Apoptosis and proliferation of fibroblasts during postnatal skin development and scleroderma in the tight-skin mouse

Journal of Histochemistry and Cytochemistry

Volumn 45, Issue 5, 1997, Pages 711-719

  Pablos, José L ^a   Carreira, Patricia E ^a   Serrano, Lourdes ^a   Del Castillo, Pedro ^b   Gomez Reino, Juan J ^a  

^a HOSPITAL UNIVERSITARIO 12 DE OCTUBRE   (Spain)

^b UNIVERSIDAD AUTÓNOMA DE MADRID   (Spain)

Author keywords

apoptosis; Bcl 2; fibroblast; PCNA; proliferation; scleroderma; skin; TUNEL

Indexed keywords

PROCOLLAGEN; PROTEIN BCL 2;

APOPTOSIS; ARTICLE; CONTROLLED STUDY; FIBROBLAST; FIBROSIS; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; POSTNATAL DEVELOPMENT; PRIORITY JOURNAL; SCLERODERMA; SKIN; TRANSCRIPTION REGULATION;

SCLERODERMA;

EID: 0030920251     PISSN: 00221554     EISSN: None     Source Type: Journal    
DOI: 10.1177/002215549704500509     Document Type: Article

References (35)

1. Bailey AJ, Black CM (1988) The role of connective tissue in the pathogenesis ofscleroderma. In Jayson MIV, Black CM, eds. Systemic Sclerosis: Scleroderma. New York, John Wiley & Sons, 75-105
2. Botstein GR, Sherer GK, LeRoy EC (1982) Fibroblast selection in scleroderma: an alternative model of fibrosis. Arthritis Rheum 25:189-195
3. Bruce SA, Deamond SF, Tsó POP (1986) In vitro senescence of Syrian hamster mesenchymal cells of fetal to aged adult on origin. Inverse relationship between in vivo donor age and in vitro proliferative capacity. Mech Ageing Dev 34:151-173
4. Chang CD, Phillips P, Lipson KE, Cristofalo VJ, Baserga R (1991) Senescent human fibroblasts have a post-transcriptional block in the expression of the proliferating cell nuclear antigen gene. J Biol Chem 266:8663-8666
5. Evan GI, Wyllie AH, Gilbert CS, Littlewood TD, Land H, Brooks M, Waters CM, Penn LZ, Hancock DC (1992) Induction of apoptosis in fibroblasts by c-myc protein. Cell 69:119-128
6. Fleischmajer R, Perlish JS, Krieg T, Timpl R (1981) Variability in collagen and fibronectin synthesis by scleroderma fibroblasts in primary cultures. J Invest Dermatol 76:400-403
7. Gavrieli Y, Sherman Y, Ben-Sasson SA (1992) Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation. J Cell Biol 119:493-501
8. Goldring SR, Stevenson ML, Downie E, Krane SM, Korn JH (1990) Heterogeneity in hormone responses and patterns of collagen synthesis in cloned dermal fibroblasts. J Clin Invest 85:798-803
9. Green MC, Sweet HO, Bunker HE (1976) Tight skin, a new mustation of the mouse causing excessive growth of connective tissue and skeleton. Am J Pathol 82:493-507
10. Hoang AT, Cohen KH, Barret JF, Bergstrom DA, Dang CV (1994) Participation of cyclin A in Myc-induced apoptosis. Proc Natl Acad Sci USA 91:6875-6879
11. Hockenbery DM, Zutter M, Hickey W, Nahm M, Korsmeyer SJ (1991) BCL2 protein is topographically restricted in tissues characterized by apoptotic cell death. Proc Natl Acad Sci USA 88: 6961-6965
12. Ignotz RA, Endo T, Massagué J (1987) Regulation of fibronectin and type I collagen mRNA levels by transforming growth factor-β. J Biol Chem 262:6443-6446
13. Ishikawa O. LeRoy EC, Trojanowska M (1990) Mitogenic effect of transforming growth factor β1 on human fibroblasts involves the induction of platelet-derived growth factor a receptors. J Cell Physiol 145:181-186
14. Jimenez SA, Williams CH, Myers JC, Bashey RI (1986) Increased collagen biosynthesis and increased expression of type I and type III procollagen genes in tight skin (Tsk) mouse fibroblasts. J Biol Chem 261:657-662
15. Jimenez SA (1988) Experimental models of scleroderma. In Jayson MIV, Black CM, eds. Systemic Sclerosis: Scleroderma. New York, John Wiley & Sons, 119-132
16. Kahari VM, Sandberg M, Kalimo H, Vuorio T, Vuorio F (1988) Identification of fibroblasts responsible for increased collagen production in localized scleroderma by in situ hybridization. J Invest Dermatol 90:664-670
17. Kahari VM, Vuorio T, Nanto-Salonen K, Vuorio L (1984) Increased type I collagen mRNA levels in cultured scleroderma fibroblasts. Biochim Biophys Acta 781:183-186
18. Korn JH, Torres D, Downie E (1983) Fibroblast prostaglandin E2 synthesis. Persistence of an abnormal phenotype after short-term exposure to mononuclear cell products. J Clin Invest 71:1240-1246
19. Leof EB, Proper JA, Goustin AS, Shipley GD, DiCorleto PE, Moses HC (1986) Induction of c-sis mRNA and platelet-derived growth factor-like activity by transforming growth factor type β: a proposed model for indirect mitogenesis involving autocrine activity. Proc Natl Acad Sci USA 83:2453-2457
20. LeRoy EC (1974) increased collagen synthesis by scleroderma skin fibroblasts in vitro. J Clin Invest 54:880-889
21. LeRoy EC, Mercurio S, Sherer GK (1982) Replication and phenotypic expression of control and scleroderma human fibroblasts: responses to growth factors. Proc Natl Acad Sci USA 79:1286-1290
22. Martin GM, Sprague CA, Epstein CJ (1970) Replicative life-span of cultivated human cells: effects of donor's age, tissue, and genotype. Lab Invest 23:86-92
23. Needelman BW, Ordonez JV, Taramelli D, Alms W, Gayer K, Choi J (1990) In vitro identification of a subpopulation of fibroblasts that produces high levels of collagen in scleroderma patients. Arthritis Rheum 33:842-852
24. Pablos JL, Everett ET, Harley R, LeRoy EC, Norris JS (1995) Transforming growth factor-β1 and collagen gene expression during skin development and fibrosis in the Tsk mouse. Lab Invest 72:670-678
25. Philips N, Bashey RI, Jimenez SA (1995) Increased α1(I) procollagen gene expression in tight skin (TSK) mice myocardial fibroblasts is due to a reduced interaction of a negative regulatory sequence with AP-1 transcription factor. J Biol Chem 270:9313-9321
26. Polakowska RR, Piacentini M, Bartlett R, Goldsmith LA, Haake AR (1994) Apoptosis in human skin development: morphogenesis, periderm, and stem cells. Dev Dyn 199:176-188
27. Scharffetter K, Lankat-Buttgereit B, Krieg T (1988) Localization of collagen mRNA in normal and scleroderma skin by in situ hybridization. Eur J Clin Invest 18:9-17
28. Schneider EL, Mitsui Y (1976) The relationship between in vitro cellular aging and in vivo human age. Proc Natl Acad Sci USA 73:3584-3588
29. Siracusa LD, McGrath R, Ma Q, Moskow JJ, Manne J, Christner PJ, Buchberg AM, Jimenez SA (1996) A tandem duplication within the fibrillin 1 gene is associated with the mouse tight skin mutation. Genome Res 6:300-313
30. Stewart CA, Dell'Orcco RT (1992) Age related decline in the expression of proliferating cell nuclear antigen in human diploid fibroblasts. Mech Ageing Dev 66:71-80
31. Trojanowska M, Wu L, LeRoy EC (1988) Elevated expression of c-myc proto-oncogene in scleroderma fibroblasts. Oncogene 3: 477-481
32. Varga J, Rosenbloom J, Jimenez SA (1987) Transforming growth factor β (TGF-β) causes a persistent increase in steady state amount of type I and type III collagen and fibronectin mRNAs in normal dermal human fibroblasts. Biochem J 247:597-604
33. Wang E (1995) Senescent human fibroblasts resist programmed cell death, and failure to suppress bcl2 is involved. Cancer Res 55:2284-2292
34. Wu X, Levine AJ (1994) p53 and E2F cooperate to mediate apoptosis. Proc Natl Acad Sci USA 91:3602-3606
35. Yamakage A, Kikuchi K, Smith EA, LeRoy EC, Trojanowska M (1992) Selective upregulation of platelet-derived growth factor α receptors by transforming growth factor β in scleroderma fibroblasts. J Exp Med 175:1227-1234