Synthetic polypeptides corresponding to the non-repeat regions from the circumsporozoite protein of Plasmodium falciparum: Recognition by human T-cells and immunogenicity in owl monkeys

Annals of Tropical Medicine and Parasitology

Volumn 91, Issue 3, 1997, Pages 253-265

  Lopez J A ^a   Gonzalez J M ^b   Kettner, A ^a   Arevalo Herrera M ^b   Herrera, S ^b   Corradin, G ^a   Roggero, M A ^a  

^a UNIVERSITY OF LAUSANNE   (Switzerland)

^b UNIVERSIDAD DEL VALLE   (Colombia)

Author keywords

[No Author keywords available]

Indexed keywords

MALARIA VACCINE; SPOROZOITE VACCINE; SYNTHETIC PEPTIDE;

ADULT; AMINO TERMINAL SEQUENCE; ANTIBODY DETECTION; ARTICLE; CARBOXY TERMINAL SEQUENCE; CONTROLLED STUDY; ENDEMIC DISEASE; FEMALE; IMMUNOGENICITY; MALE; MONKEY; NONHUMAN; NORMAL HUMAN; PLASMODIUM FALCIPARUM; PROTEIN STRUCTURE; SPOROZOITE; T LYMPHOCYTE ACTIVATION;

EID: 0030921048     PISSN: 00034983     EISSN: None     Source Type: Journal    
DOI: 10.1080/00034983.1997.11813139     Document Type: Article

References (43)

1. BALLOU, W. R., HOFFMAN, S. L., SHERWOOD, J. A., HOLLINGDALE, M. R., NEVA, F. A., HOCKMEYER, W. T., GORDON, D., SCHNKIDKR, I., WIRTZ, R. A., YOUNG, J. F., WASSERMAN, G. F., REEVK, P., DIGGS, C. L. & CHULAY, J. D. (1987). Safety and efficacy of a recombinant DNA Plasmodium falciparum sporozoite vaccine. Lancet, i, 1277-1281.
2. BLUM-TIROUVANZIAM, U., BEGHDADI-RAIS, C., ROGGERO, M. A., VALMORI, D., BERTHOLET, S., BRON, C., FASEL, N. & CORRADIN, G. (1995). Elicitation of specific cytotoxic T cells by immunization with malaria soluble synthetic polypeptides. Journal of Immunology, 153, 4134-4141.
3. BROWN, A. E., SINGHARAJ, P., WEBSTER, H. K., PIPITHKUL, J., GORDON, D. M., BOSLEGO, J. W., KRINCHAI, K., SU-ARCHAWARATANA, P., WONGSRICHANALAI, C., BALLOU, W. R., PERMPANICH, B., KAIN, K. C., HOLLINGDALE, M. R., WITTES, J., QUE, J. U., GROSS, M., CRYZ, S. J. & SADOFF, J. C. (1994). Safety, immunogenicity and limited efficacy study of a recombinant Plasmodium falciparum circumsporozoite vaccine in Thai soldiers. Vaccine, 12, 102-108.
4. CALVO-CALLE, J. M., OLIVEIRA, G. A. D., CLAVIJO, P., MARACIC, M., TAM, J. P., LU, Y. A., NARDIN, E. H., NUSSENZWEIG, R. S. & COCHRANE, A. H. (1993). Immunogenicity of multiple antigen peptides containing B and non-repeated T cell epitopes of the circumsporozoite protein of Plasmodium falciparum. Journal of Immunology, 150, 1403-1412.
5. CLYDE, D. F., MOST, H., MCCARTHY, V. C. & VANDERBERG, J. P. (1973). Immunization of man against sporozoite-induced falciparum malaria. American Journal of the Medical Sciences, 266, 169-177.
6. CURRIER, J. J., SATTABONGKOT, J. & GOOD, M. F. (1992). 'Natural' T cells for malaria: evidence of highly sensitive malaria-specific responses from non-exposed donors. International Immunology, 4, 985-994.
7. DEL GIUDICE, G., CHENG, Q., MAZIER, D., BERBIGUIER, N., COOPER, J. A., ENGERS, H. D., CHIZZOLINI, C., VERDINI, A. A., BONELLI, F., PESSI, A. & LAMBERT, P.-H. (1988). Immunogenicity of a non-repetitive sequence of Plasmodium falciparum circumsporozoite protein in man and mice. Immunology, 63, 187-191.
8. DOOLAN, D. L., HOUGHTEN, R. A. & GOOD, M. F. (1991). Location of human cytotoxic T cell epitopes within a polymorphic domain of the Plasmodium falciparum circumsporozoite protein. International Immunology, 3, 511-516.
9. DOOLAN, D. L., BECK, H. P. & GOOD, M. F. (1994). Evidence for limited activation of distinct CD4+ T cell subsets in response to the Plasmodium falciparum circumsporozoite protein in Papua New Guinea. Parasite Immunology, 16, 129-136.
10. ETLINGER, H., FELIX, A. M., GILLESSEN, D., HEIMER, E. P., JUST, M., PINK, J. R. L., SINIGAGLIA, F., STÜRCHLER, D., TAKACS, B., TRZECIAK, A. & MATILE, H. (1988). Assessment in humans of a synthetic peptide-based vaccine against the sporozoite stage of the human malaria parasite, Plasmodium falciparum. Journal of Immunology, 140, 626-633.
11. GOOD, M. F., BERZOFSKY, J. A., MALOY, W. L., HAYASHI, Y., FUJII, N., HOCKMEYER, W. T. & MILLER, L. (1986). Genetic control of the immune response in mice to a Plasmodium falciparum sporozoite vaccine. Widespread nonresponsiveness to single malaria T epitope in highly repetitive vaccine. Journal of Experimental Medicine, 164, 655-660.
12. GOOD, M. F., MILLER, L. H., KUMAR, S., QUAKYI, I. A., KEISTER, D., ADAMS, J. H., Moss, B., BERZOFSKY, J. A. & CARTER, R. (1988a). Limited immunological recognition of critical malaria vaccine candidate antigens. Science, 242, 574-577.
13. GOOD, M. F., POMBO, D., QUAKI, I. A., RILEY, E. M., HOUGHTEN, R. A., MENON, A., ALLING, D. W., BERZOFSKY, J. A. & MILLER, L. H. (1988b). Human T-cell recognition of the circumsporozoite protein of Plasmodium falciparum: immunodominant T-cell domains map to the polymorphic regions of the molecule. Proceedings of the National Academy of Sciences of the United States of America, 85, 1199-1203.
14. GOOD, M. F., ZEVERING, Y., CURRIER, J. & BILSBOROUGH, J. (1993). 'Original antigenic sin', T cell memory, and malaria sporozoite immunity: an hypothesis for immune evasion. Parasite Immunology, 15, 187-193.
15. GORDON, D. M., MCGOVERN, T. W., KRZYCH, U., COHEN, J. C., SCHNEIDER, I., LACHANCE, R., HEPPNER, D. G., YUAN, G., HOLLINGDALE, M., SLAOUI, M., HAUSER, P., VOET, P., SADOFF, J. C. & BALLOU, W. R. (1995). Safety, immunogenicity, and efficacy of a recombinantly produced Plasmodium falciparum circumsporozoite protein-hepatitis B surface antigen subunit vaccine. Journal of Infectious Diseases, 171, 1576-1585.
16. GUTTINGER, M., CASPERS, P., TAKACS, B., TRZECIAK, A., GILLESSEN, D., PINK, J. R. & SINIGAGLIA, F. (1988). Human T cells recognize polymorphic and non-polymorphic regions of the Plasmodium falciparum circumsporozoite protein. EMBO Journal, 7, 2555-2558.
17. HERRINGTON, D. A., CLYDE, F. F., LOSONDKY, G., CORTESIA, M., MURPHY, F. R., DAVIS, J., BAQAR, A., FELIX, A. M., HEIMER, E. P., GILLESSEN, D., NARDIN, E. H., NUSSENZWEIG, R. S., NUSSENZWEIG, V., HOLLINGDALE, M. R. & LEVINE, M. M. (1987). Safety and immunogenicity in man of a synthetic peptide malaria vaccine against Plasmodium falciparum sporozoites. Nature, 328, 257-259.
18. HOFFMAN, S. L., EDELMAN, R., BRYAN, J. P., SCHNEIDER, I., DAVIS, J., SEDEGAH, M., GORDON, D., CHURCH, P., GROSS, M., SILVERMAN, C., HOLLINGDALE, M., CLVDE, D., SZTEIN, M., LOSONSKY, G., PAPARELLO, S. & JONES, T. R. (1994). Safety, immunogenicity, and efficacy of a malaria sporozoite vaccine administered with monophosphoryl lipid A, cell wall skeleton of mycobacteria, and squalane as adjuvant. American Journal of Tropical Medicine and Hygiene, 51, 603-612.
19. HOFFMAN, S. L., FRANKE, K. D., HOLLINGDALE, M. R. & DRUILHE., P. (1996). Attacking the infected hepatocyte. In Malaria Vaccine Development. A Multi-immune Response Approach, ed. Hoffman, S. L. pp. 35-75. Washington, DC: American Society for Microbiology.
20. KRZYCH, U., LYON, J. A., JAREED, T., SCHNEIDER, I., HOLLINGDALE, M. R., GORDON, D. M. & BALLOU, W. R. (1995). T lymphocytes from volunteers immunized with irradiated Plasmodium falciparum sporozoites recognize liver and blood stage malaria antigens. Journal of Immunology, 155, 4072-4077.
21. LALVANI, A., HURT, N., AIDOO, M., KIBATALA, P., TANNER, M. & HILL, A. V. S. (1996). Cytotoxic lymphocytes to Plasmodium falciparum epitopes in an area of intense and perennial transmission in Tanzania. European Journal of Immunology, 26, 773-779.
22. LÓPEZ, J. A., GONZȦLEZ, J. M., TOLLK, R., RENGGLI., J., EBERI., G., BETSCHART, B., BUJARD, H., DOUMHO, O., ARÉVALO, M., HERRERA, S., CORRADIN, G. & ROGGERO., M. A. (1996a). Immunogenicity of synthetic peptides corresponding to the non-repeated regions of the Plasmodium falciparum circumsporozoite protein. In Vaccines 96, pp. 255-260. Cold Spring Harbor, NY: Cold Spring Harbor Laboratory Press.
23. LÓPEZ, J. A., ROGGERO, M. A., GONZÁLEZ, J. M., TOLLE, R., DOUMBO, O., ARÉVALO, M., HERRERA, S. & CORRADIN, G. (1996b). Recognition of synthetic 104-mer and 102-mer peptides corresponding to N- and C-terminal non-repeated regions of the Plasmodium falciparum circumsporozoite protein by sera from human donors. American Journal of Tropical Medicine and Hygiene, 55, 424-429.
24. MALIK, A., EGAN, J. E., HOUGHTEN, R. A., SADOFF, J. C. & HOFFMAN, S. L. (1991). Human eytotoxic T lymphocytes against the Plasmodium falciparum circumsporozoite protein. Proceedings of the National Academy of Sciences of the United States of America, 88, 3300-3304.
25. MIGLIORINI, P., BETSCHART, B. & CORRADIN, G. (1993). Malaria vaccine: immunization of mice with a synthetic T cell helper epitope alone leads to protective immunity. European Journal of Immunology, 23, 582-585.
26. MORENO, A., GLAVIJO, P., EDELMAN, R., DAVIS, J., SZTEIN, M., SINIGAGLIA, F. & NARDIN, L. (1993). CO4+ T cell clones obtained from Plasmodium falciparum sporoxoite-immunized volunteers recognize polymorphic sequences of the circumsporozoite protein. Journal of Immunology, 151, 489-499.
27. NARDIN, E. H. & NUSSENZWEIG, R. S. (1993). T cell responses to pre-erythrocytic stages of malaria: role in protection and vaccine development. Annual Review of Immunology, 11, 687-727.
28. NUSSENZWEIG, R. S., VANDERBERG, J., MOST, H. & ORTON, C. (1967). Protective immunity produced by the injection of X-irradiated sporozoites of Plasmodium berghei. Nature, 216, 160-162.
29. POTOCNJAK, P., YOSHIDA, N., NUSSENZWEIG, R. S. & NUSSENZWEIG, V. (1980). Monovalent fragments (Fab) of monoclonal antibodies to a sporozoite surface antigen (Pb44) protect mice against malaria infection. Journal of Experimental Medicine, 151, 1504-1513.
30. RENGGLI, J., VALMORI, D., ROMERO, J. F., EBERL, G., ROMERO, P., BETSCHART, B. & CORRADIN, G. (1995). CD8+ T-cell protective immunity induced by immunization with Plasmodium berghei CS proteinderived synthetic peptides: evidence that localization of peptide-specific CTLs is crucial for protection against malaria. Immunology Letters, 46, 199-205.
31. RIECKMANN, K. H., GARSON, P. E., BEAUUDOIN, R. L., CASSELLS, J. S. & SKLL, K. W. (1974). Sporozoite induced immunity in man against an Ethiopian strain of Plasmodium falciparum. Transactions of the Royal Society of Tropical Medicine and Hygiene, 68, 258-259.
32. RILEY, E. M., OLERUP, O., BENNETT, S., ROWE, P., ALLEN, S. J., BLACKMAN, M. J., TROVE-BLOMBERG, M., HOLDER, A. A. & GREENWOOD, B. M. (1992). MIIC and malaria: the relationship between HLA class II alleles and immune responses to Plasmodium falciparum. International Immunology, 4, 1055-1063.
33. ROGGERO, M. A., FILIPPI, B., CHURCH, P., HOFFMAN, S. L., BLUM-TIROUVANZIAM, U., LÓPEZ, J. A., ESPOSITO, F., MATILE, H., REYMOND, C. D., FASEL, N. & CORRADIN, G. (1995). Synthesis and immunological characterization of 104-mer and 102-mer peptides corresponding to the N- and C-terminal regions of the Plasmodium falciparum CS protein. Molecular Immunology, 32, 1301-1309.
34. ROMERO, P., MARYANSKI, J. L., CORRADIN, G., NUSSENZWEIG, R. S., NUSSENZWEIG, V. & ZAVALA, F. (1989). Cloned cytotoxic T cells recognize an epitope in the circumsporozoite protein and protect against malaria. Nature, 341, 323-325.
35. SINIGAGLIA, F., GUTTINGER, M., GILLESSEN, D., DORAN, D. M., TAKACS, B., MATILE, H., TRZECIAK, A. & PINK, J. R. (1988). Epitopes recognized by human T lymphocytes on malaria circumsporozoite protein. European Journal of Immunology, 18, 633-636.
36. STÜRCHLER, D., BERGER, R., RUDIN, C., JUST, M., SAUL, A., RZEPCZYK, C., BROWN, G., ANDERS, R., COPPEL, R., WOODROW, G., PYE, D., SORENSON, F., GILLESSEN, D., MATILE, H. & REBER-LISKE, R. (1995). Safety, immunogenicity and pilot efficacy of Plasmodium falciparum sporozoite and asexual blood stage combination vaccine in Swiss adults. American Journal of Tropical Medicine and Hygiene, 53, 423-431.
37. TSUJI, M., MOMBAERTS, P., LEFRANCOIS, L., NUSSENZWEIG, R. S., ZAVALA, F. & TONEGAWA, S. (1994). γδ T cells contribute to immunity against the liver stages of malaria in αβ T-cell-deficient mice. Proceedings of the National Academy of Sciences of the United States of America, 91, 345-349.
38. VALMORI, D., PESSI, A., BIANCHI, E. & CORRADIN, G. (1992). Use of human universally antigenic tetanus toxin T cell epitopes as carriers for human vaccination. Journal of Immunology, 149, 225-232.
39. WANG, L. F., LIN, J. Y., HSIEH, K. H. & LIN, R. H. (1996). Epicutaneous exposure of protein antigen induces a predominant Th2-like response with high Ig E production in mice. Journal of Immunology, 156, 4079-4082.
40. WANG, R., CHAROENVIT, Y., CORRADIN, G., PORROZZI, R., HUNTER, R. L., GLENN, G., ALVING, C. R., CHURCH, P. & HUFFMAN, S. L. (1995). Induction of protective polyclonal antibodies by immunization with a Plasmodium yoelii circumsporozoite protein multiple antigen peptide vaccine. Journal of Immunology, 154, 2784-2793.
41. WEISS, W. R., MELLOUK, S., HOUGHTEN, R. A., SEDEGAH, M., KUMAR, S., GOOD, M. F., BEZORFSKY, J. A., MILLER, L. H. & HOFFMAN, S. L. (1990). Cytotoxic T cells recognize a peptide from the circumsporozoite protein on malaria-infected hepatocytes. Journal of Experimental Medicine, 171, 763-773.
42. ZEVERING, Y., HOUGHTEN, R. A., FRAZER, I. H. & GOOD, M. F. (1990). Major population differences in T cell response to a malaria sporozoite vaccine candidate. International Immunology, 2, 945-955.
43. ZEVERING, Y., KHAMBOONRUANG, C., RUNDGRUENTHANAKIT, K., TUNGVIBOONCHAI, L., RUENGPIPATTANAPAN, J., BATHURST, I., BARR, P. & GOOD, M. F. (1994). Life-spans of human T-cell response to determinants from the circumsporozoite proteins of Plasmodium falciparum and Plasmodium vivax. Proceedings of the National Academy of Sciences of the United States of America, 91, 6118-6122.