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Benzylation under basic conditions such as NaH-benzyl halide in DMF or DMSO was not straightforward as migration of the TBDMS group was observed in ca. 30-40% yield
-
Benzylation under basic conditions such as NaH-benzyl halide in DMF or DMSO was not straightforward as migration of the TBDMS group was observed in ca. 30-40% yield.
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note
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13 The hydrogenation reactions proceeded smoothly using several BINAP-Ru-based catalysts; however, the diastereomeric purities of the product ii were less than 75% in our hands. Chemical equations presented.
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The diastereomeric excess was determined by the method of Noyori et al. (ref 13a)
-
The diastereomeric excess was determined by the method of Noyori et al. (ref 13a).
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