Flunitrazepam has an inverse agonistic effect on recombinant α6β2γ2-GABA(A) receptors via a flunitrazepam-binding site

Journal of Biological Chemistry

Volumn 272, Issue 18, 1997, Pages 11723-11727

  Hauser, Charlotte A E ^a   Wetzel, Christian H R ^a,b   Berning, Barbara ^a   Gerner, Franz M ^a   Rupprecht, Rainer ^a  

^a MAX PLANCK INSTITUTE OF PSYCHIATRY   (Germany)

^b RUHR UNIVERSITY BOCHUM   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

4 AMINOBUTYRIC ACID; 4 AMINOBUTYRIC ACID A RECEPTOR; 4 ETHYL 6,7 DIMETHOXY BETA CARBOLINE 3 CARBOXYLIC ACID METHYL ESTER; 4' CHLORODIAZEPAM; 8 AZIDO 5,6 DIHYDRO 5 METHYL 6 OXO 4H IMIDAZO[1,5 A][1,4]BENZODIAZEPINE 3 CARBOXYLIC ACID ETHYL ESTER; ALPRAZOLAM; BENZODIAZEPINE; BETA CARBOLINE 3 CARBOXYLIC ACID BUTYL ESTER; BROMAZEPAM; CHLORDIAZEPOXIDE; CLONAZEPAM; DIAZEPAM; FLUMAZENIL; FLUNITRAZEPAM; LORAZEPAM; N SEC BUTYL 1 (2 CHLOROPHENYL) N METHYL 3 ISOQUINOLINECARBOXAMIDE; NORDAZEPAM;

ARTICLE; BINDING AFFINITY; BINDING SITE; CHLORIDE CURRENT; DRUG BINDING; EMBRYO; GABAERGIC SYSTEM; HUMAN; HUMAN CELL; KIDNEY CELL; LIGAND BINDING; MEMBRANE ELECTROPHYSIOLOGY; NEUROPHARMACOLOGY; PRIORITY JOURNAL;

AFFINITY LABELS; AZIDES; BENZODIAZEPINES; BINDING SITES; BINDING, COMPETITIVE; CELL LINE; CHLORIDE CHANNELS; FLUNITRAZEPAM; GABA AGONISTS; GAMMA-AMINOBUTYRIC ACID; HUMANS; KIDNEY; KINETICS; MACROMOLECULAR SUBSTANCES; MEMBRANE POTENTIALS; RECEPTORS, GABA-A; RECOMBINANT PROTEINS; TRANSFECTION;

EID: 0030922588     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.272.18.11723     Document Type: Article

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