Inhibition of M-type K+ and N-type Ca2+ channels by the human gonadotropin-releasing-hormone receptor heterologously expressed in adult neurons

Neuroendocrinology

Volumn 66, Issue 4, 1997, Pages 234-245

  Lewis, Deborah L ^a   Ikeda, Stephen R ^a  

^a MEDICAL COLLEGE OF GEORGIA   (United States)

Author keywords

Calcium channels; Electrophysiology; Gonadotropin releasing hormone; K+ channels; Molecular neuroendocrinology

Indexed keywords

CALCIUM CHANNEL; CALCIUM CHELATING AGENT; CONOTOXIN; GONADORELIN; GONADORELIN RECEPTOR; GUANINE NUCLEOTIDE BINDING PROTEIN; PERTUSSIS TOXIN;

ANIMAL CELL; ARTICLE; BRAIN NERVE CELL; CALCIUM CURRENT; CONTROLLED STUDY; ELECTROPHYSIOLOGY; ENDOCRINE SYSTEM; FEMALE; GONADORELIN RELEASE; HORMONE RELEASE; MALE; MICROINJECTION; NERVE CELL CULTURE; NERVE CELL EXCITABILITY; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; REPRODUCTION; SECOND MESSENGER; SUPERIOR CERVICAL GANGLION;

ANIMALS; CALCIUM CHANNEL BLOCKERS; CALCIUM CHANNELS; CELLS, CULTURED; CHELATING AGENTS; ELECTRIC CONDUCTIVITY; FEMALE; GANGLIA, SYMPATHETIC; GENE EXPRESSION; GENE TRANSFER TECHNIQUES; GONADOTROPIN-RELEASING HORMONE; HUMANS; MALE; NEURONS; POTASSIUM CHANNEL BLOCKERS; POTASSIUM CHANNELS; RATS; RATS, WISTAR; RECEPTORS, LHRH;

EID: 0030922799     PISSN: 00283835     EISSN: 14230194     Source Type: Journal    
DOI: 10.1159/000127244     Document Type: Article

References (51)

1. Moss RI, McCann SM: Induction of mating behavior in rats by luteinizing hormone-releasing factor. Science 1973; 181:177-179.
2. Pfaff DW: Luteinizing hormone-releasing factor potentiates lordosis behavior in hypo-physcctomizcd ovariectoniized female rats. Science 1973; 182:1148-1149.
3. Pfaff DW, Schwanzcl-Fukuda M, Parhar IS, Lauber AH, McCarthy MM, Kow L-M: GnRH neurons and other cellular and molecular mechanisms for simple mammalian reproductive behaviors. Recent Prog Horm Res 1994; 49:1-25.
4. Wong M, Eaton MJ, Moss RL: Electrophvsio-logical actions of luteinizing hormone-releasing hormone: Intracellular studies in the rat hippocampal slice preparation. Synapse 1990:5:65-70.
5. Kawakami M, Sakuma Y: Responses of hypothalamic neurons to the microiontophoresis of LH-RH. LH and ESI I under various levels of circulating ovarian hormones. Neuroendocrinology 1974:15:290-307.
6. Chan A, Dudley CA, Moss RL: Hormonal and chemical modulation of ventromedial hypothalamic neurons responsive to vaginocervical stimulation. Neuroendocrinologv 1984:38: 328-336.
7. Dudley CA, Moss RL: Effects of a bchaviorally active LHRH fragment and septal area stimulation on the activity of mediobasal hypothalamic neurons. Synapse 1987:1:240-247.
8. Moss RL, Dudley CA, Kelly MJ: Hypothalamic polypeptide releasing hormones: Modifiers of neuronal activity. Neuropharmacology 1978:17:87-93.
9. Ikeda SR, Lovinger DM, McCool BA, Lewis DL: Heterologous expression of metabotropic glutamate receptors in adult rat sympathetic neurens: Subtype-specific coupling to ion channels. Neuron 1995:14:1029-1038.
10. 2* channels in a neuronal expression system. Mol Pharmacol 1996:49:707-714.
11. Ideda SR: Voltage-dependent modulation of N-type calcium channels by G-protein ßy subunits. Nature 1996;380:255-258.
12. Chi L, Zhou W, Prikhozhan A, Flanagan C, Davidson JS, Colombo M, Illing N, Millar RP, Seal ton SC: Cloning and characterization of the human GnRH receptor. Mol Cell Endocrinol 1993;91:R1-R6.
13. Mellon PL, Windle JJ, Goldsmith PC, Padula CA, Roberts JL, Weiner RI: Immortalization of hypothalamic GnRH neurons by genetically targeted tumorigenesis. Neuron 1990;5:1-10.
14. Bosnia MM: Ion channel properties and episodic activity in isolated immortalized gonadotropin-releasing hormone (GnRH) neurons. J McmbrBiol 1993:136:85-96.
15. Krsmanovic LZ, Stojilkovic SS, Mcrtz LM, Tomic M, Catt KJ: Expression of gonadotropin-releasing hormone receptors and autocrine regulation of neuropeptide release in immortalized hypothalamic neurons. Proc Natl Acad Sci USA 1993;90:3908-3912.
16. Brown DA, Adams PR: Muscarinic suppression of a novel voltage-sensitive K* current in a vertebrate neurone. Nature 1980:283:673-676.
17. Constanti A, Brown DA: M-currcnts in voltage-clamped mammalian sympathetic neurones. Neurosci Lett 1981:24:289-294.
18. Adams PR, Jones SW, Pennefather P, Brown DA, Koch C, Lancaster B: Slow synaptic transmission in frog sympathetic ganglia. J Exp Biol 1986;124:259-285.
19. Jones SW: Chicken II luteinizing hormone-releasing hormone inhibits the M-current of bullfrog sympathetic neurons. Neurosci Lett 1987;80:180-184.
20. 2 and K* channcls in sympathetic neurons by neuropeptides and other ganglionic transmitters. Neuron 1990:2:379-391.
21. Elmslic KS, Zhou W, Jones SW: LHRH and GTPyS modify activation of N-typc calcium currents in bullfrog sympathetic neurons. Neuron 1990;5:75-80.
22. Boland LM, Bean BP: Modulation of N-typc calcium channels in bullfrog sympathetic neurons by luteinizing hormone-releasing hormone: Kinetics and voltage dependence. J Neurosci 1993:13:516-533.
23. Galvan M, Adams PR: Control of calcium current in rat sympathetic neurons by norepinephrine. Brain Res 1982:244:135-144.
24. Marrion NV, Smart TG, Brown DA: Membrane currents in adult rat superior cervical ganglia in dissociated tissue culture. Neurosci Lett 1987:77:55-60.
25. 2* current in rat sympathetic neurons. Proc Natl Acad Sci USA 1987:84: 4313-4317.
26. Ideda SR, Schofield GG: Somatostatin blocks a calcium current in rat sympathetic ganglion neurons. J Physiol 1989;409:221-240.
27. Plummer MR, Rittenhousc A, Kanevsky M, Hess P: Neurotransmitter modulation of calcium channels in rat sympathetic neurons. J Neurosci 1991:11:2339-2348.
28. 2* channels in rat sympathetic neurons is mediated by guanine nucleotide-binding proteins. J Physiol 1992:458:339-359.
29. Beech DJ, Bcmheim L, Hille B: Pertussis toxin and voltage dependence distinguish multiple pathways modulating calcium channels of rat sympathetic neurons. Neuron 1992;8:97-106.
30. 2* current and M current in rat sympathetic neurons. Proc Natl Acad Sei USA 1992;89: 9544-9548.
31. Shapiro MS, fülle B: Substance P and somatostatin inhibit calcium channels in rat sympathetic neurons via different G protein pathways. Neuron 1993:10:11-20.
32. Foucart S, Blcakman D, Bindokas VP, Miller RI: Neuropeptide Y and pancreatic polypeptide reduce calcium currents in actuely dissociated neurons from adult rat superior cervical ganglia. J Pharmacol ExpTher 1993:265:903-909.
33. 2* channels by PTX-sensitivc G proteins is blocked by N-cthvlmalcimide rat sympathetic neurons. J Neurosci 1994; 14:7109-7116.
34. 2* channels of sympathetic neurons via a pertussis toxin-insensitive but cholera toxin-sensitive pathway. Neuron 1994:13:657-669.
35. Bean BP: Neurotransmitter inhibition of neuronal calcium currents by changes in channel voltage dependence. Nature 1989:340:153-156.
36. Ideda SR: Double-pulse calcium channel facilitation in adult rat sympathetic neurons. J Physiol 1991;439:181-214.
37. 2* channels by G-protein by subunits. Nature 1996:380:258-262.
38. 2* current and M current in rat sympathetic neurons. Proc Natl Acad Sci USA 1991:88:652-656.
39. Shapiro MS, Wollmuth LP, Hille B: Angiotensin II inhibits calcium and M current channels in rat sympathetic neurons via G proteins. Neuron 1994;12:1319-1329.
40. Hillc B: Modulation of ion-channel function by G-protein-coupled receptors. Trends Neurosci 1994:17:531-535.
41. Brown DA, Marrion NV, Smart TG: On the transduction mechanism for muscarine-induced inhibition of M-current in cultured rat sympathetic neurones. J Physiol 1989:413: 469-488.
42. Marrion NV, Smart TG, Marsh SJ, Brown DA: Muscarinic suppression of the M-current in the rat sympathetic ganglion is mediated by receptors of the MI-sublvpe. Br J Pharmacol 1989: 557-573.
43. Kaka SS, Musgrove LC, Devor DC, Sellers JC, Neill JD: Cloning, sequencing, and expression of human gonadotropin releasing hormone (GnRU) receptor. Biochem Biophys ResCom-mun 1992:189:289-295.
44. Hantill OP, Marty A, Neher E, Sakmann B, Sigworth FJ: Improved patch-clamp techniques for high-resolution recording from cells and cell-free membrane patches. Pfliigers Arch 1981;391:85-100.
45. Ideda SR, Soler F, Ziihlke RD, Joho RH, Lewis DL: Heterologous expression of the human potassium channel Kv2.l in clonal mammalian cells by direct cytoplasmic microinjection of cRNA. Pfliigers Arch 1992;422:201-203.
46. 2* influx. Proc Nall Acad Sci USA 1988:85:6566-6570.
47. 2*]i oscillations in pituitary gonadotrophs. J Biol Client 1993;268:7713-7720.
48. Hille B, Tse A, Tse FW, Aimers W: Calcium oscillations and exocytosis in pituitary gonado-tropes. A NY Acad Sci 1994:710:262-270.
49. Bcmheim L, Beech DJ, Hille B: A diffusible second messenger mediates one of the pathways coupling receptors to calcium channels in rat sympathetic neurons. Neuron 1991:6:859-867.
50. 2* current via Goo in rat sympathetic neurons. J Physiol 1994:477:415-422.
51. Pfaffinger PJ: Muscarine and t-LHRll suppress M-current by activating an IAP-sensitive G-protein. J Neurosci 1988:8:3343-3353.