. Am. J. Physiol. 1995; 268: C283-96.
8. Akiyama T, Ishida J, Nakagawa S et al. Genistein, a specific inhibitor of tyrosine-specific protein kinases. J. Biol. Chem. 1987; 262: 5592-5.
9. Parish CR, Müllbacher A. Automated colorimetric assay for T cell cytotoxicity. J. Immunol. Methods 1983; 58: 225-37.
10. Konturek SJ, Radecki T, Brzozowski T et al. Gastric cytoprotection by epidermal growth factor. Roles of endogenous prostaglandins and DNA synthesis. Gastroenterology 1981; 81: 438-43.
11. Chiba T, Hirata Y, Taminato T, Kadowaki S, Matsukura S, Fujita T. Epidermal growth factor stimulates prostaglandin E release from isolated rat stomach. Biochem. Biophys. Res. Commun. 1982; 105: 370-4.
12. 2 release by epidermal growth factor in cultured guinea pig gastric mucous cells. Dig. Dis. Sci. 1995; 40: 1679-86.
13. Ghishan FK, Knobel S, Barnard JA, Breyer M. Expression of a novel sodium-hydrogen exchanger in the gastrointestinal tract and kidney. J. Membr. Biol. 1995; 144: 267-71.
14. + exchangers. Cell Physiol. Biochem. 1994; 4: 282-300.
15. + exchange. Am. J. Physiol. 1994; 266: G647-56.
16. + exchange. J. Biol. Chem. 1996; 271: 9919-27.
17. Tepperman BL, Tan SY, Whittle BJR. Effects of calcium-modifying agents on integrity of rabbit isolated gastric mucosal cells. Am. J. Physiol. 1991; 261: G119-27.