-
1
-
-
0028854897
-
Phase I and pharmacologic studies of the camptothecin analog irinotecan administered every three weeks in cancer patients
-
Abigerges D, Chabot GG, Armand J, Herait P, Gouyette A, Gandia D (1995) Phase I and pharmacologic studies of the camptothecin analog irinotecan administered every three weeks in cancer patients. J Clin Oncol 13: 210
-
(1995)
J Clin Oncol
, vol.13
, pp. 210
-
-
Abigerges, D.1
Chabot, G.G.2
Armand, J.3
Herait, P.4
Gouyette, A.5
Gandia, D.6
-
2
-
-
0028029604
-
Kinetic studies of the hydrolysis and lactonization of camptothecin and its derivatives, CPT-11 and SN-38, in aqueous solution
-
Akimoto K, Kawai A, Ohya K (1994) Kinetic studies of the hydrolysis and lactonization of camptothecin and its derivatives, CPT-11 and SN-38, in aqueous solution. Chem Pharm Bull 42: 2135
-
(1994)
Chem Pharm Bull
, vol.42
, pp. 2135
-
-
Akimoto, K.1
Kawai, A.2
Ohya, K.3
-
3
-
-
0025858296
-
Identification of the metabolites of irinotecan, a new derivative of camptothecin, in rat bile and its biliary excretion
-
Atsumi R, Suzuki W, Hakusui H (1991) Identification of the metabolites of irinotecan, a new derivative of camptothecin, in rat bile and its biliary excretion. Xenobiotica 21: 1159
-
(1991)
Xenobiotica
, vol.21
, pp. 1159
-
-
Atsumi, R.1
Suzuki, W.2
Hakusui, H.3
-
4
-
-
0028937909
-
The important role of albumin in determining the relative human blood stabilities of the camptothecin anticancer drugs
-
Burke TG, Munshi CB, Mi Z, Jiang Y (1995) The important role of albumin in determining the relative human blood stabilities of the camptothecin anticancer drugs. J Pharm Sci 84: 518
-
(1995)
J Pharm Sci
, vol.84
, pp. 518
-
-
Burke, T.G.1
Munshi, C.B.2
Mi, Z.3
Jiang, Y.4
-
5
-
-
1842393469
-
Tumor influence on pharmacokinetics of the camptothecin analogue irinotecan (CPT-11) and active metabolite SN-38 in mice
-
Chabot GG, Gouyette A, Bissery MC (1994) Tumor influence on pharmacokinetics of the camptothecin analogue irinotecan (CPT-11) and active metabolite SN-38 in mice. Proc Am Assoc Cancer Res 35: 432
-
(1994)
Proc Am Assoc Cancer Res
, vol.35
, pp. 432
-
-
Chabot, G.G.1
Gouyette, A.2
Bissery, M.C.3
-
6
-
-
0027972726
-
New drugs: Topoisomerase I inhibitors: Topotecan and ir[e]notecan
-
Creemers GJ, Lund B, Verweij J (1994) New drugs: topoisomerase I inhibitors: topotecan and ir[e]notecan. Cancer Treat Rev 20: 73
-
(1994)
Cancer Treat Rev
, vol.20
, pp. 73
-
-
Creemers, G.J.1
Lund, B.2
Verweij, J.3
-
7
-
-
84986505863
-
The camptothecins: A reborn family of antitumor agents
-
Curran DP (1993) The camptothecins: a reborn family of antitumor agents. J Chinese Chem Soc 40: 1
-
(1993)
J Chinese Chem Soc
, vol.40
, pp. 1
-
-
Curran, D.P.1
-
9
-
-
0016052023
-
Lethal activity of camptothecin sodium on human lymphoma cells
-
Drewinko B, Freireich EJ, Gottlieb JA (1974) Lethal activity of camptothecin sodium on human lymphoma cells. Cancer Res 34: 747
-
(1974)
Cancer Res
, vol.34
, pp. 747
-
-
Drewinko, B.1
Freireich, E.J.2
Gottlieb, J.A.3
-
11
-
-
0025912553
-
Complete growth inhibition of human cancer xenografts in nude mice by treatment with 20-(S)-camptothecin
-
Giovanella BC, Hinz HR, Kozielski AJ, Stehlin JS, Silber R, Potmesil M (1991) Complete growth inhibition of human cancer xenografts in nude mice by treatment with 20-(S)-camptothecin. Cancer Res 51: 3052
-
(1991)
Cancer Res
, vol.51
, pp. 3052
-
-
Giovanella, B.C.1
Hinz, H.R.2
Kozielski, A.J.3
Stehlin, J.S.4
Silber, R.5
Potmesil, M.6
-
12
-
-
0028022585
-
Metabolic fate of irinotecan in humans: Correlation of glucuronidation with diarrhea
-
Gupta E, Lestingi TM, Mick R, Ramirez J, Vokes EE, Ratain MJ (1994) Metabolic fate of irinotecan in humans: correlation of glucuronidation with diarrhea. Cancer Res 54: 3723
-
(1994)
Cancer Res
, vol.54
, pp. 3723
-
-
Gupta, E.1
Lestingi, T.M.2
Mick, R.3
Ramirez, J.4
Vokes, E.E.5
Ratain, M.J.6
-
13
-
-
0024537205
-
Modification of the hydroxy lactone ring of camptothecin: Inhibition of mammalian topoisomerase I and biological activity
-
Hertzberg RP, Caranfa MJ, Holdern KG, Jakas DR, Gallagher G, Mattern MG (1989) Modification of the hydroxy lactone ring of camptothecin: inhibition of mammalian topoisomerase I and biological activity. J Med Chem 32: 715
-
(1989)
J Med Chem
, vol.32
, pp. 715
-
-
Hertzberg, R.P.1
Caranfa, M.J.2
Holdern, K.G.3
Jakas, D.R.4
Gallagher, G.5
Mattern, M.G.6
-
14
-
-
0024306526
-
Evaluation of N-(5-indanylsulfonyl)-N′-(4-chlorophenyl) urea against xenografts of pediatric rhabdomyosarcoma
-
Houghton PJ, Houghton JA, Myers L, Cheshire PJ, Howbert JJ, Grindey GB (1989) Evaluation of N-(5-indanylsulfonyl)-N′-(4-chlorophenyl) urea against xenografts of pediatric rhabdomyosarcoma. Cancer Chemother Pharmacol 25: 84
-
(1989)
Cancer Chemother Pharmacol
, vol.25
, pp. 84
-
-
Houghton, P.J.1
Houghton, J.A.2
Myers, L.3
Cheshire, P.J.4
Howbert, J.J.5
Grindey, G.B.6
-
15
-
-
0026487210
-
Evaluation of 9-dimethylaminomethyl-10-hydroxycamptothecin against xenografts derived from adult and childhood solid tumors
-
Houghton PJ, Chesire PJ, Myers L, Stewart CF, Synold TW, Houghton JA (1992) Evaluation of 9-dimethylaminomethyl-10-hydroxycamptothecin against xenografts derived from adult and childhood solid tumors. Cancer Chemother Pharmacol 31: 229
-
(1992)
Cancer Chemother Pharmacol
, vol.31
, pp. 229
-
-
Houghton, P.J.1
Chesire, P.J.2
Myers, L.3
Stewart, C.F.4
Synold, T.W.5
Houghton, J.A.6
-
16
-
-
0027324850
-
Therapeutic efficacy of the topoisomerase I inhibitor 7-ethyl-10(4-[1-piperidino]-1-piperidino)-carbonyloxy-camptothecin against human tumor xenografts: Lack of cross-resistance in vivo in tumors with acquired resistance to the topoisomerase I inhibitor 9-dimethylaminomethyl-10-hydroxycamptothecin
-
Houghton PJ, Cheshire PJ, Mallman JC, Bissery MC, Mathieu-Boue A, Houghton JA (1993) Therapeutic efficacy of the topoisomerase I inhibitor 7-ethyl-10(4-[1-piperidino]-1-piperidino)-carbonyloxy-camptothecin against human tumor xenografts: lack of cross-resistance in vivo in tumors with acquired resistance to the topoisomerase I inhibitor 9-dimethylaminomethyl-10-hydroxycamptothecin. Cancer Res 53: 2823
-
(1993)
Cancer Res
, vol.53
, pp. 2823
-
-
Houghton, P.J.1
Cheshire, P.J.2
Mallman, J.C.3
Bissery, M.C.4
Mathieu-Boue, A.5
Houghton, J.A.6
-
17
-
-
0024560495
-
Structure-activity study of the actions of camptothecin derivatives on mammalian topoisomerase I: Evidence for a specific receptor site and relations to antitumor activity
-
Jaxel C, Kohn KW, Wani MC, Wall ME, Pommier Y (1989) Structure-activity study of the actions of camptothecin derivatives on mammalian topoisomerase I: evidence for a specific receptor site and relations to antitumor activity. Cancer Res 49: 1465
-
(1989)
Cancer Res
, vol.49
, pp. 1465
-
-
Jaxel, C.1
Kohn, K.W.2
Wani, M.C.3
Wall, M.E.4
Pommier, Y.5
-
18
-
-
0025342506
-
Nonlinear pharmacokinetics of CPT-11 in rats
-
Kaneda N, Yokokura T (1990) Nonlinear pharmacokinetics of CPT-11 in rats. Cancer Res 50: 1721
-
(1990)
Cancer Res
, vol.50
, pp. 1721
-
-
Kaneda, N.1
Yokokura, T.2
-
19
-
-
0025272187
-
Metabolism and pharmacokinetics of the camptothecin analogue CPT-11 in the mouse
-
Kaneda N, Nagata H, Furuta T, Yokokura T (1990) Metabolism and pharmacokinetics of the camptothecin analogue CPT-11 in the mouse. Cancer Res 50: 1715
-
(1990)
Cancer Res
, vol.50
, pp. 1715
-
-
Kaneda, N.1
Nagata, H.2
Furuta, T.3
Yokokura, T.4
-
20
-
-
0023552964
-
Antitumor activity of 7-ethyl-10-[4-(1-piperidino)-1-piperidino] carbonyloxycamptothecin, a novel water-soluble derivative of camptothecin, against murine tumors
-
Kunimoto T, Nitta K, Tanka T, Uehara N, Baba H, Takeuchi M, Yokokura T, Sawada S, Miyasaka T, Mutai M (1987) Antitumor activity of 7-ethyl-10-[4-(1-piperidino)-1-piperidino] carbonyloxycamptothecin, a novel water-soluble derivative of camptothecin, against murine tumors. Cancer Res 47: 5944
-
(1987)
Cancer Res
, vol.47
, pp. 5944
-
-
Kunimoto, T.1
Nitta, K.2
Tanka, T.3
Uehara, N.4
Baba, H.5
Takeuchi, M.6
Yokokura, T.7
Sawada, S.8
Miyasaka, T.9
Mutai, M.10
-
21
-
-
0028225686
-
Comparative activity of oral and parenteral topotecan in murine tumor models: Efficacy of oral topotecan
-
McCabe FL, Johnson RL (1994) Comparative activity of oral and parenteral topotecan in murine tumor models: efficacy of oral topotecan. Cancer Invest 12: 308
-
(1994)
Cancer Invest
, vol.12
, pp. 308
-
-
McCabe, F.L.1
Johnson, R.L.2
-
22
-
-
0027937924
-
Reversed-phase high-performance liquid Chromatographic method for the simultaneous quantification of the carboxylate and lactone forms of the camptothecin derivative irinotecan, CPT-11, and its metabolite SN-38 in plasma
-
Rivory LP, Robert J (1994) Reversed-phase high-performance liquid Chromatographic method for the simultaneous quantification of the carboxylate and lactone forms of the camptothecin derivative irinotecan, CPT-11, and its metabolite SN-38 in plasma. J Chromatogr B Biomed Appl 661: 133
-
(1994)
J Chromatogr B Biomed Appl
, vol.661
, pp. 133
-
-
Rivory, L.P.1
Robert, J.2
-
23
-
-
0028670840
-
Kinetics of the in vivo interconversion of the carboxylate and lactone forms of irinotecan (CPT-11) and of its metabolite SN-38 in patients
-
Rivory LP, Chatelut E, Canal P, Mathieu-Boue A, Robert J (1994) Kinetics of the in vivo interconversion of the carboxylate and lactone forms of irinotecan (CPT-11) and of its metabolite SN-38 in patients. Cancer Res 54: 6330
-
(1994)
Cancer Res
, vol.54
, pp. 6330
-
-
Rivory, L.P.1
Chatelut, E.2
Canal, P.3
Mathieu-Boue, A.4
Robert, J.5
-
24
-
-
0028158012
-
Phase I and pharmacological study of the novel topoisomerase I inhibitor 7-ethyl-10-[4-1-(1-piperidino)-1-piperdino]carbonyloxycamptothecin (CPT-11) administered as a ninety-minute infusion every 3 weeks
-
Rowinsky EK, Grochow LB, Ettinger DS, Sartorius SE, Lubejko BG, Chen T (1994) Phase I and pharmacological study of the novel topoisomerase I inhibitor 7-ethyl-10-[4-1-(1-piperidino)-1-piperdino]carbonyloxycamptothecin (CPT-11) administered as a ninety-minute infusion every 3 weeks. Cancer Res 54: 427
-
(1994)
Cancer Res
, vol.54
, pp. 427
-
-
Rowinsky, E.K.1
Grochow, L.B.2
Ettinger, D.S.3
Sartorius, S.E.4
Lubejko, B.G.5
Chen, T.6
-
25
-
-
0028813952
-
A pharmacokinetic and pharmacodynamic analysis of CPT-11 and its active metabolite, SN-38
-
Sasaki Y, Hakusui Y, Mizuno S, Morita M, Miya T, Eguchi K (1995) A pharmacokinetic and pharmacodynamic analysis of CPT-11 and its active metabolite, SN-38. Jpn J Cancer Res 86: 101
-
(1995)
Jpn J Cancer Res
, vol.86
, pp. 101
-
-
Sasaki, Y.1
Hakusui, Y.2
Mizuno, S.3
Morita, M.4
Miya, T.5
Eguchi, K.6
-
26
-
-
0028843263
-
Pharmacological correlation between total drug concentration and lactones of CPT-11 and SN-38 in patients treated with CPT-11
-
Sasaki Y, Yoshida Y, Sudoh K, Hakusui H, Fuji H, Ohtsu T (1995) Pharmacological correlation between total drug concentration and lactones of CPT-11 and SN-38 in patients treated with CPT-11. Jpn J Cancer Res 86: 111
-
(1995)
Jpn J Cancer Res
, vol.86
, pp. 111
-
-
Sasaki, Y.1
Yoshida, Y.2
Sudoh, K.3
Hakusui, H.4
Fuji, H.5
Ohtsu, T.6
-
28
-
-
0028225471
-
Comparison of topoisomerase I inhibition, DNA damage, and cytotoxicity of camptothecin derivatives presently in clinical trials
-
Tanizawa A, Fujimori A, Fujimori Y, Pommier Y (1994) Comparison of topoisomerase I inhibition, DNA damage, and cytotoxicity of camptothecin derivatives presently in clinical trials. J Natl Cancer Inst 86: 836
-
(1994)
J Natl Cancer Inst
, vol.86
, pp. 836
-
-
Tanizawa, A.1
Fujimori, A.2
Fujimori, Y.3
Pommier, Y.4
-
29
-
-
0030974770
-
Efficacy of oral irinotecan against neuroblastoma xenografts
-
in press
-
28a. Thompson J, Zamboni WC, Cheshire PJ, Richmond L, Luo X, Houghton JA, Stewart CF, Houthton PJ (1997) Efficacy of oral irinotecan against neuroblastoma xenografts. Anti-Cancer Drugs (in press)
-
(1997)
Anti-Cancer Drugs
-
-
Thompson, J.1
Zamboni, W.C.2
Cheshire, P.J.3
Richmond, L.4
Luo, X.5
Houghton, J.A.6
Stewart, C.F.7
Houthton, P.J.8
-
30
-
-
0025827281
-
CPT-11 converting enzyme from rat serum: Purification and some properties
-
Tsuji T, Kaneda N, Kado K, Yokokura T, Yoshimoto T, Tsuru D (1991) CPT-11 converting enzyme from rat serum: purification and some properties. J Pharmacobiol Dynamics 14: 341
-
(1991)
J Pharmacobiol Dynamics
, vol.14
, pp. 341
-
-
Tsuji, T.1
Kaneda, N.2
Kado, K.3
Yokokura, T.4
Yoshimoto, T.5
Tsuru, D.6
-
31
-
-
0343029631
-
Chemistry and antitumor activity of camptothecins
-
Potmesil M, Kohn KW (eds) Oxford University Press, New York
-
Wall ME, Wani MC (1991) Chemistry and antitumor activity of camptothecins. In: Potmesil M, Kohn KW (eds) DNA topoisomerases in cancer. Oxford University Press, New York, p 93
-
(1991)
DNA Topoisomerases in Cancer
, pp. 93
-
-
Wall, M.E.1
Wani, M.C.2
|