A 4-week and a 26-week repeated oral toxicity studies of betotastine besilate in rats

Pharmacometrics

Volumn 53, Issue 4-5, 1997, Pages 299-318

  Koguchi, Atsushi ^a   Kawai, Yoshiaki ^a   Suetake, Kazumi ^b   Ohta, Hiroshi ^b   Hamamura, Masao ^b  

^a MITSUBISHI TANABE PHARMA CORPORATION   (Japan)

^b Panapharm Laboratories Co Ltd   (Japan)

Author keywords

(rats, po); Betotastine besilate; Toxicity study

Indexed keywords

ANTIALLERGIC AGENT; BETOTASTINE; LIVER ENZYME; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; DRUG STRUCTURE; ENZYME ACTIVITY; FEMALE; HYPERPLASIA; LIVER HYPERTROPHY; MALE; MYDRIASIS; NONHUMAN; ORAL DRUG ADMINISTRATION; RAT; TOXICITY TESTING; URINE PH; WEIGHT REDUCTION;

EID: 0030917639     PISSN: 03008533     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (6)

1. de Groot, A.P., Feron, V.J. and Immel, H.R. (1988): Induction of hyperplasia in the bladder epithelium of rats by a dietary excess of acid or base: implications for toxicity/ carcinogenicity testing, Fd. Chem. Toxic., 26(5), 425-434.
2. Glaister, J. (1986): Liver hypertrophy, Target-organ pathology; in "Principles of toxicological pathology" pp. 83-85, Taylar & Francis, London and Philadelphia.
3. Peter, C., Burger, A.B., Peter, B. and Herdson, H.B. (1966): Phenobarbital induced fine structual change in rat liver, Am. J. Path., 793-809.