Changes in sensitivity to the rate-decreasing effects of opioids in pigeons treated acutely or chronically with I-α-acetylmethadol

Journal of Pharmacology and Experimental Therapeutics

Volumn 281, Issue 2, 1997, Pages 799-809

  Gerak, Lisa R ^a   France, Charles P ^a  

^a LOUISIANA STATE UNIV MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLMETHADOL; ENADOLINE; ETONITAZENE; FENTANYL; KETAMINE; MORPHINE; NALBUPHINE; NALORPHINE; NALTREXONE; OPIATE AGONIST; OPIATE ANTAGONIST;

ADOLESCENT; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; DOSE TIME EFFECT RELATION; DRUG CROSS TOLERANCE; DRUG DEPENDENCE; DRUG DEPENDENCE TREATMENT; DRUG SENSITIVITY; DRUG TOLERANCE; INTRAMUSCULAR DRUG ADMINISTRATION; NONHUMAN; PIGEON; PRIORITY JOURNAL;

ANALGESICS, OPIOID; ANIMALS; COLUMBIDAE; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG TOLERANCE; KETAMINE; METHADYL ACETATE; NALTREXONE;

EID: 0030922753     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (32)

1. ADAMS, J. U. AND HOLTZMAN, S. G.: Pharmacologic characterization of the sensitization to the rate-decreasing effects of naltrexone induced by acute opioid pretreatment in rats. J. Pharmacol. Exp. Ther. 253: 483-489, 1990.
2. AIGNER, T. G., FORD, R. D. AND BALSTER, R. L.: Levo-alpha-acetylmethadol and metabolites: some effects on schedule-controlled behavior in the rat. Pharmacol. Biochem. Behav. 8: 735-737, 1978.
3. CRAFT, R. M., PICKER, M. J. AND DYKSTRA, L. A.: Differential cross-tolerance to opioid agonists in morphine-tolerant pigeons responding under a schedule of food presentation. J. Pharmacol. Exp. Ther. 249: 386-393, 1989.
4. FRANCE, C. P. AND WOODS, J. H.: Effects of morphine, naltrexone and dextrorphan in untreated and morphine-treated pigeons. Psychopharmacology 85: 377-382, 1985.
5. FRANCE, C. P. AND WOODS, J. H.: Acute supersensitivity to the discriminative stimulus effects of naltrexone in pigeons. J. Pharmacol. Exp. Ther. 244: 599-605, 1988.
6. FRANCE, C. P. AND WOODS, J. H.: Discriminative stimulus effects of opioid agonists in morphine-dependent pigeons. J. Pharmacol. Exp. Ther. 254: 626-632, 1990.
7. FRASER, H. F. AND ISBELL, H.: Actions and addiction liabilities of α-acetylmethadols in man. J. Pharmacol. Exp. Ther. 105: 458-465, 1952.
8. GERAK, L. R. AND FRANCE, C. P.: Interactions among LAAM, naltrexone and morphine: effects on schedule-controlled behavior in pigeons. In Problems of Drug Dependence 1995, ed. by L. S. Harris, pp. 339, NIDA Research Monograph, 1996a.
9. GERAK, L. R. AND FRANCE, C. P.: Changes in sensitivity to the rate-decreasing effects of opioids in pigeons treated chronically with LAAM. In Problems of Drug Dependence 1996, ed. by L. S.Harris, NIDA Research Monograph, in press.
10. GERAK, L. R. AND FRANCE, C. P.: Changes in sensitivity to the rate-decreasing effects of opioids in pigeons treated acutely or chronically with nalbuphine. Behav. Pharmacol. 7: 437-447, 1996b.
11. HOLTZMAN, S. G.: Discriminative stimulus properties of levo-alpha-acetylmethadol and its metabolites. Pharmacol. Biochem. Behav. 10: 565-568, 1979.
12. HOLTZMAN, S. G. AND VILLARREAL, J. E.: Operant behavior in the morphine-dependent rhesus monkey. J. Pharmacol. Exp. Ther. 184: 528-541, 1973.
13. JACOB, J. J. C., BARTHELEMY, C. D., TREMBLAY, E. C. AND COLOMBEL, M. L.: Potential usefulness of single-dose acute physical dependence on and tolerance to morphine for the evaluation of narcotic antagonists. In Narcotic antagonists. Advances in Biochemical Psychopharmacology, vol. 8, ed. by M. C. Braude, L. S. Harris, E. L. May, J. P. Smith and J. E. Villarreal, pp. 299-318, Raven Press, New York, 1974.
14. JAFFE, J. H., SCHUSTER, C. R., SMITH, B. B. AND BLACHLEY, P. H.: Comparison of acetylmethadol and methadone in the treatment of long-term heroin users. JAMA 211: 1834-1836, 1970.
15. JAFFE, J. H. AND SENAY, E. C.: Methadone and l-methadyl acetate: Use in management of narcotics addicts. JAMA 216: 1303-1305, 1971.
16. JAFFE, J. H., SENAY, E. C., SCHUSTER, C. R., RENAULT, P. R., SMITH, B. AND DIMENZA, S.: Methadyl acetate vs methadone: A double-blind study in heroin users. JAMA 222: 431-442, 1972.
17. KOSTEN T. R.: Current pharmacotherapies for opioid dependence. Psychopharmacol. Bull. 26: 69-74, 1990.
18. LING, W., RAWSON, R. A. AND COMPTON, M. A.: Substitution pharmacotherapies for opioid addiction: From methadone to LAAM and buprenorphine. J. Psychoactive Drugs 26: 119-128, 1994.
19. MCGIVNEY, W. T. AND MCMILLAN, D. E.: The effects of acetylmethadol on motor activity and schedule-controlled responding. Pharmacol. Biochem. Behav. 10: 261-265, 1979.
20. MCGIVNEY, W. T. AND MCMILLAN D. E.: The effects of levo-α-acetylmethadol and its metabolites on schedule-controlled behavior in the pigeon. J. Pharmacol. Exp. Ther. 216: 299-305, 1981.
21. MCMILLAN, D. E. AND BROCCO, M.: Modification of drug effects by l-α-acetylmethadol. Pharmacol. Biochem. Behav. 20: 543-546, 1984.
22. MCMILLAN, D. E., WOLF, P. S. AND CARCHMAN, R. A.: Antagonism of the behavioral effects of morphine and methadone by the narcotic antagonists in the pigeon. J. Pharmacol. Exp. Ther. 175: 443-458, 1970.
23. OLIVETO, A. H., PICKER, M. J. AND DYKSTKA, L. A.: Acute and chronic morphine administration: Effects of mixed-action opioids in rats and squirrel monkeys responding under a schedule of food presentation. J. Pharmacol. Exp. Ther. 257: 8-18, 1991.
24. PICKER, M. J. AND DYKSTRA, L. A.: Discriminative stimulus effects of mu and kappa opioids in the pigeon: Analysis of the effects of full and partial mu and kappa agonists. J. Pharmacol. Exp. Ther. 249: 557-566, 1989.
25. PICKER, M. J., NEGUS, S. S. AND POWELL, K. R.: Differential cross-tolerance to mu and kappa opioid agonists in morphine-tolerant rats responding under a schedule of food presentation. Psychopharmacology 103: 129-135, 1991.
26. PICKER, M. J. AND YARBROUGH, J.: Cross-tolerance and enhanced sensitivity to the response rate-decreasing effects of opioids with varying degrees of efficacy at the mu receptor. Psychopharmacology 105: 459-466, 1991.
27. SMITH, J. B.: Prevention by naltrexone of tolerance to the rate-decreasing effects of morphine on schedule-controlled responding in the pigeon. Psychopharmacology 63: 49-54, 1979.
28. TENNANT, F. S., RAWSON, R. A., PUMPHREY, E. AND SEECOF, R.: Clinical experiences with 959 opioid-dependent patients treated with levo-alpha-acetylmethadol (LAAM). J. Substance Abuse Treatment 3: 195-202, 1986.
29. WHITE-GBADEBO, D. AND HOLTZMAN, S. G.: Acute sensitization to opioid antagonists. Pharmacol. Biochem. Behav. 47: 559-566, 1994.
30. YANO, I. AND TAKEMORI, A. E.: Inhibition by naloxone of tolerance and dependence in mice treated acutely and chronically with morphine. Res. Commun. Chem. Pathol. Pharmacol. 16: 721-734, 1977.
31. YOUNG, A. M.: Effects of acute morphine pretreatment on the rate-decreasing and antagonist activity of naloxone. Psychopharmacology 88: 201-208, 1986.
32. YOUNG, G. A., STEINFELS, G. F. AND KHAZAN, N.: Spontaneous vs. naloxone-induced abstinence in dependent rats self-administering l-alpha-acetylmethadol (LAAM) or morphine. Pharmacol. Biochem. Behav. 10: 585-589, 1979.