Budesonide, a locally acting steroid, prevents graft rejection in a rat model of intestinal transplantation

Transplantation

Volumn 63, Issue 9, 1997, Pages 1220-1225

  Ozcay, Necdet ^c   Fryer, Jonathan ^a   Grant, David ^c   Freeman, David ^c   Garcia, Bertha ^c   Zhong, Robert ^b  

^a NORTHWESTERN UNIVERSITY   (United States)

^b LONDON HEALTH SCIENCES CENTRE   (Canada)

^c NONE

Author keywords

[No Author keywords available]

Indexed keywords

BUDESONIDE; CORTICOTROPIN; CYCLOSPORIN A; METHYLPREDNISOLONE; STEROID;

ADRENAL GLAND; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; GRAFT REJECTION; GRAFT SURVIVAL; IMMUNOSUPPRESSIVE TREATMENT; INTESTINE TRANSPLANTATION; LYMPHOPROLIFERATIVE DISEASE; MALE; NONHUMAN; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL; RAT; SPLEEN WEIGHT; SUBCUTANEOUS DRUG ADMINISTRATION;

ADRENOCORTICOTROPIC HORMONE; ANIMALS; BUDESONIDE; CYCLOSPORINE; DISEASE MODELS, ANIMAL; GRAFT REJECTION; GRAFT SURVIVAL; IMMUNOSUPPRESSIVE AGENTS; INTESTINES; MALE; PREGNENEDIONES; RATS; RATS, INBRED BN; RATS, INBRED LEW;

EID: 0030920831     PISSN: 00411337     EISSN: None     Source Type: Journal    
DOI: 10.1097/00007890-199705150-00006     Document Type: Article

References (37)

1. Asfar S, Zhong R, Grant D. Small bowel transplantation. Surg Clin North Am 1994; 74: 1197.
2. Fryer JP, Granger DK, Leventhal JR, et al. Steroid-related complications in the cyclosporine era. Clin Transplant 1994; 8: 224.
3. Morris PJ, French ME, Chan L, Ting A. Low dose oral prednisolone in renal transplantation. Lancet 1982; 6: 525.
4. Punch JD, Shieck VL, Campbell DA, et al. Corticosteroid withdrawal after liver transplantation. Surgery 1995; 118: 783.
5. McGeown GM, Douglas JF, Brown WA, et al. Advantages of low dose steroid from the day after renal transplantation. Transplantation 1979; 29: 287.
6. Orta-Sibu N, Chantier C, Bewick M, Haycock G. Comparison of high-dose methylprednisolone with low-dose oral prednisolone in acute renal allograft rejection in children. Br Med J 1982; 285: 258.
7. Salaman JR. Influence of steroid dosage on the survival of cardiac allografts in the rat. Transplantation 1983; 35: 510.
8. Heublein B, Wahlers T, Haverich A. Pulsed steroids for treatment of cardiac rejection after transplantation. Circulation 1989; 80: 97.
9. Sinclair NR. Low dose steroid therapy in cyclosporine-treated renal transplant recipients with well-functioning grafts: the Canadian Multicentre Transplant Study Group. Can Med Assoc J 1992; 147: 613.
10. Chanoine F, Grenod C, Heidmann P, Junien JL. Pharmacokinetics of butixocort 21- propionate, budesonide, and beclomethasone dipropionate in the rat after intratracheal, intravenous, and oral treatments. Drug Metab Dispos 1991; 19: 546.
11. Brattsand RL. Steroid development: a case of enhanced selectivity for the bowel wall. Res Clin Forums 1993; 15: 17.
12. Brattsand RL. Overview of newer glucocorticosteroid preparations for inflammatory bowel disease. Can J Gastroenterol 1990; 4: 407.
13. Canadian Council on Animal Care. Guide to the care and use of experimental animals, Vol. 1. Ottawa: Bradda Printing Services, Inc., 1993.
14. Zhong R, Wang P, Chen H, et al. Surgical technique for orthotopic intestinal transplantation in rat. Transplant Proc 1990; 22: 2443.
15. Gill TJ III, Kunz HW, Dhirendra NM, et al. The major histocompatibility complex of the rat. Transplantation 1987; 43: 773.
16. Gustafsson B, Persson CGA. Allergen-induced mucosal exudation of plasma into rat ileum and its inhibition by budesonide. Scand J Gastroenterol 1992; 27: 587.
17. Garcia B, Zhong R, Wijsman J, et al. Pathological changes following intestinal transplantation in the rat. Transplant Proc 1989; 22: 2469.
18. Rutgeerts P, Lofberg R, Malchow H, et al. A comparison of budesonide with prednisolone for active Crohn's disease. N Engl J Med 1994; 331: 842.
19. Greenberg GR, Feagan BG, Martin F, et al. Oral budesonide for active Crohn's disease. N Engl J Med 1994; 331: 836.
20. Brodgen RN, McTavish D. Budesonide: an updated review of its pharmacological properties, and therapeutic efficacy in asthma and rhinitis. Drugs 1992; 44: 375.
21. Cui N, Friend DR, Fedorak RN. A budesonide prodrug accelerates treatment of colitis in rats. Gut 1994; 35: 1439.
22. Johansson SA, Andersson KE, Brattsand R, et al. Topical and systemic glucocorticoid potencies of budesonide and beclomethasone dipropionate in man. Eur J Clin Pharmacol 1982; 22: 523.
23. Ruers TJM, Daemen MJAP, Thijssen HHW, et al. Sensitivity of graft rejection in rats to local immunosuppressive therapy. Transplantation 1988; 46: 820.
24. Ruers TJM, Buurman W, Daemen MJAP, et al. Local budesonide treatment of rat cardiac allografts results in effective immunosuppression without systemic immunological side effects. Transplant Proc 1990; 22: 1998.
25. Ruers TJM, Buurman W, Van der Linden CJ. Graft rejection can be treated effectively by local immunosuppression. Transplant Proc 1989; 21: 1127.
26. Kahan BD, Ghobrial R. Immunosuppressive agents. Surg Clin North Am 1994; 74(5): 1029.
27. Guengerich PF. Human cytochrome P450 enzymes. In: Ortiz de Montellano PR, ed. Cytochrome P450, 2nd ed. New York: Plenum Press, 1994: 473.
28. Jonsson G, Astrom A, Andersson P. Budesonide is metabolized by cytochrome P450 3A (CYP3A) enzymes in human liver. Drug Metab Dispos 1995; 23: 137.
29. Langhoff E, Madsen S, Flachs H, et al. Inhibition of prednisolone metabolism by cyclosporine in kidney-transplanted patients. Transplantation 1985; 39: 107.
30. Ost L, Klintmalm G, Ringden O. Mutual interaction between prednisolone and cyclosporine in renal transplant patients. Transplant Proc 1985; 17: 1252.
31. Henricsson S, Lindholm A. Inhibition of cyclosporine metabolism by other drugs in vitro. Transplant Proc 1988; 20: 569.
32. Klintmalm G, Sawe J. High dose methylprednisolone increases plasma cyclosporin levels in renal transplant recipients. Lancet 1984; 1: 731.
33. Rogerson ME, Marsden JT, Reid KE, et al. Cyclosporine blood concentrations in the management of renal transplant recipients. Transplantation 1986; 41: 276.
34. Grant D, Zhong R, Gunn H, et al. Graft-versus-host disease associated with intestinal transplantation in the rat. Transplantation 48: 545, 1989.
35. Schlaghecke R, Kornely E, Santen R, et al. The effect of long-term glucocorticoid therapy on pituitary-adrenal responses to exogenous corticotropin-releasing hormone. N Engl J Med 1992; 326: 226.
36. Ryrfeldt A, Andersson P, Edsbacker S, et al. Pharmacokinetics of and metabolism of budesonide, a selective glucocorticoid. Eur J Respir Dis 1982; 63: 86.
37. Grant D, Zhong R, Hurlbut D, et al. A comparison of heterotopic and orthotopic intestinal transplantation in rats. Transplantation 51; 948, 1991.