A 13-week oral repeated dose toxicity study of (±)-4-diethylamino-1,1- dimethylbut-2-yn-1-yl 2-cyclohexyl-2-hydroxy-2-phenylacetate monohydrochloride monohydrate (NS-21), a novel drug for urinary frequency and incontinence, in rats followed by a 5-week recovery test

Journal of Toxicological Sciences

Volumn 22, Issue SUPPL. 1, 1997, Pages 27-57

  Nishiguchi, Yasuyuki ^a   Adachi, Takahiro ^a   Nakazawa, Motokuni ^a   Tawaratani, Takeharu ^a   Uchimoto, Hiroshi ^a   Yoshida, Masaru ^a   Ishibashi, Seitaro ^a   Kitayama, Eita ^a   Iwakura, Keiko ^a   Sumi, Nobuyoshi ^a  

^a NIPPON SHINYAKU CO LTD   (Japan)

Author keywords

13 week oral toxicity; NS 21; Rats; Recovery test; Urinary frequency; Urinary incontinence

Indexed keywords

TEMIVERINE; UNCLASSIFIED DRUG;

ADRENAL CORTEX HYPERFUNCTION; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFECT; DRUG WITHDRAWAL; FEMALE; LACRIMATION; LIVER HYPERTROPHY; LUNG CONGESTION; LUNG EDEMA; MALE; MYDRIASIS; NONHUMAN; ORAL DRUG ADMINISTRATION; RAT; SALIVATION; TESTIS INJURY; TOXICITY TESTING; URINE INCONTINENCE;

EID: 0030920046     PISSN: 03881350     EISSN: 18803989     Source Type: Journal    
DOI: 10.2131/jts.22.supplementi_27     Document Type: Article

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