Quantitation of vascular endothelial growth factor mRNA levels in human breast tumors and metastatic lymph nodes

Experimental and Molecular Pathology

Volumn 64, Issue 1, 1997, Pages 41-51

  Wright, Paul S ^a   Loudy, David E ^a   Cross Doersen, Doreen E ^a   Montgomery, Lauren R ^a   Sprinkle Cavallo, Jean ^a   Miller, Jerry A ^a   Distler, Carole M ^b   Lower, Elyse E ^b   Woessner, Richard D ^a  

^a SANOFI   (France)

^b UNIVERSITY OF CINCINNATI   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GLYCERALDEHYDE 3 PHOSPHATE DEHYDROGENASE; MESSENGER RNA; VASCULOTROPIN;

ARTICLE; BREAST CARCINOMA; FEMALE; HUMAN; HUMAN TISSUE; IMAGE ANALYSIS; IN SITU HYBRIDIZATION; LYMPH NODE METASTASIS; ONCOGENE C MYC; OXIDATIVE STRESS;

EID: 0030918342     PISSN: 00144800     EISSN: None     Source Type: Journal    
DOI: 10.1006/exmp.1997.2208     Document Type: Article

References (35)

1. Blood C. H., Zetter B. R. Tumor interactions with the vasculature: Angiogenesis and tumor metastasis. Biochim. Biophys. Acta. 1032:1990;89-118.
2. Brown L. F., Berse B., Jackman R. W., Tognazzi K., Guidi A. J., Dvorak H. F., Senger D. R., Connolly J. L., Schnitt S. J. Expression of vascular permeability factor (vascular endothelial growth factor) and its receptors in breast cancer. Hum. Pathol. 26:1995;86-91.
3. Cox K. H., DeLeon D. V., Angerer L. M., Angerer R. C. Detection of mRNAs in Sea Urchin embryos byin situ. Dev. Biol. 101:1984;485-502.
4. Folkman J. The influence of angiogenesis research on the management of patients with breast cancer. Breast Cancer Res. Treat. 36:1995;109-118.
5. Folkman J., Shing Y. Angiogenesis. J. Biol. Chem. 267:1992;10931-10934.
6. Forsythe J. A., Jiang B.-H., Iyer N. V., Agani F., Leung S. W., Koos R. D., Semenza G. L. Activation of vascular endothelial growth factor gene transcription by hypoxia-inducible factor 1. Mol. Cell Biol. 16:1996;4604-4613.
7. Guidi A. J., Abu-Jawdeh G., Berse B., Jackman R. W., Tognazzi K., Dvorak H. F., Brown L. F. Vascular permeability factor (vascular endothelial growth factor) expression and angiogenesis in cervical neoplasia. J. Natl. Cancer Inst. 87:1995;1237-1245.
8. Hanahan D., Folkman J. Patterns and emerging mechanisms of the angiogenic switch during tumorigenesis. Cell. 86:1996;353-364.
9. Johnston R. F., Pickett S. C., Barker D. L. Autoradiography using storage phosphor technology. Electrophoresis. 11:1990;355-360.
10. Kacinski B. M., Yee L. D., Carter D., Li D., Kuo M. T. Human breast carcinoma cell levels of MDR-1 (P-glycoprotein) transcripts correlatein vivo. Cancer Commun. 1:1989;1-6.
11. Le Roy X., Escot C., Brouillet J.-P., Theillet C., Maudelonde T., Simony-Lafontaine J., Pujol H., Rochefort H. Decrease of c-erbmyc. Oncogene. 6:1991;431-437.
12. Levy A. P., Levy N. S., Wegner S., Goldberg M. A. Transcriptional regulation of the rat vascular endothelial growth factor gene by hypoxia. J. Biol. Chem. 270:1995;13333-13340.
13. Minchenko A., Salceda S., Bauer T., Caro J. Hypoxia regulatory elements of the human vascular endothelial growth factor gene. Cell. Mol. Biol. Res. 40:1994;35-39.
14. 14. Neurosci. Lett. 121:1991;211-214.
15. Miller J. A., Hoffer B. J., Zahnser N. R. An improved calibration procedure for computer-based quantitative autoradiography utilizing a mathematical model for the non-linear response of camera and film. J. Neurosci. Methods. 22:1988;233-238.
16. Plate K. H., Breier G., Weich H. A., Risau W. Vascular endothelial growth factor is a potential tumour angiogenesis factor in human gliomas in vivo. Nature. 359:1992;845-848.
17. Plate K. H., Breier B., Millauer B., Ullrich A., Risau W. Up-regulation of vascular endothelial growth factor and its cognate receptors in a rat glioma model of tumor angiogenesis. Cancer Res. 53:1993;5822-5827.
18. Shao Z.-M., Sheikh M. S., Ordonez J. V., Feng P., Kute T., Chen J.-C., Aisner S., Schnaper L., LeRoith D., Roberts C. T. Jr., Fontana J. IGFBP-3 gene expression and estrogen receptor status in human breast carcinoma. Cancer Res. 52:1992;5100-5103.
19. Shima D. T., Deutsch U., D'Amore P. A. Hypoxic induction of vascular endothelial growth factor (VEGF) in human epithelial cells is mediated by increases in mRNA stability. FEBS Lett. 370:1995;203-208.
20. Shweki D., Itin A., Soffer D., Keshet E. Vascular endothelial growth factor induced by hypoxia may mediate hypoxia-initiated angiogenesis. Nature. 359:1992;843-845.
21. Simmons D. M., Arriza J. L., Swanson L. W. A complete protocol forin situ. J. Histotech. 12:1989;169-181.
22. Takahashi Y., Kitadai Y., Bucana C. D., Cleary K. R., Ellis L. M. Expression of vascular endothelial growth factor and its receptor, KDR, correlates with vascularity, metastasis, and proliferation of human colon cancer. Cancer Res. 55:1995;3964-3968.
23. Thomas K. A. Vascular endothelial growth factor, a potent and selective angiogenic agent. J. Biol. Chem. 271:1996;603-606.
24. Tischer E., Mitchell R., Hartman T., Silva M., Gospodarowicz D., Fiddes J. C., Abraham J. A. The human gene for vascular endothelial growth factor. Multiple protein forms are encoded through alternative exon splicing. J. Biol. Chem. 266:1991;11947-11954.
25. Toi M., Hoshina S., Takayanagi T., Tominaga T. Association of vascular endothelial growth factor expression with tumor angiogenesis and with early relapse in primary breast cancer. Jpn. J. Cancer Res. 85:1994;1045-1049.
26. Toi M., Inada K., Suzuki H., Tominaga T. Tumor angiogenesis in breast cancer: Its importance as a prognostic indicator and the association with vascular endothelial growth factor expression. Breast Cancer Res. Treat. 36:1995;193-204.
27. Tso J. Y., Sun X.-H., Kao T.-h., Reece K. S., Wu R. Isolation and characterization of rat and human glyceraldehyde-3-phosphate dehydrogenase cDNAs: genomic complexity and molecular evolution of the gene. Nucleic Acids Res. 13:1985;2485-2502.
28. Wang G. L., Semenza G. L. General involvement of hypoxia-inducible factor 1 in transcriptional response to hypoxia. Proc. Natl. Acad. Sci., USA. 90:1993;4304-4308.
29. 2. Proc. Natl. Acad. Sci., USA. 92:1995;5510-5514.
30. Weidner N., Folkman J., Pozza F., Bevilacqua P., Allred E. N., Moore D. H., Meli S., Gasparini G. Tumor angiogenesis: A new significant and independent prognostic indicator in early-stage breast carcinoma. J. Natl. Cancer Inst. 84:1992;1875-1887.
31. Weidner N., Semple J. P., Welch W. R., Folkman J. Tumor angiogenesis and metastasis - Correlation in invasive breast carcinoma. N. Engl. J. Med. 324:1991;1-8.
32. White F. C., Carroll S. M., Kamps M. P. VEGF mRNA is reversibly stabilized by hypoxia and persistently stabilized in VEGF-overexpressing human tumor cell lines. Growth Factors. 12:1995;289-301.
33. Wright P. S., Cross-Doersen D. E., Chmielewski P. A., Bush T. L., Bitonti A. J., Miller J. A. Measurement of mRNA levels in tumor xenografts with quantitative autoradiography andin situ. FASEB J. 9:1995a;279-283.
34. Wright P. S., Cooper J. R., Cross-Doersen D. E., Miller J. A., Chmielewski P. A., Wagner R. L., Streng K. A., Flanagan M. A. Regulation of ornithine decarboxylase mRNA levels in human breast cancer cells: Pattern of expression and involvement of core enhancer promoter element. Cell Growth Differ. 6:1995b;1097-1102.
35. Wright P. S., Cross-Doersen D. E., Th'ng J. P.H., Guo X.-W., Crissman H. A., Bradbury E. M., Montgomery L. R., Thompson F. Y., Loudy D. E., Johnston J. O., Bitonti A. J. A ribonucleotide reductase inhibitor, MDL 101,731, induces apoptosis and elevates TRPM-2 mRNA levels in human prostate xenografts. Exp. Cell Res. 222:1996;54-60.