Donor-dependent and dose-dependent variations in the induction of T lymphocyte locomotion in a three-dimensional collagen matrix system by a mistletoe preparation (Iscador)

Anti-Cancer Drugs

Volumn 8, Issue SUPPL. 1, 1997, Pages

  Nikolai, G ^a   Friedl, P ^a,b   Werner, M ^c   Zanker K S ^a  

^a UNIVERSITY OF WITTEN HERDECKE   (Germany)

^b UNIVERSITY OF WÜRZBURG   (Germany)

^c Hiscia Institute   (Switzerland)

Author keywords

Collagen matrix; Locomotion; Mistletoe preparation; T lymphocyte

Indexed keywords

CD4 ANTIGEN; CD8 ANTIGEN; COLLAGEN; ISCADOR QUFRF; PLANT EXTRACT; UNCLASSIFIED DRUG;

CONCENTRATION RESPONSE; CONFERENCE PAPER; CONTROLLED STUDY; DONOR; HOST RESISTANCE; HUMAN; HUMAN CELL; LYMPHOCYTE MIGRATION; NORMAL HUMAN; PERIPHERAL LYMPHOCYTE; PRIORITY JOURNAL; T LYMPHOCYTE; TECHNIQUE; VISCUM ALBUM;

EID: 0030922039     PISSN: 09594973     EISSN: None     Source Type: Journal    
DOI: 10.1097/00001813-199704001-00014     Document Type: Conference Paper

References (12)

1. Salzer G, Hellan J, Babits R, Engelhard I, Günezler P, Die Mistel am Ludwig-Boltzmann-Instiut für klinische Onkologie. Dtsch Z Onkol 1987; 3: 59-63.
2. Kissel D. Misteltherapie. In: Kombinierte Tumortherapie: Grundlagen. Möglichkeiten und Grenzen adjuvanter Methoden. Edited by Wrba H, Stuttgart: Hippokrates Verlag: 1990.
3. Jurin M, Zarkovic N, Hrzenjak M, Ilic Z. Antitumorous and immunomodulatory effects of the Viscum album L. Preparation Isorel. Oncology 1993; 50: 393-398.
4. Stein G, Berg PA. Non-lectin component in a fermented extratct from Viscum album L. grown on pines induces proliferation of lymphocytes from healthy and allergic individuals in vitro. Eur J Clin Pharmacol 1994; 47: 33-38.
5. Hajto T. Immunomodulatory effects of Iscador: a Viscum album preparation. Oncology 1986; 43 (suppl 1): 51-65.
6. Hajto T, Hostanska K, Gabius H-J. Modulatory potency of the β-galactoside-specific lectin from mistletoe extract (Iscador) on the host defense system in vivo in rabbits and patients. Cancer Res 1989; 49: 4803-4808.
7. Friedl P, Noble PB, Zänker KS. Lymphocyte locomotion in three-dimensional collagen gels. Comparison of three quantitative methods for analysing cell trajectories. J Immunol Meth 1993; 165: 157-165.
8. Nikolai G, Friedl P, Werner M, Niggemann B, Zänker KS. Effect of a mistletoe extract (Iscador QuFrF) on viability and migratory behavior of human peripheral CD4+ and CD8+ T lymphocytes in three-dimensional collagen lattices. In vitro - Cellular and Developmental Biology (in press).
9. Jäggy C, Musielski H, Urech K, Schaller G. Quantitative determination of lectins in mistletoe preparations. Arzneim Forsch/ Drug Res 1995; 45: 905-909.
10. Mossmann TR, Cherwinsky H, Bond MW, Giedlin MA, Coffman RL. Two types of murine helper T cell clones. I. Definition according to profiles of lymphokine activities and secreted proteins. J Immunol 1986; 136: 2348-2357.
11. Romagnani S. Human Th1 and Th2 subsets: doubts no more. Immunol Today 1991; 12: 256-257.
12. high CD4+ and CD8+ lymphocytes in three-dimensional collagen lattices. Immunology 1994; 82: 617-624.