Exploring vascular nitric oxide in health and disease: The Goulstonian Lecture 1996

Journal of the Royal College of Physicians of London

Volumn 31, Issue 3, 1997, Pages 321-327

  Vallance, Patrick ^a  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLCHOLINE; ENDOTHELIUM DERIVED RELAXING FACTOR; GLYCERYL TRINITRATE; N(G) METHYLARGININE; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE INHIBITOR; NORADRENALIN; VASODILATOR AGENT;

ANIMAL TISSUE; AORTA; ARTICLE; ATHEROMA; BLOOD LEVEL; BLOOD VESSEL FUNCTION; DIABETES MELLITUS; ESSENTIAL HYPERTENSION; HUMAN; HYPERCHOLESTEROLEMIA; NONHUMAN; RABBIT; VASCULAR ENDOTHELIUM; VASODILATATION;

ANIMALS; ENDOTHELIUM, VASCULAR; HUMANS; NITRIC OXIDE; SEPSIS; SHOCK, SEPTIC; VASODILATION;

EID: 0030922633     PISSN: 00358819     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (24)

1. Lauder Brunton T. Medicine past and present. London: Macmillan, 1880.
2. Furchgott RF, Zawadzki JV. The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine. Nature 1980;288:373-6.
3. Collier J, Vallance P. EDRF is an endogenous vasodilator in man. Br J Pharmacol 1989;97:639-41.
4. Vallance P, Collier J. Biphasic response to acetylcholine in human veins: the role of the endothelium. Clin Sci 1990;78:101-4.
5. Palmer R, Ferrige A, Moncada S. Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factor. Nature 1987;327:524-6.
6. Palmer R, Ashton D, Moncada S. Vascular endothelial cells synthesize nitric oxide from L-arginine. Nature 1988;333:664-6.
7. Vallance P, Collier J, Moncada S. Nitric oxide synthesised from L-arginine mediates endothelium-dependent dilatation in human veins in vivo. Cardiovasc Res 1989;23:1053-7.
8. Vallance P, Patton S, Bhagat K, MacAllister R, et al. Direct measurement of nitric oxide in humans. Lancet 1995;346:153-4.
9. Vallance P, Collier J, Moncada S. Effects of endothelium-derived nitric oxide on peripheral arterial tone in man. Lancet 1989;ii:997-1000.
10. Haynes W, Noon J, Walker B, Webb D. Inhibition of nitric oxide synthesis increases blood pressure in healthy humans. J Hypertens 1993;11:1375-80.
11. G monomethyl-L-arginine in patients with hypertension: the nitric oxide dilator mechanism appears abnormal. J Hypertens 1992;10:1025-31.
12. Calver A, Collier J, Vallance P. Effects of L-NMMA in patients with treated hypertension. Cardiovasc Res 1994;28:1720-5.
13. Radomski M, Palmer R, Moncada S. Endogenous nitric oxide inhibits human platelet adhesion to vascular endothelium. Lancet 1987;ii:1057-8.
14. Cayatte A, Palacino J, Horten K, Cohen R. Chronic inhibition of nitric oxide production accelerates neointima formation and impairs endothelial function in hypercholesterolemic rabbits. Arterioscler Thromb 1994;14:753-9.
15. 2 does not contribute to impaired endothelium-dependent relaxation. Arterioscler Thromb 1994;14:746-52.
16. Wang X, Sim A, Badenhop R, McCredie R, Wilcken D. A smoking-dependent risk of coronary artery disease associated with a polymorphism of the endothelial nitric oxide synthase gene. Nat Med 1996;2:41-5.
17. Feelisch M, Noack E. Nitric oxide formation from nitrovasodilators occurs independently of haemoglobin or non-heme iron. Eur J Pharmacol 1987;142:465-9.
18. de Belder A, MacAllister R, Radomski M, Moncada S, Vallance P. Selective inhibition of platelet aggregation by nitrosoglutathione. Cardiovasc Res 1994;5:691-4.
19. Vallance P, Leone A, Calver A, Collier J, Moncada S. Accumulation of an endogenous inhibitor of nitric oxide synthesis in chronic renal failure. Lancet 1992;339:572-6.
20. MacAllister R, Whitley G, Parry H, Kimoto M, et al. Regulation of nitric oxide synthase by endogenous dimethylarginine. Br J Pharmacol 1996;119:1533-40.
21. Vallance P, Moncada S. The role of endogenous nitric oxide in human septic shock. New Horizons 1993;1:77-86.
22. Petros A, Bennett D, Vallance P. Effect of nitric oxide synthase inhibitors on hypertension in patients with septic shock. Lancet 1991;338:1557-8.
23. Petros A, Leone A, Moncada S, Bennett D, Vallance P. Effect of a nitric oxide synthase inhibitor in patients with septic shock: a randomised study. Cardiovasc Res 1994;28:34-9.
24. Bhagat K, Vallance P. The local venous responses to endotoxin in humans. Circulation 1996;94:490-7.