A selective inhibitor of arachidonate 5-lipoxygenase scavenging peroxide activator

Biochemical Pharmacology

Volumn 54, Issue 4, 1997, Pages 529-532

  Suzuki, Hiroshi ^a   Miyauchi, Daiji ^a   Yamamoto, Shozo ^a  

^a UNIVERSITY OF TOKUSHIMA   (Japan)

Author keywords

5 Lipoxygenase; Arachidonic acid; Coumaran; Cyclooxygenase; Leukotriene; Peroxide

Indexed keywords

ARACHIDONATE 5 LIPOXYGENASE; LIPOXYGENASE INHIBITOR; UNCLASSIFIED DRUG; YT 18;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; ENZYME INHIBITION; HUMAN; HUMAN CELL; LEUKEMIA CELL; LEUKOCYTE; MAST CELL LEUKEMIA; NONHUMAN; PRIORITY JOURNAL; RAT; SWINE; THROMBOCYTE;

ANIMALS; ANTIOXIDANTS; ARACHIDONATE 5-LIPOXYGENASE; ARACHIDONIC ACID; HUMANS; LEUKOTRIENES; LIPOXYGENASE INHIBITORS; PEROXIDES; RATS; SWINE;

EID: 0030921521     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-2952(97)00248-7     Document Type: Article

References (14)

1. Yamamoto S, Mammalian lipoxygenases: molecular structures and functions. Biochim Biophys Acta 1128: 117-131, 1992.
2. Smith WL and DeWitt D, Cyclooxygenases. In: Molecular Biology of the Kidney in Health and Disease Eds. Schlondorff D and Bonventre J, pp. 183-199. Marcel Dekker, Inc., 1994.
3. Samuelsson B, Leukotrienes: mediators of immediate hypersensitivity reactions and inflammation. Science 220: 568-575, 1983.
4. Ueda N, Kaneko S, Yoshimoto T and Yamamoto S, Purification of arachidonate 5-lipoxygenase from porcine leukocytes and its reactivity with hydroperoxyeicosatetraenoic acids. J Biol Chem 261: 7982-7988, 1986.
5. Riendeau D, Falgueyret JP, Nathaniel DJ, Rokach J, Ueda N and Yamamoto S, Sensitivity of immunoaffinity-purified porcine 5-lipoxygenase to inhibitors and activating lipid peroxides. Biochem Pharmacol 38: 2313-2321, 1989.
6. Furukawa M, Yoshimoto T, Ochi K and Yamamoto S, Biochim Biophys Acta 795: 458-465, 1984.
7. Suzuki H, Kishimoto K, Yoshimoto T, Yamamoto S, Kanai F, Ebina Y, Miyatake A and Tanabe T, Site-directed mutagenesis studies on the iron-binding domain and the determinant for the substrate oxygenation site of porcine leukocyte arachidonate 12-lipoxygenase. Biochim Biophys Acta 1210: 308-316, 1994.
8. Nakamura M, Ueda N, Kishimoto K, Yoshimoto T, Yamamoto S and Ishimura K, Immunocytochernical localization of platelet-type arachidonate 12-lipoxygenase in mouse blood cells. J Histochem Cytochem 43: 237-244, 1995.
9. Kühn H, Belkner J, Suzuki H and Yamamoto S, J Lipid Res 35: 1749-1759, 1994.
10. Lowry OH, Rosebrough NJ, Farr AL and Randall RJ, Protein measurement with the Folin phenol reagent. J Biol Chem 193: 265-275, 1951.
11. Ueda N, Yamashita R, Yamamoto S and Ishimura K, Biochim Biophys Acta 1344: 103-110, 1997.
12. Okamoto K, Imada I and Imamoto T, Effect of 6-(10-hydroxydecyl)-2, 3-dimethoxy-5-methyl-1,4-benzoquinone(CV-2619) on microsomal lipid peroxidation. Chem Pharm Bull (Tokyo) 34: 2821-2827, 1986.
13. Chamulitrat W, Mason RP and Riendeau D, Nitroxide metabolites from alkylhydroxylamines and N-hydroxyurea derivatives resulting from reductive inhibition of soybean lipoxygenase. J Biol Chem 267: 9574-9579, 1992.
14. Kemal C, Louis-Flamberg P, Krupinski-Olsen R and Shorter AL, Reductive inactivation of soybean lipoxygenase 1 by catechols: a possible mechanism for regulation of lipoxygenase activity. Biochemistry 26: 7064-7072, 1987.