Structural change and receptor binding in a chemokine mutant with a rearranged disulfide: X-ray structure of E38C/C50A IL-8 at 2 Å resolution

Proteins: Structure, Function and Genetics

Volumn 27, Issue 4, 1997, Pages 556-566

  Eigenbrot, Charles ^a   Lowman, Henry B ^a   Chee, Linda ^a,b   Artis, Dean R ^a  

^a GENENTECH INC   (United States)

^b GENOME THERAPEUTICS CORPORATION   (United States)

Author keywords

disulfide mutant; protein engineering; protein minimization

Indexed keywords

CHEMOKINE; INTERLEUKIN 8; INTERLEUKIN 8 RECEPTOR;

AMINO ACID SUBSTITUTION; ARTICLE; CRYSTAL STRUCTURE; DISULFIDE BOND; PRIORITY JOURNAL; RECEPTOR BINDING; X RAY CRYSTALLOGRAPHY;

ANTIGENS, CD; BINDING SITES; BINDING, COMPETITIVE; COMPUTER SIMULATION; CRYSTALLOGRAPHY, X-RAY; CYSTEINE; DISULFIDES; ERYTHROCYTES; INTERLEUKIN-8; MODELS, MOLECULAR; MUTATION; NEUTROPHILS; PROTEIN CONFORMATION; RECEPTORS, INTERLEUKIN; RECEPTORS, INTERLEUKIN-8A; WATER;

EID: 0030919228     PISSN: 08873585     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1097-0134(199704)27:4<556::AID-PROT8>3.0.CO;2-8     Document Type: Article

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