Alternative delivery systems for antiviral nucleosides and antisense oligonucleotides to the brain

Journal of NeuroVirology

Volumn 3, Issue SUPPL. 1, 1997, Pages

  Levy, Robert M ^a   Ward, Sherman ^a   Schalgeter, Kurt ^a   Groothuis, Dennis ^a  

^a NORTHWESTERN UNIVERSITY   (United States)

Author keywords

Antisense oligonucleotides; Antiviral nucleosides; Blood brain barrier (BBB); Convection enhanced delivery (CED); Cytosine arabinoside (Ara C); Zidovudine (AZT)

Indexed keywords

ANTISENSE OLIGONUCLEOTIDE; ANTIVIRUS AGENT; CYTARABINE; NUCLEOSIDE; ZIDOVUDINE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; BLOOD BRAIN BARRIER; CONFERENCE PAPER; CONTROLLED STUDY; DRUG BRAIN LEVEL; DRUG DELIVERY SYSTEM; INTRACEREBROVENTRICULAR DRUG ADMINISTRATION; INTRAVENOUS DRUG ADMINISTRATION; NONHUMAN; PRIORITY JOURNAL; RAT;

ANIMALS; ANTIVIRAL AGENTS; BRAIN; CARBON RADIOISOTOPES; CAUDATE NUCLEUS; CEREBRAL VENTRICLES; CYTARABINE; DRUG CARRIERS; FUNCTIONAL LATERALITY; INFUSIONS, INTRAVENOUS; INFUSIONS, PARENTERAL; MICE; MICE, INBRED STRAINS; OLIGONUCLEOTIDES, ANTISENSE; ORGAN SPECIFICITY; RATS; RATS, SPRAGUE-DAWLEY; SULFUR RADIOISOTOPES; THIONUCLEOTIDES; ZIDOVUDINE;

EID: 0030919747     PISSN: 13550284     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Conference Paper

References (3)

1. Bobo RH, Laske DW, Akbasak A, Morrison PF et al (1994). Convection enhanced delivery of macromolecules in the brain. Proc Natl Acad Sci USA 91: 2076-2080.
2. Lieberman DM, Laske DW, Morrison PF, Bankiewicz KS et al (1995). Convection enhanced distribution of large molecules in gray matter during interstitial drug infusion. J Neurosurg 82: 1021-1029.
3. Morrison PF, Laske DW, Bobo H, Oldfield EH et al (1994). High flow microinfusion: tissue penetration and pharmacodynamics. Am J Physiol 266: R292-305.