메뉴 건너뛰기




Volumn 53, Issue 6, 1997, Pages 1054-1080

Zalcitabine: An Update of Its Pharmacodynamic and Pharmacokinetic Properties and Clinical Efficacy in the Management of HIV Infection

Author keywords

Didanosine; Human Immuno Deficiency Virus Type; Triple Combination Therapy; Zalcitabine; Zidovudine

Indexed keywords

DRUG; ZALCITABINE; ANTIRETROVIRUS AGENT; ANTIVIRUS AGENT; CASTANOSPERMINE 6 BUTYRATE; CD4 ANTIGEN; DELAVIRDINE; EMIVIRINE; FOSCARNET; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; INTERFERON; LAMIVUDINE; NUCLEOSIDE ANALOG; PROTEINASE INHIBITOR; RITONAVIR; RNA DIRECTED DNA POLYMERASE INHIBITOR; SAQUINAVIR; ZIDOVUDINE;

EID: 0030918031     PISSN: 00126667     EISSN: 11791950     Source Type: Journal    
DOI: 10.2165/00003495-199753060-00009     Document Type: Article
Times cited : (42)

References (178)
  • 1
    • 0026799290 scopus 로고
    • Zalcitabine: a review of its pharmacology and clinical potential in acquired immunodeficiency syndrome (AIDS)
    • Whittinglon R, Brogden RN. Zalcitabine: a review of its pharmacology and clinical potential in acquired immunodeficiency syndrome (AIDS). Drugs 1992 Oct; 44: 656–83
    • (1992) Drugs , vol.44 , pp. 656-683
    • Whittinglon, R.1    Brogden, R.N.2
  • 2
    • 0022471697 scopus 로고
    • Initial studies on the cellular pharmacology of 2′,3′-dideoxycytidine, an inhibitor of HTLV-III infectivity
    • PID: 3015143, COI: 1:CAS:528:DyaL28XltVOqtbk%3D
    • Cooney DA, Dalai M, Mitsuyu H, et al. Initial studies on the cellular pharmacology of 2′,3′-dideoxycytidine, an inhibitor of HTLV-III infectivity. Biochem Pharmacol 1986; 35: 2065–8
    • (1986) Biochem Pharmacol , vol.35 , pp. 2065-2068
    • Cooney, D.A.1    Dalai, M.2    Mitsuyu, H.3
  • 3
    • 0029871192 scopus 로고    scopus 로고
    • Consensus symposium on combined antiviral therapy
    • PID: 8721539
    • De Jong MD, Boucher CAB, Galasso GJ, et al. Consensus symposium on combined antiviral therapy. Antiviral Res 1996 Jan; 29: 5–29
    • (1996) Antiviral Res , vol.29 , pp. 5-29
    • De Jong, M.D.1    Boucher, C.A.B.2    Galasso, G.J.3
  • 4
    • 0001587762 scopus 로고
    • Inhibition of the in vitro infectivity and cytopathic effect of human T-lymphotropic virus type III/lymphadenopathy-associated virus (HTLV-III/LAV) by 2′,3′-dideoxynucleosides
    • PID: 3006077, COI: 1:CAS:528:DyaL28XhvVehs7g%3D
    • Mitsuya H, Broder S. Inhibition of the in vitro infectivity and cytopathic effect of human T-lymphotropic virus type III/lymphadenopathy-associated virus (HTLV-III/LAV) by 2′,3′-dideoxynucleosides. Proc Natl Acad Sci USA 1986 Mar; 83: 1911–5
    • (1986) Proc Natl Acad Sci USA , vol.83 , pp. 1911-1915
    • Mitsuya, H.1    Broder, S.2
  • 5
    • 0028919933 scopus 로고
    • The inhibition of human immunodeficiency virus type 1 in vitro by a non-nucleoside reverse transcriptase inhibitor MKC-442, alone and in combination with other anti-HIV compounds
    • PID: 7541619, COI: 1:CAS:528:DyaK2MXksVymu7g%3D
    • Brennan TM, Taylor DL, Bridges CG. The inhibition of human immunodeficiency virus type 1 in vitro by a non-nucleoside reverse transcriptase inhibitor MKC-442, alone and in combination with other anti-HIV compounds. Antiviral Res 1995 Mar; 26: 173–87
    • (1995) Antiviral Res , vol.26 , pp. 173-187
    • Brennan, T.M.1    Taylor, D.L.2    Bridges, C.G.3
  • 6
    • 0029965190 scopus 로고    scopus 로고
    • Favorable interaction of β-L(−) nucleoside analogues with clinically approved anti-HIV nucleoside analogues for the treatment of human immunodeficiency virus
    • PID: 8602867, COI: 1:CAS:528:DyaK28XhslKntbY%3D
    • Bridges EG, Dutschman GE, Gullen EA, et al. Favorable interaction of β-L(−) nucleoside analogues with clinically approved anti-HIV nucleoside analogues for the treatment of human immunodeficiency virus. Biochem Pharmacol 1996 Mar 22; 51: 731–6
    • (1996) Biochem Pharmacol , vol.51 , pp. 731-736
    • Bridges, E.G.1    Dutschman, G.E.2    Gullen, E.A.3
  • 7
    • 0028044916 scopus 로고
    • Bisheteroarylpiperazine reverse transcriptase inhibitor in combination with 3′-azido-3′-deoxythymidine or 2′,3′-dideoxycytidine synergistically inhibits human immunodeficiency virus type 1 replication in vitro
    • PID: 7514857, COI: 1:CAS:528:DyaK2cXhvVant78%3D
    • Chong K-T, Pagano PJ, Hinshaw RR. Bisheteroarylpiperazine reverse transcriptase inhibitor in combination with 3′-azido-3′-deoxythymidine or 2′,3′-dideoxycytidine synergistically inhibits human immunodeficiency virus type 1 replication in vitro. Antimicrob Agents Chemother 1994 Feb; 38: 288–93
    • (1994) Antimicrob Agents Chemother , vol.38 , pp. 288-293
    • Chong, K.-T.1    Pagano, P.J.2    Hinshaw, R.R.3
  • 8
    • 0028008793 scopus 로고
    • Combinative interactions of a human immunodeficiency virus (HIV) Tat antagonist with HIV reverse transcriptase inhibitors and an HIV protease inhibitor
    • PID: 7514858, COI: 1:CAS:528:DyaK2cXhvVant7s%3D
    • Connell EV, Hsu M-C, Richman DD. Combinative interactions of a human immunodeficiency virus (HIV) Tat antagonist with HIV reverse transcriptase inhibitors and an HIV protease inhibitor. Antimicrob Agents Chemother 1994 Feb; 38: 348–52
    • (1994) Antimicrob Agents Chemother , vol.38 , pp. 348-352
    • Connell, E.V.1    Hsu, M.-C.2    Richman, D.D.3
  • 9
    • 0028126771 scopus 로고
    • In vitro anti-HIV and cytotoxicological evaluation of the triple combination: AZT and ddC with HIV proteinase inhibitor saquinavir (Ro 31-8959)
    • COI: 1:CAS:528:DyaK2MXitVKrsbc%3D
    • Craig JC, Whittaker L, Duncan IB. In vitro anti-HIV and cytotoxicological evaluation of the triple combination: AZT and ddC with HIV proteinase inhibitor saquinavir (Ro 31-8959). Antiviral Chem Chemother 1994 Nov; 5: 380–6
    • (1994) Antiviral Chem Chemother , vol.5 , pp. 380-386
    • Craig, J.C.1    Whittaker, L.2    Duncan, I.B.3
  • 10
    • 0027302144 scopus 로고
    • Antiviral synergy between inhibitors of HIV proteinase and reverse transcriptase
    • COI: 1:CAS:528:DyaK3sXltlSqtLs%3D
    • Craig JC, Duncan IB, Whittaker L, et al. Antiviral synergy between inhibitors of HIV proteinase and reverse transcriptase. Antiviral Chem Chemother 1993; 4(3): 161–6
    • (1993) Antiviral Chem Chemother , vol.4 , Issue.3 , pp. 161-166
    • Craig, J.C.1    Duncan, I.B.2    Whittaker, L.3
  • 11
    • 0028222980 scopus 로고
    • Anti-HIV activity of dideoxynucleosides, foscarnet and fusidic acid is potentiated by human leukocyte interferon in blood-derived macrophages
    • PID: 7515781
    • Degré M, Beck S. Anti-HIV activity of dideoxynucleosides, foscarnet and fusidic acid is potentiated by human leukocyte interferon in blood-derived macrophages. Chemotherapy 1994 May–Jun; 40: 201–8
    • (1994) Chemotherapy , vol.40 , pp. 201-208
    • Degré, M.1    Beck, S.2
  • 12
    • 8944263470 scopus 로고    scopus 로고
    • Evaluation of reverse transcriptase and protease inhibitors in two-drug combinations against human immunodeficiency virus replication
    • Demine CA, Bechtold CM, Stock D, et al. Evaluation of reverse transcriptase and protease inhibitors in two-drug combinations against human immunodeficiency virus replication. Antimicrob Agents Chemother 1996 Jun; 40: 1346–51
    • (1996) Antimicrob Agents Chemother , vol.40 , pp. 1346-1351
    • Demine, C.A.1    Bechtold, C.M.2    Stock, D.3
  • 13
    • 0026693361 scopus 로고
    • Synergistic inhibition of replication of human immunodeficiency virus type 1, including that of a zidovudine-resistant isolate, by zidovudine and 2′,3′-dideoxycytidine in vitro
    • PID: 1324648, COI: 1:CAS:528:DyaK38XkvVaqtbg%3D
    • Eron Jr JJ, Johnson VA, Merrill DP, et al. Synergistic inhibition of replication of human immunodeficiency virus type 1, including that of a zidovudine-resistant isolate, by zidovudine and 2′,3′-dideoxycytidine in vitro. Antimicrob Agents Chemother 1992 Jul; 36: 1559–62
    • (1992) Antimicrob Agents Chemother , vol.36 , pp. 1559-1562
    • Eron, J.J.1    Johnson, V.A.2    Merrill, D.P.3
  • 14
    • 0026701152 scopus 로고
    • Human immunodeficiency virus type 1 (HIV-1) inhibitory interactions between protease inhibitor Ro 31-8959 and zidovudine, 2′,3′-dideoxy-cytidine, or recombinant interferon-α-A against zidovudine-sensitive or -resistant HIV-1 in vitro
    • PID: 1328402, COI: 1:CAS:528:DyaK3sXitVCktr4%3D
    • Johnson VA, Merrill DP, Chou T-C, et al. Human immunodeficiency virus type 1 (HIV-1) inhibitory interactions between protease inhibitor Ro 31-8959 and zidovudine, 2′,3′-dideoxy-cytidine, or recombinant interferon-α-A against zidovudine-sensitive or -resistant HIV-1 in vitro. J Infect Dis 1992 Nov; 166: 1143–6
    • (1992) J Infect Dis , vol.166 , pp. 1143-1146
    • Johnson, V.A.1    Merrill, D.P.2    Chou, T.-C.3
  • 15
    • 0027379732 scopus 로고
    • Infectious amplification of wild-type human immunodeficiency virus from patients’ lymphocytes and modulation by reverse transcriptase inhibitors in vitro
    • PID: 7504908, COI: 1:CAS:528:DyaK2cXmvV2jtg%3D%3D
    • Mathez D, Schinazi RF, Liotta DC, et al. Infectious amplification of wild-type human immunodeficiency virus from patients’ lymphocytes and modulation by reverse transcriptase inhibitors in vitro. Antimicrob Agents Chemother 1993 Oct; 37: 2206–11
    • (1993) Antimicrob Agents Chemother , vol.37 , pp. 2206-2211
    • Mathez, D.1    Schinazi, R.F.2    Liotta, D.C.3
  • 16
    • 0029865323 scopus 로고    scopus 로고
    • Synergistic inhibition of human immunodeficiency virus isolates (including 3′-azido-3′-deoxythymidine-resistant isolates) by foscarnet in combination with 2′,3′-dideoxyinosine or 2′,3′-dideoxycytidine
    • PID: 8723486, COI: 1:CAS:528:DyaK28XislClurs%3D
    • Palmer S, Harmenberg J, Cox S. Synergistic inhibition of human immunodeficiency virus isolates (including 3′-azido-3′-deoxythymidine-resistant isolates) by foscarnet in combination with 2′,3′-dideoxyinosine or 2′,3′-dideoxycytidine. Antimicrob Agents Chemother 1996 May; 40: 1285–8
    • (1996) Antimicrob Agents Chemother , vol.40 , pp. 1285-1288
    • Palmer, S.1    Harmenberg, J.2    Cox, S.3
  • 17
    • 0026648436 scopus 로고
    • Effects of bone marrow stimulatory cytokines on human immunodeficiency virus replication and the antiviral activity of dideoxynucleosides in cultures of monocyte/macrophages
    • PID: 1379854, COI: 1:CAS:528:DyaK3sXlsl2itg%3D%3D
    • Perno C-F, Cooney DA, Gao W-Y, et al. Effects of bone marrow stimulatory cytokines on human immunodeficiency virus replication and the antiviral activity of dideoxynucleosides in cultures of monocyte/macrophages. Blood 1992 Aug 15; 80: 995–1003
    • (1992) Blood , vol.80 , pp. 995-1003
    • Perno, C.-F.1    Cooney, D.A.2    Gao, W.-Y.3
  • 18
    • 0028958321 scopus 로고
    • Synergistic inhibition of human immunodeficiency virus type 1 in vitro by 6-0-butanoylcastanospermine (MDL 28 574) in combination with inhibitors of the virus-encoded reverse transcriptase and proteinase
    • COI: 1:CAS:528:DyaK2MXlsFKmsb8%3D
    • Taylor DL, Brennan TM, Bridges CG, et al. Synergistic inhibition of human immunodeficiency virus type 1 in vitro by 6-0-butanoylcastanospermine (MDL 28 574) in combination with inhibitors of the virus-encoded reverse transcriptase and proteinase. Antiviral Chem Chemother 1995 May; 6: 143–52
    • (1995) Antiviral Chem Chemother , vol.6 , pp. 143-152
    • Taylor, D.L.1    Brennan, T.M.2    Bridges, C.G.3
  • 19
    • 0028349644 scopus 로고
    • Alternating versus continuous drug regimens in combination chemotherapy of human immunodeficiency virus type 1 infection in vitro
    • PID: 8031028, COI: 1:CAS:528:DyaK2cXis1SltL0%3D
    • Mazzulli T, Rusconi S, Merrill DP, et al. Alternating versus continuous drug regimens in combination chemotherapy of human immunodeficiency virus type 1 infection in vitro. Antimicrob Agents Chemother 1994 Apr; 38: 656–61
    • (1994) Antimicrob Agents Chemother , vol.38 , pp. 656-661
    • Mazzulli, T.1    Rusconi, S.2    Merrill, D.P.3
  • 20
    • 0028886715 scopus 로고
    • Zalcitabine (ddC) phosphorylation and drug interactions
    • COI: 1:CAS:528:DyaK2MXptlaktbw%3D
    • Veal GJ, Barry MG, Back DJ. Zalcitabine (ddC) phosphorylation and drug interactions. Antiviral Chem Chemother 1995 Nov; 6: 379–84
    • (1995) Antiviral Chem Chemother , vol.6 , pp. 379-384
    • Veal, G.J.1    Barry, M.G.2    Back, D.J.3
  • 21
    • 0027939485 scopus 로고
    • Effects of dideoxyinosine and dideoxycytidine on the intracellular phosphorylation of zidovudine in human mononuclear cells
    • PID: 7833221, COI: 1:CAS:528:DyaK2MXhvFegt7g%3D
    • Veal GJ, Wild MJ, Barry MG, et al. Effects of dideoxyinosine and dideoxycytidine on the intracellular phosphorylation of zidovudine in human mononuclear cells. Br J Clin Pharmacol 1994 Oct; 38: 323–8
    • (1994) Br J Clin Pharmacol , vol.38 , pp. 323-328
    • Veal, G.J.1    Wild, M.J.2    Barry, M.G.3
  • 22
    • 0029869720 scopus 로고    scopus 로고
    • Interaction between lamivudine (3TC) and other nucleoside analogues for intracellular phosphorylation
    • PID: 8724049, COI: 1:STN:280:DyaK28zhsVWjtw%3D%3D
    • Veal GJ, Hoggard PG, Barry MG, et al. Interaction between lamivudine (3TC) and other nucleoside analogues for intracellular phosphorylation. AIDS 1996 May; 10: 546–8
    • (1996) AIDS , vol.10 , pp. 546-548
    • Veal, G.J.1    Hoggard, P.G.2    Barry, M.G.3
  • 23
    • 0023636684 scopus 로고
    • Ribavirin antagonizes inhibitory effects of pyrimidine 2′,3′-dideoxynucleosides on replication of human immunodeficiency virus in vitro
    • PID: 3435108, COI: 1:CAS:528:DyaL2sXmt1ymsLo%3D
    • Baba M, Pauwels R, Balzarini J, et al. Ribavirin antagonizes inhibitory effects of pyrimidine 2′,3′-dideoxynucleosides on replication of human immunodeficiency virus in vitro. Antimicrob Agents Chemother 1987 Oct; 31(10): 1613–7
    • (1987) Antimicrob Agents Chemother , vol.31 , Issue.10 , pp. 1613-1617
    • Baba, M.1    Pauwels, R.2    Balzarini, J.3
  • 24
    • 0028216549 scopus 로고
    • Effects of 2′,3′-dideoxynucleosides on proliferation and differentiation of human pluripotent progenitors in liquid culture and their effects on mitochondrial DNA synthesis
    • PID: 7520683, COI: 1:CAS:528:DyaK2cXkt1Kgs7k%3D
    • Faraj A, Fowler DA, Bridges EG, et al. Effects of 2′,3′-dideoxynucleosides on proliferation and differentiation of human pluripotent progenitors in liquid culture and their effects on mitochondrial DNA synthesis. Antimicrob Agents Chemother 1994 May; 38: 924–30
    • (1994) Antimicrob Agents Chemother , vol.38 , pp. 924-930
    • Faraj, A.1    Fowler, D.A.2    Bridges, E.G.3
  • 25
    • 0023735544 scopus 로고
    • Inhibition of bone marrow myelopoiesis and erythropoiesis in vitro by anti-retroviral nucleoside derivatives
    • PID: 2847772, COI: 1:CAS:528:DyaL1cXmt1Wqu74%3D
    • Johnson M, Caiazzo T, Molina J-M, et al. Inhibition of bone marrow myelopoiesis and erythropoiesis in vitro by anti-retroviral nucleoside derivatives. Br J Haematol 1988 Oct; 70: 137–41
    • (1988) Br J Haematol , vol.70 , pp. 137-141
    • Johnson, M.1    Caiazzo, T.2    Molina, J.-M.3
  • 26
    • 85025901829 scopus 로고
    • The effect of the antiviral dideoxycytidine (DDC) on the growth of human bone marrow progenitor cells in vitro
    • Steinberg HN, Zekdis JB. The effect of the antiviral dideoxycytidine (DDC) on the growth of human bone marrow progenitor cells in vitro. Proc Am Soc Clin Oncol 1988 Mar; 7: abstr. 14
    • (1988) Proc Am Soc Clin Oncol , vol.7 , pp. 14
    • Steinberg, H.N.1    Zekdis, J.B.2
  • 27
    • 0029671392 scopus 로고    scopus 로고
    • Combination antiretroviral chemotherapy: a potential strategy in AIDS-related malignancy
    • PID: 8742107, COI: 1:CAS:528:DyaK28Xht1Gmtro%3D
    • Nusbaum NJ, Abraham T. Combination antiretroviral chemotherapy: a potential strategy in AIDS-related malignancy. Anticancer Drugs 1996 Jan; 7: 109–13
    • (1996) Anticancer Drugs , vol.7 , pp. 109-113
    • Nusbaum, N.J.1    Abraham, T.2
  • 28
    • 0028607374 scopus 로고
    • Quantitation of mito-chondrial DNA in human lymphoblasts by a competitive polymerase chain reaction method: application to the study of inhibitors of mitochondrial DNA content
    • PID: 7808425, COI: 1:CAS:528:DyaK2MXivFKqtrw%3D
    • Zhang H, Cooney DA, Sreenath A, et al. Quantitation of mito-chondrial DNA in human lymphoblasts by a competitive polymerase chain reaction method: application to the study of inhibitors of mitochondrial DNA content. Mol Pharmacol 1994 Dec; 46: 1063–9
    • (1994) Mol Pharmacol , vol.46 , pp. 1063-1069
    • Zhang, H.1    Cooney, D.A.2    Sreenath, A.3
  • 29
    • 0026686864 scopus 로고
    • Ultrastructural changes associated with reduced mitochondrial DNA and impaired mitochondrial function in the prescence of 2′3′-dideoxycytidine
    • PID: 1329643, COI: 1:CAS:528:DyaK38XlvVCgtrs%3D
    • Lewis LD, Hamezeh FM, Lietman PS. Ultrastructural changes associated with reduced mitochondrial DNA and impaired mitochondrial function in the prescence of 2′3′-dideoxycytidine. Antimicrob Agents Chemother 1992 Sep; 36: 2061–5
    • (1992) Antimicrob Agents Chemother , vol.36 , pp. 2061-2065
    • Lewis, L.D.1    Hamezeh, F.M.2    Lietman, P.S.3
  • 30
    • 0028109345 scopus 로고
    • Comparison of mitochondrial morphology, mitochondrial DNA content, and cell viability in cultured cells treated with three anti-human immunodeficiency virus dideoxynucleosides
    • PID: 7986014, COI: 1:CAS:528:DyaK2cXlt1Cltb8%3D
    • Medina DJ, Tsai C-H, Hsiung GD, et al. Comparison of mitochondrial morphology, mitochondrial DNA content, and cell viability in cultured cells treated with three anti-human immunodeficiency virus dideoxynucleosides. Antimicrob Agents Chemother 1994 Aug; 38: 1824–8
    • (1994) Antimicrob Agents Chemother , vol.38 , pp. 1824-1828
    • Medina, D.J.1    Tsai, C.-H.2    Hsiung, G.D.3
  • 31
    • 0029120149 scopus 로고
    • Inhibition of HIV-1 and LP-BM5 replication in macrophages by dideoxycytidine and dideoxycytidine 5′-triphosphate
    • COI: 1:CAS:528:DyaK2MXotFWrs7c%3D
    • Magnani M, Casabianca A, Rossi L, et al. Inhibition of HIV-1 and LP-BM5 replication in macrophages by dideoxycytidine and dideoxycytidine 5′-triphosphate. Antiviral Chem Chemother 1995 Sep; 6: 312–9
    • (1995) Antiviral Chem Chemother , vol.6 , pp. 312-319
    • Magnani, M.1    Casabianca, A.2    Rossi, L.3
  • 32
    • 0027504790 scopus 로고
    • Anti-human immunodeficiency virus type 1 therapy and peripheral neuropathy: prevention of 2′,3′-dideoxycytidine toxicity in PC12 cells, a neuronal model, by uridine and pyruvate
    • PID: 8232219, COI: 1:CAS:528:DyaK2cXksFamsQ%3D%3D
    • Keilbaugh SA, Hobbs GA, Simpson MV. Anti-human immunodeficiency virus type 1 therapy and peripheral neuropathy: prevention of 2′,3′-dideoxycytidine toxicity in PC12 cells, a neuronal model, by uridine and pyruvate. Mol Pharmacol 1993 Oct; 44: 702–6
    • (1993) Mol Pharmacol , vol.44 , pp. 702-706
    • Keilbaugh, S.A.1    Hobbs, G.A.2    Simpson, M.V.3
  • 33
    • 0028990381 scopus 로고
    • Mitochondrial toxicity of antiviral drugs
    • PID: 7585087, COI: 1:CAS:528:DyaK2MXls1Sgt7k%3D
    • Lewis W, Dalakas MC. Mitochondrial toxicity of antiviral drugs. Nat Med 1995 May; 1: 417–22
    • (1995) Nat Med , vol.1 , pp. 417-422
    • Lewis, W.1    Dalakas, M.C.2
  • 34
    • 0027407484 scopus 로고
    • Nucleoside analogs: similarities and differences
    • PID: 8425021
    • Sommadossi J-P. Nucleoside analogs: similarities and differences. Clin Infect Dis 1993 Feb; 16 Suppl. 1: S7–15
    • (1993) Clin Infect Dis , vol.16 , Issue.1 , pp. S7-S15
    • Sommadossi, J.-P.1
  • 35
    • 0024381627 scopus 로고
    • Delayed cytotoxicity and selective loss of mitochondrial DNA in cells treated with the anti-human immunodeficiency virus compound 2′,3′-dideoxycytidine
    • PID: 2745424, COI: 1:CAS:528:DyaL1MXkslSns7s%3D
    • Chen C-H, Cheng Y-C. Delayed cytotoxicity and selective loss of mitochondrial DNA in cells treated with the anti-human immunodeficiency virus compound 2′,3′-dideoxycytidine. J Biol Chem 1989 Jul 15; 264: 11934–7
    • (1989) J Biol Chem , vol.264 , pp. 11934-11937
    • Chen, C.-H.1    Cheng, Y.-C.2
  • 36
    • 0028332125 scopus 로고
    • Mitochondrial schwannopathy and peripheral myelinopathy in a rabbit model of dideoxycytidine neurotoxicity
    • PID: 7515130, COI: 1:CAS:528:DyaK2cXlt1Cltrk%3D
    • Anderson TD, Davidovich A, Feldman D, et al. Mitochondrial schwannopathy and peripheral myelinopathy in a rabbit model of dideoxycytidine neurotoxicity. Lab Invest 1994 May; 70: 724–39
    • (1994) Lab Invest , vol.70 , pp. 724-739
    • Anderson, T.D.1    Davidovich, A.2    Feldman, D.3
  • 37
    • 0028142405 scopus 로고
    • Comparative embryonic cytotoxicity of antiretroviral nucleosides
    • PID: 8169400, COI: 1:CAS:528:DyaK2cXlt1Clsb8%3D
    • Toltzis P, Mourton T, Magnuson T. Comparative embryonic cytotoxicity of antiretroviral nucleosides. J Infect Dis 1994 May; 169: 1100–2
    • (1994) J Infect Dis , vol.169 , pp. 1100-1102
    • Toltzis, P.1    Mourton, T.2    Magnuson, T.3
  • 38
    • 0026356276 scopus 로고
    • Experimental studies of the hematologic and immune system toxicity of nucleoside derivatives used against HIV infection
    • PID: 1668555, COI: 1:CAS:528:DyaK38XktVSgsbs%3D
    • Luster MI, Rosenthal GJ, Cao W, et al. Experimental studies of the hematologic and immune system toxicity of nucleoside derivatives used against HIV infection. Int J Immunopharmacol 1991; 13 Suppl 1: 99–107
    • (1991) Int J Immunopharmacol , vol.13 , Issue.1 , pp. 99-107
    • Luster, M.I.1    Rosenthal, G.J.2    Cao, W.3
  • 39
    • 0028965317 scopus 로고
    • Efficacy and toxicity of long-term administration of 2′,3′-dideoxycytidine in the LP-BM5 murine-induced immunodeficiency model
    • COI: 1:CAS:528:DyaK2MXlsFKmsbw%3D
    • Brandi G, Casabianca A, Schiavano GF, et al. Efficacy and toxicity of long-term administration of 2′,3′-dideoxycytidine in the LP-BM5 murine-induced immunodeficiency model. Antiviral Chem Chemother 1995 May; 6: 153–61
    • (1995) Antiviral Chem Chemother , vol.6 , pp. 153-161
    • Brandi, G.1    Casabianca, A.2    Schiavano, G.F.3
  • 40
    • 0028952146 scopus 로고
    • HIV population dynamics in vivo: implications for genetic variation, pathogenesis, and therapy
    • PID: 7824947, COI: 1:CAS:528:DyaK2MXjsFShu7w%3D
    • Coffin JM. HIV population dynamics in vivo: implications for genetic variation, pathogenesis, and therapy. Science 1995; 267: 483–9
    • (1995) Science , vol.267 , pp. 483-489
    • Coffin, J.M.1
  • 41
    • 0029774808 scopus 로고    scopus 로고
    • Use of viral resistance patterns to antiretroviral drugs in optimising selection of drug combinations and sequences
    • PID: 8841736, COI: 1:CAS:528:DyaK28XltFWjsr8%3D
    • Moyle GJ. Use of viral resistance patterns to antiretroviral drugs in optimising selection of drug combinations and sequences. Drugs 1996 Aug; 52: 168–85
    • (1996) Drugs , vol.52 , pp. 168-185
    • Moyle, G.J.1
  • 42
    • 0029912274 scopus 로고    scopus 로고
    • Mechanisms of nucleoside analog antiviral activity and resistance during human immunodeficiency virus reverse transcription
    • PID: 8851566, COI: 1:CAS:528:DyaK28XhsVektrg%3D
    • Arts EJ, Wainberg MA. Mechanisms of nucleoside analog antiviral activity and resistance during human immunodeficiency virus reverse transcription. Antimicrob Agents Chemother 1996; 40: 527–40
    • (1996) Antimicrob Agents Chemother , vol.40 , pp. 527-540
    • Arts, E.J.1    Wainberg, M.A.2
  • 43
    • 0031029291 scopus 로고    scopus 로고
    • The development of resistance of HIV-1 to zalcitabine
    • PID: 9147417, COI: 1:CAS:528:DyaK2sXitlOmsbg%3D
    • Craig C, Moyle G. The development of resistance of HIV-1 to zalcitabine. AIDS 1997; 11: 271–9
    • (1997) AIDS , vol.11 , pp. 271-279
    • Craig, C.1    Moyle, G.2
  • 44
    • 0028200360 scopus 로고
    • Development and significance of nucleoside drug resistance in infection caused by the human immunodeficiency virus type 1
    • PID: 7523016, COI: 1:CAS:528:DyaK2cXlvFCks7Y%3D
    • Smith M, Salomon W, Wainberg MA. Development and significance of nucleoside drug resistance in infection caused by the human immunodeficiency virus type 1. Clin Invest Med 1994 Jun; 17: 226–43
    • (1994) Clin Invest Med , vol.17 , pp. 226-243
    • Smith, M.1    Salomon, W.2    Wainberg, M.A.3
  • 45
    • 0029559244 scopus 로고
    • Viral resistance and the selection of antiretroviral combinations
    • Larder BA. Viral resistance and the selection of antiretroviral combinations. J Acquir Immune Defic Syndrom Hum Retrovirol 1995; 10 Suppl. 1: 28–33
    • (1995) J Acquir Immune Defic Syndrom Hum Retrovirol , vol.10 , Issue.1 , pp. 28-33
    • Larder, B.A.1
  • 46
    • 0028172345 scopus 로고
    • Locations of antiAIDS drug binding sites and resistance mutations in the three-dimensional structure of HIV-1 reverse transcriptase: implications for mechanisms of drug inhibition and resistance
    • PID: 7525966, COI: 1:CAS:528:DyaK2cXmvFWrt7k%3D
    • Tantillo C, Ding JP, Jacobo-Molina A, et al. Locations of antiAIDS drug binding sites and resistance mutations in the three-dimensional structure of HIV-1 reverse transcriptase: implications for mechanisms of drug inhibition and resistance. J Mol Biol 1994 Oct 28; 243: 369–87
    • (1994) J Mol Biol , vol.243 , pp. 369-387
    • Tantillo, C.1    Ding, J.P.2    Jacobo-Molina, A.3
  • 47
    • 0027398296 scopus 로고
    • Changes in drug sensitivity of human immunodeficiency virus type 1 during therapy with azidothymidine, dideoxycytidine, and dideoxy-inosine: an in vitro comparative study
    • PID: 8380641, COI: 1:CAS:528:DyaK3sXptlymtg%3D%3D
    • Shirasaka T, Yarchoan R, O’Brien MC, et al. Changes in drug sensitivity of human immunodeficiency virus type 1 during therapy with azidothymidine, dideoxycytidine, and dideoxy-inosine: an in vitro comparative study. Proc Natl Acad Sci USA 1993 Jan 15; 90: 562–6
    • (1993) Proc Natl Acad Sci USA , vol.90 , pp. 562-566
    • Shirasaka, T.1    Yarchoan, R.2    O’Brien, M.C.3
  • 49
    • 85083237683 scopus 로고
    • Harrigan PR, Kemp SD, Kinghorn I, et al. A placebo controlled trial of AZT alone or in combination with DDI or DDC: viral load and drug resistance [abstract]. AIDS 1994 Nov; 8 Suppl. 4: S20
    • (1994) AIDS , vol.8 , Issue.4
  • 50
    • 0028137794 scopus 로고
    • Resistance to AZT and ddC during long-term combination therapy in patients with advanced infection with human immunodeficiency virus
    • PID: 7905522, COI: 1:STN:280:DyaK2c7jtlSrsA%3D%3D
    • Richman DD, Meng T-C, Spector SA, et al. Resistance to AZT and ddC during long-term combination therapy in patients with advanced infection with human immunodeficiency virus. J Acquir Immune Defic Syndr 1994 Feb; 7: 135–8
    • (1994) J Acquir Immune Defic Syndr , vol.7 , pp. 135-138
    • Richman, D.D.1    Meng, T.-C.2    Spector, S.A.3
  • 51
    • 0026529145 scopus 로고
    • Human immunodeficiency virus type 1 pol gene mutations which cause decreased susceptibility to 2′,3′-dideoxycytidine
    • PID: 1317143, COI: 1:CAS:528:DyaK38XotVamtg%3D%3D
    • Fitzgibbon JE, Howell RM, Haberzettl CA, et al. Human immunodeficiency virus type 1 pol gene mutations which cause decreased susceptibility to 2′,3′-dideoxycytidine. Antimicrob Agents Chemother 1992 Jan; 36: 153–7
    • (1992) Antimicrob Agents Chemother , vol.36 , pp. 153-157
    • Fitzgibbon, J.E.1    Howell, R.M.2    Haberzettl, C.A.3
  • 52
    • 0028031833 scopus 로고
    • Resistance to 2′,3′-dideoxycytidine conferred by a mutation in codon 65 of the human immunodeficiency virus type 1 reverse transcriptase
    • PID: 7514856, COI: 1:CAS:528:DyaK2cXhvVOjtL4%3D
    • Zhang D, Caliendo AM, Eron JJ, et al. Resistance to 2′,3′-dideoxycytidine conferred by a mutation in codon 65 of the human immunodeficiency virus type 1 reverse transcriptase. Antimicrob Agents Chemother 1994 Feb; 38: 282–7
    • (1994) Antimicrob Agents Chemother , vol.38 , pp. 282-287
    • Zhang, D.1    Caliendo, A.M.2    Eron, J.J.3
  • 53
    • 0028057581 scopus 로고
    • Identification of a mutation at codon 65 in the IKKK motif of reverse transcriptase that encodes human immunodeficiency virus resistance to 2′,3′-dideoxy-cytidine and 2′,3′-dideoxy-3′-thiacytidine
    • PID: 7514855, COI: 1:CAS:528:DyaK2cXhvVOjt7c%3D
    • Gu Z, Gao Q, Fang H, et al. Identification of a mutation at codon 65 in the IKKK motif of reverse transcriptase that encodes human immunodeficiency virus resistance to 2′,3′-dideoxy-cytidine and 2′,3′-dideoxy-3′-thiacytidine. Antimicrob Agents Chemother 1994 Feb; 38: 275–81
    • (1994) Antimicrob Agents Chemother , vol.38 , pp. 275-281
    • Gu, Z.1    Gao, Q.2    Fang, H.3
  • 54
    • 0028940368 scopus 로고
    • Mutated K65R recombinant reverse transcriptase of human immunodeficiency virus type 1 shows diminished chain termination in the presence of 2′,3′-dideoxycytidine 5′-triphosphate and other drugs
    • PID: 7535930, COI: 1:CAS:528:DyaK2MXksl2rsbk%3D
    • Gu Z, Arts EJ, Parniak MA, et al. Mutated K65R recombinant reverse transcriptase of human immunodeficiency virus type 1 shows diminished chain termination in the presence of 2′,3′-dideoxycytidine 5′-triphosphate and other drugs. Proc Natl Acad Sci USA 1995 Mar 28; 92: 2760–4
    • (1995) Proc Natl Acad Sci USA , vol.92 , pp. 2760-2764
    • Gu, Z.1    Arts, E.J.2    Parniak, M.A.3
  • 55
    • 0029154895 scopus 로고
    • K65R mutation of human immunodeficiency virus type 1 reverse transcriptase encodes cross-resistance to 9-(2-phosphonylmethoxy-ethyl) adenine
    • PID: 7486942, COI: 1:CAS:528:DyaK2MXnt1ygsLg%3D
    • Gu Z, Salomon H, Cherrington JM, et al. K65R mutation of human immunodeficiency virus type 1 reverse transcriptase encodes cross-resistance to 9-(2-phosphonylmethoxy-ethyl) adenine. Antimicrob Agents Chemother 1995 Aug; 39: 1888–91
    • (1995) Antimicrob Agents Chemother , vol.39 , pp. 1888-1891
    • Gu, Z.1    Salomon, H.2    Cherrington, J.M.3
  • 56
    • 0026465275 scopus 로고
    • Novel mutation in the human immunodeficiency virus type-1 reverse transcriptase gene that encodes cross-resistance to 2′,3′-dideoxyinosine and 2′,3′-dideoxycytidine
    • PID: 1279198, COI: 1:CAS:528:DyaK3sXjsFOitg%3D%3D
    • Gu ZX, Gao Q, Li XG, et al. Novel mutation in the human immunodeficiency virus type-1 reverse transcriptase gene that encodes cross-resistance to 2′,3′-dideoxyinosine and 2′,3′-dideoxycytidine. J Virol 1992 Dec; 66: 7128–35
    • (1992) J Virol , vol.66 , pp. 7128-7135
    • Gu, Z.X.1    Gao, Q.2    Li, X.G.3
  • 57
    • 0027155374 scopus 로고
    • The same mutation that encodes low-level human immunodeficiency virus type 1 resistance to 2′,3′-dideoxyinosine and 2′,3′-dideoxycytidine confers high-level resistance to the (−) enantiomer of 2′,3′-dideoxy-3′-thiacytidine
    • PID: 8392313, COI: 1:CAS:528:DyaK3sXkvVGnu7g%3D
    • Gao Q, Gu Z, Parniak MA, et al. The same mutation that encodes low-level human immunodeficiency virus type 1 resistance to 2′,3′-dideoxyinosine and 2′,3′-dideoxycytidine confers high-level resistance to the (−) enantiomer of 2′,3′-dideoxy-3′-thiacytidine. Antimicrob Agents Chemother 1993 Jun; 37: 1390–2
    • (1993) Antimicrob Agents Chemother , vol.37 , pp. 1390-1392
    • Gao, Q.1    Gu, Z.2    Parniak, M.A.3
  • 58
    • 0027363310 scopus 로고
    • Human immunodeficiency virus type-1 pol gene mutations in an AIDS patient treated with multiple antiretroviral drugs
    • PID: 8230450, COI: 1:CAS:528:DyaK2cXksFaqtw%3D%3D
    • Fitzgibbon JE, Farnham AE, Sperber SJ, et al. Human immunodeficiency virus type-1 pol gene mutations in an AIDS patient treated with multiple antiretroviral drugs. J Virol 1993 Dec; 67: 7271–5
    • (1993) J Virol , vol.67 , pp. 7271-7275
    • Fitzgibbon, J.E.1    Farnham, A.E.2    Sperber, S.J.3
  • 59
    • 85083234010 scopus 로고    scopus 로고
    • HIV-1 genotypic and phenotypic resistance in Delta patients [abstract no. Th.B4354]
    • Vancouver July
    • Loveday C. HIV-1 genotypic and phenotypic resistance in Delta patients [abstract no. Th.B4354]. 11th International Conference on AIDS, Vancouver July 1996
    • (1996) 11Th International Conference on AIDS
    • Loveday, C.1
  • 60
    • 0029836432 scopus 로고    scopus 로고
    • Human immunodeficiency virus type I drug susceptibility during zidovudine (AZT) monotherapy compared with AZT plus 2′,3′-dideoxyinosine or AZT plus 2′,3′-dideoxycytidine combination therapy
    • PID: 8709213, COI: 1:CAS:528:DyaK28XkvFGhsbo%3D
    • Larder BA, Kohli A, Bloor S, et al. Human immunodeficiency virus type I drug susceptibility during zidovudine (AZT) monotherapy compared with AZT plus 2′,3′-dideoxyinosine or AZT plus 2′,3′-dideoxycytidine combination therapy. J Virol 1996; 70: 5922–9
    • (1996) J Virol , vol.70 , pp. 5922-5929
    • Larder, B.A.1    Kohli, A.2    Bloor, S.3
  • 61
    • 0028332029 scopus 로고
    • Novel mutation (V75T) in human immunodeficiency virus type 1 reverse transcriptase confers resistance to 2′,3′-didehydro-2′,3′-dideoxythymidine in cell culture
    • PID: 7522429, COI: 1:CAS:528:DyaK2cXksV2ltLk%3D
    • Lacey SF, Larder BA. Novel mutation (V75T) in human immunodeficiency virus type 1 reverse transcriptase confers resistance to 2′,3′-didehydro-2′,3′-dideoxythymidine in cell culture. Antimicrob Agents Chemother 1994 Jun; 38: 1428–32
    • (1994) Antimicrob Agents Chemother , vol.38 , pp. 1428-1432
    • Lacey, S.F.1    Larder, B.A.2
  • 62
    • 0028940084 scopus 로고
    • Emergence of human immunodeficiency virus type 1 variants with resistance to multiple dideoxynucleosides in patients receiving therapy with dideoxynucleosides
    • PID: 7534421, COI: 1:CAS:528:DyaK2MXksVGjsrY%3D
    • Shirasaka T, Kavlick MF, Ueno T, et al. Emergence of human immunodeficiency virus type 1 variants with resistance to multiple dideoxynucleosides in patients receiving therapy with dideoxynucleosides. Proc Natl Acad Sci USA 1995 Mar 14; 92: 2398–402
    • (1995) Proc Natl Acad Sci USA , vol.92 , pp. 2398-2402
    • Shirasaka, T.1    Kavlick, M.F.2    Ueno, T.3
  • 63
    • 19244363136 scopus 로고    scopus 로고
    • Multiple drug resistance to nucleotide analogues and nonnucleoside reverse transcriptase inhibitors in an efficiently replicating human immunodeficiency virus type 1 patient strain
    • PID: 8896496, COI: 1:CAS:528:DyaK28XmvF2jt7k%3D
    • Schmit JC, Cogniaux J, Hermans P, et al. Multiple drug resistance to nucleotide analogues and nonnucleoside reverse transcriptase inhibitors in an efficiently replicating human immunodeficiency virus type 1 patient strain. J Infect Dis 1996; 174: 962–8
    • (1996) J Infect Dis , vol.174 , pp. 962-968
    • Schmit, J.C.1    Cogniaux, J.2    Hermans, P.3
  • 64
    • 0028051329 scopus 로고
    • Natural occurrence of drug resistance mutations in the reverse transcriptase of human immunodeficiency virus type 1 isolates
    • PID: 7534096
    • Nájera I, Richman DD, Olivares I, et al. Natural occurrence of drug resistance mutations in the reverse transcriptase of human immunodeficiency virus type 1 isolates. AIDS Res Hum Retroviruses 1994 Nov; 10: 1479–88
    • (1994) AIDS Res Hum Retroviruses , vol.10 , pp. 1479-1488
    • Nájera, I.1    Richman, D.D.2    Olivares, I.3
  • 65
    • 0027722907 scopus 로고
    • Decreased anti-human immunodeficiency virus type-1 activities of 2′,3′-dideoxy-nucleoside analogs in MOLT-4 cell sublines resistant to 2′,3′-dideoxynucleoside analogs
    • PID: 8184788, COI: 1:CAS:528:DyaK2cXpsVylug%3D%3D
    • Cinatl Jr J, Cinatl J, Weber B, et al. Decreased anti-human immunodeficiency virus type-1 activities of 2′,3′-dideoxy-nucleoside analogs in MOLT-4 cell sublines resistant to 2′,3′-dideoxynucleoside analogs. Acta Virol 1993 Oct; 37: 360–8
    • (1993) Acta Virol , vol.37 , pp. 360-368
    • Cinatl, J.1    Cinatl, J.2    Weber, B.3
  • 66
    • 0028674632 scopus 로고
    • Failure of antiretroviral therapy: role of viral and cellular factors
    • PID: 8586528, COI: 1:CAS:528:DyaK2MXpsVWntbc%3D
    • Cinatl Jr J, Cinatl J, Rabenau H, et al. Failure of antiretroviral therapy: role of viral and cellular factors. Intervirology 1994 Nov–Dec; 37: 307–14
    • (1994) Intervirology , vol.37 , pp. 307-314
    • Cinatl, J.1    Cinatl, J.2    Rabenau, H.3
  • 67
    • 0026515054 scopus 로고
    • Different pattern of activity of inhibitors of the human immunodeficiency virus in lymphocytes and monocyte/macrophages
    • PID: 1322645, COI: 1:CAS:528:DyaK38XktVSgt70%3D
    • Perno CF, Yarchoan R, Bulzarini J, et al. Different pattern of activity of inhibitors of the human immunodeficiency virus in lymphocytes and monocyte/macrophages. Antiviral Res 1992 Apr; 17: 289–304
    • (1992) Antiviral Res , vol.17 , pp. 289-304
    • Perno, C.F.1    Yarchoan, R.2    Bulzarini, J.3
  • 68
    • 0023785829 scopus 로고
    • Inhibition of human immunodeficiency virus (HIV-1/HTLV-IIIBa-L) replication in fresh and cultured human peripheral blood monocytes/ macrophages by azidothymidine and related 2′,3′-dideoxy-nucleosides
    • PID: 2844951, COI: 1:CAS:528:DyaL1cXmtVCnt7s%3D
    • Perno CF, Yarchoan R, Cooney DA, et al. Inhibition of human immunodeficiency virus (HIV-1/HTLV-IIIBa-L) replication in fresh and cultured human peripheral blood monocytes/ macrophages by azidothymidine and related 2′,3′-dideoxy-nucleosides. J Exp Med 1988 Sep 1; 168: 1111–25
    • (1988) J Exp Med , vol.168 , pp. 1111-1125
    • Perno, C.F.1    Yarchoan, R.2    Cooney, D.A.3
  • 69
    • 85025888830 scopus 로고
    • Inhibition of human immunodeficiency virus (HIV) infections of fresh peripheral blood monocyte/macrophages (M/M) by dideoxynucleosides and phosphonoformate
    • Perno CF, Cooney D, Yarchona R, et al. Inhibition of human immunodeficiency virus (HIV) infections of fresh peripheral blood monocyte/macrophages (M/M) by dideoxynucleosides and phosphonoformate. Antiviral Res 1988; 9: 157
    • (1988) Antiviral Res , vol.9 , pp. 157
    • Perno, C.F.1    Cooney, D.2    Yarchona, R.3
  • 70
    • 0027399054 scopus 로고
    • Cell cycle regulation of deoxycytidine kinase. Evidence for post-transcriptional control
    • PID: 8386681
    • Hengstschläger M, Denk C, Wawra E. Cell cycle regulation of deoxycytidine kinase. Evidence for post-transcriptional control. FEBS Lett 1993; 321: 237–40 7.
    • (1993) FEBS Lett , vol.321 , pp. 237-240
    • Hengstschläger, M.1    Denk, C.2    Wawra, E.3
  • 71
    • 0029162556 scopus 로고
    • Mammalian deoxyribonucleoside kinases
    • PID: 7494863
    • Arnér ESJ, Eriksson S. Mammalian deoxyribonucleoside kinases. Pharmacol Ther 1995; 67: 155–86
    • (1995) Pharmacol Ther , vol.67 , pp. 155-186
    • Arnér, E.S.J.1    Eriksson, S.2
  • 72
    • 0028300765 scopus 로고
    • Divergent anti-human immunodeficiency virus activity and anabolic phosphorylation of 2′,3′-dideoxynucleoside analogs in resting and activated human cells
    • PID: 8175673, COI: 1:CAS:528:DyaK2cXjtFGht7s%3D
    • Gao W-Y, Agbaria R, Driscoll JS, et al. Divergent anti-human immunodeficiency virus activity and anabolic phosphorylation of 2′,3′-dideoxynucleoside analogs in resting and activated human cells. J Biol Chem 1994 Apr 29; 269: 12633–8
    • (1994) J Biol Chem , vol.269 , pp. 12633-12638
    • Gao, W.-Y.1    Agbaria, R.2    Driscoll, J.S.3
  • 73
    • 0027287973 scopus 로고
    • Differential phosphorylation of azidothymidine, dideoxycytidine, and dideoxyinosine in resting and activated peripheral blood mononuclear cells
    • PID: 8387546, COI: 1:CAS:528:DyaK3sXkt1Sjsrc%3D
    • Gao W-Y, Shirasaka T, Johns DG, et al. Differential phosphorylation of azidothymidine, dideoxycytidine, and dideoxyinosine in resting and activated peripheral blood mononuclear cells. J Clin Invest 1993 May; 91: 2326–33
    • (1993) J Clin Invest , vol.91 , pp. 2326-2333
    • Gao, W.-Y.1    Shirasaka, T.2    Johns, D.G.3
  • 74
    • 0026783587 scopus 로고
    • Inhibition of HIV infection of resting peripheral blood lymphocytes by nucleosides
    • PID: 1325818, COI: 1:CAS:528:DyaK38Xmt1Gku7c%3D
    • Watson AJ, Wilburn LM. Inhibition of HIV infection of resting peripheral blood lymphocytes by nucleosides. AIDS Res Hum Retroviruses 1992 Jul; 8: 1221–7
    • (1992) AIDS Res Hum Retroviruses , vol.8 , pp. 1221-1227
    • Watson, A.J.1    Wilburn, L.M.2
  • 75
    • 0028022166 scopus 로고
    • In vitro activity of inhibitors of late stages of the replication of HIV in chronically infected macrophages
    • PID: 8083612, COI: 1:CAS:528:DyaK2MXntlSkuw%3D%3D
    • Perno CF, Aquaro S, Rosenwirth B, et al. In vitro activity of inhibitors of late stages of the replication of HIV in chronically infected macrophages. J Leukoc Biol 1994 Sep; 56: 381–6
    • (1994) J Leukoc Biol , vol.56 , pp. 381-386
    • Perno, C.F.1    Aquaro, S.2    Rosenwirth, B.3
  • 76
    • 0029153423 scopus 로고
    • 2′,3′-Dideoxycytidine induced drug resistance in human cells
    • PID: 7630317, COI: 1:CAS:528:DyaK2MXntFaqur8%3D
    • Magnani M, Gazzanelli G, Brandi G, et al. 2′,3′-Dideoxycytidine induced drug resistance in human cells. Life Sci 1995 Jul 21; 57: 881–7
    • (1995) Life Sci , vol.57 , pp. 881-887
    • Magnani, M.1    Gazzanelli, G.2    Brandi, G.3
  • 77
    • 0028820702 scopus 로고
    • 2′,3′-Dideoxycytidine metabolism in a new drug-resistant cell line
    • PID: 7492300, COI: 1:CAS:528:DyaK2MXpsFSgs7w%3D
    • Magnani M, Brandi G, Casablanca A, et al. 2′,3′-Dideoxycytidine metabolism in a new drug-resistant cell line. Biochem J 1995 Nov 15; 312 (Pt 1): 115–23
    • (1995) Biochem J , vol.312 , pp. 115-123
    • Magnani, M.1    Brandi, G.2    Casablanca, A.3
  • 78
    • 0025141473 scopus 로고
    • A pilot study of the bioavailability and pharmacokinetics of 2′,3′-dideoxycytidine in patients with AIDS or AIDS-related complex
    • PID: 2152803, COI: 1:CAS:528:DyaK3cXmvFeksA%3D%3D
    • Gustavson LE, Fukuda EK, Rubio FA, et al. A pilot study of the bioavailability and pharmacokinetics of 2′,3′-dideoxycytidine in patients with AIDS or AIDS-related complex. J Acquir Immune Defic Syndr 1990; 3: 28–31
    • (1990) J Acquir Immune Defic Syndr , vol.3 , pp. 28-31
    • Gustavson, L.E.1    Fukuda, E.K.2    Rubio, F.A.3
  • 79
    • 0024265003 scopus 로고
    • Pharmacokinetics of 2′,3′-dideoxycytidine in patients with AIDS and related disorders
    • PID: 2852679
    • Klecker Jr RW, Collins JM, Yarchoan RC, et al. Pharmacokinetics of 2′,3′-dideoxycytidine in patients with AIDS and related disorders. J Clin Pharmacol 1988 Sep; 28: 837–42
    • (1988) J Clin Pharmacol , vol.28 , pp. 837-842
    • Klecker, R.W.1    Collins, J.M.2    Yarchoan, R.C.3
  • 80
    • 0028886476 scopus 로고
    • Phase I evaluation of zalcitabine administered to human immunodeficiency virus-infected children
    • Gould Chadwick E, Nazareno LA, Nieuwenhuis TJ, et al. Phase I evaluation of zalcitabine administered to human immunodeficiency virus-infected children. J Infect Dis 1995 Dec; 172: 1475–9
    • (1995) J Infect Dis , vol.172 , pp. 1475-1479
    • Gould Chadwick, E.1    Nazareno, L.A.2    Nieuwenhuis, T.J.3
  • 81
    • 0025119701 scopus 로고
    • Dideoxycytidine alone and in an alternating schedule with zidovudine in children with symptomatic human immunodeficiency virus infection
    • PID: 2172501, COI: 1:STN:280:DyaK3M%2FjvVKnsg%3D%3D
    • Pizzo PA, Butler K, Balis F, et al. Dideoxycytidine alone and in an alternating schedule with zidovudine in children with symptomatic human immunodeficiency virus infection. J Pediatr 1990 Nov; 117: 799–808
    • (1990) J Pediatr , vol.117 , pp. 799-808
    • Pizzo, P.A.1    Butler, K.2    Balis, F.3
  • 82
    • 0028911385 scopus 로고
    • Clinical pharmacokinetics of nucleoside antiretroviral agents
    • PID: 7861025
    • Dudley MN. Clinical pharmacokinetics of nucleoside antiretroviral agents. J Infect Dis 1995 Mar; 171 Suppl. 2: S99–112
    • (1995) J Infect Dis , vol.171 , Issue.2 , pp. S99-S112
    • Dudley, M.N.1
  • 83
    • 0027480434 scopus 로고
    • Comparative pharmacokinetics of antiviral nucleoside analogues
    • COI: 1:CAS:528:DyaK3sXktl2qtbY%3D
    • Morse GD, Shelton MJ, O’Donnell AM. Comparative pharmacokinetics of antiviral nucleoside analogues. Clin Pharmacokinel 1993 Feb; 24: 101–23
    • (1993) Clin Pharmacokinel , vol.24 , pp. 101-123
    • Morse, G.D.1    Shelton, M.J.2    O’Donnell, A.M.3
  • 84
    • 0029038269 scopus 로고
    • Zalcilabine: clinical pharmacokinetics and efficacy
    • PID: 7614775, COI: 1:CAS:528:DyaK2MXmsV2itbw%3D
    • Devineni D, Gallo JM. Zalcilabine: clinical pharmacokinetics and efficacy. Clin Pharmacokinet 1995 May; 28: 351–60
    • (1995) Clin Pharmacokinet , vol.28 , pp. 351-360
    • Devineni, D.1    Gallo, J.M.2
  • 86
    • 0029930004 scopus 로고    scopus 로고
    • Improved combined solid-phase extraction-RIA method for quantifying zalcitabine in plasma
    • Kaslrissios H, Nakano M, Burton P, et al. Improved combined solid-phase extraction-RIA method for quantifying zalcitabine in plasma. Clin Chem 1996 Mar; 42: 465–6
    • (1996) Clin Chem , vol.42 , pp. 465-466
    • Kaslrissios, H.1    Nakano, M.2    Burton, P.3
  • 87
    • 0028073363 scopus 로고
    • Application of a radioimmunoassay for determination of levels of zalcitabine (ddC) in human plasma, urine, and cerebrospinal fluid
    • COI: 1:CAS:528:DyaK2MXisVCrsLY%3D
    • Burger DM, Rosing H, ten Napel CHH, el al. Application of a radioimmunoassay for determination of levels of zalcitabine (ddC) in human plasma, urine, and cerebrospinal fluid. Anli-microb Agents Chemother 1994 Dec; 38: 2763–7
    • (1994) Anli-microb Agents Chemother , vol.38 , pp. 2763-2767
    • Burger, D.M.1    Rosing, H.2    ten Napel, C.3
  • 88
    • 0028295413 scopus 로고
    • Solid-phase extraction combined with radioimmunoassay for measurement of zalcitabine (2′,3′-dideoxycytidine) in plasma and serum
    • PID: 8313596, COI: 1:CAS:528:DyaK2cXitVOrs74%3D
    • Roberts WL, Buckley TJ, Rainey PM, et al. Solid-phase extraction combined with radioimmunoassay for measurement of zalcitabine (2′,3′-dideoxycytidine) in plasma and serum. Clin Chem 1994 Feb; 40: 211–5
    • (1994) Clin Chem , vol.40 , pp. 211-215
    • Roberts, W.L.1    Buckley, T.J.2    Rainey, P.M.3
  • 89
    • 0028848484 scopus 로고
    • The effect of food on pharmacokinetics of zalcitabine in HIV-positive patients
    • PID: 8584481, COI: 1:CAS:528:DyaK2MXoslerurc%3D
    • Nazareno LA, Holazo AA, Limjuco R, et al. The effect of food on pharmacokinetics of zalcitabine in HIV-positive patients. Pharm Res 1995 Oct; 12: 1462–5
    • (1995) Pharm Res , vol.12 , pp. 1462-1465
    • Nazareno, L.A.1    Holazo, A.A.2    Limjuco, R.3
  • 90
    • 0023837875 scopus 로고
    • Phase I studies of 2′,3′-dideoxycytidine in severe human immunodeficiency virus infection as a single agent and alternating with zidovudine (AZT)
    • Yarchoan R, Perno CF, Thomas RV, el al. Phase I studies of 2′,3′-dideoxycytidine in severe human immunodeficiency virus infection as a single agent and alternating with zidovudine (AZT). Lancet 1988 Jan 16; I: 76–81
    • (1988) Lancet , vol.1 , pp. 76-81
    • Yarchoan, R.1    Perno, C.F.2    Thomas, R.3
  • 91
    • 85083283153 scopus 로고    scopus 로고
    • The effects of renal impairment on the pharmacokinetics of Zalcitabine (ddC) [abstract]
    • Bazunga M, Tran HT, Kertland H, et al. The effects of renal impairment on the pharmacokinetics of Zalcitabine (ddC) [abstract]. J Clin Pharmacol 1996 Sep; 36: 851
    • (1996) J Clin Pharmacol , vol.36 , pp. 851
    • Bazunga, M.1    Tran, H.T.2    Kertland, H.3
  • 93
    • 0029553799 scopus 로고    scopus 로고
    • Consensus conference on laboratory markers in HIV infection
    • Aiuti F, Boucher C, Dianzani F, et al. Consensus conference on laboratory markers in HIV infection. J Biol Regul Homeost Agents l995 Jul–Sep; 9: 119–20
    • J Biol Regul Homeost Agents , vol.9 , pp. 119-120
    • Aiuti, F.1    Boucher, C.2    Dianzani, F.3
  • 94
    • 0030031884 scopus 로고    scopus 로고
    • Response of CD4 lymphocytes and clinical consequences of treatment using ddI or ddC in patients with advanced HIV infection
    • COI: 1:STN:280:DyaK287ksleitA%3D%3D
    • Goldman AI, Carlin BP, Crane LR, et al. Response of CD4 lymphocytes and clinical consequences of treatment using ddI or ddC in patients with advanced HIV infection. J Acquir Immune Defic Syndrom Hum Retrovirol 1996 Feb 1; 11: 161–9
    • (1996) J Acquir Immune Defic Syndrom Hum Retrovirol , vol.11 , pp. 161-169
    • Goldman, A.I.1    Carlin, B.P.2    Crane, L.R.3
  • 95
    • 0027403928 scopus 로고
    • + lymphocytes are an incomplete surrogate marker for clinical progression in persons with asymptomatic HIV infection taking zidovudine
    • PID: 8096373, COI: 1:STN:280:DyaK3s3htlSjtw%3D%3D
    • + lymphocytes are an incomplete surrogate marker for clinical progression in persons with asymptomatic HIV infection taking zidovudine. Ann Intern Med 1993; 118: 674–80
    • (1993) Ann Intern Med , vol.118 , pp. 674-680
    • Choi, S.1    Lagakos, S.W.2    Schooley, R.T.3
  • 96
    • 79960386385 scopus 로고    scopus 로고
    • The XI International Conference on AIDS Vancouver 7–12 July 1996. Areview of Clinical Science Track B
    • PID: 8976856, COI: 1:STN:280:DyaK2s7jtFajtg%3D%3D
    • Williams IG, De Cock KM. The XI International Conference on AIDS Vancouver 7–12 July 1996. Areview of Clinical Science Track B. Genitourin Med 1996; 72: 365–9
    • (1996) Genitourin Med , vol.72 , pp. 365-369
    • Williams, I.G.1    De Cock, K.M.2
  • 97
    • 0029609080 scopus 로고
    • Measuring viral load in the clinical setting
    • COI: 1:CAS:528:DyaK28XitVGmsbk%3D
    • Harrigan R. Measuring viral load in the clinical setting. J Acquir Immune Defic Syndrom Hum Retrovirol 1995; 10 Suppl. 1: S34–40
    • (1995) J Acquir Immune Defic Syndrom Hum Retrovirol , vol.10 , Issue.1 , pp. S34-S40
    • Harrigan, R.1
  • 98
    • 0005150171 scopus 로고    scopus 로고
    • The relation of virologic and immunologic markers to clinical outcomes after nucleoside therapy in HIV-infecled adults with 200 to 500 CD4 cells per cubic millimeter
    • PID: 8813039, COI: 1:CAS:528:DyaK28XmsValtrc%3D
    • Katzenstein DA, Hammer SM, Hughes MD, et al. The relation of virologic and immunologic markers to clinical outcomes after nucleoside therapy in HIV-infecled adults with 200 to 500 CD4 cells per cubic millimeter. N Engl J Med 1996 Oct 10; 335: 1091–8
    • (1996) N Engl J Med , vol.335 , pp. 1091-1098
    • Katzenstein, D.A.1    Hammer, S.M.2    Hughes, M.D.3
  • 99
    • 0029683044 scopus 로고    scopus 로고
    • Importance of surrogate markers in evaluation of antiviral therapy in HIV infection
    • PID: 8656509, COI: 1:STN:280:DyaK283nt12mtQ%3D%3D
    • Deyton L. Importance of surrogate markers in evaluation of antiviral therapy in HIV infection. JAMA 1996; 276: 159–60
    • (1996) JAMA , vol.276 , pp. 159-160
    • Deyton, L.1
  • 100
    • 0029680701 scopus 로고    scopus 로고
    • Surrogate markers in AIDS research
    • COI: 1:STN:280:DyaK283nt12mug%3D%3D
    • Levy JA. Surrogate markers in AIDS research. Is there truth in numbers? JAMA 1996; 276: 161–2
    • (1996) Is there truth in numbers? JAMA , vol.276 , pp. 161-162
    • Levy, J.A.1
  • 101
    • 0028864179 scopus 로고
    • Primary care of children with HIV infection
    • PID: 8541949, COI: 1:STN:280:DyaK287itVyktg%3D%3D
    • Forsyth BWC. Primary care of children with HIV infection. Curr Opin Pediatr 1995 Oct; 7: 502–12
    • (1995) Curr Opin Pediatr , vol.7 , pp. 502-512
    • Forsyth, B.W.C.1
  • 102
    • 0028360789 scopus 로고
    • Antiretroviral therapy for infection due to human immunodeficiency virus in children
    • PID: 7948527, COI: 1:STN:280:DyaK2M%2FjsFKhsg%3D%3D
    • Pizzo PA, Wilfert C. Antiretroviral therapy for infection due to human immunodeficiency virus in children. Clin Infect Dis 1994 Jul; 19: 177–96
    • (1994) Clin Infect Dis , vol.19 , pp. 177-196
    • Pizzo, P.A.1    Wilfert, C.2
  • 103
    • 0028765439 scopus 로고
    • Recommendations of the U.S. Public Health Service Task Force on the use of zidovudine to reduce perinatal transmission of human immunodeficiency virus
    • Mofenson L, Balsley J, Simonds RJ, et al. Recommendations of the U.S. Public Health Service Task Force on the use of zidovudine to reduce perinatal transmission of human immunodeficiency virus. MMWR 1994 Aug 5; 43: 1–20
    • (1994) MMWR , vol.43 , pp. 1-20
    • Mofenson, L.1    Balsley, J.2    Simonds, R.J.3
  • 104
    • 0028199778 scopus 로고
    • Prophylactic zalcilabine and interferon-α for a large-bore needlestick exposure to human immunodeficiency virus
    • PID: 8133452, COI: 1:STN:280:DyaK2c7otVeiuw%3D%3D
    • Mildvan D, Bergé P. Prophylactic zalcilabine and interferon-α for a large-bore needlestick exposure to human immunodeficiency virus. J Acquir Immune Defic Syndr 1994 Apr; 7: 416–7
    • (1994) J Acquir Immune Defic Syndr , vol.7 , pp. 416-417
    • Mildvan, D.1    Bergé, P.2
  • 105
    • 0030573421 scopus 로고    scopus 로고
    • Update: Provisional Public Health Service recommendations for chemoprophyIaxis after occupational exposure to HIV
    • Jun 7
    • Update: Provisional Public Health Service recommendations for chemoprophyIaxis after occupational exposure to HIV. MMWR 1996 Jun 7; 45: 468–72
    • (1996) MMWR , vol.45 , pp. 468-472
  • 106
    • 0028786146 scopus 로고
    • HIV-1, the brain, and combination therapy
    • PID: 7475712, COI: 1:STN:280:DyaK28%2FmsVyktA%3D%3D
    • Portegies P. HIV-1, the brain, and combination therapy. Lancet 1995 Nov 11; 346: 1244–5
    • (1995) Lancet , vol.346 , pp. 1244-1245
    • Portegies, P.1
  • 107
    • 0028925278 scopus 로고
    • Neuropsychiatric aspects of HIV infection
    • PID: 7738542, COI: 1:STN:280:DyaK2M3ls1ymsw%3D%3D
    • Everall IP. Neuropsychiatric aspects of HIV infection. J Neurol Neurosurg Psychiatry 1995 Apr; 58: 399–402
    • (1995) J Neurol Neurosurg Psychiatry , vol.58 , pp. 399-402
    • Everall, I.P.1
  • 108
    • 0029588264 scopus 로고
    • Combination therapy from a clinician’s perspective
    • COI: 1:CAS:528:DyaK28XitVGmtr0%3D
    • Goebel FD. Combination therapy from a clinician’s perspective. J Acquir Immune Defic Syndrom Hum Retrovirol 1995; 10 Suppl. 1: S62–68
    • (1995) J Acquir Immune Defic Syndrom Hum Retrovirol , vol.10 , Issue.1 , pp. S62-S68
    • Goebel, F.D.1
  • 109
    • 0000248534 scopus 로고
    • Pilot study of zidovudine (AZT) and zalcitabine (ddC) combination in HIV-associated dementia [abstract]
    • McIntyre K, Torres R, Luck D, et al. Pilot study of zidovudine (AZT) and zalcitabine (ddC) combination in HIV-associated dementia [abstract]. 10th International Conference on AIDS 1994; 1: 201
    • (1994) 10th International Conference on AIDS , vol.1 , pp. 201
    • McIntyre, K.1    Torres, R.2    Luck, D.3
  • 110
    • 4243703741 scopus 로고
    • The efficacy of zalcitabine (ddC, HIVID) versus zidovudine (ZDV) as monotherapy in ZDV naive patients with advanced HIV disease: a randomized, double-blind, comparative trial (ACTG 114: N3300) [abstract]
    • Follansbee S, Drew L, Olson R, et al. The efficacy of zalcitabine (ddC, HIVID) versus zidovudine (ZDV) as monotherapy in ZDV naive patients with advanced HIV disease: a randomized, double-blind, comparative trial (ACTG 114: N3300) [abstract]. 9th Int Conf Aids 1993; 1: 487
    • (1993) 9th Int Conf Aids , vol.1 , pp. 487
    • Follansbee, S.1    Drew, L.2    Olson, R.3
  • 111
    • 0028798335 scopus 로고
    • Health status and function with zidovudine or zalcitabine as initial therapy for AIDS: a randomized controlled trial
    • PID: 7815656, COI: 1:STN:280:DyaK2M7hsFanug%3D%3D
    • Bozzette SA, Kanouse DE, Berry S, et al. Health status and function with zidovudine or zalcitabine as initial therapy for AIDS: a randomized controlled trial. JAMA 1995 Jan 25; 273: 295–301
    • (1995) JAMA , vol.273 , pp. 295-301
    • Bozzette, S.A.1    Kanouse, D.E.2    Berry, S.3
  • 112
    • 0028891512 scopus 로고
    • A comparison of zidovudine, didanosine, zalcitabine and no antiretroviral therapy in patients with advanced HIV disease
    • PID: 7727578, COI: 1:STN:280:DyaK2M3ksVKmuw%3D%3D
    • Torres RA, Barr MR, Mclntyre KI, et al. A comparison of zidovudine, didanosine, zalcitabine and no antiretroviral therapy in patients with advanced HIV disease. Int J STD AIDS 1995 Jan–Feb; 6: 19–26
    • (1995) Int J STD AIDS , vol.6 , pp. 19-26
    • Torres, R.A.1    Barr, M.R.2    Mclntyre, K.I.3
  • 113
    • 0028091097 scopus 로고
    • A comparative trial of didanosine or zalcitabine after treatment with zidovudine in patients with human immunodeficiency virus infection
    • PID: 7906384, COI: 1:STN:280:DyaK2c7ltVGitA%3D%3D
    • Abrams DI, Goldman AI, Launer C, et al. A comparative trial of didanosine or zalcitabine after treatment with zidovudine in patients with human immunodeficiency virus infection. N Engl J Med 1994 Mar 10; 330: 657–62
    • (1994) N Engl J Med , vol.330 , pp. 657-662
    • Abrams, D.I.1    Goldman, A.I.2    Launer, C.3
  • 114
    • 0027309149 scopus 로고
    • Zalcitabine compared with zidovudine in patients with advanced HI V-1 infection who received previous zidovudine therapy
    • PID: 8097082, COI: 1:STN:280:DyaK3s3ivValug%3D%3D
    • Fischl MA, Olson RM, Follansbee SE, et al. Zalcitabine compared with zidovudine in patients with advanced HI V-1 infection who received previous zidovudine therapy. Ann Intern Med 1993 May 15; 118: 762–9
    • (1993) Ann Intern Med , vol.118 , pp. 762-769
    • Fischl, M.A.1    Olson, R.M.2    Follansbee, S.E.3
  • 115
    • 0028837503 scopus 로고
    • Combination and monotherapy with zidovudine and zalcitabine in patients with advanced HIV disease
    • PID: 7985892, COI: 1:STN:280:DyaK2M%2Fnslaisw%3D%3D
    • Fischl MA, Stanley K, Collier AC. Combination and monotherapy with zidovudine and zalcitabine in patients with advanced HIV disease. Ann Intern Med 1995 Jan 1; 122: 24–32
    • (1995) Ann Intern Med , vol.122 , pp. 24-32
    • Fischl, M.A.1    Stanley, K.2    Collier, A.C.3
  • 116
    • 10144244674 scopus 로고    scopus 로고
    • A trial comparing nucleoside monotherapy with combination therapy in HI V-infected adults with CD4 cell counts from 200 to 500 per cubic millimeter
    • PID: 8813038, COI: 1:CAS:528:DyaK28XmsValtrY%3D
    • Hammer SM, Katzenstein DA, Hughes MD, et al. A trial comparing nucleoside monotherapy with combination therapy in HI V-infected adults with CD4 cell counts from 200 to 500 per cubic millimeter. N Engl J Med 1996 Oct 10; 335: 1081–90
    • (1996) N Engl J Med , vol.335 , pp. 1081-1090
    • Hammer, S.M.1    Katzenstein, D.A.2    Hughes, M.D.3
  • 117
    • 2442723342 scopus 로고    scopus 로고
    • Treatment of human immunodeficiency virus infection with saquinavir, zidovudine, and zalcitabine
    • PID: 8598838, COI: 1:CAS:528:DyaK28XivFait74%3D
    • Collier AC, Coombs RW, Schoenfeld DA, et al. Treatment of human immunodeficiency virus infection with saquinavir, zidovudine, and zalcitabine. N Engl J Med 1996 Apr 18; 334: 1011–7
    • (1996) N Engl J Med , vol.334 , pp. 1011-1017
    • Collier, A.C.1    Coombs, R.W.2    Schoenfeld, D.A.3
  • 118
    • 9444290697 scopus 로고    scopus 로고
    • Virologic and immunologic benefits of initial combination therapy with zidovudine and zalcitabine or didanosine compared with zidovudine monotherapy
    • PID: 8648207, COI: 1:CAS:528:DyaK28XjvVegsb4%3D
    • Schooley RT, Ramirez-Ronda C, Lange JMA, et al. Virologic and immunologic benefits of initial combination therapy with zidovudine and zalcitabine or didanosine compared with zidovudine monotherapy. J Infect Dis 1996 Jun; 173: 1354–66
    • (1996) J Infect Dis , vol.173 , pp. 1354-1366
    • Schooley, R.T.1    Ramirez-Ronda, C.2    Lange, J.M.A.3
  • 119
    • 33748616134 scopus 로고    scopus 로고
    • Clinical and survival benefit of 3TC™ in combination with zidovudine-containing regimens in HIV-1 infection: interim results of the CAESAR study [abstract no. SS2.1]
    • Katlama C. Clinical and survival benefit of 3TC™ in combination with zidovudine-containing regimens in HIV-1 infection: interim results of the CAESAR study [abstract no. SS2.1]. AIDS 1996; 10 Suppl.: S9
    • (1996) AIDS , vol.10 , pp. S9
    • Katlama, C.1
  • 120
    • 10144258702 scopus 로고    scopus 로고
    • Zidovudine alone or in combination with didanosine or zalcitabine in HIV-inlected patients with the acquired immunodeficiency syndrome or fewer than 200 CD4 cells per cubic millimeter
    • PID: 8813040, COI: 1:CAS:528:DyaK28XmsValt74%3D
    • Saravolatz LD, Winslow DL, Collins G, et al. Zidovudine alone or in combination with didanosine or zalcitabine in HIV-inlected patients with the acquired immunodeficiency syndrome or fewer than 200 CD4 cells per cubic millimeter. N Engl J Med 1996 Oct 10; 335: 1099–106
    • (1996) N Engl J Med , vol.335 , pp. 1099-1106
    • Saravolatz, L.D.1    Winslow, D.L.2    Collins, G.3
  • 121
    • 0030567824 scopus 로고    scopus 로고
    • Delta: a randomised double-blind controlled trial comparing combinations of zidovudine plus didanosine or zalcitabine with zidovudine alone in HIV-infected individuals
    • Delta Coordinating Committee. Delta: a randomised double-blind controlled trial comparing combinations of zidovudine plus didanosine or zalcitabine with zidovudine alone in HIV-infected individuals. Lancet 1996 Aug 3; 348: 283–91
    • (1996) Lancet , vol.348 , pp. 283-291
  • 122
    • 85084025511 scopus 로고    scopus 로고
    • 3: a double-blind placebo controlled trial (Roche study M50003) [abslract no. P49]
    • 3: a double-blind placebo controlled trial (Roche study M50003) [abslract no. P49]. AIDS 1996; 10 Suppl. 2: S31
    • (1996) AIDS , vol.10 , Issue.2 , pp. S31
    • Moyle, G.J.1    Walker, M.2    Harris, R.3
  • 123
    • 0030215471 scopus 로고    scopus 로고
    • Lamivudine plus zidovudine compared with zalcilabine plus zidovudine in patients with HIV infection: a randomized, double-blind, placebo-controlled trial
    • PID: 8686973, COI: 1:CAS:528:DyaK28XltVansbg%3D
    • Bartlett JA, Benoit SL, Johnson VA. Lamivudine plus zidovudine compared with zalcilabine plus zidovudine in patients with HIV infection: a randomized, double-blind, placebo-controlled trial. Ann Intern Med 1996 Aug 1; 125: 161–72
    • (1996) Ann Intern Med , vol.125 , pp. 161-172
    • Bartlett, J.A.1    Benoit, S.L.2    Johnson, V.A.3
  • 125
    • 0026513969 scopus 로고
    • Combination therapy with zidovudine and dideoxycytidine in patients with advanced human immunodeficiency virus infection
    • COI: 1:STN:280:DyaK38%2FnsVOjtw%3D%3D
    • Meng T-C, Fischl MA, Boota AM, et al. Combination therapy with zidovudine and dideoxycytidine in patients with advanced human immunodeficiency virus infection. Ann Med 1992; 116(1): 13–20
    • (1992) Ann Med , vol.116 , Issue.1 , pp. 13-20
    • Meng, T.-C.1    Fischl, M.A.2    Boota, A.M.3
  • 126
    • 0013490522 scopus 로고    scopus 로고
    • A randomized, double-blind, placebo-controlled study comparing combination nucleoside and triple therapy for the treatment of advanced HIV disease (CD4 < = 50/mm3) [abstract]
    • Jan 22–26; Washington, DC
    • Henry K, Tierney C, Kahn J, et al. A randomized, double-blind, placebo-controlled study comparing combination nucleoside and triple therapy for the treatment of advanced HIV disease (CD4 < = 50/mm3) [abstract]. 4th Conference on Retroviruses and Opportunistic Infections; 1997 Jan 22–26; Washington, DC
    • (1997) 4Th Conference on Retroviruses and Opportunistic Infections
    • Henry, K.1    Tierney, C.2    Kahn, J.3
  • 127
    • 9444261412 scopus 로고    scopus 로고
    • Impact on survival of combination or sequential antiretroviral therapy compared with AZT monotherapy [abstract]
    • Thompson M, Creagh T, Harmon M, et al. Impact on survival of combination or sequential antiretroviral therapy compared with AZT monotherapy [abstract]. 3rd Conference on Retroviruses and Opportunistic Infections 1996 Jan 28: 106
    • (1996) 3rd Conference on Retroviruses and Opportunistic Infections , vol.28 , pp. 106
    • Thompson, M.1    Creagh, T.2    Harmon, M.3
  • 128
    • 0030317628 scopus 로고    scopus 로고
    • Survival in HIV-infected patients who have received zidovudine: comparison of combination therapy with sequential monotherapy and continued zidovudine monotherapy
    • Graham NMH, Hoover DR, Park LP, et al. Survival in HIV-infected patients who have received zidovudine: comparison of combination therapy with sequential monotherapy and continued zidovudine monotherapy. Ann Intern Med 1996 Jun 15; 124: 10310–1038
    • (1996) Ann Intern Med , vol.124 , pp. 10310-11038
    • Graham, N.M.H.1    Hoover, D.R.2    Park, L.P.3
  • 130
    • 0342718057 scopus 로고    scopus 로고
    • Effects of combination therapy with saquinavir, zidovudine and zalcitabine on quality of life [abstract]
    • Testa MA, Lenderking WR, Fischer L, et al. Effects of combination therapy with saquinavir, zidovudine and zalcitabine on quality of life [abstract]. 11th International Conference on AIDS 1996 Jul 7; 1: 239
    • (1996) 11th International Conference on AIDS , vol.1 , pp. 239
    • Testa, M.A.1    Lenderking, W.R.2    Fischer, L.3
  • 131
    • 10544249459 scopus 로고    scopus 로고
    • Efficacy of triple combination therapy with zidovudine (ZDV) plus zalcitabine (ddC) plus lamivudine (3TC) versus double (ZDV + 3TC) combination therapy in patients previously treated with ZDV + ddC
    • PID: 8970679, COI: 1:CAS:528:DyaK2sXmtVGktw%3D%3D
    • Ruiz L, Romeu J, Martinez-Picado J, et al. Efficacy of triple combination therapy with zidovudine (ZDV) plus zalcitabine (ddC) plus lamivudine (3TC) versus double (ZDV + 3TC) combination therapy in patients previously treated with ZDV + ddC. AIDS 1996; 10: F61–6
    • (1996) AIDS , vol.10 , pp. F61-F66
    • Ruiz, L.1    Romeu, J.2    Martinez-Picado, J.3
  • 132
    • 0008913115 scopus 로고    scopus 로고
    • A triple combination of ritonavir+AZT+DDC as a first line treatment of patients with AIDS: update [abstract]
    • Mathez D, Bagnarelli P, De Truehis P, et al. A triple combination of ritonavir+AZT+DDC as a first line treatment of patients with AIDS: update [abstract]. 11th International Conference on AIDS 1996 Jul 7; 1: 19
    • (1996) 11th International Conference on AIDS , vol.1 , pp. 19
    • Mathez, D.1    Bagnarelli, P.2    De Truehis, P.3
  • 133
    • 85083285150 scopus 로고
    • Antiviral combined and thymostimulin in patients with HIV stages III and IV. Effects on the CD4 cells counts [abstract]
    • Conde-Mercado JM, Feregrino GM, Eid Lidt G, et al. Antiviral combined and thymostimulin in patients with HIV stages III and IV. Effects on the CD4 cells counts [abstract]. 10th International Conference on AIDS 1994; 1: 211
    • (1994) 10th International Conference on AIDS , vol.1 , pp. 211
    • Conde-Mercado, J.M.1    Feregrino, G.M.2    Eid Lidt, G.3
  • 134
    • 85083258870 scopus 로고    scopus 로고
    • Long-term safety and efficacy of initial triple combination therapy with ZDV, ddC and interferon alpha-n1 vs ZDV and ddC in patients with CD4+ cell counts 300–500 cells/mm3
    • Lavelle J, Haas D, HIV/Wellferon® Clinical Trial Team. Long-term safety and efficacy of initial triple combination therapy with ZDV, ddC and interferon alpha-n1 vs ZDV and ddC in patients with CD4+ cell counts 300–500 cells/mm3. 3rd Conference on Retroviruses and Opportunistic Infections 1996 Jan 28: 107
    • (1996) 3rd Conference on Retroviruses and Opportunistic Infections , vol.28 , pp. 107
    • Lavelle, J.1    Haas, D.2
  • 135
    • 11544253931 scopus 로고    scopus 로고
    • Surrogate marker responses from an open-label, extended use delavirdine mesylate (DLV) treatment in triple combination (ZDV+DLV +DDI or ZDV+DLV+DDC) for HIV-1+ patients [abstiact]
    • Freimuth W, Wang Y, Docsa S, et al. Surrogate marker responses from an open-label, extended use delavirdine mesylate (DLV) treatment in triple combination (ZDV+DLV +DDI or ZDV+DLV+DDC) for HIV-1+ patients [abstiact]. 11th International Conference on AIDS 1996 Jul 7; 1: 78
    • (1996) 11th International Conference on AIDS , vol.1 , pp. 78
    • Freimuth, W.1    Wang, Y.2    Docsa, S.3
  • 136
    • 10544222714 scopus 로고    scopus 로고
    • Extreme suppression of HIV-1 plasma RNA using a combination of zidovudine, didanosine, zalcitabine, epivir, saquinavir, and interferon-α in patients with HIV-I infection [abstract]
    • Scheibel SF, Saget B, Elbeik T, et al. Extreme suppression of HIV-1 plasma RNA using a combination of zidovudine, didanosine, zalcitabine, epivir, saquinavir, and interferon-α in patients with HIV-I infection [abstract]. 11th International Conference on AIDS 1996 Jul 7; 2: 78
    • (1996) 11th International Conference on AIDS , vol.2 , pp. 78
    • Scheibel, S.F.1    Saget, B.2    Elbeik, T.3
  • 137
    • 9244263827 scopus 로고
    • Results of a clinical trial comparing two doses of 2′3′-dideoxycytidine (ddC) in the treatment of children with symptomatic human immunodeficiency virus (HIV) infection who were intolerant or had failed zidovudine (ZDV) therapy (ACTG 138) [abstract]
    • Spector SA, Blanchard S, Connor EM, et al. Results of a clinical trial comparing two doses of 2′3′-dideoxycytidine (ddC) in the treatment of children with symptomatic human immunodeficiency virus (HIV) infection who were intolerant or had failed zidovudine (ZDV) therapy (ACTG 138) [abstract]. Pediatr Res 1994 Apr; 35 (Pt 2): 197A
    • (1994) Pediatr Res , vol.35 , pp. 197A
    • Spector, S.A.1    Blanchard, S.2    Connor, E.M.3
  • 138
    • 85083195626 scopus 로고
    • Effect of salvage dideoxycytidine on growth, nutritional parameters and metabolic rates of children with advanced HIV disease [abstract]
    • Dankner WM, Rice M, Nyhan WL, et al. Effect of salvage dideoxycytidine on growth, nutritional parameters and metabolic rates of children with advanced HIV disease [abstract]. 2nd National Conference on Human Retroviruses 1995 Jan 29: 104
    • (1995) 2nd National Conference on Human Retroviruses , vol.29 , pp. 104
    • Dankner, W.M.1    Rice, M.2    Nyhan, W.L.3
  • 139
    • 85083266745 scopus 로고
    • High level resistance to AZT, but not to ddC or ddI in HIV from children receiving long-term antiretroviral therapy [abslract no. 571]
    • Husson R, Shirasaka T, Butler K, et al. High level resistance to AZT, but not to ddC or ddI in HIV from children receiving long-term antiretroviral therapy [abslract no. 571]. 32nd Inl Conf Antimicro Ag Chemother 1992: 206
    • (1992) 32Nd Inl Conf Antimicro Ag Chemother , pp. 206
    • Husson, R.1    Shirasaka, T.2    Butler, K.3
  • 140
    • 0028686317 scopus 로고
    • Cost effectiveness of antiviral treatment with zalcitabine plus zidovudine for AIDS patients with CD4+ counts less than 33/μl in 5 European countries
    • PID: 10155284, COI: 1:STN:280:DyaK28%2FlvVeqtA%3D%3D
    • Simpson K, Hatziandreu EJ, Andersson F, et al. Cost effectiveness of antiviral treatment with zalcitabine plus zidovudine for AIDS patients with CD4+ counts less than 33/μl in 5 European countries. PharmacoEconomics 1994 Dec; 6: 553–62
    • (1994) PharmacoEconomics , vol.6 , pp. 553-562
    • Simpson, K.1    Hatziandreu, E.J.2    Andersson, F.3
  • 141
    • 44949278865 scopus 로고
    • Treatment of AIDS with combinations of anti-retroviralagents
    • PID: 1850192, COI: 1:STN:280:DyaK3M3gs1Chsw%3D%3D
    • Merigan TC. Treatment of AIDS with combinations of anti-retroviralagents. Am J Med 1991; 90 Suppl. 4A: 8S–17S
    • (1991) Am J Med , vol.90 , Issue.4A , pp. 8S-17S
    • Merigan, T.C.1
  • 142
    • 0029998229 scopus 로고    scopus 로고
    • Safety and tolerability of zalcitabine (ddC) in patients with AIDS or advanced AIDS-related complex in the European Expanded Access Programme
    • PID: 18611734, COI: 1:CAS:528:DyaK28XjvVWltb8%3D
    • Moyle G, Goll A, Snape S, et al. Safety and tolerability of zalcitabine (ddC) in patients with AIDS or advanced AIDS-related complex in the European Expanded Access Programme. Int J Antimicrob Agents 1996; 7(1): 41–8
    • (1996) Int J Antimicrob Agents , vol.7 , Issue.1 , pp. 41-48
    • Moyle, G.1    Goll, A.2    Snape, S.3
  • 143
    • 0030199251 scopus 로고    scopus 로고
    • Adverse events from drug therapy for human immunodeficiency virus disease
    • PID: 8686712, COI: 1:STN:280:DyaK28zgt1WmtQ%3D%3D
    • Moore RD, Fortgang I, Keruly J, et al. Adverse events from drug therapy for human immunodeficiency virus disease. Am J Med 1996 Jul; 101: 34–40
    • (1996) Am J Med , vol.101 , pp. 34-40
    • Moore, R.D.1    Fortgang, I.2    Keruly, J.3
  • 144
    • 0029030096 scopus 로고
    • Nucleoside analogue-associated peripheral neuropathy in human immunodeficiency virus infection
    • COI: 1:STN:280:DyaK2M3mvVyrtg%3D%3D
    • Simpson DM, Tagliati M. Nucleoside analogue-associated peripheral neuropathy in human immunodeficiency virus infection. J Acquir Immune Defic Syndrom Hum Retrovirol 1995 Jun 1; 9: 153–61
    • (1995) J Acquir Immune Defic Syndrom Hum Retrovirol , vol.9 , pp. 153-161
    • Simpson, D.M.1    Tagliati, M.2
  • 145
    • 9244235985 scopus 로고    scopus 로고
    • Low-dose zalcitabine-related toxic neuropathy: frequency, natural history, and risk factors
    • PID: 8780079, COI: 1:STN:280:DyaK28zntlOrug%3D%3D
    • Blum AS, Dal PGJ, Feinberg J, et al. Low-dose zalcitabine-related toxic neuropathy: frequency, natural history, and risk factors. Neurology 1996 Apr; 46: 999–1003
    • (1996) Neurology , vol.46 , pp. 999-1003
    • Blum, A.S.1    Dal, P.G.J.2    Feinberg, J.3
  • 146
    • 0029092663 scopus 로고
    • Risk factors for dideoxynucleoside-induced toxic neuropathy in patients with the human immunodeficiency virus infection
    • COI: 1:CAS:528:DyaK2MXptlaltLs%3D
    • Fichtenbaum CJ, Clifford DB, Powderly WG. Risk factors for dideoxynucleoside-induced toxic neuropathy in patients with the human immunodeficiency virus infection. J Acquir Immune Defic Syndrom Hum Retrovirol 1995 Oct 1; 10: 169–74
    • (1995) J Acquir Immune Defic Syndrom Hum Retrovirol , vol.10 , pp. 169-174
    • Fichtenbaum, C.J.1    Clifford, D.B.2    Powderly, W.G.3
  • 147
    • 0027400984 scopus 로고
    • 2′,3′-dideoxy-cytidine (ddC) toxic neuropathy: a study of 52 patients
    • PID: 8382349, COI: 1:STN:280:DyaK3s7ntleisg%3D%3D
    • Berger AR, Arezzo JC, Schaumburg HH, et al. 2′,3′-dideoxy-cytidine (ddC) toxic neuropathy: a study of 52 patients. Neurology 1993 Feb; 43: 358–62
    • (1993) Neurology , vol.43 , pp. 358-362
    • Berger, A.R.1    Arezzo, J.C.2    Schaumburg, H.H.3
  • 148
    • 0024451358 scopus 로고
    • Reversible axonal neuropathy from the treatment of AIDS and related disorders with 2′,3′-dideoxycytidine (ddC)
    • PID: 2558314, COI: 1:STN:280:DyaK3c7hsVaquw%3D%3D
    • Dubinsky RM, Yarchoan R, Dalakas M, et al. Reversible axonal neuropathy from the treatment of AIDS and related disorders with 2′,3′-dideoxycytidine (ddC). Muscle Nerve 1989; 12: 856–60
    • (1989) Muscle Nerve , vol.12 , pp. 856-860
    • Dubinsky, R.M.1    Yarchoan, R.2    Dalakas, M.3
  • 149
    • 0027469393 scopus 로고
    • Zalcitabine and didanosine
    • PID: 8093278, COI: 1:STN:280:DyaK3s7gvV2rsA%3D%3D
    • Lipsky JJ. Zalcitabine and didanosine. Lancet 1993 Jan 2; 341: 30–2
    • (1993) Lancet , vol.341 , pp. 30-32
    • Lipsky, J.J.1
  • 150
    • 0025342533 scopus 로고
    • Ototoxicity associated with dideoxycytidine [letter]
    • PID: 1970411, COI: 1:STN:280:DyaK3c3jtV2rsQ%3D%3D
    • Powderly WG, Klebert MK, Clifford DB. Ototoxicity associated with dideoxycytidine [letter]. Lancet 1990 May 5; 335: 1106
    • (1990) Lancet , vol.335 , pp. 1106
    • Powderly, W.G.1    Klebert, M.K.2    Clifford, D.B.3
  • 151
    • 0027250832 scopus 로고
    • Acoustic neuropathy associated with zalcitabine-induced peripheral neuropathy
    • PID: 8395858, COI: 1:STN:280:DyaK3szntFOhuw%3D%3D
    • Martinez OP, French MAH. Acoustic neuropathy associated with zalcitabine-induced peripheral neuropathy. AIDS 1993 Jun; 7: 901–2
    • (1993) AIDS , vol.7 , pp. 901-902
    • Martinez, O.P.1    French, M.A.H.2
  • 152
    • 85083253774 scopus 로고
    • Acute paralysis of the serratus muscle in an HIV positive patient treated by DDC [abstract]
    • Faller JP, Ziegler F, Balblanc JC, et al. Acute paralysis of the serratus muscle in an HIV positive patient treated by DDC [abstract]. 10th International Conference on AIDS 1994; 1: 191
    • (1994) 10th International Conference on AIDS , vol.1 , pp. 191
    • Faller, J.P.1    Ziegler, F.2    Balblanc, J.C.3
  • 153
    • 0028363423 scopus 로고
    • The drugs 2′,3′-dideoxyinosine (ddI) and 2′,3′-dideoxycytidine (ddC) are safe alternatives in people with AIDS with zidovudine-induced myopathy
    • PID: 8176648, COI: 1:STN:280:DyaK2c3jtFCksA%3D%3D
    • Jay C, Ropka M, Dalakas MC. The drugs 2′,3′-dideoxyinosine (ddI) and 2′,3′-dideoxycytidine (ddC) are safe alternatives in people with AIDS with zidovudine-induced myopathy. J Acquir Immune Defic Syndr 1994 Jun; 7: 630–1
    • (1994) J Acquir Immune Defic Syndr , vol.7 , pp. 630-631
    • Jay, C.1    Ropka, M.2    Dalakas, M.C.3
  • 156
    • 0026753937 scopus 로고
    • Esophageal ulceration related to zalcitabine (ddC)
    • PID: 1318649, COI: 1:STN:280:DyaK383ps1ChtA%3D%3D
    • Indorf AS, Pegram PS. Esophageal ulceration related to zalcitabine (ddC). Ann Intern Med 1992 Jul 15; 117: 133–4
    • (1992) Ann Intern Med , vol.117 , pp. 133-134
    • Indorf, A.S.1    Pegram, P.S.2
  • 157
    • 0024535081 scopus 로고
    • Circulating p24 antigen levels and responses to dideoxycytidine in human immunodeficiency virus (HIV) infections. A phase I and II study
    • PID: 2536257, COI: 1:STN:280:DyaL1M7gsVWhsg%3D%3D
    • Merigan TC, Skowron G, Bozzette SA, et al. Circulating p24 antigen levels and responses to dideoxycytidine in human immunodeficiency virus (HIV) infections. A phase I and II study. Ann Intern Med 1989 Feb 1; 110: 189–94
    • (1989) Ann Intern Med , vol.110 , pp. 189-194
    • Merigan, T.C.1    Skowron, G.2    Bozzette, S.A.3
  • 158
    • 0024950232 scopus 로고
    • Dermatologic complications associated with administration of 2′,3′-dideoxy-cytidine in patients with human immunodeficiency virus infection
    • PID: 2555402, COI: 1:STN:280:DyaK3c%2Fmt1KnsQ%3D%3D
    • McNeely MC, Yarchoan R, Broder S, et al. Dermatologic complications associated with administration of 2′,3′-dideoxy-cytidine in patients with human immunodeficiency virus infection. J Am Acad Dermatol 1989 Dec; 21: 1213–7
    • (1989) J Am Acad Dermatol , vol.21 , pp. 1213-1217
    • McNeely, M.C.1    Yarchoan, R.2    Broder, S.3
  • 159
    • 0029561442 scopus 로고
    • Erythema multiforme secondary to dideoxycytidine (DDC)
    • PID: 8845407, COI: 1:STN:280:DyaK283ls1Smsw%3D%3D
    • Wardropper AG, Ong ELC. Erythema multiforme secondary to dideoxycytidine (DDC). Int J STD AIDS 1995 Nov–Dec; 6: 450
    • (1995) Int J STD AIDS , vol.6 , pp. 450
    • Wardropper, A.G.1    Ong, E.L.C.2
  • 160
    • 13344277339 scopus 로고    scopus 로고
    • Hypersensitivity syndrome associated with zalcitabine therapy
    • Tancrede-Bohlin E, Grange F, Bournerias I. Hypersensitivity syndrome associated with zalcitabine therapy. Lancet 1996 Apr 6; 347: 971
    • (1996) Lancet , vol.347 , pp. 971
    • Tancrede-Bohlin, E.1    Grange, F.2    Bournerias, I.3
  • 161
    • 0030009401 scopus 로고    scopus 로고
    • Hepatotoxicity and rash associated with zidovudine and zalcitabine chemoprophylaxis
    • PID: 8610958, COI: 1:STN:280:DyaK283gvVCiug%3D%3D
    • Henry K, Acosta EP. Hepatotoxicity and rash associated with zidovudine and zalcitabine chemoprophylaxis. Ann Intern Med 1996 May 1; 124: 855
    • (1996) Ann Intern Med , vol.124 , pp. 855
    • Henry, K.1    Acosta, E.P.2
  • 163
    • 0027426016 scopus 로고
    • Pancreatitis possibly related to 2′-3′-dideoxycytidine
    • PID: 8395145, COI: 1:STN:280:DyaK3szmt1ygsA%3D%3D
    • Aponte-Cipriani SL, Teplitz C, Yancovitz S. Pancreatitis possibly related to 2′-3′-dideoxycytidine. Ann Intern Med 1993 Sep 15; 119: 539–40
    • (1993) Ann Intern Med , vol.119 , pp. 539-540
    • Aponte-Cipriani, S.L.1    Teplitz, C.2    Yancovitz, S.3
  • 164
    • 0030447929 scopus 로고    scopus 로고
    • Occurrence of lymphomas during ddC or ddC/ zidovudine combination therapy in persons infected with HIV type I [letter]
    • COI: 1:CAS:528:DyaK2sXktVOqtw%3D%3D
    • Moyle GJ. Occurrence of lymphomas during ddC or ddC/ zidovudine combination therapy in persons infected with HIV type I [letter]. J Acquir Immune Defic Syndrom Hum Retrovirol 1996; 13(5): 464–5
    • (1996) J Acquir Immune Defic Syndrom Hum Retrovirol , vol.13 , Issue.5 , pp. 464-465
    • Moyle, G.J.1
  • 166
    • 0028937855 scopus 로고
    • Antiretroviral drug interactions
    • PID: 18611653, COI: 1:CAS:528:DyaK2MXls1SqsbY%3D
    • Acosta EP, Fletcher CV. Antiretroviral drug interactions. Int J Antimicrob Agents 1995 Apr; 5: 73–83
    • (1995) Int J Antimicrob Agents , vol.5 , pp. 73-83
    • Acosta, E.P.1    Fletcher, C.V.2
  • 167
    • 0029974261 scopus 로고    scopus 로고
    • Drug interactions with antiviral drugs
    • PID: 8743337, COI: 1:CAS:528:DyaK28XjvVegt7o%3D
    • Taburet A-M, Singlas E. Drug interactions with antiviral drugs. Clin Pharmacokinet 1996 May; 30: 385–401
    • (1996) Clin Pharmacokinet , vol.30 , pp. 385-401
    • Taburet, A.-M.1    Singlas, E.2
  • 168
    • 3042735224 scopus 로고
    • Interactions with antiretroviral drugs
    • Heylen R, Miller R. Interactions with antiretroviral drugs. Pharm J 1993 Feb 13; 250: 214–6
    • (1993) Pharm J , vol.250 , pp. 214-216
    • Heylen, R.1    Miller, R.2
  • 169
    • 85035164851 scopus 로고
    • (Rm) on the pharmacokinetics of zalcitabine in HIV-positive patients [abstract]
    • Oct
    • (Rm) on the pharmacokinetics of zalcitabine in HIV-positive patients [abstract]. Pharm Res 1994 Oct; 11 Suppl.: S-415
    • (1994) Pharm Res , Issue.11 , pp. 415
    • Massarella, J.W.1    Holazo, A.A.2    Koss-Twardy, S.3
  • 170
    • 0029923717 scopus 로고    scopus 로고
    • The effect of probenecid on the pharmacokinetics of zalcitabine in HIV-positive patients
    • PID: 8692740, COI: 1:CAS:528:DyaK28XhvVOiu7k%3D
    • Massarella JW, Nazareno LA, Passe S, et al. The effect of probenecid on the pharmacokinetics of zalcitabine in HIV-positive patients. Pharm Res 1996 Mar; 13: 449–52
    • (1996) Pharm Res , vol.13 , pp. 449-452
    • Massarella, J.W.1    Nazareno, L.A.2    Passe, S.3
  • 171
    • 0013584264 scopus 로고
    • The effect of trimethoprim on the pharmacokinetics of zalcitabine in HIV-infected patients [abstract]
    • Lee BL, Tauber MG, Chambers HF, et al. The effect of trimethoprim on the pharmacokinetics of zalcitabine in HIV-infected patients [abstract]. 35th Int Conf Antimicro Ag Chemother 1995 Sep 17: 6
    • (1995) 35th Int Conf Antimicro Ag Chemother , vol.17 , pp. 6
    • Lee, B.L.1    Tauber, M.G.2    Chambers, H.F.3
  • 172
    • 0025875109 scopus 로고
    • Exacerbation of dideoxycytidine-induced neuropathy with dideoxyinosine
    • PID: 1849990, COI: 1:STN:280:DyaK3M3gt1ektg%3D%3D
    • LeLacheur SF, Simon GL. Exacerbation of dideoxycytidine-induced neuropathy with dideoxyinosine. J Acquir Immune Defic Syndr 1991; 4: 538–9
    • (1991) J Acquir Immune Defic Syndr , vol.4 , pp. 538-539
    • LeLacheur, S.F.1    Simon, G.L.2
  • 173
    • 0026564682 scopus 로고
    • Cardiomyopathy associated with antiretroviral therapy in patients with HIV infection: a report of six cases
    • PID: 1733387, COI: 1:STN:280:DyaK387isFKqtw%3D%3D
    • Herskowitz A, Willoughby SB, Baughman KL, et al. Cardiomyopathy associated with antiretroviral therapy in patients with HIV infection: a report of six cases. Ann Intern Med 1992 Feb 15; 116: 311–3
    • (1992) Ann Intern Med , vol.116 , pp. 311-313
    • Herskowitz, A.1    Willoughby, S.B.2    Baughman, K.L.3
  • 174
    • 0008959157 scopus 로고
    • Steady state pharmacokinetics of nevirapine, didanosine, zalcitabine, and zidovudine combination therapy in HIV-1 positive patients [abstract]
    • Sep
    • MacGregor TR, Lamson MJ, Cort S, et al. Steady state pharmacokinetics of nevirapine, didanosine, zalcitabine, and zidovudine combination therapy in HIV-1 positive patients [abstract]. Pharm Res 1995 Sep; 12 Suppl.: S101
    • (1995) Pharm Res
    • Macgregor, T.R.1    Lamson, M.J.2    Cort, S.3
  • 175
    • 8944240799 scopus 로고
    • Zalcitabine and dapsone pharmacokinetic interaction in HIV-infected patients [abstract]
    • Lee BL, Tauber MG, Chambers HF, et al. Zalcitabine and dapsone pharmacokinetic interaction in HIV-infected patients [abstract]. Clin Pharmacol Ther 1995 Feb; 57: 186
    • (1995) Clin Pharmacol Ther , vol.57 , pp. 186
    • Lee, B.L.1    Tauber, M.G.2    Chambers, H.F.3
  • 176
    • 0004975279 scopus 로고
    • The effect of zalcitabine on the pharmacokinetics of isoniazid in HIV-infected patients [abstract no. A4]
    • Lee BL, Täuber MG, Chambers HF, et al. The effect of zalcitabine on the pharmacokinetics of isoniazid in HIV-infected patients [abstract no. A4]. 34th Int Conf Antimicro Ag Chemother 1994: 3
    • (1994) 34Th Int Conf Antimicro Ag Chemother , pp. 3
    • Lee, B.L.1    Täuber, M.G.2    Chambers, H.F.3
  • 178
    • 0345334246 scopus 로고    scopus 로고
    • Antiretroviral therapy for HIV infection in 1996: recommendations of an international panel
    • PID: 8656507, COI: 1:STN:280:DyaK283nt12mtw%3D%3D
    • Carpenter CCJ, Fischl MA, Hammer SM, et al. Antiretroviral therapy for HIV infection in 1996: recommendations of an international panel. JAMA 1996 Jul 10; 276: 146–54
    • (1996) JAMA , vol.276 , pp. 146-154
    • Carpenter, C.C.J.1    Fischl, M.A.2    Hammer, S.M.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.