Deactivation retards recovery from inactivation in Shaker K+ channels

Journal of Neuroscience

Volumn 17, Issue 10, 1997, Pages 3436-3444

  Kuo, Chung Chin ^a,b,c  

^a NATIONAL TAIWAN UNIVERSITY   (Taiwan)

^b NATIONAL TAIWAN UNIVERSITY HOSPITAL   (Taiwan)

^c NATIONAL TAIWAN UNIVERSITY   (Taiwan)

Author keywords

ball and chain model of inactivation; deactivation; K+ ion binding site; recovery from inactivation; Shaker K+ channel; two electrode voltage clamp

Indexed keywords

POTASSIUM CHANNEL; POTASSIUM ION;

ANIMAL CELL; ARTICLE; CELL MEMBRANE TRANSPORT; CHANNEL GATING; CONTROLLED STUDY; HYPERPOLARIZATION; NONHUMAN; POTASSIUM CURRENT; PRIORITY JOURNAL; REPOLARIZATION; TRANSPORT KINETICS; XENOPUS LAEVIS;

EID: 0030919179     PISSN: 02706474     EISSN: None     Source Type: Journal    
DOI: 10.1523/jneurosci.17-10-03436.1997     Document Type: Article

References (22)

1. Armstrong CM (1971) Interaction of tetraethylammonium ion derivatives with the potassium channels of giant axons. J Gen Physiol 58:413-437.
2. Armstrong CM (1981) Sodium channels and gating currents. Physiol Rev 61:644-683.
3. Armstrong CM, Bezanilla F (1977) Inactivation of the sodium channel. II. Gating current experiments. J Gen Physiol 70:567-590.
4. +]: a tale of two inactivation mechanisms. Neuron 15:951-960.
5. Bezanilla F, Perozo E, Papazian DM, Stefani E (1991) Molecular basis of gating charge immobilization in Shaker potassium channels. Science 254:679-683.
6. Demo SD, Yellen G (1991) The inactivation gate of the Shaker potassium channel behaves like an open channel blocker. Neuron 7:743-753.
7. + channels. Biophys J 67:1806-1815.
8. + channel. Biophys J 65:2089-2096.
9. Hille B (1992) Potassium channels and chloride channels. In: Ionic channels of excitable membranes, pp 116-121. Sunderland, MA: Sinauer.
10. Hoshi T, Zagotta WN, Aldrich RW (1990) Biophysical and molecular mechanisms of Shaker potassium channel inactivation. Science 250:533-538.
11. Hoshi T, Zagotta WN, Aldrich RW (1991) Two types of inactivation in Shaker potassium channels: effects of alterations in the carboxy-terminal region. Neuron 7:547-556.
12. Iverson LE, Rudy B (1990) The role of divergent amino and carboxyl domains on the inactivation properties of potassium channels derived from the shaker gene of Drosophila. J Neurosci 10:2903-2916.
13. Kamb A, Iverson LE, Tanouye MA (1987) Molecular characterization of shaker, a Drosophila gene that encodes a potassium channel. Cell 50:405-413.
14. Kuo C-C, Bean BP (1994) Sodium channels must deactivate to recover from inactivation. Neuron 12:819-829.
15. 2+ channel pore in rat phaeochromocytoma cells. J Physiol (Lond) 466:657-682.
16. + channels. Science 250:276-279.
17. Murrell-Lagnado RD, Aldrich RW (1993) Energetics of Shaker K channels blocked by inactivation peptides. J Gen Physiol 102:977-1003.
18. + channels. Neuron 11:353-358.
19. Rudy B (1988) Diversity and ubiquity of K channels. Neuroscience 25:729-749.
20. Ruppersberg JP, Frank R, Pongs O, Stocker M (1991) Cloned neuronal Ik(A) channels reopen during recovery from inactivation. Nature 353:657-660.
21. + channels in nerve. J Gen Physiol 61:687-708.
22. Zagotta WN, Hoshi T, Aldrich RW (1990) Restoration of inactivation in mutant Shaker potassium channels by a peptide derived from ShB. Science 250:568-571.