Pterulinic acid and pterulone, two novel inhibitors of NADH:ubiquinone oxidoreductase (complex I) produced by a Pterula species. I. Production, isolation and biological activities

Journal of Antibiotics

Volumn 50, Issue 4, 1997, Pages 325-329

  Engler, Michaela ^a   Anke, Timm ^a   Sterner, Olov ^b   Brandt, Ulrich ^c  

^a Rheinland Pfälzische Technische Universität Kaiserslautern Landau   (Germany)

^b LUND UNIVERSITY   (Sweden)

^c UNIVERSITY HOSPITAL FRANKFURT   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ENZYME INHIBITOR; MITOCHONDRIAL ENZYME; PTERULINIC ACID; PTERULONE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE DEHYDROGENASE (UBIQUINONE); UNCLASSIFIED DRUG;

ANIMAL CELL; ANTIBIOTIC BIOSYNTHESIS; ANTIFUNGAL ACTIVITY; ARTICLE; CELL RESPIRATION; CELL STRAIN BHK; CELL STRAIN HL 60; CYTOTOXICITY; DRUG ISOLATION; DRUG STRUCTURE; EUKARYOTIC CELL; FERMENTATION; HELA CELL; HUMAN; HUMAN CELL; LEUKEMIA L 1210; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; PRIORITY JOURNAL;

EID: 0030918519     PISSN: 00218820     EISSN: None     Source Type: Journal    
DOI: 10.7164/antibiotics.50.325     Document Type: Article

References (17)

1. ANKE, T.; F. OBERWINKLER, W. STEGLICH & G. SCHRAMM: The strobilurins - new antifungal antibiotics from basidiomycete Strobilurus tenacellus (pers. ex Fr.) Sing. J. Antibiotics 30: 806-810, 1977
2. ENGLER, M.; T. ANKE, D. KLOSTERMEYER & W. STEGLICH: Hydroxystrobilurin A, a new antifungal E-β-methoxyacrylate from a Pterula species. J. Antibiotics 48: 884-885, 1995
3. ANKE, T.; H. J. HECHT, G. SCHRAMM & W. STEGLICH: Antibiotics from basidiomycetes IX. Oudemansin, an antifungal antibiotic from Oudemansiella mucida (Schrader ex Fr.) Hoehnel (Agaricales). J. Antibiotics 32: 1112-1117, 1979
4. 1 segment of the respiratory chain with a E-β-methoxyacrylate system as common structural element. FEBS-Letters 132: 329-333, 1981
5. 1 complex from strobilurin-producing basidiomycetes to Center Qp inhibitors. Eur. J. Biochem. 235: 54-63, 1996
6. ENGLER, M.; T. ANKE & O. STERNER: Pterulinic acid and pterulone, two novel inhibitors of NADH : ubiquinone oxidoreductase (complex 1) produced by a Pterula species. II. Physico-chemical properties and structure elucidation. J. Antibiotics 50: 330-333, 1997
7. ANKE, H.; O. BERGENDORFF & O. STERNER: Assays of the biological activities of guaiane sesquiterpenoids isolated from the fruit bodies of edible Lactarius species. Food Chem. Toxicol. 27: 393-398, 1989
8. ZAPF, S.; M. HOßFELD, H. ANKE, R. VELTEN & W. STEGLICH: Darlucins A and B, new isocyanide antibiotics from Sphaerellopsis filum (Darluca filum). J. Antibiotics 48: 36-41, 1995
9. STADLER, M.; H. ANKE & O. STERNER: Linoleic acid - the nematicidal principle of several nematophagous fungi and its production in trap-forming submerged cultures. Arch. Microbiol. 160: 401-405, 1993
10. ANKE, H.; M. STADLER, A. MAVER & O. STERNER: Secondary metabolites with nematicidal and antimicrobial activity from nematophagous fungi and ascomycetes. Can. J. Bot. 73: 932-939, 1995
11. KUSCHEL, A.; T. ANKE, R. VELTEN, D. KLOSTERMEYER, W. STEGLICH & B. KÖNOG: The mniopetals, new inhibitors of the reverse transcriptases from a Mniopetalum species (Basidiomycetes). J. Antibiotics 47: 733-739, 1994
12. WEBER, W.; T. ANKE, B. STEFFAN & W. STEGLICH: Strobilurin E: A new cytostatic and antifungal (E)-β-methoxyacrylate antibiotic from Crepidotus fulvotomentosus Peck. J. Antibiotics 43: 207-212, 1990
13. SMITH, A. L.: Preparation, properties and conditions for assay of mitochondria: Slaugtherhouse material, small-scale. Methods Enzymol. X: 81-86, 1967
14. ENGEL, W. E.; H. SCHÄGGER & G. VON JAGOW: Isolation of complex III from various mitochondria. Comparison of the structural and functional properties of the preparations from beaf heart, calf liver and Neurospora crassa. Hoppe-Seylers's Z. Physiol. Chem. 364: 1753-1763, 1983
15. BRANDT, U.; H. SCHÄGGER & G. VON JAGOW: Characterisation of binding of methoxyacrylate (MOA) inhibitors of mitochondrial cytochrom c reductase. Eur. J. Biochem. 173: 499-506, 1988
16. ANKE, T.: The antifungal strobilurins and their possible ecological role. Can. J. Bot. 73: 940-945, 1995
17. BÜSCHGES, R.; G. BAHRENBERG, M. ZIMMERMANN & K. WOLF: NADH : ubiquinone oxidoreductase in obligate aerobic yeasts. Yeast 10: 475-479, 1994