Compaction simulator study of a novel triple-layer tablet matrix for industrial tableting

International Journal of Pharmaceutics

Volumn 152, Issue 1, 1997, Pages 45-52

  Yang, Libo ^a   Venkatesh, Gopi ^b   Fassihi, Reza ^a  

^a TEMPLE UNIVERSITY   (United States)

^b GLAXOSMITHKLINE   (United Kingdom)

Author keywords

Compactibility; Compaction simulator; Heckel equation; Industrial tableting; Mechanism of densification; Poly(ethylene oxide)(PEO); Three layer matrix system; Triple layer tablet

Indexed keywords

BICARBONATE; CALCIUM CARBONATE; LACTOSE; MACROGOL; MAGNESIUM STEARATE; THEOPHYLLINE;

ARTICLE; PRIORITY JOURNAL; SIMULATOR; TABLET COMPRESSION; TABLET MANUFACTURE; TABLET MATRIX;

EID: 0030919390     PISSN: 03785173     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0378-5173(97)04911-9     Document Type: Article

References (16)

1. Armstrong, N.A. and Palfrey, L.P., The effect of machine speed on the consolidation of four directly compressibile tablet diluents. J. Parm. Pharmacol., 41 (1989) 149-151.
2. Celik, M. and Marshall, K., Use of a compaction simulator system in tableting research. Drug Dev. Ind. Pharm., 15 (1989) 758-800.
3. Conte, U., Maggi, L., Colombo, P. and Lamanna, A., Multilayered hydrophilic matrix as constant release device (Geomatrix™ systems). J. Control. Release, 26(1993) 39-47.
4. Fassihi, R., In vitro and in vivo evaluation of a controlled preparation of theophylline. J. Pharm. Pharmacol., 40 (1988) 32P.
5. Fassihi, R. and Ritschel, W.A., Multiple-layer, direct-compression, controlled-release system: in vitro and in vivo evaluation. J. Pharm. Sci., 82 (1993) 750-754.
6. Fassihi, R., Fabian, J. and Sakr, A.M., Application of response surface methodology to design optimization in formulation of a typical controlled release system. Pharm. Ind., 57 (1995) 1039-1043.
7. Fell, J.T. and Newton, J.M., Determination of tablet strength by the diametrical-compression test. J. Pharm. Sci., 59 (1970) 688-691.
8. Heckel, R.W., Density-pressure relationships in powder compaction. Trans. Metall. Soc. AIME, 221 (1961a) 671-675.
9. Heckel, R.W., An analysis of powder compaction phenomena. Trans. Metall. Soc. AIME, 221 (1961b) 1001-1008.
10. Marshall, P.V., York, P. and Maclaine, Q.J., An investigation of the effect of the punch velocity on the compaction properties of ibuprofen. Powder Technol, 74 (1993) 171-177.
11. Rippie, E.D. and Danielson, D.W., Viscoelastic stress/strain behavior of pharmaceutical tablets: analysis during unloading and postcompression periods. J. Pharm. Sci., 70 (1981) 476-482.
12. Roberts, R.J. and Rowe, R.C., The effect of the relationship between punch velocity and particle size on the compaction behavior of materials with varying deformation mechanisms. J. Pharm. Pharmacol., 38(1986) 567-571.
13. Roberts, R.J. and Rowe, R.C., The effect of punch velocity on the compaction of a variety materials. J Pharm. Pharmacol., 37 (1985) 377-384.
14. Yang, L. and Fassihi, R., Zero-order kinetics from self-correcting floatable asymmetric configuration drug delivery system. J. Pharm. Sci., 85 (1996) 170-173.
15. Yang, L. and Fassihi, R., Modulation of diclofenac release from a totally soluble controlled release drug delivery system. J. Control. Release, 44 (1997) 135-140.
16. Yang, L., Venkatesh, G. and Fassihi, R., Characterization of compactibility and compressibilty of poly(ethylene oxide) polymers for modified release application by compaction simulator. J. Pharm Sci., 85 (1996) 1085-1090.